The Ligandable Human Proteome

(This resource was generated by Jiayan Wang, Setayesh Yazdani, and Ana Han in Matthieu Schapira's group. Questions/Requests: matthieu.schapira@utoronto.ca)

Index Domain ID Domain Name Proteins in the Human Genome
Proteins Bound to Approved Drugs in the PDB
Targets in Clinical Trials
Essential Genes from Broad Institute CDM
Essential Genes from Sanger Institute CDM
Median ligand desolvation (%)
Median affinity (nM)
Druglike ligands in PDB
Structures with bound ligand in the PDB
Proteins with bound ligand in the PDB
Proteins with structures in the PDB with or without ligand
Structures with affinity data
1IPR000276G protein-coupled receptor, rhodopsin-like71022571095.412.6798373912
2IPR000719Protein kinase domain4825295142090.164.5520912536195268138
3IPR001680WD40 repeat26601546477.147.831334532
4IPR001611Leucine-rich repeat2610166657.29no data221310
5IPR002048EF-hand domain22816118518.371541
6IPR000210BTB/POZ domain178011365.893.772291
7IPR001478PDZ domain152020065.16no data111520
8IPR001806Small GTPase137032586.26340000.33352731
9IPR001254Serine proteases, trypsin domain1211140086.152.7427449185316
10IPR000980SH2 domain1090112460.55120.331431
11IPR001650Helicase, C-terminal10803223263.235300.111231
12IPR005821Ion transport domain1061140192.82no data33120
13IPR011161MHC class I-like antigen recognition-like92000097.08no data131170
14IPR001304C-type lectin-like860100044.04no data111350
15IPR002035von Willebrand factor, type A76034561.762.5772131
16IPR001394Peptidase C19, ubiquitin carboxyl-terminal hydrolase74102681.5965.15153171
17IPR006652Kelch repeat type 161000181.381.31314191
18IPR001791Laminin G domain6112001000.18247171
19IPR001128Cytochrome P450601680098.29no data658018240
20IPR002347Short-chain dehydrogenase/reductase SDR55040089.09no data882220
21IPR001214SET domain51021181.0827.521278293
22IPR000832GPCR, family 2, secretin-like49080098.366.711121
23IPR000536Nuclear hormone receptor, ligand-binding domain481960099.741.515686253621
24IPR001752Kinesin motor domain45013590.931.625291151
25IPR000225Armadillo42002266.11900000.331151
26IPR001487Bromodomain41251277.342.7297365223415
27IPR001590Peptidase M12B, ADAM/reprolysin40030079.915.88393
28IPR000608Ubiquitin-conjugating enzyme E240014777.221720.111321
29IPR001609Myosin head, motor domain39010088.74290.12151
30IPR000242PTP type protein phosphatase38041289.58166.66815304
31IPR023796Serpin domain38140089.79290.232211
32IPR005828Major facilitator, sugar transporter-like36010066.16no data22220
33IPR001828Receptor, ligand binding region36050095.6980.65564132
34IPR000566Lipocalin/cytosolic fatty-acid binding domain34600094.6629.3510911249
35IPR018499Tetraspanin/Peripherin33110062.35no data11110
36IPR000863Sulfotransferase domain33300095.1783200.453151
37IPR003347JmjC domain32000089.0260.394810245
38IPR004000Actin family32006588.22no data229140
39IPR000330SNF2-related, N-terminal domain32002395.08no data22110
40IPR001895Ras guanine-nucleotide exchange factors catalytic domain30000095.78322000.3131171
41IPR000873AMP-dependent synthetase/ligase30100088.81no data11110
42IPR003594Histidine kinase/HSP90-like ATPase28031284.15229.5180205696
43IPR000073Alpha/beta hydrolase fold-128030097.480.664647161
44IPR004045Glutathione S-transferase, N-terminal27311088.77300.27337195
45IPR001251CRAL-TRIO lipid binding domain27100099.6110.39371
46IPR000086NUDIX hydrolase domain27101294.630.429302191
47IPR005135Endonuclease/exonuclease/phosphatase25020081.117.5111111
48IPR004046Glutathione S-transferase, C-terminal24124388.971950.18195183
49IPR002130Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain24102678.631600.18192142
50IPR003008Tubulin/FtsZ, GTPase domain24012597.53no data11140
51IPR001818Peptidase M10, metallopeptidase23050090.151.765738117
52IPR000313PWWP domain23010077.51no data331130
53IPR000421Coagulation factor 5/8 C-terminal domain23000038.127800.11181
54IPR000834Peptidase M14, carboxypeptidase A23010097.618.11181
