| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 1di | Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor | 3sfh | 90 |
| 2 | nhb | Crystal structure of inhibited human HDAC8 | 1w22 | 175.5 |
| 3 | 0di | Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor | 3sff | 200 |
| 4 | l6g | Crystal structure of S39D HDAC8 in complex with a largazole analogue. | 4rn0 | 255 |
| 5 | l7g | Crystal structure of S39D HDAC8 in complex with a largazole analogue. | 4rn2 | 1500 |
| 6 | l8g | Crystal structure of S39D HDAC8 in complex with a largazole analogue. | 4rn1 | 1e+004 |