The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	CATB	Cathepsin B	P07858	CPSB	c1g	Structure of CathB with covalently linked Compound 28	6ay2	57.33	no data
2	CATC	Dipeptidyl peptidase 1	P53634	CPPI	lxv	Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C	3pdf	84.79	no data
3	CATF	Cathepsin F	Q9UBX1		myp	Crystal structure of human cathepsin F	1m6d	58.31	no data
4	CATK	Cathepsin K	P43235	CTSO CTSO2	pos	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PROPANONE INHIBITOR	1au2	66.36	13.
5	CATK	Cathepsin K	P43235	CTSO CTSO2	o75	Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.	3o1g	62.22	1.
6	CATK	Cathepsin K	P43235	CTSO CTSO2	kwz	Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor	3kwz	64.57	4.
7	CATK	Cathepsin K	P43235	CTSO CTSO2	7as	Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.	5tdi	65	0.18
8	CATK	Cathepsin K	P43235	CTSO CTSO2	4pr	Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor	2bdl	59.19	15.
9	CATK	Cathepsin K	P43235	CTSO CTSO2	3fc	Cathepsin K complexed with a constrained ketoamide inhibitor	1yt7	67.2	0.13
10	CATK	Cathepsin K	P43235	CTSO CTSO2	2ca	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR	1nlj	75.25	0.16
11	CATK	Cathepsin K	P43235	CTSO CTSO2	i10	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR	1bgo	69.88	3.5
12	CATK	Cathepsin K	P43235	CTSO CTSO2	ihe	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854	1u9v	55.66	6.
13	CATK	Cathepsin K	P43235	CTSO CTSO2	ihi	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491	1u9w	62.28	3.5
14	CATK	Cathepsin K	P43235	CTSO CTSO2	ihj	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688	1u9x	54.05	7.
15	CATK	Cathepsin K	P43235	CTSO CTSO2	noq	A mutant rabbit cathepsin K with a nitrile inhibitor	2f7d	72.36	no data
16	CATK	Cathepsin K	P43235	CTSO CTSO2	cke	Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K	2r6n	66.73	1.
17	CATK	Cathepsin K	P43235	CTSO CTSO2	orh	Structure of CatK covalently bound to a dioxo-triazine inhibitor	3kwb	66.67	17.
18	CATK	Cathepsin K	P43235	CTSO CTSO2	kx1	Cathepsin K in complex with a selective 2-cyano-pyrimidine inhibitor	3kx1	52.11	100.
