The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	5HT1B	5-hydroxytryptamine receptor 1B	P28222	HTR1DB	erm	Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)	4iar	89.47	no data
2	5HT1B	5-hydroxytryptamine receptor 1B	P28222	HTR1DB	2gm	Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)	4iaq	89.36	no data
3	5HT2A	5-hydroxytryptamine receptor 2A	P28223	HTR2	zot	Crystal structure of 5-HT2AR in complex with zotepine	6a94	95.5	no data
4	5HT2A	5-hydroxytryptamine receptor 2A	P28223	HTR2	clr	Crystal structure of 5-HT2AR in complex with risperidone	6a93	55.24	no data
5	5HT2A	5-hydroxytryptamine receptor 2A	P28223	HTR2	clr	Crystal structure of 5-HT2AR in complex with zotepine	6a94	58.58	no data
6	5HT2B	5-hydroxytryptamine receptor 2B	P41595		erm	Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine	4ib4	92.68	no data
7	5HT2B	5-hydroxytryptamine receptor 2B	P41595		erm	Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody	5tud	92.97	no data
8	5HT2B	5-hydroxytryptamine receptor 2B	P41595		erm	Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.	4nc3	91.63	no data
9	5HT2B	5-hydroxytryptamine receptor 2B	P41595		7ld	Crystal structure of the LSD-bound 5-HT2B receptor	5tvn	92.59	0.91
10	5HT2B	5-hydroxytryptamine receptor 2B	P41595		h8d	Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor	6dry	94.2	no data
11	5HT2C	5-hydroxytryptamine receptor 2C	P28335	HTR1C	erm	Crystal structure of 5-HT2C in complex with ergotamine	6bqg	90.98	no data
12	5HT2C	5-hydroxytryptamine receptor 2C	P28335	HTR1C	e2j	Crystal structure of 5-HT2C in complex with ritanserin	6bqh	90.18	no data
13	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Structure of human A2A adenosine receptor in complex with ZM241385 obtained from SFX experiments under atmospheric pressure	6jzh	81.79	no data
14	AA2AR	Adenosine receptor A2a	P29274	ADORA2	clr	A2A Adenosine receptor room-temperature structure determined by serial millisecond crystallography	5nlx	71.91	no data
15	AA2AR	Adenosine receptor A2a	P29274	ADORA2	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.86A obtained from in meso soaking experiments (24 hour soak).	5om4	96.38	no data
16	AA2AR	Adenosine receptor A2a	P29274	ADORA2	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 2.1A obtained from in meso soaking experiments (1 hour soak).	5om1	96.13	no data
17	AA2AR	Adenosine receptor A2a	P29274	ADORA2	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.9A obtained from bespoke co-crystallisation experiments.	5olz	96.22	no data
18	AA2AR	Adenosine receptor A2a	P29274	ADORA2	adn	Thermostabilised HUMAN A2a Receptor with adenosine bound	2ydo	92.74	30.9
19	AA2AR	Adenosine receptor A2a	P29274	ADORA2	6dy	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12c at 1.9A resolution	5iu7	75.81	1.1
20	AA2AR	Adenosine receptor A2a	P29274	ADORA2	6dz	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution	5iu8	78.56	18.
21	AA2AR	Adenosine receptor A2a	P29274	ADORA2	6dx	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12b at 2.2A resolution	5iua	77.39	1.5
22	AA2AR	Adenosine receptor A2a	P29274	ADORA2	6dv	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution	5iub	75.83	0.35
23	AA2AR	Adenosine receptor A2a	P29274	ADORA2	9y2	Structure of the A2A-StaR2-bRIL562-LUAA47070 complex at 2.0A obtained from in meso soaking experiments.	5olv	88.76	no data
24	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution	3vg9	76.28	no data
25	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Crystal structure of the chimeric protein of A2aAR-BRIL in complex with ZM241385 at 1.8A resolution	4eiy	81.12	no data
26	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Crystal structure of the chimeric protein of A2aAR-BRIL with bound iodide ions	5jtb	81.22	no data
27	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	1.9A angstrom A2a adenosine receptor structure with MR phasing using XFEL data	5k2d	80.34	no data
28	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.	3eml	81.93	1.8
29	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	2.5 angstrom A2a adenosine receptor structure with sulfur SAD phasing using XFEL data	5k2a	82	no data
30	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	1.9 angstrom A2a adenosine receptor structure with sulfur SAD phasing and phase extension using XFEL data	5k2c	80.07	no data
31	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data	5k2b	81.54	no data
32	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris	6aqf	81.85	no data
33	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	A2A Adenosine receptor cryo structure	5nm2	82.79	no data
34	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with ZM241385 at 1.7A resolution	5iu4	83.76	0.53
35	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	Structure of the A2A-StaR2-bRIL562-ZM241385 complex at 1.86A obtained from in meso soaking experiments.	5olg	81.56	no data
