The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	AAK1	AP2-associated protein kinase 1	Q2M2I8	KIAA1048	xin	Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with BIBF 1120	5te0	70.65	no data
2	AAK1	AP2-associated protein kinase 1	Q2M2I8	KIAA1048	lkb	Crystal Structure of Adaptor Protein 2 Associated Kinase 1 (AAK1) in Complex with LKB1 (AAK1 Dual Inhibitor)	5l4q	79.93	no data
3	AAPK2	5'-AMP-activated protein kinase catalytic subunit alpha-2	P54646	AMPK AMPK2	tak	Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C	3aqv	76.57	no data
4	AAPK2	5'-AMP-activated protein kinase catalytic subunit alpha-2	P54646	AMPK AMPK2	edj	AMP-Activated protein kinase (AMPK) inhibition by SBI-0206965: alpha 2 kinase domain bound to SBI-0206965	6bx6	74.1	no data
5	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	xy3	Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589	3oy3	86.3	35.8
6	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide	6npe	89.29	no data
7	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	C-abl Kinase domain with the activator(cmpd51), N-(1-(3,4-dichlorophenyl)-4-(2-hydroxyethyl)-4,5-dihydro-1H-pyrazol-3-yl)isonicotinamide	6npv	88.81	no data
8	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	C-abl Kinase domain with the activator(cmpd29), N-(1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)acetamide	6npu	89.6	no data
9	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	ABL1 IN COMPLEX WITH COMPOUND 7 AND IMATINIB (STI-571)	6hd4	91.3	no data
10	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p17	Crystal Structure of the c-Abl Kinase domain in complex with PD173955	1m52	86.89	no data
11	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	nil	Human ABL kinase in complex with nilotinib	3cs9	91.25	no data
12	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	nil	ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib	5mo4	91.26	no data
13	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	kwv	C-abl Kinase domain with the activator(cmpd29), N-(1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)acetamide	6npu	86.41	no data
14	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	kwp	C-abl Kinase domain with the activator(cmpd51), N-(1-(3,4-dichlorophenyl)-4-(2-hydroxyethyl)-4,5-dihydro-1H-pyrazol-3-yl)isonicotinamide	6npv	79.62	no data
15	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	jin	Abl kinase domain in complex with PD180970	2hzi	89.94	70.
16	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	db8	Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain	3ue4	68.78	1.1
17	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	b91	Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template	3kfa	90.13	25.
18	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	9dp	The crystal structure of human abl1 kinase domain in complex with DP-987	3qrk	88.26	57.
19	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	4b7	C-Helix-Out Binding of Dasatinib Analog to c-Abl Kinase	4yc8	72.19	14.
20	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	406	Crystal structure of the c-Abl kinase domain in complex with INNO-406	2e2b	89.11	11.
21	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	0li	AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance	3ik3	89.64	2.
22	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	0li	Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534	3oxz	90.4	8.6
23	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	pvb	Predicting the Conformational Variability of Abl Tyrosine Kinase Using Molecular Dynamics Simulations and Markov State Models	6bl8	72.08	no data
24	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	prc	CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR	1fpu	91.14	no data
25	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p16	Structural basis for the auto-inhibition of c-Abl tyrosine kinase	1opk	89.12	no data
26	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p16	A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain	2g2h	86.41	no data
27	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p16	Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase	2fo0	89.93	no data
28	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	7mp	Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor	2hiw	95.75	8.
29	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	gin	Abl kinase domain in complex with NVP-AEG082	2hz0	98.46	330.
30	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p3y	Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A	2z60	84.4	9.
31	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	p3y	Crystal Structure of Abl kinase bound with PPY-A	2qoh	84.66	20.
32	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	1n1	X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain	2gqg	74.77	no data
33	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	1n1	Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase	4xey	68.26	no data
34	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sx7	Crystal structure of mutant ABL kinase domain in complex with small molecule fragment	3dk7	83.89	no data
35	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sx7	Crystal structure of mutant ABL kinase domain in complex with small molecule fragment	3dk6	78.14	no data
36	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sx7	Crystal structure of mutant ABL kinase domain in complex with small molecule fragment	3dk3	83.19	no data
37	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	ABL kinase in complex with imatinib and a fragment (FRAG1) in the myristate pocket	3ms9	91.79	no data
38	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	Structural basis for the auto-inhibition of c-Abl tyrosine kinase	1opj	90.95	no data
39	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.	1iep	92.43	100.
40	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	Structure of Abl kinase in complex with imatinib and GNF-2	3k5v	91.6	no data
41	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site	3pyy	89.11	no data
42	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	Human Abl kinase domain in complex with imatinib (STI571, Glivec)	2hyy	89.34	170.
43	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	ABL1 IN COMPLEX WITH COMPOUND6 AND IMATINIB (STI-571)	6hd6	91.25	no data
44	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	sti	Abl kinase in complex with imatinib and fragment (FRAG2) in the myristate site	3mss	89.06	no data
45	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	3yy	Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site	3pyy	75.56	137.
46	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	axi	The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib	4twp	83.52	0.1
47	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	axi	The crystal structure of human abl1 wild type kinase domain in complex with axitinib	4wa9	85.02	3.8
48	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	vx6	Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680	2f4j	79.69	2200.
49	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	vx6	VX-680/MK-0457 binds to human ABL1 also in inactive DFG conformations.	4zog	76.64	no data
50	ABL1	Tyrosine-protein kinase ABL1	P00519	ABL JTK7	627	Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358	2v7a	74.09	5.
51	ABL2	Tyrosine-protein kinase ABL2	P42684	ABLL ARG	dki	The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE	3hmi	82.21	no data
52	ABL2	Tyrosine-protein kinase ABL2	P42684	ABLL ARG	1n1	Crystal structure of Abl2/Arg kinase in complex with dasatinib	4xli	72.87	no data
53	ABL2	Tyrosine-protein kinase ABL2	P42684	ABLL ARG	vx6	HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680	2xyn	79.76	4.