55IPR018316Tubulin/FtsZ, 2-layer sandwich domain22012557.5no data12140
56IPR017978GPCR family 3, C-terminal22130096.78no data21110
57IPR0020733'5'-cyclic nucleotide phosphodiesterase, catalytic domain21540090.530.5170202111211
58IPR005123Oxoglutarate/iron-dependent dioxygenase21030090.3515.8922171
59IPR015590Aldehyde dehydrogenase domain19110090.75105.13145112
60IPR001353Proteasome, subunit alpha/beta1900121454.33no data111170
61IPR001054Adenylyl cyclase class-3/4/guanylyl cyclase190200100360.23131
62IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain19055479.54no data11170
63IPR001148Alpha carbonic anhydrase domain18810088.2310.851481938136
64IPR023210NADP-dependent oxidoreductase domain18600198.64no data861627110
65IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domain18000090.54157.1415463
66IPR000001Kringle18140062.42370.44281
67IPR001320Ionotropic glutamate receptor18000054.23no data11150
68IPR001179FKBP-type peptidyl-prolyl cis-trans isomerase domain17000171.1473.513143102
69IPR001699Transcription factor, T-box17010061.87no data99140
70IPR004839Aminotransferase, class I/classII17000064.74no data11170
71IPR012317Poly(ADP-ribose) polymerase, catalytic domain17200088.5935.551161227116
72IPR001079Galectin, carbohydrate recognition domain16010060.33910000.222101
73IPR013126Heat shock protein 70 family15043390.751850.1726383
74IPR002018Carboxylesterase, type B153100942.712333361
75IPR002913START domain15000097.96no data78150
76IPR013149Alcohol dehydrogenase, C-terminal15000088.56no data111140
77IPR001607Zinc finger, UBP-type14011279.06no data66230
78IPR018502Annexin repeat14010071.32no data11180
79IPR000668Peptidase C1A, papain C-terminal13040070.681.56161793
80IPR013655PAS fold-3130200100no data22120
81IPR000562Fibronectin type II domain13040092.010.4333161
82IPR001759Pentraxin-related13030049.29no data11120
83IPR007484Peptidase M2812011198.890.04491010161
84IPR024810Mab-21 domain12000088.85no data55130
85IPR013078Histidine phosphatase superfamily, clade-112010290.43no data33180
86IPR000648Oxysterol-binding protein12100197.33no data11140
87IPR000555JAB1/MPN/MOV34 metalloenzyme domain12007662.665.833171
88IPR023753FAD/NAD(P)-binding domain12001151.28no data11150
89IPR000539Frizzled/Smoothened, transmembrane domain11110098.3no data66110
90IPR016090Phospholipase A2 domain11011087.2612.89241
91IPR023801Histone deacetylase domain11041192.6363.1719464
92IPR006680Amidohydrolase-related11000090.17no data11180
93IPR033121Peptidase family A1 domain10130092.870.3311325373
94IPR026298Blc2 family10041288.3921.3440383
95IPR004092Mbt repeat10000068.385000.33171
96IPR013818Lipase/vitellogenin10010057.86no data11140
97IPR003349JmjN domain10000077.27no data22180
98IPR002591Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase10010093.6513.1313151
99IPR002937Amine oxidase10110091.22310.88261
100IPR019791Haem peroxidase, animal type10210099.06no data1114230
101IPR000994Peptidase M249011289.31296.2830272
102IPR006076FAD dependent oxidoreductase9010099.49no data33110
103IPR001375Peptidase S9, prolyl oligopeptidase, catalytic domain9140068.521.22161
104IPR001370BIR repeat8061161.6744.2829363
105IPR001236Lactate/malate dehydrogenase, N-terminal8000095.3239.66141
106IPR022383Lactate/malate dehydrogenase, C-terminal8000096.44no data11140
107IPR022742Serine aminopeptidase, S338010099.6129.44111
108IPR008753Peptidase M13, N-terminal domain8010084.930.611121
109IPR004274FCP1 homology domain8101159.65000.11131
110IPR002314Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)8015498.370.7634141
111IPR003000Sirtuin family7010098.74163.1723453
112IPR007728Pre-SET domain7000033.79no data11140
113IPR02341014-3-3 domain7000070.32no data55270
114IPR015415Vps4 oligomerisation, C-terminal7011162.44no data22150
115IPR001223Glycoside hydrolase family 18, catalytic domain7000093.82420.88251
116IPR005479Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain7000082.63no data11130