36	AA2AR	Adenosine receptor A2a	P29274	ADORA2	zma	2.35-Angstrom In situ Mylar structure of human A2A adenosine receptor at 100 K	5vra	80.8	no data
37	AA2AR	Adenosine receptor A2a	P29274	ADORA2	nec	Thermostabilised HUMAN A2a Receptor with NECA bound	2ydv	94.64	13.8
38	AA2AR	Adenosine receptor A2a	P29274	ADORA2	8jn	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with PSB36 at 2.8A resolution	5n2r	92.7	no data
39	ACM1	Muscarinic acetylcholine receptor M1	P11229		y01	Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium	5cxv	53.14	no data
40	ACM1	Muscarinic acetylcholine receptor M1	P11229		0hk	Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium	5cxv	99.39	no data
41	ACM2	Muscarinic acetylcholine receptor M2	P08172		qnb	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB	5zk3	99.58	no data
42	ACM2	Muscarinic acetylcholine receptor M2	P08172		82f	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384	5zkb	92.69	no data
43	ACM2	Muscarinic acetylcholine receptor M2	P08172		3c0	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative)	5yc8	97.91	no data
44	ACM2	Muscarinic acetylcholine receptor M2	P08172		3c0	Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS	5zk8	98.22	no data
45	ACM2	Muscarinic acetylcholine receptor M2	P08172		3c0	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS	5zkc	98.04	no data
46	ACM2	Muscarinic acetylcholine receptor M2	P08172		qnb	Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist	3uon	99.18	no data
47	ACM3	Muscarinic acetylcholine receptor M3	P20309		0hk	M3-mT4L receptor bound to tiotropium	4u15	99.09	no data
48	ACM4	Muscarinic acetylcholine receptor M4	P08173		0hk	Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium	5dsg	99.49	no data
49	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	k5y	Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71	6mxt	93.06	no data
50	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	8vs	Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist	5x7d	80.85	no data
51	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	tim	Cholesterol bound form of human beta2 adrenergic receptor.	3d4s	95.98	no data
52	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	jrz	Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551	3ny8	92.79	no data
53	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	jsz	Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist	3ny9	92.67	no data
54	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	p0g	Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody	4lde	95.57	no data
55	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	cau	In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K	5d5a	90.88	no data
56	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	cau	High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.	2rh1	90.76	no data
57	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2R B2AR	cau	Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist	5x7d	92.88	no data
58	AGTR1	Type-1 angiotensin II receptor	P30556	AGTR1A AGTR1B AT2R1 AT2R1B	zd7	XFEL structure of human Angiotensin Receptor	4yay	80.69	2.9
59	AGTR1	Type-1 angiotensin II receptor	P30556	AGTR1A AGTR1B AT2R1 AT2R1B	olm	Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution.	4zud	81.25	6.9
60	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21730	C5AR C5R1	efd	Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist avacopan	6c1r	83.82	no data
61	CCR5	C-C chemokine receptor type 5	P51681	CMKBR5	mrv	Crystal Structure of the CCR5 Chemokine Receptor	4mbs	80.82	no data
62	CCR5	C-C chemokine receptor type 5	P51681	CMKBR5	a4x	The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34	6aky	82.34	no data
63	CCR5	C-C chemokine receptor type 5	P51681	CMKBR5	a4r	The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 21	6akx	79.75	no data
64	CCR7	C-C chemokine receptor type 7	P32248	CMKBR7 EBI1 EVI1	jlw	Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA	6qzh	87.35	no data
65	CCR9	C-C chemokine receptor type 9	P51686	GPR28	clr	Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon	5lwe	55.18	no data
66	CCR9	C-C chemokine receptor type 9	P51686	GPR28	79k	Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon	5lwe	98.69	0.11
67	CNR1	Cannabinoid receptor 1	P21554	CNR	zdg	Crystal Structure of the Human Cannabinoid Receptor CB1	5tgz	93.68	no data
68	CNR1	Cannabinoid receptor 1	P21554	CNR	kca	Cannabinoid Receptor 1-G Protein Complex	6n4b	94.82	no data
69	CNR1	Cannabinoid receptor 1	P21554	CNR	clr	Crystal structure of the human CB1 in complex with agonist AM11542	5xra	66.02	no data
70	CNR1	Cannabinoid receptor 1	P21554	CNR	clr	Crystal structure of the human CB1 in complex with agonist AM841	5xr8	60.51	no data
71	CNR1	Cannabinoid receptor 1	P21554	CNR	clr	Cannabinoid Receptor 1-G Protein Complex	6n4b	47.72	no data
72	CNR1	Cannabinoid receptor 1	P21554	CNR	8d0	Crystal structure of the human CB1 in complex with agonist AM841	5xr8	96.72	no data