54	ACK1	Activated CDC42 kinase 1	Q07912	ACK1	t95	Crystal Structure of Ack1 with compound T95	3eqp	72.63	no data
55	ACK1	Activated CDC42 kinase 1	Q07912	ACK1	t77	Co-crystal structure of ACK1 with inhibitor	4ewh	72.09	0.3
56	ACK1	Activated CDC42 kinase 1	Q07912	ACK1	t74	Crystal Structure of Ack1 with compound T74	3eqr	77.68	2.
57	ACK1	Activated CDC42 kinase 1	Q07912	ACK1	9ko	Crystal structure of ACK1 with compound 10d	5zxb	73.95	no data
58	ACK1	Activated CDC42 kinase 1	Q07912	ACK1	1g0	ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol	4id7	86.26	no data
59	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	mm8	Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149	6t6d	77.6	no data
60	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	lu8	Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2117	6srh	73.65	no data
61	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	e26	Crystal structure of the ACVR1 (ALK2) kinase in complex with FKBP12 and the inhibitor E6201	6i1s	88.65	no data
62	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	9to	Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638	6acr	80.99	no data
63	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	a3f	Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288	6eix	88.67	no data
64	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	a3f	Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor	3mtf	88.52	no data
65	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	844	Crystal structure of the ACVR1 kinase in complex with LDN-213844	4bgg	77.39	15.
66	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	tak	Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin	3h9r	66.75	no data
67	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	tak	Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin	4c02	75.64	no data
68	ACVR1	Activin receptor type-1	Q04771	ACVRLK2	ezb	Crystal structure of the ACVR1 (ALK2) kinase in complex with a Quinazolinone based ALK2 inhibitor with a 5-methyl core.	6gi6	91.01	no data
69	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	sm9	Spirocyclic sulfonamides as AKT inhibitors	3qkm	86.39	38.
70	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	ex4	Crystal structure of Akt1 in complex with a selective inhibitor	6ccy	78.1	no data
71	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	0rf	Akt1 with GDC0068	4ekl	82.62	no data
72	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	0xz	PKB alpha in complex with AZD5363	4gv1	90.82	3.
73	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	smy	Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors	3ow4	84.75	22.
74	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	wfe	Crystal structure of Akt-1-inhibitor complexes	3mvh	91.73	0.5
75	AKT1	RAC-alpha serine/threonine-protein kinase	P31749	PKB RAC	xfe	Crystal structure of Akt-1-inhibitor complexes	3mv5	95.34	180.
76	AKT2	RAC-beta serine/threonine-protein kinase	P31751		g93	Crystal structure of human Akt2 in complex with GSK690693	3d0e	94.8	4.
77	AKT2	RAC-beta serine/threonine-protein kinase	P31751		x37	Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB	2xh5	87.85	27.
78	ALK	ALK tyrosine kinase receptor	Q9UM73		ymx	Crystal structure of the ALK kinase domain in complex with Entrectinib	5fto	75.11	6.2
79	ALK	ALK tyrosine kinase receptor	Q9UM73		u4w	Crystal structure of the ALK kinase domain in complex with Cmpd 17	5ftq	72.55	10.
80	ALK	ALK tyrosine kinase receptor	Q9UM73		nzf	Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2	4fnz	81.78	16.
81	ALK	ALK tyrosine kinase receptor	Q9UM73		j3y	hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone	6ebw	76.7	no data
82	ALK	ALK tyrosine kinase receptor	Q9UM73		i3k	Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor	4fny	91.78	16.
83	ALK	ALK tyrosine kinase receptor	Q9UM73		hkj	hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine	6e0r	74.88	no data
84	ALK	ALK tyrosine kinase receptor	Q9UM73		cz4	Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine	5imx	72.74	no data
85	ALK	ALK tyrosine kinase receptor	Q9UM73		awj	Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol	4cd0	78.64	0.2
86	ALK	ALK tyrosine kinase receptor	Q9UM73		729	Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a	5iug	78.73	46.4
87	ALK	ALK tyrosine kinase receptor	Q9UM73		4mk	Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378	4mkc	76.46	no data
88	ALK	ALK tyrosine kinase receptor	Q9UM73		4lo	Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378	4z55	74.89	no data
89	ALK	ALK tyrosine kinase receptor	Q9UM73		34y	Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d	5iuh	76.55	402.
90	ALK	ALK tyrosine kinase receptor	Q9UM73		0uv	Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36	4fod	66.93	1.2
91	ALK	ALK tyrosine kinase receptor	Q9UM73		0uu	Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2	4foc	69.27	3.
92	ALK	ALK tyrosine kinase receptor	Q9UM73		0us	Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1	4fob	73.56	5.
93	ALK	ALK tyrosine kinase receptor	Q9UM73		571	Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429	2xba	67.07	23.68
94	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib	2yfx	70.84	8.2
95	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib	4anq	71.58	605.
96	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib	4ans	72.04	no data
97	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)	2xp2	71.2	1.
98	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib	5aab	74.7	0.88
99	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib	5aac	72.89	1.3
100	ALK	ALK tyrosine kinase receptor	Q9UM73		vgh	Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib	5aaa	73.41	0.38
101	ALK	ALK tyrosine kinase receptor	Q9UM73		5p8	Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).	5a9u	81.23	0.08
102	ALK	ALK tyrosine kinase receptor	Q9UM73		5p8	Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).	5aa8	82.14	8.6
103	ALK	ALK tyrosine kinase receptor	Q9UM73		5p8	Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).	5aa9	79.81	6.4
104	ALK	ALK tyrosine kinase receptor	Q9UM73		5p8	Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).	4cli	79.02	1.3
105	ALK	ALK tyrosine kinase receptor	Q9UM73		5p8	Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).	4clj	79.7	0.7
106	ALK	ALK tyrosine kinase receptor	Q9UM73		ypw	Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide	4cmo	78.73	0.85
107	ALK	ALK tyrosine kinase receptor	Q9UM73		iv7	Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one	4cmu	79.22	0.2
108	ALK	ALK tyrosine kinase receptor	Q9UM73		3u9	Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine	4cnh	75.53	4.
109	ALK	ALK tyrosine kinase receptor	Q9UM73		j99	Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one	4ctc	79.3	no data
110	ALK	ALK tyrosine kinase receptor	Q9UM73		0jf	Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor	4dce	80.3	174.
111	ALK	ALK tyrosine kinase receptor	Q9UM73		45q	Crystal Structure of Anaplastic Lyphoma Kinase (ALK) in complex with 4	5iui	77.52	10000.
112	ALK	ALK tyrosine kinase receptor	Q9UM73		6yl	Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide	5kz0	82.58	22.
113	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	ff1	Bovine GRK2 in complex with Gbetagamma subunits and CCG224411	5he3	69.77	280.
