The Ligandable Human Proteome

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PTP type protein phosphatase

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bun7Protein tyrosine phosphatase 1B with sulfamic acid inhibitors2f7173.262500.
2PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bun5Protein tyrosine phosphatase 1B with sulfamic acid inhibitors2f6z72.594800.
3PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bjq7PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000540a5qga48.35no data
4PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjpdPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000666a5qg454.42no data
5PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bjn1PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000505a5qfd48.92no data
6PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjlyPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000194a5qf354.41no data
7PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjjmPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_PKTTA024495b5qei45.73no data
8PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjjgPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000323a5qeh87.05no data
9PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bjj4PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000240a5qee47.6no data
10PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bjh1PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000449a5qe329.09no data
11PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjgyPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000398a5qe289.58no data
12PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjgsPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000648a5qe071.65no data
13PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjfyPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000163a5qdn61.71no data
14PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BjfvPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000072a5qdl69.89no data
15PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BizeStructural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B2cng66.32110.
16PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BizdStructural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics2cm765.11210.
17PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BizbStructural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B2cnh55.6259.
18PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Biz5CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR2vey66.8243.
19PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Biz4CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR2vex67.94180.
20PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Biz3CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR2vew63.5764.
21PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bix1PTP1B complexed with Isoxazole Carboxylic Acid1xbo78.43920.
22PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BguyPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000475a5qdt78.77no data
23PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bf32Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B2cnf60.19240.
24PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bf20Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics2cma59.82185.
25PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BdbdCrystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid1l8g71.47600.
26PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BawdPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000740a5qde54.18no data
27PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B964Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic1nwl61.544.1e+006
28PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B598Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.2b0768.5370.
29PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B4b3Crystal structure of ptp1b-inhibitor complex2qbq73.3536.
30PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B429Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B1qxk69.779000.
31PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B410CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes2zn767.7113.
32PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B35bCrystal structure of PTP1B-inhibitor complex2zmm72.2225.
33PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B1cgCRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID4i8n60.7335000.
34PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B024Crystal structure of ptp1b-inhibitor complex2qbs78.11210.
35PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B761CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID1c84839900.
36PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BobaCRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID1c8589.2423000.
37PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BopaCRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID1c8685.7520000.
38PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BopaCRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID1c8782.663000.
39PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B878CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID1ecv87.0314000.
40PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BcolRESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA1gfy83.398320.
41PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B968Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b1onz73.138000.
42PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B234A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors1q1m77.946900.
43PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B982Crystal structure of PTP1B with Bicyclic Thiophene inhibitor2azr86.33230000.
44PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1B694Crystal structure of PTP1B with monocyclic thiophene inhibitor2h4g80.6300.
45PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state5ka974.2939000.
46PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state5ka785.9745000.
47PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state5ka186.9233000.
48PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state5ka385.2926000.
49PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaCRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID1c8886.45100.
50PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state5kab75.0221000.
51PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state5kad84.6237000.
52PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1BotaProtein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state5k9w85.9826000.
53PTN1Tyrosine-protein phosphatase non-receptor type 1P18031PTP1Bd0pMulticonformer model of K197C PTP1B tethered to compound 2 at 100 K6b9565.42no data
54PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2jzgCrystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor3o5x49.085200.
55PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2jeaNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 1 SHP3896mdc83.29no data
56PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2je7Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 246mdd84.05no data
57PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2je4Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 56mdb86no data
58PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2je1Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 76md788.47no data
59PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP2dzjNon-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-26bn572.6no data
60PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odCrystal Structure of Shp2 E76K GOF Mutant in complex with SHP0996crg88.06no data
61PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odClosed structure of active SHP2 mutant E76K bound to SHP099 inhibitor6cms90.62no data
62PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odClosed structure of active SHP2 mutant E76D bound to SHP099 inhibitor6cmr90.57no data
63PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP23luCo-crystal structure of SHP2 in complex with a Cefsulodin derivative4rdd55.82no data
64PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP22wtCrystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N794pvg37.56no data
65PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25oaNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP8365ehp88.2412000.
66PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP2446bmu90.64no data
67PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP5046bmw90.86no data
68PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP8446bmy89.97no data
69PTN11Tyrosine-protein phosphatase non-receptor type 11Q06124PTP2C SHPTP25odNon-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP0995ehr90.5173.
70PTN22Tyrosine-protein phosphatase non-receptor type 22Q9Y2R2PTPN8n75Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N044j5150.32259.
71PTN22Tyrosine-protein phosphatase non-receptor type 22Q9Y2R2PTPN8561Structure of Lyp with inhibitor I-C112qct41.96no data
72PTN5Tyrosine-protein phosphatase non-receptor type 5P54829fszCRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-03146h8s75.69no data
73PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnxwHuman receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid3qcm79.03no data
74PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnx4Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid3qcj80.58500.
75PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnxvHuman receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid3qcl87.354000.
76PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnx5Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid3qck94.85800.
77PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnx3Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide3qci81.283800.
78PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnx2Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]-N-(methylsulfonyl)thiophene-2-carboxamide3qch86.13300.
79PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnx1Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid3qcg96.32no data
80PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnxyHuman receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid via co-crystallization3qcf96.382500.
81PTPRGReceptor-type tyrosine-protein phosphatase gammaP23470PTPGnxyHuman receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid via soaking3qce95.732500.