The Ligandable Human Proteome

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Son of sevenless homolog 1

Ras guanine-nucleotide exchange factors catalytic domain

IndexLigand NameStructurePDB codeCompound Potency nM
12pzApproach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange4nyj3.22e+005
22pxApproach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange4nyi8.68e+005
3rv1The crystal structure of H-Ras and SOS in complex with ligands4ury6e+006