114	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	f0s	Bovine GRK2 in complex with Gbetagamma subunits and CCG224406	5he2	80.16	130.
115	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	ejs	Human GRK2 in complex with Gbetagamma subunits and CCG257142	6c2y	86.87	no data
116	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	qrw	Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure	5uuu	85.29	18.
117	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	qrw	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)	3pvu	82.37	290.
118	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	qrx	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)	3pvw	83.24	54.
119	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	29x	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative	4mk0	94.52	6300.
120	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	kzq	G protein-coupled receptor kinase 2 in complex with GSK180736A	4pnk	88.27	250.
121	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	453	Bovine GRK2 in complex with Gbetagamma subunits and CCG215022	5he0	85.36	150.
122	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	8dj	Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)	5ukk	93.07	610.
123	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	six	Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)	5ukl	81.79	630.
124	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	8pv	Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure	5uvc	71.88	6.1
125	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	afm	Human GRK2 in complex with Gbetagamma subunits and CCG258748	5wg3	91.85	8.
126	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	afv	Human GRK2 in complex with Gbetagamma subunits and CCG257284	5wg4	92.99	100.
127	ARBK1	Beta-adrenergic receptor kinase 1	P25098	ADRBK1 BARK BARK1	8pr	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine	3v5w	94.41	no data
128	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	zzl	Aurora-A Inhibitor Structure	2wtv	87.64	1.8
129	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	zzl	STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054	2x81	75.04	5.
130	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	yph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbp	80.38	41.
131	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	x6d	Aurora-A bound to an inhibitor	2x6d	77.9	12.
132	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	wph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbo	81.98	24.
133	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	l0g	Structure determination of Aurora Kinase in complex with inhibitor	2w1g	68.29	3.
134	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	jsn	Aurora-A in complex with shape-diverse fragment 56	6r4b	66.29	no data
135	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	jsb	Aurora-A in complex with shape-diverse fragment 39	6r49	67.51	no data
136	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	jrw	Aurora-A in complex with shape-diverse fragment 58	6r4d	73.44	no data
137	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	hpm	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor	2c6e	79.76	0.8
138	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	g7w	Crystal Structure of Aurora-A L210C catalytic domain in complex with ASDO2	6hjk	87.02	no data
139	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	g7t	Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand	6hjj	84.44	no data
140	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	f8z	Human AURKA bound to BRD-7880	6gra	90.17	no data
141	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	egj	Aurora A ligand complex	6c2t	67.46	no data
142	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	eg7	Aurora A ligand complex	6c2r	78.34	no data
143	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	cj5	Aurora A in complex with CD532	4j8m	93.29	48.
144	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	cc3	Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors	2np8	76.32	42.
145	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	aki	Crystal Structure of Aurora A Kinase complexed with inhibitor	3m11	85.1	43.
146	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak8	Structure of AuroraA with pyridyl-pyrimidine urea inhibitor	3efw	86.26	4.
147	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak7	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 130.	3dj7	94.32	no data
148	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak5	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.	3dj5	94.37	no data
149	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a0h	Structure of Aurora-A bound to a selective imidazopyrazine inhibitor	2xng	65.49	60.
150	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	9yq	Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)	5one	69.44	52.
151	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	9a6	Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor	5zan	66.66	no data
152	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	97b	Aurora A inhibitor complex	3h10	77.28	no data
153	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	6f2	Aurora A kinase bound to an imidazopyridine inhibitor (14b)	5aag	67.38	46.
154	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5vc	Crystal Structure of Aurora A Kinase Domain Bound to MK-5108	5ew9	86.68	0.01
155	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	4rk	Human Aurora A catalytic domain bound to FK1142	4zts	83.78	25.
156	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	48b	Aurora A in complex with a bisanilinopyrimidine	3h0y	71.98	6.
157	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	45b	Aurora A in complex with a bisanilinopyrimidine	3h0z	72	4.3
158	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	400	AURORA-A T288E COMPLEXED WITH PHA-828300	2xru	75.58	31.
159	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	2jz	Crystal structure of aurora A in complex with TPX2 and compound 10	3ha6	70.21	2100.
160	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0fy	Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity	3vap	77.55	4.
161	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c0	Aurora A in complex with RPM1680	3uo4	85.56	299.
162	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	mpy	Aurora-2 T287D T288D complexed with PHA-680632	2bmc	63.69	27.
163	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	pfq	Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor	3k5u	80.92	309.
164	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	626	Structure of Aurora-2 in complex with PHA-680626	2j4z	74.31	65.
165	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	l0e	Structure determination of Aurora Kinase in complex with inhibitor	2w1e	78.21	12.
166	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak1	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea	3d14	93.34	22.
167	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak2	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]	3d15	92.19	no data
168	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak3	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea	3d2i	92.23	no data
169	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak4	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid	3d2k	90.76	no data
170	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	fxg	Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering	3daj	75.66	2900.
171	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ak6	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823.	3dj6	94.91	no data
172	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	mmh	Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity	3fdn	71.39	33.
173	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ofi	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor	3lau	78.43	30000.
174	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	eml	Aurora A Kinase complexed with SCH 1473759	3myg	74.68	0.02
175	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	lje	Crystal structure of benzamide 9 bound to AuroraA	3o50	83.81	no data
176	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	p9j	Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III	3w16	73.32	no data
177	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	p9j	Aurora A kinase domain with phthalazinone pyrazole inhibitor	3p9j	75.98	31.
178	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	d36	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r21	74.48	180.
179	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	d37	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r22	76.97	17.
180	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0bx	Aurora A in complex with YL1-038-31	3uo5	81.98	39.
181	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0by	Aurora A in complex with YL5-083	3uo6	87.92	15.
182	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0bz	Aurora A in Complex with RPM1679	3unz	92.7	16.
183	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c3	Aurora A in complex with RPM1693	3uod	85.28	49.
184	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c4	Aurora A in complex with RPM1722	3uoh	93.23	13.
185	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c5	Aurora A in complex with RPM1715	3uoj	87.44	51.
186	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c6	Aurora A in complex with YL5-81-1	3uok	90.81	0.8
187	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c7	Aurora A in complex with SO2-162	3uol	85.15	3.1
188	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0c8	Aurora A in complex with RPM1686	3up2	88.39	40.
189	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	n13	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII	3w18	76.38	no data
190	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	n15	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV	3w2c	85.3	no data
191	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	vek	Complex of Aurora-A bound to an Imidazopyridine-based inhibitor	4b0g	84.76	15.