117IPR007863Peptidase M16, C-terminal7002251.07100.22121
118IPR016040NAD(P)-binding domain6000066.83no data22150
119IPR001506Peptidase M12A6000082.52no data44130
120IPR001365Adenosine/AMP deaminase domain6000097.4no data11120
121IPR002469Dipeptidylpeptidase IV, N-terminal domain6030072.280.8255151
122IPR001129Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein6010037.2443.22121
123IPR003121SWIB/MDM2 domain5020091.840.12525121
124IPR013530Protein-arginine deiminase, C-terminal5000072.951900.77131
125IPR022673Hexokinase, C-terminal5020095.2no data2326140
126IPR003671Spindlin/spermiogenesis-specific protein5000063.5314200.33141
127IPR006204GHMP kinase N-terminal domain5002184.69no data12140
128IPR024084Isopropylmalate dehydrogenase-like domain5010090.52no data77140
129IPR005481Biotin carboxylase-like, N-terminal domain5000082.63no data11120
130IPR005076Glycosyl transferase, family 65000087.42261000.22111
131IPR018955Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal5000070.9987.27241
132IPR031778Sortilin, N-terminal5000073.51330.11121
133IPR004364Aminoacyl-tRNA synthetase, class II (D/K/N)5003394.42100.12131
134IPR007275YTH domain5000084.951200.11131
135IPR008380HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase5000064.9790000.11111
136IPR004198Zinc finger, C5HC2-type5000077.48no data11130
137IPR006085XPG N-terminal5001067.25182.11121
138IPR000845Nucleoside phosphorylase domain4010099.020.00522135341
139IPR006140D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain4000083.24no data66140
140IPR006139D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain4000083.24no data66140
141IPR019774Aromatic amino acid hydroxylase, C-terminal4010092.876.55141
142IPR014760Serum albumin, N-terminal4110085.232900.1012231
143IPR000323Copper type II, ascorbate-dependent monooxygenase, N-terminal4010073.51no data11120
144IPR013750GHMP kinase, C-terminal domain4001195.5no data11130
145IPR0130796-phosphofructo-2-kinase4010095.8811.1212131
146IPR005033YEATS4001067.06no data44140
147IPR002376Formyl transferase, N-terminal4010077.72no data11120
148IPR003172MD-2-related lipid-recognition domain4010078.9no data11140
149IPR020631Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain4000073.37no data22120
150IPR020630Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain4000073.37no data11120
151IPR011040Sialidase4100069.27330000.11111
152IPR000092Polyprenyl synthetase4001196.731200.33121
153IPR001040Translation Initiation factor eIF- 4e4001159.7920500.33121
154IPR031314Deoxynucleoside kinase domain4100099.890.53036121
155IPR034733Acetyl-CoA carboxylase4000062.295.422121
156IPR001093IMP dehydrogenase/GMP reductase4100081.086.11141
157IPR031330Glycoside hydrolase 35, catalytic domain4000085.44no data11110
158IPR000811Glycosyl transferase, family 353200084.888920.3943232
159IPR015878S-adenosyl-L-homocysteine hydrolase, NAD binding domain30010100no data1014130
160IPR006035Ureohydrolase3020072.8541.546222
161IPR004030Nitric oxide synthase, N-terminal3030092.07no data111195330
162IPR011615p53, DNA-binding domain3010086470.2121131
163IPR008015GMP phosphodiesterase, delta subunit3000099.892.366121
164IPR031968VASt domain3000095.68no data11120
165IPR022768Fascin domain3010083.75no data99110
166IPR001548Peptidase M2, peptidyl-dipeptidase A3110084.340.2745231
167IPR029054dUTPase-like3011156.37no data11110
168IPR002159CD36 family3100085.95no data11120
169IPR001310Histidine triad (HIT) protein3000084.3755900.26231
170IPR011084DNA repair metallo-beta-lactamase3101047.1no data11120
171IPR001424Superoxide dismutase, copper/zinc binding domain3011177.58no data44130
172IPR000940Methyltransferase, NNMT/PNMT/TEMT3000099.911.347131
173IPR011611Carbohydrate kinase PfkB3010092.654.4566232
174IPR015883Glycoside hydrolase family 20, catalytic domain3100083.18no data11120
175IPR001563Peptidase S10, serine carboxypeptidase3010070.56no data11110
176IPR010513KEN domain3000062.265400.11121
177IPR004294Carotenoid oxygenase3010098.89106.78111