19	CATK	Cathepsin K	P43235	CTSO CTSO2	o96	Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead	3ovz	66.64	8.7
20	CATK	Cathepsin K	P43235	CTSO CTSO2	0lc	Cathepsin K inhibitor	4dmy	72.18	1.
21	CATK	Cathepsin K	P43235	CTSO CTSO2	i37	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6h	85.24	no data
22	CATK	Cathepsin K	P43235	CTSO CTSO2	3xt	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6h	89.14	no data
23	CATK	Cathepsin K	P43235	CTSO CTSO2	3y1	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6i	72.41	10.
24	CATK	Cathepsin K	P43235	CTSO CTSO2	3y2	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6j	73.9	16.
25	CATK	Cathepsin K	P43235	CTSO CTSO2	1xf	Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345	5j94	71.05	no data
26	CATL1	Cathepsin L1	P07711	CTSL1	yj8	CATHEPSIN L WITH A NITRILE INHIBITOR	2yj8	68.64	6.5
27	CATL1	Cathepsin L1	P07711	CTSL1	yj2	CATHEPSIN L WITH A NITRILE INHIBITOR	2yj2	68.48	12.
28	CATL1	Cathepsin L1	P07711	CTSL1	xu5	CATHEPSIN L WITH A NITRILE INHIBITOR	2xu5	65.72	130.
29	CATL1	Cathepsin L1	P07711	CTSL1	xu3	CATHEPSIN L WITH A NITRILE INHIBITOR	2xu3	70.68	160.
30	CATL1	Cathepsin L1	P07711	CTSL1	djt	CATHEPSIN L WITH A NITRILE INHIBITOR	2xu4	68.79	340.
31	CATL1	Cathepsin L1	P07711	CTSL1	c7t	CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide	6f06	65.01	no data
32	CATL1	Cathepsin L1	P07711	CTSL1	5t9	CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide	5f02	65.07	36.
33	CATL1	Cathepsin L1	P07711	CTSL1	424	CATHEPSIN L WITH A NITRILE INHIBITOR	2xu1	68.19	22.
34	CATL1	Cathepsin L1	P07711	CTSL1	424	CATHEPSIN L WITH A NITRILE INHIBITOR	2yjc	68.01	22.
35	CATL1	Cathepsin L1	P07711	CTSL1	v65	TRIAZINE CATHEPSIN INHIBITOR COMPLEX	4axm	64.22	13.
36	CATL1	Cathepsin L1	P07711	CTSL1	7kn	CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide	5mae	59.88	146.
37	CATL1	Cathepsin L1	P07711	CTSL1	7kh	CATHEPSIN L IN COMPLEX WITH 4-[cyclopentyl(imidazo[1,2-a]pyridin-2-ylmethyl)amino]-6-morpholino-1,3,5-triazine-2-carbonitrile	5maj	67.16	35.
38	CATL2	Cathepsin L2	O60911	CATL2 CTSL2 CTSU	0iw	CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR	1fh0	64.87	no data
39	CATS	Cathepsin S	P25774		mo9	Human Cathepsin S with inhibitor CRA-16981	2g7y	74.63	no data
40	CATS	Cathepsin S	P25774		c71	Human Cathepsin S with Inhibitor CRA-26871	2frq	60.45	no data
41	CATS	Cathepsin S	P25774		bjy	Crystal structure of human Cathepsin-S with bound ligand	5qcj	54.11	no data
42	CATS	Cathepsin S	P25774		bjs	Crystal structure of human Cathepsin-S with bound ligand	5qch	58.37	no data
43	CATS	Cathepsin S	P25774		bg7	Crystal structure of human Cathepsin-S with bound ligand	5qc9	54.72	no data
44	CATS	Cathepsin S	P25774		bc7	Crystal structure of human Cathepsin-S with bound ligand	5qc4	56.73	150.
45	CATS	Cathepsin S	P25774		b9y	Crystal structure of human Cathepsin-S with bound ligand	5qc3	60.81	no data
46	CATS	Cathepsin S	P25774		b9s	Crystal structure of human Cathepsin-S with bound ligand	5qc1	57.05	no data
47	CATS	Cathepsin S	P25774		b8y	Crystal structure of human Cathepsin-S with bound ligand	5qbz	53.28	no data
48	CATS	Cathepsin S	P25774		b8j	Crystal structure of human Cathepsin-S with bound ligand	5qbu	55.07	no data
49	CATS	Cathepsin S	P25774		599	Pyrazole-based Cathepsin S Inhibitors with Arylalkynes as P1 Binding Elements	3iej	61.4	220.
50	CATS	Cathepsin S	P25774		gnf	Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide	2f1g	70.95	29.
51	CATS	Cathepsin S	P25774		crj	Cathepsin S with nitrile inhibitor	2fq9	75.36	no data
52	CATS	Cathepsin S	P25774		crv	Human Cathepsin S with CRA-27934, a Nitrile Inhibitor	2fra	75.22	no data
53	CATS	Cathepsin S	P25774		c28	Human Cathepsin S with Inhibitor CRA-29728	2ft2	73.2	no data
54	CATS	Cathepsin S	P25774		h7j	Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.	2h7j	78.69	no data
55	CATS	Cathepsin S	P25774		h7j	Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)	2hxz	76.44	no data
56	CATS	Cathepsin S	P25774		y11	Cathepsin S complexed with Compound 15	2r9m	72.78	1.5
57	CATS	Cathepsin S	P25774		y14	Cathepsin S complexed with Compound 26	2r9n	73.63	no data
58	CATS	Cathepsin S	P25774		935	4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important	3n3g	76.34	no data
59	CATS	Cathepsin S	P25774		93n	4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important	3n3g	71	58.
60	CATS	Cathepsin S	P25774		ef3	6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors	3n4c	77.48	9.5
61	CATS	Cathepsin S	P25774		o64	Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead	3ovx	75.19	31.
62	CATS	Cathepsin S	P25774		2fc	Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor	4p6e	85.06	1290.
63	CATS	Cathepsin S	P25774		2fz	Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.	4p6g	61.04	7.7

The Ligandable Human Proteome

Peptidase C1A, papain C-terminal