192	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	fh3	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byi	75.08	9.
193	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	fh5	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byj	82.31	270.
194	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	nhi	Aurora A in complex with YL1-038-18	4dea	76.77	256.
195	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	0k6	Structure of Aurora A mutant bound to Biogenidec cpd 15	4dhf	71.02	28.
196	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	adn	CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE	1muo	81.99	no data
197	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	adn	Crystal structures of human kinase Aurora A	4o0s	87.58	no data
198	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	adn	Crystal structures of human kinase Aurora A	4o0u	79.16	no data
199	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	adn	Crystal structures of human kinase Aurora A	4o0w	79.94	no data
200	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	2vu	Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)	4prj	78.81	72.
201	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	y3m	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uyn	85.97	4.
202	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	jve	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uzh	81.67	9800.
203	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	vx6	Crystal structure of Aurora A in complex with VX-680 and TPX2	3e5a	82.04	5.9
204	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	vx6	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbq	78.65	no data
205	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	4rm	Human Aurora A catalytic domain bound to FK932	4ztq	84.33	480.
206	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	4rj	Human Aurora A catalytic domain bound to FK1141	4ztr	87.68	5.
207	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	nl4	Aurora A kinase bound to an imidazopyridine inhibitor (14a)	5aaf	74.6	36.
208	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5dn	Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122	5dt4	76.88	no data
209	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5dn	Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122	5dpv	82.61	no data
210	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5dn	Aurora A in complex with ATP and AA35.	5dn3	66.79	no data
211	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5dn	Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122	5dos	79.11	no data
212	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5e1	Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122	5dr6	81.49	no data
213	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	5e1	Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122	5dr2	81.43	no data
214	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	627	Structure of Aurora-2 in complex with PHA-739358	2j50	69.64	13.
215	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	35r	Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation	6cpg	68.67	no data
216	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	9qk	Aurora A kinase in complex with 2-(3-fluorophenyl)quinoline-4-carboxylic acid and ATP	5obj	84.5	16500.
217	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a4w	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5orl	81.16	15000.
218	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a5h	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5oro	59.98	no data
219	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a5w	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5ors	72.77	no data
220	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a8h	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5os4	78.49	1.665e+006
221	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	a9e	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5osf	53.01	no data
222	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ske	Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122	5dt0	84.05	no data
223	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ske	Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122	5dr6	81.67	no data
224	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ske	Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621	5obr	77.65	no data
225	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ske	Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122	5dr9	81.74	no data
226	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	ske	Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122	5dpv	81.5	no data
227	AURKA	Aurora kinase A	O14965	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	l0f	Structure determination of Aurora Kinase in complex with inhibitor	2w1f	79.47	5.9
228	AURKB	Aurora kinase B	Q96GD4	AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	vx6	Human Aurora B Kinase in complex with INCENP and VX-680	4af3	77.33	31.
229	AURKC	Aurora kinase C	Q9UQB9	AIE2 AIK3 AIRK3 ARK3 STK13	vx6	Human AURKC INCENP complex bound to VX-680	6gr9	73.55	no data
230	AURKC	Aurora kinase C	Q9UQB9	AIE2 AIK3 AIRK3 ARK3 STK13	f8z	Human AURKC INCENP complex bound to BRD-7880	6gr8	93.51	no data
231	AVR2A	Activin receptor type-2A	P27037	ACVR2	gvd	Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin	3soc	88.73	no data
232	AVR2A	Activin receptor type-2A	P27037	ACVR2	tak	Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin	3q4t	67.76	no data
233	BMP2K	BMP-2-inducible protein kinase	Q9NSY1	BIKE	idv	Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor	5i3o	88.37	no data
234	BMP2K	BMP-2-inducible protein kinase	Q9NSY1	BIKE	idk	Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor	5i3r	89.45	no data
235	BMP2K	BMP-2-inducible protein kinase	Q9NSY1	BIKE	6bu	Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor	5ikw	87.74	no data
236	BMP2K	BMP-2-inducible protein kinase	Q9NSY1	BIKE	ydj	Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762	4w9w	77.26	33.1
237	BMX	Cytoplasmic tyrosine-protein kinase BMX	P51813		pp2	Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2	3sxs	92.28	no data
238	BMX	Cytoplasmic tyrosine-protein kinase BMX	P51813		1n1	Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib	3sxr	69.85	no data
239	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	p06	BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib	5hie	93.13	no data
240	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	p06	B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib	4xv2	90.29	5.4
241	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	p06	B-RAF in complex with Dabrafenib	5csw	90.33	4.
242	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	l1e	B-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor	3idp	91.24	1.6
243	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	k81	BRAF in complex with N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254)	6n0p	89.65	no data
244	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	92j	BRAF in Complex with RAF709	5vam	90.99	no data
245	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	904	B-Raf Kinase V600E oncogenic mutant in complex with PLX7904	4xv1	81.61	4.2
246	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	8en	Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor	6b8u	91.27	0.2
247	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	831	The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor	3ii5	73.87	24.
248	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	54j	CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370	5csx	79.7	6.
249	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	4z5	CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND	5c9c	92.35	no data
250	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	29l	BRAF dimer bound to 14-3-3	6u2h	89.01	no data
251	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	1su	Crystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-632	4ksp	85.91	1.6
252	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	1oo	B-Raf Kinase domain in complex with PLX5568	4xv9	94.16	190.
253	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	0t2	Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor	4fc0	86.17	69.
254	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	032	Crystal structure of the BRAF (R509H) kinase domain monomer bound to Vemurafenib	4rzv	90.65	no data
255	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	032	B-Raf Kinase V600E oncogenic mutant in complex with PLX4032	3og7	84.1	31.
256	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	215	Structure of the B-Raf kinase domain bound to SB-590885	2fb8	67.65	0.16
257	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	bax	BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib	5hi2	88.91	no data
258	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	bax	The complex of wild type B-RAF and BAY439006.	1uwh	90.75	22.
259	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	sm5	Pyrazole-based inhibitors of B-Raf kinase	3d4q	81.51	0.03
260	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	fni	Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor	3ppk	82.45	1.4
261	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	fp3	Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor	3prf	84.23	1.4
262	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	734	BRAF in complex with an organic inhibitor 7898734	4e26	70.76	no data
263	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	325	B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX3203	4fk3	85.51	no data
264	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	29l	Crystal structure of BRAF-V600E bound to GDC0879	4mnf	87.18	no data
265	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	324	B-Raf Kinase in Complex with PLX4720	3c4c	88.96	160.
