The Ligandable Human Proteome

• Protein domains are ranked based on their recurrence in human proteins (column #4)
• Clinical Coverage: number of approved drugs in the PDB (column #5), and number of targets in clinical trials (column #6)
• Cancer Association: numbers of genes essential in 3 or more cancer types according to the Broad (column #7) and Sanger (column #8) cancer dependency maps.
• Ligandability: the median desolvation of ligands co-crystallized with these domains (column #9) and, when available, their median affinity (column #10), are indicative of the domain's ligandability
• Chemistry: to view 2D structures of ligands, click numbers under "Druglike ligands in PDB" (column #11)
• Binding pockets: to interactively view 3D structures of binding pockets, click numbers under "Structures with bound ligand in the PDB" (column #12), and click a PDB code
• Chemical coverage: "Proteins with bound ligands in the PDB" (column #13) is indicative of the chemical coverage of this domain
• Structural coverage: "Proteins with structures in the PDB with or without ligand" (column #14) is indicative of the structural coverage of this domain

(This resource was generated by Jiayan Wang, Setayesh Yazdani, and Ana Han in Matthieu Schapira's group. Questions/Requests: matthieu.schapira@utoronto.ca)

Index	Domain ID	Domain Name	Proteins in the Human Genome Number of human proteins containing the specified domain (based on Uniprot annotations)	Proteins Bound to Approved Drugs in the PDB List of proteins with a structure in complex with an approved drug (from the DrugBank database) in the PDB.	Targets in Clinical Trials Number of targets in clinical trials based on the Therapeutic Target Database.	Essential Genes from Broad Institute CDM Number of genes that have a median essentiality score of less than -1 in three or more cancer types, based on CRISPR KO data from the Broad Institute Cancer Dependency Mapping (cancer types represented by less than three cell lines are ignored)	Essential Genes from Sanger Institute CDM Number of genes that have a median essentiality score of less than -1 in three or more cancer types, based on CRISPR KO data from the Wellcome Sanger Institute (cancer types represented by less than three cell lines are ignored)	Median ligand desolvation (%) For each 3D structure of a drug-like ligand bound to the specified domain of a human protein, the % of the ligand surface that becomes shielded from solvent upon binding is calculated. If multiple structures are available for a given protein, the highest value is retained. The percentages shown in this column are the median values across all proteins for the specified domain. The higher the number, the more desolvated the compound, the more enclosed - and presumably ligandable - the pocket. This value is less reliable when it is derived from few proteins (column "Proteins with bound ligand in the PDB") > 80%: ligandable. < 70% not ligandable	Median affinity (nM) For each 3D structure of a drug-like ligand bound to the specified domain of a human protein, the affinity of the ligand for the protein domain is extracted from the PDBbind database (http://www.pdbbind.org.cn/). If multiple structures are available for a given protein, the lowest value (i.e. highest affinity) is retained. The values shown in this column are the median values across all proteins for the specified domain. The lower the number, the more ligandable the pocket. This value is less reliable when it is derived from few proteins (column "Proteins with ligand affinity data")	Druglike ligands in PDB Number of drug-like ligands for which a 3D structure is solved in complex with the specified domain of a human protein	Structures with bound ligand in the PDB Number of solved 3D structures of human proteins where the specified domain is in complex with a drug-like ligand	Proteins with bound ligand in the PDB Number of human proteins for which the 3D structure of the specified domain was solved in complex with a drug-like ligand	Proteins with structures in the PDB with or without ligand Number of human proteins where the 3D structure of the specified domain was solved	Structures with affinity data Structures with ligand affinity data from PDBbind database (http://www.pdbbind.org.cn/).
