The Ligandable Human Proteome

Home

Transthyretin

Transthyretin/hydroxyisourate hydrolase domain

IndexLigand NameStructurePDB codeCompound Potency nM
116vThe Structure of V122I Mutant Transthyretin in Complex with AG104hiq6.2
2tcwV122I Transthyretin structure in complex with Tolcalpone5a6i56
33m3Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole3p3t57.91
41flHuman transthyretin (ttr) complexed with diflunisal3d2t75
56j3Crystal Structure of Human Transthyretin in Complex with Clonixin5l4i260
63m4Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole3p3u329.1
76b5Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution5ihh390
8xloWild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]benzoic Acid5u4d470
9agiCrystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API)4der490
10ft2CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-34abv850
11g24V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24)3nex1000
12g24Wild type human transthyretin (TTR) complexed with GC-24 (TTRwt:GC-24)3neo1200
13genWild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.53kgu1200
1457dCrystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR)4des1400
15a93Transthyretin in complex with a covalent small molecule kinetic stabilizer3hj01960
16kmpCrystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE)4det2100
17b72V30M mutant human transthyretin (TTR) complexed with GC-1 (V30M:GC-1)3nes2400
18genV30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.53kgt3100
19ifaCrystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe3fc84100
20b72Wild type human transthyretin (TTR) complexed with GC-1 (TTRwt:GC-1)3nee4600
21ifbCrystal structure of transthyretin in complex with iododiflunisal-betaAlaOH3fcb4900