73	CNR1	Cannabinoid receptor 1	P21554	CNR	7dy	High-resolution crystal structure of the human CB1 cannabinoid receptor	5u09	95.94	no data
74	CNR2	Cannabinoid receptor 2	P34972	CB2A CB2B	9ju	Crystal structure of human G protein coupled receptor	5zty	96.47	no data
75	CXCR4	C-X-C chemokine receptor type 4	P61073		itd	The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t	3odu	83.78	7.3
76	DRD3	D(3) dopamine receptor	P35462		etq	Structure of the human dopamine D3 receptor in complex with eticlopride	3pbl	95.41	no data
77	DRD4	D(4) dopamine receptor	P21917		aqd	Structure of the human D4 Dopamine receptor in complex with Nemonapride	5wiu	94.76	no data
78	EDNRB	Endothelin receptor type B	P24530	ETRB	d2u	Human endothelin receptor type-B in complex with inverse agonist IRL2500	6k1q	89.5	no data
79	LPAR1	Lysophosphatidic acid receptor 1	Q92633	EDG2 LPA1	on9	Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539	4z35	96.82	no data
80	LPAR1	Lysophosphatidic acid receptor 1	Q92633	EDG2 LPA1	on7	Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO9780307	4z34	96.17	no data
81	LPAR1	Lysophosphatidic acid receptor 1	Q92633	EDG2 LPA1	on3	Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573	4z36	93.32	no data
82	MTR1A	Melatonin receptor type 1A	P48039		jey	XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin	6me3	97.5	no data
83	MTR1A	Melatonin receptor type 1A	P48039		jev	XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon	6me2	96.51	no data
84	MTR1B	Melatonin receptor type 1B	P49286		jey	XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin	6me6	96.97	no data
85	NK1R	Substance-P receptor	P25103	NK1R TAC1R	gbq	Crystal structure of the human NK1 substance P receptor	6j20	90.8	no data
86	NK1R	Substance-P receptor	P25103	NK1R TAC1R	gbq	Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant	6hlo	90.38	no data
87	NK1R	Substance-P receptor	P25103	NK1R TAC1R	gaw	Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Netupitant	6hlp	80.09	no data
88	NPY1R	Neuropeptide Y receptor type 1	P25929	NPYR NPYY1	9af	The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885	5zbh	87.07	no data
89	OPRK	Kappa-type opioid receptor	P41145	OPRK	jdc	Structure of the human kappa opioid receptor in complex with JDTic	4djh	90.43	0.32
90	OPRM	Mu-type opioid receptor	P35372	MOR1	clr	Crystal structure of active mu-opioid receptor bound to the agonist BU72	5c1m	66.64	no data
91	OPRM	Mu-type opioid receptor	P35372	MOR1	clr	Crystal structure of the mu-opioid receptor bound to a morphinan antagonist	4dkl	53.51	no data
92	OPRX	Nociceptin receptor	P41146	OOR ORL1	dgv	The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target)	5dhg	85.75	0.72
93	OX1R	Orexin receptor type 1	O43613		4ot	Structures of the human OX1 orexin receptor bound to selective and dual antagonists	4zjc	87.75	1.1
94	P2RY1	P2Y purinoceptor 1	P47900		clr	The human P2Y1 receptor in complex with BPTU	4xnv	52.23	no data
95	P2RY1	P2Y purinoceptor 1	P47900		bur	The human P2Y1 receptor in complex with BPTU	4xnv	70.54	161.
96	P2Y12	P2Y purinoceptor 12	Q9H244	HORK3	clr	Crystal structure of P2Y12 receptor in complex with 2MeSADP	4pxz	61.84	no data
97	P2Y12	P2Y purinoceptor 12	Q9H244	HORK3	clr	Structure of the human P2Y12 receptor in complex with an antithrombotic drug	4ntj	41.59	no data
98	P2Y12	P2Y purinoceptor 12	Q9H244	HORK3	azj	Structure of the human P2Y12 receptor in complex with an antithrombotic drug	4ntj	85.89	43.9
99	PAR1	Proteinase-activated receptor 1	P25116	CF2R PAR1 TR	vpx	Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom	3vw7	96.06	8.
100	PAR2	Proteinase-activated receptor 2	P55085	GPR11 PAR2	8tz	Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution	5ndd	99.39	344.
101	PE2R3	Prostaglandin E2 receptor EP3 subtype	P43115		p2e	Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2	6ak3	99.52	no data
102	PE2R3	Prostaglandin E2 receptor EP3 subtype	P43115		j9p	Crystal structure of EP3 receptor bound to misoprostol-FA	6m9t	98.38	no data
103	PTAFR	Platelet-activating factor receptor	P25105	PAFR	9er	Crystal structure of the human platelet-activating factor receptor in complex with SR 27417	5zkp	94.61	no data
104	PTAFR	Platelet-activating factor receptor	P25105	PAFR	9eu	Crystal structure of the human platelet-activating factor receptor in complex with ABT-491	5zkq	96.46	no data
105	TA2R	Thromboxane A2 receptor	P21731		clr	Crystal structure of the human thromboxane A2 receptor bound to daltroban	6iiv	35.87	no data
106	TA2R	Thromboxane A2 receptor	P21731		clr	Crystal structure of the human thromboxane A2 receptor bound to ramatroban	6iiu	42.78	no data
107	TA2R	Thromboxane A2 receptor	P21731		a90	Crystal structure of the human thromboxane A2 receptor bound to daltroban	6iiv	95.03	no data
108	TA2R	Thromboxane A2 receptor	P21731		a8x	Crystal structure of the human thromboxane A2 receptor bound to ramatroban	6iiu	98.06	no data

The Ligandable Human Proteome

G protein-coupled receptor, rhodopsin-like