1	IPR000276	G protein-coupled receptor, rhodopsin-like	710	22	57	1	0	95.41	2.	67	98	37	39	12
2	IPR000719	Protein kinase domain	482	52	95	14	20	90.16	4.55	2091	2536	195	268	138
3	IPR001680	WD40 repeat	266	0	1	54	64	77.1	47.8	31	33	4	53	2
4	IPR001611	Leucine-rich repeat	261	0	16	6	6	57.29	no data	2	2	1	31	0
5	IPR002048	EF-hand domain	228	1	6	1	1	85	18.	3	7	1	54	1
6	IPR000210	BTB/POZ domain	178	0	1	1	3	65.89	3.	7	7	2	29	1
7	IPR001478	PDZ domain	152	0	2	0	0	65.16	no data	1	1	1	52	0
8	IPR001806	Small GTPase	137	0	3	2	5	86.26	340000.	33	35	2	73	1
9	IPR001254	Serine proteases, trypsin domain	121	1	14	0	0	86.15	2.7	427	449	18	53	16
10	IPR000980	SH2 domain	109	0	11	2	4	60.55	120.	3	3	1	43	1
11	IPR001650	Helicase, C-terminal	108	0	3	22	32	63.23	5300.	1	1	1	23	1
12	IPR005821	Ion transport domain	106	1	14	0	1	92.82	no data	3	3	1	2	0
13	IPR011161	MHC class I-like antigen recognition-like	92	0	0	0	0	97.08	no data	1	3	1	17	0
14	IPR001304	C-type lectin-like	86	0	10	0	0	44.04	no data	1	1	1	35	0
15	IPR002035	von Willebrand factor, type A	76	0	3	4	5	61.76	2.5	7	7	2	13	1
16	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	74	1	0	2	6	81.59	65.	15	15	3	17	1
17	IPR006652	Kelch repeat type 1	61	0	0	0	1	81.38	1.3	13	14	1	9	1
18	IPR001791	Laminin G domain	61	1	2	0	0	100	0.182	4	7	1	7	1
19	IPR001128	Cytochrome P450	60	16	8	0	0	98.29	no data	65	80	18	24	0
20	IPR002347	Short-chain dehydrogenase/reductase SDR	55	0	4	0	0	89.09	no data	8	8	2	22	0
21	IPR001214	SET domain	51	0	2	1	1	81.08	27.5	21	27	8	29	3
22	IPR000832	GPCR, family 2, secretin-like	49	0	8	0	0	98.36	6.7	1	1	1	2	1
23	IPR000536	Nuclear hormone receptor, ligand-binding domain	48	19	6	0	0	99.74	1.	515	686	25	36	21
24	IPR001752	Kinesin motor domain	45	0	1	3	5	90.93	1.6	25	29	1	15	1
25	IPR000225	Armadillo	42	0	0	2	2	66.11	900000.	3	3	1	15	1
26	IPR001487	Bromodomain	41	2	5	1	2	77.3	42.7	297	365	22	34	15
27	IPR001590	Peptidase M12B, ADAM/reprolysin	40	0	3	0	0	79.91	5.	8	8	3	9	3
28	IPR000608	Ubiquitin-conjugating enzyme E2	40	0	1	4	7	77.22	1720.	1	1	1	32	1
29	IPR001609	Myosin head, motor domain	39	0	1	0	0	88.74	290.	1	2	1	5	1
30	IPR000242	PTP type protein phosphatase	38	0	4	1	2	89.58	166.	66	81	5	30	4
31	IPR023796	Serpin domain	38	1	4	0	0	89.79	290.	2	3	2	21	1
32	IPR005828	Major facilitator, sugar transporter-like	36	0	1	0	0	66.16	no data	2	2	2	2	0
33	IPR001828	Receptor, ligand binding region	36	0	5	0	0	95.69	80.65	5	6	4	13	2
34	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	34	6	0	0	0	94.66	29.	35	109	11	24	9
35	IPR018499	Tetraspanin/Peripherin	33	1	1	0	0	62.35	no data	1	1	1	1	0
36	IPR000863	Sulfotransferase domain	33	3	0	0	0	95.17	83200.	4	5	3	15	1