266	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	324	Crystal structure of a BRAF kinase domain monomer	4wo5	97.3	no data
267	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	p02	B-Raf Kinase V600E oncogenic mutant in complex with PLX7922	4xv3	88.12	12.
268	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	5xj	B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor	5fd2	91.05	90.
269	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	b1e	BRAF Kinase domain b3aC loop deletion mutant in complex with AZ628	5hid	89.23	no data
270	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	6dc	Crystal Structure of BRAF Kinase Domain Bound to AZ-VEM	5ita	93.31	no data
271	BRAF	Serine/threonine-protein kinase B-raf	P15056	BRAF1 RAFB1	6n9	BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM	5jrq	91.41	169.
272	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	mzj	Structure of human Bruton's Tyrosine Kinase in complex with Evobrutinib	6omu	84.86	no data
273	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	ltj	BTK In Complex With Inhibitor	6o8i	80.73	no data
274	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	lhl	Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one	3pj1	68.76	48.
275	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	l9s	Brutons tyrosine kinase in complex with compound 50.	6nzm	85.88	no data
276	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	l0z	BTK in complex with an inhibitor	6s90	69.03	no data
277	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	klp	BTK in complex with inhibitor N-(3-{[(2,6-dimethylphenyl)methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide	6nfi	79.19	no data
278	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	klm	BTK in complex with inhibitor 8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[(2S)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8-dihydropteridine-6,7-dione	6nfh	65.85	no data
279	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	khd	Discovery of affinity-based probes for Btk occupancy assay	6n9p	84.63	no data
280	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	jvp	Crystal structure of mouse BTK kinase domain in complex with compound 9a	6mny	91.26	no data
281	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gmw	CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 12-(6-tert-butyl-8-fluoro-1-oxo-phthalazin-2-yl)-9-hydroxy-6-methyl-4-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-azatricyclo[9.4.0.02,7]pentadeca-1(15),2(7),3,11,13-pentaen-5-one	6hrt	75.43	no data
282	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gjg	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH FRAGMENT LIGAND	6di0	79.15	no data
283	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gjd	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT FRAGMENT LIGAND	6di1	81.86	no data
284	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	dy4	BTK complex with compound 13	6bln	78.38	no data
285	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	dxm	BTK complex with compound 12	6bkw	80.58	no data
286	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	dvj	BTK complex with compound 10	6bke	75.71	no data
287	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	dvd	BTK complex with compound 11	6bkh	74.51	no data
288	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	dtj	BTK complex with compound 7	6bik	72.49	no data
289	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	bxm	CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR CGI2815	6aub	72.64	no data
290	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	bxj	CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR CGI2625	6aua	70.81	no data
291	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	bnb	Crystal structure of BTK kinase domain complexed with N-[2-methyl-3-[4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin-2-yl]phenyl]-4-(1-piperidyl)benzamide	6ep9	72.4	no data
292	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	ba0	Co-crystal structure of BTK kinase domain with Zanubrutinib	6j6m	86.66	no data
293	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	9m3	Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e	5zz4	72.44	no data
294	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	9b1	Bruton's tyrosine kinase (BTK) with compound G-744	5vgo	90.27	2.
295	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	9aj	Bruton's tyrosine kinase (BTK) with GDC-0853	5vfi	69.83	no data
296	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	7g8	CRYSTAL STRUCTURE OF BTK with CNX 774	5p9k	58.69	no data
297	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	7g7	BTK1 COCRYSTALLIZED WITH RN983	5p9h	70.78	no data
298	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	7g6	Structure of BTK with RN486	5p9g	72.41	no data
299	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	746	Crystal structure of bruton's tyrosine kinase in complex with inhibitor CGI1746	3ocs	72.37	no data
300	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	746	Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk)	4y93	75.04	no data
301	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	746	Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop	4y95	72.59	no data
302	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	73t	Crystal structure of Bruton agammabulinemia tyrosine kinase complexed with BMS-986142 aka (2s)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide	5t18	67.47	0.5
303	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	6xl	Bruton's tyrosine kinase (BTK) with pyridazinone compound 9	5kup	82.14	7.2
304	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	6mv	CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH 4-[2-FLUORO-3-(4-OXO -3,4-DIHYDROQUINAZOLIN-3-YL)PHENYL]-7-(2-HYDROXYPROPAN-2-Y L)-9H-CARBAZOLE-1-CARBOXAMIDE	5jrs	70.71	4.
305	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	5wh	BTK-inhibitor co-structure	5fbo	82.51	0.31
306	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	5wf	BTK kinase domain with inhibitor 1	5fbn	85.34	0.27
307	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	5we	BTK kinase domain with inhibitor 1	5fbn	71.23	no data
308	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	4uq	Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171 AKA 6-[(3R)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide	5bpy	57.04	no data
309	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	4c9	Bruton's tyrosine kinase in complex with a t-butyl cyanoacrylamide inhibitor	4yhf	82.75	4.6
310	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	481	Crystal structure of BTK kinase domain complexed with 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide	4ot5	74.23	no data
311	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	3yo	Bruton's tyrosine kinase (BTK) with pyridazinone compound 23	4rx5	74.07	3.
312	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	3p0	Crystal structure of BTK kinase domain complexed with 2-[8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]-2-methyl-propanenitrile	4rg0	72.96	50.
313	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	3ov	Crystal structure of BTK kinase domain complexed with 6-(dimethylamino)-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]isoquinolin-1-one	4rfz	74.36	40.
314	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	3ou	Crystal structure of BTK kinase domain complexed with 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4-dihydroisoquinolin-1-one	4rfy	74.39	100.
315	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2vl	BTK IN COMPLEX WITH GDC-0834	5p9f	76.19	no data
316	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2vl	Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834	4otf	74.27	6.
317	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2v3	Crystal structure of BTK kinase domain complexed with 6-cyclopropyl-2-[3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3-pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one	4otr	72.26	no data
318	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2v1	Crystal structure of BTK kinase domain complexed with 4-Methanesulfonyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide	4ot6	52.23	1200.
319	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2p5	Crystal structure of Bruton agammaglobulinemia tyrosine kinase complexed with BMS-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4-(morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide	4nwm	75.28	8.
