The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	SMO	Smoothened homolog	Q99835	SMOH	sg8	Structure of the human smoothened receptor in complex with SAG1.5	4qin	95.24	no data
2	SMO	Smoothened homolog	Q99835	SMOH	lkd	Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8	6o3c	95.03	no data
3	SMO	Smoothened homolog	Q99835	SMOH	clr	Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8	6o3c	97.14	no data
4	SMO	Smoothened homolog	Q99835	SMOH	836	3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114	5v57	97.59	no data
5	SMO	Smoothened homolog	Q99835	SMOH	836	2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114	5v56	97.22	no data
6	SMO	Smoothened homolog	Q99835	SMOH	1ks	Structure of the human smoothened 7TM receptor in complex with an antitumor agent	4jkv	98.3	no data
7	SMO	Smoothened homolog	Q99835	SMOH	snt	Structure of the human smoothened receptor in complex with SANT-1.	4n4w	98	no data

Frizzled/Smoothened, transmembrane domain