37	IPR003347	JmjC domain	32	0	0	0	0	89.02	60.	39	48	10	24	5
38	IPR004000	Actin family	32	0	0	6	5	88.22	no data	2	29	1	4	0
39	IPR000330	SNF2-related, N-terminal domain	32	0	0	2	3	95.08	no data	2	2	1	1	0
40	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	30	0	0	0	0	95.78	322000.	31	31	1	7	1
41	IPR000873	AMP-dependent synthetase/ligase	30	1	0	0	0	88.81	no data	1	1	1	1	0
42	IPR003594	Histidine kinase/HSP90-like ATPase	28	0	3	1	2	84.15	229.5	180	205	6	9	6
43	IPR000073	Alpha/beta hydrolase fold-1	28	0	3	0	0	97.48	0.66	46	47	1	6	1
44	IPR004045	Glutathione S-transferase, N-terminal	27	3	1	1	0	88.77	300.	27	33	7	19	5
45	IPR001251	CRAL-TRIO lipid binding domain	27	1	0	0	0	99.61	10.	3	9	3	7	1
46	IPR000086	NUDIX hydrolase domain	27	1	0	1	2	94.63	0.4	29	30	2	19	1
47	IPR005135	Endonuclease/exonuclease/phosphatase	25	0	2	0	0	81.1	17.5	1	1	1	11	1
48	IPR004046	Glutathione S-transferase, C-terminal	24	1	2	4	3	88.97	1950.	18	19	5	18	3
49	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	24	1	0	2	6	78.63	1600.	18	19	2	14	2
50	IPR003008	Tubulin/FtsZ, GTPase domain	24	0	1	2	5	97.53	no data	1	1	1	4	0
51	IPR001818	Peptidase M10, metallopeptidase	23	0	5	0	0	90.15	1.7	65	73	8	11	7
52	IPR000313	PWWP domain	23	0	1	0	0	77.51	no data	3	3	1	13	0
53	IPR000421	Coagulation factor 5/8 C-terminal domain	23	0	0	0	0	38.12	7800.	1	1	1	8	1
54	IPR000834	Peptidase M14, carboxypeptidase A	23	0	1	0	0	97.61	8.	1	1	1	8	1
55	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	22	0	1	2	5	57.5	no data	1	2	1	4	0
56	IPR017978	GPCR family 3, C-terminal	22	1	3	0	0	96.78	no data	2	1	1	1	0
57	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	21	5	4	0	0	90.53	0.5	170	202	11	12	11
58	IPR005123	Oxoglutarate/iron-dependent dioxygenase	21	0	3	0	0	90.35	15.8	9	22	1	7	1
59	IPR015590	Aldehyde dehydrogenase domain	19	1	1	0	0	90.75	105.	13	14	5	11	2
60	IPR001353	Proteasome, subunit alpha/beta	19	0	0	12	14	54.33	no data	1	1	1	17	0
61	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	19	0	2	0	0	100	360.	2	3	1	3	1
62	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	19	0	5	5	4	79.54	no data	1	1	1	7	0
63	IPR001148	Alpha carbonic anhydrase domain	18	8	1	0	0	88.23	10.85	148	193	8	13	6
64	IPR023210	NADP-dependent oxidoreductase domain	18	6	0	0	1	98.64	no data	86	162	7	11	0
65	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	18	0	0	0	0	90.54	157.	14	15	4	6	3
66	IPR000001	Kringle	18	1	4	0	0	62.42	370.	4	4	2	8	1
67	IPR001320	Ionotropic glutamate receptor	18	0	0	0	0	54.23	no data	1	1	1	5	0
68	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	17	0	0	0	1	71.14	73.5	13	14	3	10	2