320	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	04l	Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide	3pj3	84.93	5600.
321	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	04k	Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one	3pj2	66.06	7200.
322	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	1n1	Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib	3oct	79.71	no data
323	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	1n1	Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.	3k54	73.67	1.
324	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	027	Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one	3pix	63.5	100.
325	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	585	Crystal structure of BTK kinase domain complexed with R406	3piy	74.38	290.
326	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	03c	Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone	3piz	71.49	3500.
327	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	b43	The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound	3gen	89.07	0.72
328	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	2v2	Crystal structure of BTK kinase domain complexed with 1-[5-[3-(7-tert-butyl-4-oxo-quinazolin-3-yl)-2-methyl-phenyl]-1-methyl-2-oxo-3-pyridyl]-3-methyl-urea	4otq	84.62	no data
329	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	4rv	Crystal Structure of Bruton's Tyrosine Kinase in complex with a substituted Cinnoline	4zlz	91.96	100.
330	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	4us	Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171 AKA 6-[(3R)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide	5bq0	67.17	15.
331	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	8e8	BTK1 COCRYSTALLIZED WITH IBRUTINIB	5p9j	85.03	no data
332	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	7g9	BTK1 IN COMPLEX WITH CC 292	5p9l	62.94	no data
333	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	7gb	BTK1 BINDS COVALENTLY TO HY-15771 ONO-4059	5p9m	92.58	no data
334	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	83p	Discovery of a potent BTK inhibitor with a novel binding mode using parallel selections with a DNA-encoded chemical library	5u9d	86.16	0.55
335	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gyl	The structure of human BTK kinase domain in complex with a covalent inhibitor	5xyz	81.76	no data
336	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	1e8	BTK1 SOAKED WITH IBRUTINIB-Rev	5p9i	86.65	no data
337	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gja	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH FRAGMENT LIGAND	6di3	84.63	no data
338	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gj7	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT INHIBITOR	6di5	85.06	no data
339	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	gjj	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT INHIBITOR	6di9	58.25	no data
340	BTK	Tyrosine-protein kinase BTK	Q06187	AGMX1 ATK BPK	hra	Crystal structure of ARQ 531 in complex with the kinase domain of BTK	6e4f	85.42	no data
341	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	O43683	BUB1L	cvq	Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032	6f7b	96.28	no data
342	CDC7	Cell division cycle 7-related protein kinase	O00311	CDC7L1	0sy	Human CDC7 kinase in complex with DBF4 and PHA767491	4f9b	87.02	no data
343	CDC7	Cell division cycle 7-related protein kinase	O00311	CDC7L1	0sx	Human CDC7 kinase in complex with DBF4 and XL413	4f9c	91.78	no data
344	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	fc8	CDK1/CyclinB/Cks2 in complex with CGP74514A	6gu4	82.64	no data
345	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	fb8	CDK1/Cks2 in complex with AZD5438	6gu7	87.26	no data
346	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	fb8	CDK1/CyclinB/Cks2 in complex with AZD5438	6gu3	87.89	no data
347	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	f9z	CDK1/CyclinB/Cks2 in complex with Flavopiridol	6gu2	82.54	no data
348	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	1qk	CDK1/Cks2 in complex with Dinaciclib	6gu6	89.85	no data
349	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	lz9	Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor	5hq0	90.87	no data
350	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	lz9	Human CDK1/CyclinB1/CKS2 With Inhibitor	4y72	90.87	no data
351	CDK1	Cyclin-dependent kinase 1	P06493	CDC2 CDC28A CDKN1 P34CDC2	4sp	CDK1/CyclinB1/CKS2 in complex with NU6102	5lqf	85.18	250.
352	CDK12	Cyclin-dependent kinase 12	Q9NYV4	CRK7 CRKRS KIAA0904	5i1	Crystal Structure of the Human Cdk12-Cyclink Complex	5acb	72.73	158.
353	CDK12	Cyclin-dependent kinase 12	Q9NYV4	CRK7 CRKRS KIAA0904	8m1	Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide	6ckx	67.12	no data
354	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z71	CDK2 in complex with inhibitor RC-2-143	3r9o	86.22	100000.
355	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z67	CDK2 in complex with inhibitor RC-2-142	3r9h	85.72	100000.
356	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z14	CDK2 in complex with inhibitor KVR-2-92	3r83	80.26	no data
357	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x87	CDK2 in complex with inhibitor KVR-1-164	3r73	78.79	no data
358	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x6b	CDK2 in complex with inhibitor RC-2-135	3r9d	85.19	71000.
359	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x63	CDK2 in complex with inhibitor KVR-1-190	3qx2	81.24	no data
360	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	t7z	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcm	80.13	123.
361	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	o1z	CDK2 in complex with inhibitor RC-2-22	3rah	88.64	12.
362	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls5	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkp	84.6	no data
363	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls5	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	1ke9	80.66	660.
364	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hjk	CDK2 in complex with FragLite37	6q4g	90.32	no data
365	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hhw	CDK2 in complex with FragLite38	6q4k	50.26	no data
366	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hhb	CDK2 in complex with FragLite34	6q4j	94.7	no data
367	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hgh	CDK2 in complex with FragLite36	6q4h	88.87	no data
368	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fcq	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455	6gva	77.82	no data
369	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fc8	CDK2 in complex with CGP74514A	6guk	82.37	no data
370	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fb8	CDK2 in complex with AZD5438	6guh	88	no data
371	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fb8	CDK2/CyclinA in complex with AZD5438	6gue	88.67	no data
372	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	f9z	CDK2/CyclinA in complex with Flavopiridol	6gub	88.61	no data
373	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dt4	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6l	85.15	270.
374	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	d23	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325	2b53	83.33	600.
375	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	cdk	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xmy	76.41	0.11
376	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ajr	Crystal structure of CDK2 IN complex with Inhibitor CVT-313	6inl	83	no data
377	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	a27	Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor	3lfn	85.41	3160.
378	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	7yg	CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE	4acm	76.5	210.
379	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6cp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086	1h1r	86.23	2300.
380	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	62k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkw	86.95	no data
381	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	60k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fku	26.38	no data
382	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	60k	Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor	4fx3	84.54	no data
383	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	2kd	Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor	4nj3	92.44	300.
384	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	27z	CDK2 in complex with inhibitor RC-2-40	3rpy	85.07	4800.
385	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	26z	CDK2 in complex with inhibitor RC-2-88	3rpv	87.05	70.
