The Ligandable Human Proteome

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Collagenase 3

Peptidase M10, metallopeptidase

IndexLigand NameStructurePDB codeCompound Potency nM
1whhCrystal structure of the catalytic domain of MMP-13 complexed with 4-(2-((6-fluoro-2-((3-methoxybenzyl)carbamoyl)-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)benzoic acid3wv10.0039
23krCrystal structure of MMP-13 in complex with SC-780803kry0.1
3cbpCRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID456c0.17
424fCrystal Structure of MMP-13 Complexed with Inhibitor 24f3elm0.19
5wnnCrystal structure of the catalytic domain of MMP-13 complexed with 4-oxo-N-(3-(2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy)benzyl)-3,4-dihydroquinazoline-2-carboxamide5b5p0.2
6rs1COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID830c0.52
7gg1MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid2ozr0.67
8pfdCrystal structure of the catalytic domain of MMP-13 complexed with a potent pyrimidinetrione inhibitor1you0.87
94ufX-RAY Co-structure of MMP-13 with 4-[({5-[2-(ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}formamido)methyl]benzoate5bpa1
10033Crystal structure of the catalytic domain of MMP-13 complexed with WAY-0331ztq1.3
118omMatrix metalloproteinase-13 complexed with selective inhibitor compound (S)-10a5uwk2.3
12e41MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor3zxh3
13az6Mmp13 in complex with a piperazine hydantoin ligand4jpa3.3
143ekCrystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound3kek4.4
15la3Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound3ljz7.3
16pb4Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor1xud8
178ojMatrix metalloproteinase-13 complexed with selective inhibitor compound (S)-17a5uwl9.4
18wggCrystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide3wv212
19wllCrystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide3wv324
203w5MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD224a7b39.8
213keCrystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound3kec58
22pb3Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor1xuc72
233ejCrystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound3kej75.9
245elMMP13 in complex with a novel selective non zinc binding inhibitor2yig79.4
25732MMP-13 in complex with a non zinc-chelating inhibitor3i7g430
26518MMP-13 in complex with a non zinc-chelating inhibitor3i7i620
27347Crystal structure of the catalytic domain of MMP-13 complexed with WAY-3442pjt860
28pb5Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor1xur6600