69	IPR001699	Transcription factor, T-box	17	0	1	0	0	61.87	no data	9	9	1	4	0
70	IPR004839	Aminotransferase, class I/classII	17	0	0	0	0	64.74	no data	1	1	1	7	0
71	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	17	2	0	0	0	88.59	35.55	116	122	7	11	6
72	IPR001079	Galectin, carbohydrate recognition domain	16	0	1	0	0	60.33	910000.	2	2	2	10	1
73	IPR013126	Heat shock protein 70 family	15	0	4	3	3	90.75	1850.	17	26	3	8	3
74	IPR002018	Carboxylesterase, type B	15	3	1	0	0	94	2.71	23	33	3	6	1
75	IPR002913	START domain	15	0	0	0	0	97.96	no data	7	8	1	5	0
76	IPR013149	Alcohol dehydrogenase, C-terminal	15	0	0	0	0	88.56	no data	1	1	1	14	0
77	IPR001607	Zinc finger, UBP-type	14	0	1	1	2	79.06	no data	6	6	2	3	0
78	IPR018502	Annexin repeat	14	0	1	0	0	71.32	no data	1	1	1	8	0
79	IPR000668	Peptidase C1A, papain C-terminal	13	0	4	0	0	70.68	1.5	61	61	7	9	3
80	IPR013655	PAS fold-3	13	0	2	0	0	100	no data	2	2	1	2	0
81	IPR000562	Fibronectin type II domain	13	0	4	0	0	92.01	0.43	3	3	1	6	1
82	IPR001759	Pentraxin-related	13	0	3	0	0	49.29	no data	1	1	1	2	0
83	IPR007484	Peptidase M28	12	0	1	1	1	98.89	0.0449	10	10	1	6	1
84	IPR024810	Mab-21 domain	12	0	0	0	0	88.85	no data	5	5	1	3	0
85	IPR013078	Histidine phosphatase superfamily, clade-1	12	0	1	0	2	90.43	no data	3	3	1	8	0
86	IPR000648	Oxysterol-binding protein	12	1	0	0	1	97.33	no data	1	1	1	4	0
87	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	12	0	0	7	6	62.66	5.8	3	3	1	7	1
88	IPR023753	FAD/NAD(P)-binding domain	12	0	0	1	1	51.28	no data	1	1	1	5	0
89	IPR000539	Frizzled/Smoothened, transmembrane domain	11	1	1	0	0	98.3	no data	6	6	1	1	0
90	IPR016090	Phospholipase A2 domain	11	0	1	1	0	87.26	12.	8	9	2	4	1
91	IPR023801	Histone deacetylase domain	11	0	4	1	1	92.63	63.	17	19	4	6	4
92	IPR006680	Amidohydrolase-related	11	0	0	0	0	90.17	no data	1	1	1	8	0
93	IPR033121	Peptidase family A1 domain	10	1	3	0	0	92.87	0.3	311	325	3	7	3
94	IPR026298	Blc2 family	10	0	4	1	2	88.39	21.	34	40	3	8	3
95	IPR004092	Mbt repeat	10	0	0	0	0	68.38	5000.	3	3	1	7	1
96	IPR013818	Lipase/vitellogenin	10	0	1	0	0	57.86	no data	1	1	1	4	0
97	IPR003349	JmjN domain	10	0	0	0	0	77.27	no data	2	2	1	8	0
98	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	10	0	1	0	0	93.65	13.	13	13	1	5	1
99	IPR002937	Amine oxidase	10	1	1	0	0	91.22	310.	8	8	2	6	1
100	IPR019791	Haem peroxidase, animal type	10	2	1	0	0	99.06	no data	11	14	2	3	0
101	IPR000994	Peptidase M24	9	0	1	1	2	89.31	296.	28	30	2	7	2
102	IPR006076	FAD dependent oxidoreductase	9	0	1	0	0	99.49	no data	3	3	1	1	0
103	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain	9	1	4	0	0	68.52	1.	2	2	1	6	1
104	IPR001370	BIR repeat	8	0	6	1	1	61.67	44.	28	29	3	6	3
