| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 410 | CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes | 2zn7 | 13 |
| 2 | 35b | Crystal structure of PTP1B-inhibitor complex | 2zmm | 25 |
| 3 | 4b3 | Crystal structure of ptp1b-inhibitor complex | 2qbq | 36 |
| 4 | iz5 | CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR | 2vey | 43 |
| 5 | izb | Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B | 2cnh | 59 |
| 6 | iz3 | CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR | 2vew | 64 |
| 7 | ize | Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B | 2cng | 110 |
| 8 | iz4 | CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR | 2vex | 180 |
| 9 | f20 | Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics | 2cma | 185 |
| 10 | izd | Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics | 2cm7 | 210 |
| 11 | 024 | Crystal structure of ptp1b-inhibitor complex | 2qbs | 210 |
| 12 | f32 | Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B | 2cnf | 240 |
| 13 | 694 | Crystal structure of PTP1B with monocyclic thiophene inhibitor | 2h4g | 300 |
| 14 | 598 | Crystal structure of PTP1B with Tricyclic Thiophene inhibitor. | 2b07 | 370 |
| 15 | dbd | Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid | 1l8g | 600 |
| 16 | ix1 | PTP1B complexed with Isoxazole Carboxylic Acid | 1xbo | 920 |
| 17 | un7 | Protein tyrosine phosphatase 1B with sulfamic acid inhibitors | 2f71 | 2500 |
| 18 | un5 | Protein tyrosine phosphatase 1B with sulfamic acid inhibitors | 2f6z | 4800 |
| 19 | ota | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID | 1c88 | 5100 |
| 20 | 234 | A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors | 1q1m | 6900 |
| 21 | 968 | Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b | 1onz | 8000 |
| 22 | col | RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA | 1gfy | 8320 |
| 23 | 429 | Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B | 1qxk | 9000 |
| 24 | 761 | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID | 1c84 | 9900 |
| 25 | 878 | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID | 1ecv | 1.4e+004 |
| 26 | opa | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | 1c86 | 2e+004 |
| 27 | ota | Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state | 5kab | 2.1e+004 |
| 28 | oba | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID | 1c85 | 2.3e+004 |
| 29 | ota | Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state | 5ka3 | 2.6e+004 |
| 30 | ota | Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state | 5k9w | 2.6e+004 |
| 31 | ota | Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state | 5ka1 | 3.3e+004 |
| 32 | 1cg | CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID | 4i8n | 3.5e+004 |
| 33 | ota | Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state | 5kad | 3.7e+004 |
| 34 | ota | Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state | 5ka9 | 3.9e+004 |
| 35 | ota | Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state | 5ka7 | 4.5e+004 |
| 36 | opa | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | 1c87 | 6.3e+004 |
| 37 | 982 | Crystal structure of PTP1B with Bicyclic Thiophene inhibitor | 2azr | 2.3e+005 |
| 38 | 964 | Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic | 1nwl | 4.1e+006 |