386	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	23d	CDK2/CyclinA in complex with CGP74514A	6guf	81.22	no data
387	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	18z	CDK2 in complex with inhibitor KVR-2-80	3rm6	82.32	no data
388	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	pvb	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B	1ckp	84.12	no data
389	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	nw1	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027	1e1x	88.39	1300.
390	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	i17	CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717	1g5s	82.34	48.
391	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gih	90.51	no data
392	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gii	86.18	no data
393	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	2pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gij	82.23	no data
394	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fap	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	81.12	38000.
395	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fcp	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	85.06	38000.
396	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fal	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h01	80.3	22000.
397	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	fbl	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h01	90.97	no data
398	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	bwp	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h08	89.7	no data
399	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	byp	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h08	83.29	28000.
400	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	un4	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[(R)-pyrrolidino-5'-yl]methoxypurine	1h0v	92.53	no data
401	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	207	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[cyclohex-3-enyl]methoxypurine	1h0w	84.26	13000.
402	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	cmg	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058	1e1v	92.45	12000.
403	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	cmg	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058	1h1p	88.88	12000.
404	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	2a6	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094	1h1q	86.11	1000.
405	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	u55	The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide	1jsv	82.1	2000.
406	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls1	CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide	1ke5	81.96	560.
407	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls2	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE	1ke6	76.62	5.7
408	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls3	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE	1ke7	82.58	8.9
409	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ls4	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE	1ke8	80.99	1000.
410	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	st8	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR	1ogu	85.31	34.
411	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	n20	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oi9	83.85	69.
412	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hdu	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oiq	87.68	2900.
413	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	hdy	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oir	69.58	32.
414	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	n76	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiu	81.71	210.
415	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	n41	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiy	85.78	64.
416	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ck5	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxm	87.8	60.
417	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ck6	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxn	91.71	70.
418	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	pm1	Crystal structure of CDK2 with inhibitor	1pye	88.06	386.
419	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	i1p	CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE	1urw	70.75	3.
420	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	3fp	CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR	1v1k	70.65	35000.
421	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	292	Structure of CDK2/Cyclin A with PNU-292137	1vyw	83.4	37.
422	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	n5b	Structure of CDK2 complexed with PNU-181227	1vyz	86.01	290.
423	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	olo	Crystal structure of human CDK2 in complex with the inhibitor olomoucine.	1w0x	83.15	5000.
424	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	n69	CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2	1w8c	84.4	no data
425	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ct7	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor	1y8y	80.83	no data
426	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ct9	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor	1y91	82.63	59.
427	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	628	Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor	1ykr	83.22	560.
428	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ck9	Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor	2a0c	87.21	50.
429	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	d42	Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562	2b52	84.46	8.
430	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	d05	Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305	2b54	82.66	20.
431	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	d31	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312	2b55	88.24	96.
432	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	bry	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE	2bhe	86.31	no data
433	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ryu	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 4-HYDROXYPIPERINDINESULFONYL-INDIRUBINE	2bhh	88.75	no data
434	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	529	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529	2bpm	75.56	2.
435	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	u73	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873	2btr	82.49	95.
436	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	u32	STRUCTURE OF CDK2 COMPLEXED WITH PNU-230032	2bts	83.09	20.
437	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ct8	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c69	90.05	26000.
438	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dt1	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6i	88.01	11000.
439	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dt2	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6k	85.78	730.
440	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dt5	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6m	84.37	350.
441	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dt5	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6t	84.52	no data
442	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	371	Structure of CDK2 with a 3-hydroxychromones	2duv	90.41	87.
443	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lia	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor	2fvd	81.44	3.
444	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	nu5	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271	2g9x	77.59	45.
445	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	blz	Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor	2i40	87.95	1580.
446	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	qq2	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw6	70.4	140.
447	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	sc8	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3f	91.52	500.
448	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	sc9	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3g	90.62	800.
449	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	sce	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3h	82.82	20000.
450	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	scf	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3i	87.92	1000.
451	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	scj	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3j	84.33	10.
452	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	scx	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3m	93.45	10.
453	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	scz	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3n	91.12	70.
454	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	2sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3o	91.05	600.
455	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	3sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3p	89.25	900.
456	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	5sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3q	89.74	no data
457	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3r	90.18	no data
458	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	740	Crystal structure of a 3-aminoindazole compound with CDK2	2r64	79.47	30.
459	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lz3	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vti	84.65	660.
460	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lz4	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design	2vtj	79.92	1900.
461	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lz7	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtn	87.99	850.
462	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lz8	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vto	86.2	140.
463	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lza	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtq	84.18	140.
464	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lzc	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vts	88.34	30.
465	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lzd	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtt	86.48	44.
466	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lze	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vu3	84.72	47.
467	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	im9	CDK2 in complex with an imidazole piperazine	2vv9	72.33	17.
468	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	frt	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b	2w05	74.98	1.
469	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	frv	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c	2w06	83.98	83.
470	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	i19	CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b	2w17	77.47	2.
471	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	l0f	Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity	2w1h	88.32	52.
472	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	p48	STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125	2wih	77.68	45.
473	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	p49	STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID	2wip	86.49	no data
474	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	889	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing	2wpa	88.64	8.
475	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	wxv	Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor	2wxv	82.48	2.
476	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x1n	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design	2x1n	89.93	no data
477	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	y8l	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xnb	81.41	149.
478	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	mhr	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5	3bhu	92.95	no data
479	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	rc8	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8	3ddp	81.18	72.
480	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	rrc	Human cyclin-dependent kinase 2 in complex with roscovitine	2a4l	86.15	400.
481	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	rrc	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine	3ddq	85.93	210.
482	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	nnn	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1	3dog	84.44	40.
483	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ezr	CDK-2 with indazole inhibitor 17 bound at its active site	3ezr	83.19	10000.
484	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	efp	Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2	3ig7	84	63.
485	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	efq	Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2	3igg	83.61	66.5
486	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	a28	Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor	3lfq	87.42	no data
487	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	a07	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor	3lfs	90.6	2500.
488	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	rfz	CDk2/cyclinA in complex with DRB	3my5	85.52	65000.
489	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	ns9	Crystal structure of CDK2 in complex with inhibitor BS-194	3ns9	90.47	3.
490	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	404	Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.	3pj8	88.75	40.