105	IPR001236	Lactate/malate dehydrogenase, N-terminal	8	0	0	0	0	95.32	39.	6	6	1	4	1
106	IPR022383	Lactate/malate dehydrogenase, C-terminal	8	0	0	0	0	96.44	no data	1	1	1	4	0
107	IPR022742	Serine aminopeptidase, S33	8	0	1	0	0	99.61	29.	4	4	1	1	1
108	IPR008753	Peptidase M13, N-terminal domain	8	0	1	0	0	84.93	0.6	1	1	1	2	1
109	IPR004274	FCP1 homology domain	8	1	0	1	1	59.6	5000.	1	1	1	3	1
110	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	8	0	1	5	4	98.37	0.76	3	4	1	4	1
111	IPR003000	Sirtuin family	7	0	1	0	0	98.74	163.	17	23	4	5	3
112	IPR007728	Pre-SET domain	7	0	0	0	0	33.79	no data	1	1	1	4	0
113	IPR023410	14-3-3 domain	7	0	0	0	0	70.32	no data	5	5	2	7	0
114	IPR015415	Vps4 oligomerisation, C-terminal	7	0	1	1	1	62.44	no data	2	2	1	5	0
115	IPR001223	Glycoside hydrolase family 18, catalytic domain	7	0	0	0	0	93.82	420.	8	8	2	5	1
116	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	7	0	0	0	0	82.63	no data	1	1	1	3	0
117	IPR007863	Peptidase M16, C-terminal	7	0	0	2	2	51.07	100.	2	2	1	2	1
118	IPR016040	NAD(P)-binding domain	6	0	0	0	0	66.83	no data	2	2	1	5	0
119	IPR001506	Peptidase M12A	6	0	0	0	0	82.52	no data	4	4	1	3	0
120	IPR001365	Adenosine/AMP deaminase domain	6	0	0	0	0	97.4	no data	1	1	1	2	0
121	IPR002469	Dipeptidylpeptidase IV, N-terminal domain	6	0	3	0	0	72.28	0.82	5	5	1	5	1
122	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	6	0	1	0	0	37.24	43.	2	2	1	2	1
123	IPR003121	SWIB/MDM2 domain	5	0	2	0	0	91.84	0.1	25	25	1	2	1
124	IPR013530	Protein-arginine deiminase, C-terminal	5	0	0	0	0	72.95	1900.	7	7	1	3	1
125	IPR022673	Hexokinase, C-terminal	5	0	2	0	0	95.2	no data	23	26	1	4	0
126	IPR003671	Spindlin/spermiogenesis-specific protein	5	0	0	0	0	63.53	14200.	3	3	1	4	1
127	IPR006204	GHMP kinase N-terminal domain	5	0	0	2	1	84.69	no data	1	2	1	4	0
128	IPR024084	Isopropylmalate dehydrogenase-like domain	5	0	1	0	0	90.52	no data	7	7	1	4	0
129	IPR005481	Biotin carboxylase-like, N-terminal domain	5	0	0	0	0	82.63	no data	1	1	1	2	0
130	IPR005076	Glycosyl transferase, family 6	5	0	0	0	0	87.42	261000.	2	2	1	1	1
131	IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal	5	0	0	0	0	70.99	87.	2	7	2	4	1
132	IPR031778	Sortilin, N-terminal	5	0	0	0	0	73.51	330.	1	1	1	2	1
133	IPR004364	Aminoacyl-tRNA synthetase, class II (D/K/N)	5	0	0	3	3	94.4	2100.	1	2	1	3	1
134	IPR007275	YTH domain	5	0	0	0	0	84.95	1200.	1	1	1	3	1
135	IPR008380	HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase	5	0	0	0	0	64.9	790000.	1	1	1	1	1
136	IPR004198	Zinc finger, C5HC2-type	5	0	0	0	0	77.48	no data	1	1	1	3	0
137	IPR006085	XPG N-terminal	5	0	0	1	0	67.25	182.	1	1	1	2	1
138	IPR000845	Nucleoside phosphorylase domain	4	0	1	0	0	99.02	0.0052	21	35	3	4	1