178IPR003140Phospholipase/carboxylesterase/thioesterase3000096.24280.11131
179IPR004937Urea transporter2000048.75no data11110
180IPR005065Platelet-activating factor acetylhydrolase-like2010082.52120.44111
181IPR035077Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain2000067.95630.33111
182IPR000297Peptidyl-prolyl cis-trans isomerase, PpiC-type2110082.9780.77121
183IPR002616tRNA-guanine(15) transglycosylase-like2000088.07no data11110
184IPR033391Fructose-1-6-bisphosphatase class I, N-terminal2020086.75830.33121
185IPR005720Dihydroorotate dehydrogenase domain2000099.84no data4242110
186IPR000898Indoleamine 2,3-dioxygenase2000097.27no data99110
187IPR019539Galactokinase galactose-binding domain2000074.11no data11120
188IPR032190Niemann-Pick C1, N-terminal2100097.15no data22120
189IPR005122Uracil-DNA glycosylase-like2000083.471300.55121
190IPR022677Myristoyl-CoA:protein N-myristoyltransferase, C-terminal2001093.84no data78120
191IPR016053Haem oxygenase-like2010098.36no data34120
192IPR022629S-adenosylmethionine synthetase, central domain2011173.43no data12120
193IPR001796Dihydrofolate reductase domain2100298.711.13042111
194IPR024053von Hippel-Lindau disease tumour suppressor, beta domain2001071.9490.3232111
195IPR013178Histone acetyltransferase Rtt109/CBP2010091.29no data11110
196IPR015868Glutaminase2020039.2740.22121
197IPR000692Fibrillarin2001179.26no data11110
198IPR003680Flavodoxin-like fold2010056.27no data11120
199IPR000819Peptidase M17, leucyl aminopeptidase, C-terminal2000065.05800.11111
200IPR0107085'(3')-deoxyribonucleotidase2000091.49no data11120
201IPR003101Coactivator CBP, KIX domain2010070.061900.11111
202IPR002241Glycoside hydrolase, family 272000076.9843.11121
203IPR001576Phosphoglycerate kinase2100071.412780.23111
204IPR003193ADP-ribosyl cyclase (CD38/157)2000087.3376.22121
205IPR000262FMN-dependent dehydrogenase2000099.86no data33110
206IPR021991UHRF1, tandem tudor domain2000045.95no data11120
207IPR023416Transthyretin/hydroxyisourate hydrolase domain1100060.386.25366111
208IPR022649Proliferating cell nuclear antigen, PCNA, C-terminal1111188.381300.22111
209IPR025789Histone-lysine N-methyltransferase DOT1 domain1010098.920.11213111
210IPR032696Squalene cyclase, C-terminal1000098.766.522111
211IPR032697Squalene cyclase, N-terminal1000098.766.522111
212IPR024367Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain1100095.822110.1111111
213IPR023451Thymidylate synthase/dCMP hydroxymethylase domain1100093.129.58111
214IPR013968Polyketide synthase, ketoreductase domain1000094.37no data33110
215IPR010347Tyrosyl-DNA phosphodiesterase I1000072no data66110
216IPR003829Pirin, N-terminal domain1000086.88no data44110
217IPR004963Pectinacetylesterase/NOTUM1000091.93no data22110
218IPR029489O-GlcNAc transferase, C-terminal1000167.64no data22110
219IPR033453Glycosyl hydrolase family 30, TIM-barrel domain1100086.57300.33111
220IPR029158Stimulator of interferon genes protein1010049.68no data11110
221IPR006716ERG2/sigma1 receptor-like1000096.684.322111
222IPR000779Interleukin-21000092.896000.33111
223IPR007747Menin1000094.239.32524111
224IPR013698Squalene epoxidase1000099.54no data22110
225IPR035075PRMT5 arginine-N-methyltransferase1011199.021.910111
226IPR000883Cytochrome c oxidase subunit I1100090.81no data11110
227IPR007724Poly(ADP-ribose) glycohydrolase1000079.03no data44110
228IPR007199Replication factor-A protein 1, N-terminal1001180.23190.33111
229IPR015865Riboflavin kinase domain, bacterial/eukaryotic1100076.03no data11110
230IPR011496Beta-N-acetylglucosaminidase1010096.470.912111
231IPR032259Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type1000079.14no data11110
232IPR0083345'-Nucleotidase, C-terminal1010067.69no data12110
233IPR023485Phosphotyrosine protein phosphatase I1000083.227100.11111
234IPR006099Methylmalonyl-CoA mutase, alpha/beta chain, catalytic1000097.58no data12110
235IPR001015Ferrochelatase1100188.17no data119110
236IPR002818DJ-1/PfpI1000073.63no data22110