139	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain	4	0	0	0	0	83.24	no data	6	6	1	4	0
140	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	4	0	0	0	0	83.24	no data	6	6	1	4	0
141	IPR019774	Aromatic amino acid hydroxylase, C-terminal	4	0	1	0	0	92.87	6.	5	5	1	4	1
142	IPR014760	Serum albumin, N-terminal	4	1	1	0	0	85.23	2900.	10	12	2	3	1
143	IPR000323	Copper type II, ascorbate-dependent monooxygenase, N-terminal	4	0	1	0	0	73.51	no data	1	1	1	2	0
144	IPR013750	GHMP kinase, C-terminal domain	4	0	0	1	1	95.5	no data	1	1	1	3	0
145	IPR013079	6-phosphofructo-2-kinase	4	0	1	0	0	95.88	11.	12	12	1	3	1
146	IPR005033	YEATS	4	0	0	1	0	67.06	no data	4	4	1	4	0
147	IPR002376	Formyl transferase, N-terminal	4	0	1	0	0	77.72	no data	1	1	1	2	0
148	IPR003172	MD-2-related lipid-recognition domain	4	0	1	0	0	78.9	no data	1	1	1	4	0
149	IPR020631	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	4	0	0	0	0	73.37	no data	2	2	1	2	0
150	IPR020630	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	4	0	0	0	0	73.37	no data	1	1	1	2	0
151	IPR011040	Sialidase	4	1	0	0	0	69.27	330000.	1	1	1	1	1
152	IPR000092	Polyprenyl synthetase	4	0	0	1	1	96.73	1200.	3	3	1	2	1
153	IPR001040	Translation Initiation factor eIF- 4e	4	0	0	1	1	59.79	20500.	3	3	1	2	1
154	IPR031314	Deoxynucleoside kinase domain	4	1	0	0	0	99.89	0.5	30	36	1	2	1
155	IPR034733	Acetyl-CoA carboxylase	4	0	0	0	0	62.29	5.4	2	2	1	2	1
156	IPR001093	IMP dehydrogenase/GMP reductase	4	1	0	0	0	81.08	6.	1	1	1	4	1
157	IPR031330	Glycoside hydrolase 35, catalytic domain	4	0	0	0	0	85.44	no data	1	1	1	1	0
158	IPR000811	Glycosyl transferase, family 35	3	2	0	0	0	84.88	8920.	39	43	2	3	2
159	IPR015878	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	3	0	0	1	0	100	no data	10	14	1	3	0
160	IPR006035	Ureohydrolase	3	0	2	0	0	72.85	41.5	4	6	2	2	2
161	IPR004030	Nitric oxide synthase, N-terminal	3	0	3	0	0	92.07	no data	111	195	3	3	0
162	IPR011615	p53, DNA-binding domain	3	0	1	0	0	86	470.	21	21	1	3	1
163	IPR008015	GMP phosphodiesterase, delta subunit	3	0	0	0	0	99.89	2.3	6	6	1	2	1
164	IPR031968	VASt domain	3	0	0	0	0	95.68	no data	1	1	1	2	0
165	IPR022768	Fascin domain	3	0	1	0	0	83.75	no data	9	9	1	1	0
166	IPR001548	Peptidase M2, peptidyl-dipeptidase A	3	1	1	0	0	84.34	0.27	4	5	2	3	1
167	IPR029054	dUTPase-like	3	0	1	1	1	56.37	no data	1	1	1	1	0
168	IPR002159	CD36 family	3	1	0	0	0	85.95	no data	1	1	1	2	0
169	IPR001310	Histidine triad (HIT) protein	3	0	0	0	0	84.37	55900.	2	6	2	3	1
170	IPR011084	DNA repair metallo-beta-lactamase	3	1	0	1	0	47.1	no data	1	1	1	2	0
171	IPR001424	Superoxide dismutase, copper/zinc binding domain	3	0	1	1	1	77.58	no data	4	4	1	3	0
172	IPR000940	Methyltransferase, NNMT/PNMT/TEMT	3	0	0	0	0	99.91	1.3	4	7	1	3	1
173	IPR011611	Carbohydrate kinase PfkB	3	0	1	0	0	92.65	4.45	6	6	2	3	2
174	IPR015883	Glycoside hydrolase family 20, catalytic domain	3	1	0	0	0	83.18	no data	1	1	1	2	0
175	IPR001563	Peptidase S10, serine carboxypeptidase	3	0	1	0	0	70.56	no data	1	1	1	1	0
176	IPR010513	KEN domain	3	0	0	0	0	62.26	5400.	1	1	1	2	1
177	IPR004294	Carotenoid oxygenase	3	0	1	0	0	98.89	106.	7	8	1	1	1
178	IPR003140	Phospholipase/carboxylesterase/thioesterase	3	0	0	0	0	96.24	280.	1	1	1	3	1
179	IPR004937	Urea transporter	2	0	0	0	0	48.75	no data	1	1	1	1	0
180	IPR005065	Platelet-activating factor acetylhydrolase-like	2	0	1	0	0	82.52	120.	4	4	1	1	1
181	IPR035077	Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain	2	0	0	0	0	67.95	630.	3	3	1	1	1
182	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type	2	1	1	0	0	82.97	80.	7	7	1	2	1
183	IPR002616	tRNA-guanine(15) transglycosylase-like	2	0	0	0	0	88.07	no data	1	1	1	1	0
184	IPR033391	Fructose-1-6-bisphosphatase class I, N-terminal	2	0	2	0	0	86.75	830.	3	3	1	2	1
185	IPR005720	Dihydroorotate dehydrogenase domain	2	0	0	0	0	99.84	no data	42	42	1	1	0
186	IPR000898	Indoleamine 2,3-dioxygenase	2	0	0	0	0	97.27	no data	9	9	1	1	0
187	IPR019539	Galactokinase galactose-binding domain	2	0	0	0	0	74.11	no data	1	1	1	2	0
188	IPR032190	Niemann-Pick C1, N-terminal	2	1	0	0	0	97.15	no data	2	2	1	2	0
189	IPR005122	Uracil-DNA glycosylase-like	2	0	0	0	0	83.47	1300.	5	5	1	2	1
190	IPR022677	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal	2	0	0	1	0	93.84	no data	7	8	1	2	0
191	IPR016053	Haem oxygenase-like	2	0	1	0	0	98.36	no data	3	4	1	2	0
192	IPR022629	S-adenosylmethionine synthetase, central domain	2	0	1	1	1	73.43	no data	1	2	1	2	0
193	IPR001796	Dihydrofolate reductase domain	2	1	0	0	2	98.71	1.1	30	42	1	1	1
194	IPR024053	von Hippel-Lindau disease tumour suppressor, beta domain	2	0	0	1	0	71.94	90.	32	32	1	1	1
195	IPR013178	Histone acetyltransferase Rtt109/CBP	2	0	1	0	0	91.29	no data	1	1	1	1	0
196	IPR015868	Glutaminase	2	0	2	0	0	39.27	40.	2	2	1	2	1
197	IPR000692	Fibrillarin	2	0	0	1	1	79.26	no data	1	1	1	1	0
198	IPR003680	Flavodoxin-like fold	2	0	1	0	0	56.27	no data	1	1	1	2	0
199	IPR000819	Peptidase M17, leucyl aminopeptidase, C-terminal	2	0	0	0	0	65.05	800.	1	1	1	1	1
200	IPR010708	5'(3')-deoxyribonucleotidase	2	0	0	0	0	91.49	no data	1	1	1	2	0
201	IPR003101	Coactivator CBP, KIX domain	2	0	1	0	0	70.06	1900.	1	1	1	1	1
202	IPR002241	Glycoside hydrolase, family 27	2	0	0	0	0	76.98	43.	1	1	1	2	1
203	IPR001576	Phosphoglycerate kinase	2	1	0	0	0	71.41	2780.	2	3	1	1	1
204	IPR003193	ADP-ribosyl cyclase (CD38/157)	2	0	0	0	0	87.33	76.	2	2	1	2	1
205	IPR000262	FMN-dependent dehydrogenase	2	0	0	0	0	99.86	no data	3	3	1	1	0
206	IPR021991	UHRF1, tandem tudor domain	2	0	0	0	0	45.95	no data	1	1	1	2	0
207	IPR023416	Transthyretin/hydroxyisourate hydrolase domain	1	1	0	0	0	60.38	6.2	53	66	1	1	1
208	IPR022649	Proliferating cell nuclear antigen, PCNA, C-terminal	1	1	1	1	1	88.38	1300.	2	2	1	1	1
209	IPR025789	Histone-lysine N-methyltransferase DOT1 domain	1	0	1	0	0	98.92	0.1	12	13	1	1	1
210	IPR032696	Squalene cyclase, C-terminal	1	0	0	0	0	98.76	6.5	2	2	1	1	1
211	IPR032697	Squalene cyclase, N-terminal	1	0	0	0	0	98.76	6.5	2	2	1	1	1
212	IPR024367	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain	1	1	0	0	0	95.82	2110.	11	11	1	1	1
213	IPR023451	Thymidylate synthase/dCMP hydroxymethylase domain	1	1	0	0	0	93.1	29.	5	8	1	1	1
214	IPR013968	Polyketide synthase, ketoreductase domain	1	0	0	0	0	94.37	no data	3	3	1	1	0
215	IPR010347	Tyrosyl-DNA phosphodiesterase I	1	0	0	0	0	72	no data	6	6	1	1	0
216	IPR003829	Pirin, N-terminal domain	1	0	0	0	0	86.88	no data	4	4	1	1	0
217	IPR004963	Pectinacetylesterase/NOTUM	1	0	0	0	0	91.93	no data	2	2	1	1	0
218	IPR029489	O-GlcNAc transferase, C-terminal	1	0	0	0	1	67.64	no data	2	2	1	1	0
219	IPR033453	Glycosyl hydrolase family 30, TIM-barrel domain	1	1	0	0	0	86.57	300.	3	3	1	1	1
220	IPR029158	Stimulator of interferon genes protein	1	0	1	0	0	49.68	no data	1	1	1	1	0
221	IPR006716	ERG2/sigma1 receptor-like	1	0	0	0	0	96.68	4.3	2	2	1	1	1
222	IPR000779	Interleukin-2	1	0	0	0	0	92.89	6000.	3	3	1	1	1
223	IPR007747	Menin	1	0	0	0	0	94.23	9.3	25	24	1	1	1
224	IPR013698	Squalene epoxidase	1	0	0	0	0	99.54	no data	2	2	1	1	0
225	IPR035075	PRMT5 arginine-N-methyltransferase	1	0	1	1	1	99.02	1.	9	10	1	1	1
226	IPR000883	Cytochrome c oxidase subunit I	1	1	0	0	0	90.81	no data	1	1	1	1	0
227	IPR007724	Poly(ADP-ribose) glycohydrolase	1	0	0	0	0	79.03	no data	4	4	1	1	0
228	IPR007199	Replication factor-A protein 1, N-terminal	1	0	0	1	1	80.23	190.	3	3	1	1	1
229	IPR015865	Riboflavin kinase domain, bacterial/eukaryotic	1	1	0	0	0	76.03	no data	1	1	1	1	0
230	IPR011496	Beta-N-acetylglucosaminidase	1	0	1	0	0	96.47	0.9	1	2	1	1	1
231	IPR032259	Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type	1	0	0	0	0	79.14	no data	1	1	1	1	0
232	IPR008334	5'-Nucleotidase, C-terminal	1	0	1	0	0	67.69	no data	1	2	1	1	0
233	IPR023485	Phosphotyrosine protein phosphatase I	1	0	0	0	0	83.22	7100.	1	1	1	1	1
234	IPR006099	Methylmalonyl-CoA mutase, alpha/beta chain, catalytic	1	0	0	0	0	97.58	no data	1	2	1	1	0
235	IPR001015	Ferrochelatase	1	1	0	0	1	88.17	no data	1	19	1	1	0
236	IPR002818	DJ-1/PfpI	1	0	0	0	0	73.63	no data	2	2	1	1	0