491	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x0a	CDK2 in complex with inhibitor L2-2	3qqh	93.66	no data
492	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x02	CDK2 in complex with inhibitor L4	3qqk	89.92	15000.
493	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x03	CDK2 in complex with inhibitor L3	3qql	87.85	no data
494	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x14	CDK2 in complex with inhibitor NSK-MC2-55	3qrt	78.5	no data
495	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x19	CDK2 in complex with inhibitor NSK-MC1-12	3qru	89.23	no data
496	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x35	CDK2 in complex with inhibitor RC-1-137	3qtq	89.98	3100.
497	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x36	CDK2 in complex with inhibitor RC-1-148	3qtr	89.99	930.
498	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x46	CDK2 in complex with inhibitor RC-2-12	3qts	89.36	3100.
499	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x3a	CDK2 in complex with inhibitor RC-2-13	3qtw	91.98	650.
500	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x42	CDK2 in complex with inhibitor RC-2-36	3qtz	86.52	50.
501	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x40	CDK2 in complex with inhibitor RC-2-38	3qu0	87.25	20.
502	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x6a	CDK2 in complex with inhibitor KVR-1-142	3qwj	82.44	no data
503	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x4b	CDK2 in complex with inhibitor KVR-1-78	3qx4	83.06	no data
504	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x69	CDK2 in complex with inhibitor KVR-1-124	3qzh	78.38	no data
505	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x75	CDK2 in complex with inhibitor KVR-1-102	3r1q	74.11	no data
506	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x76	CDK2 in complex with inhibitor KVR-1-134	3r1y	81.94	no data
507	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x84	CDK2 in complex with inhibitor KVR-1-158	3r6x	76.91	no data
508	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x86	CDK2 in complex with inhibitor KVR-1-162	3r71	85.09	no data
509	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z04	CDK2 in complex with inhibitor KVR-2-88	3r7y	85.69	no data
510	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z30	CDK2 in complex with inhibitor L3-4	3r8l	87.47	no data
511	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z46	CDK2 in complex with inhibitor NSK-MC1-6	3r8p	89.27	no data
512	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z31	CDK2 in complex with inhibitor RC-1-132	3r8u	89.94	5000.
513	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z63	CDK2 in complex with inhibitor RC-1-136	3r8z	90.65	49000.
514	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z68	CDK2 in complex with inhibitor RC-2-21	3r9n	89.39	1400.
515	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x85	CDK2 in complex with inhibitor KVR-1-160	3rai	75.73	no data
516	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	03z	CDK2 in complex with inhibitor RC-2-32	3rak	84.69	130.
517	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	04z	CDK2 in complex with inhibitor RC-2-34	3ral	88.04	100.
518	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	06z	CDK2 in complex with inhibitor L4-12	3rjc	85.35	5700.
519	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	07z	CDK2 in complex with inhibitor RC-2-72	3rk5	85.98	4000.
520	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	08z	CDK2 in complex with inhibitor RC-2-71	3rk7	84.12	200.
521	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	09z	CDK2 in complex with inhibitor RC-2-74	3rk9	88.99	520.
522	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	12z	CDK2 in complex with inhibitor RC-2-73	3rkb	86.98	380.
523	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	20z	CDK2 in complex with inhibitor RC-2-33	3rmf	87.9	82000.
524	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	22z	CDK2 in complex with inhibitor KVR-1-154	3roy	71.97	no data
525	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	24z	CDK2 in complex with inhibitor KVR-1-156	3rpo	77.88	no data
526	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	z60	CDK2 in complex with inhibitor L4-14	3s00	84.86	12000.
527	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	50z	CDK2 in complex with inhibitor RC-1-138	3s0o	88.36	33000.
528	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	56z	CDK2 in complex with inhibitor RC-2-39	3s1h	87.75	17000.
529	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	99z	CDK2 in complex with inhibitor RC-3-96	3sqq	86.25	4800.
530	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	18k	Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor	3sw4	84.08	no data
531	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1n3	Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative	3uli	86.37	70.
532	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	0bx	CDK2 in complex with inhibitor YL1-038-31	3unj	88.9	11000.
533	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	0by	CDK2 in complex with inhibitor YL5-083	3unk	88.74	15000.
534	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	tjf	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcq	74.4	147.
535	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	3i6	Crystal Structure of CDK2 in complex with pan-CDK Inhibitor	4bgh	86.26	4.
536	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	d6i	Structure of CDK2 in complex with a benzimidazopyrimidine	4bzd	75.55	no data
537	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4qe	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfm	83.59	18200.
538	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	jym	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfn	85.14	no data
539	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	2wc	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfu	81.13	100000.
540	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	75x	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfv	78.73	23600.
541	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	sq9	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfw	74.99	510.
542	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1ck	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek4	82.02	no data
543	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	03k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek5	81.88	no data
544	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	10k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek6	77.74	no data
545	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4ck	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4fkg	81.08	no data
546	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	09k	Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor	4fki	84.21	no data
547	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	11k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4fkj	69.09	no data
548	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	48k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkt	77.49	no data
549	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	b49	CDK2 in complex with SUNITINIB	3ti1	79.37	130000.
550	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1yg	Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide	4lyn	87	60.
551	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	3qs	CDK2 with EGFR inhibitor compound 8	4rj3	83.92	93.
552	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	lz9	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtp	84.7	3.
553	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	dtq	THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di8	84.48	1000.
554	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	wy3	Crystal structure of CDK2 in complex with 7-hydroxy-4-(morpholinomethyl)chromen-2-one processed with the CrystalDirect automated mounting and cryo-cooling technology	5ang	93.92	no data
555	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	zxc	Crystal structure of CDK2 in complex with N-(9H-purin-6-yl)thiophene- 2-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology	5anj	83.46	no data
556	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	rji	Crystal structure of CDK2 in complex with 2,4,6-trioxo-1-phenyl- hexahydropyrimidine-5-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology	5ank	90.65	no data
557	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	55s	CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)	5cyi	81.19	1310.
558	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	56h	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032)	5d1j	89.03	48.
559	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	r0n	Crystal structure of BAY 1000394 (Roniciclib) bound to CDK2	5iev	81.85	no data
560	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6af	Crystal structure of (R,S)-S-{4-[(5-Bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide bound to CDK2	5iex	82.09	no data
561	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6ae	Crystal structure of a CDK inhibitor bound to CDK2	5iey	84.94	no data
562	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	i74	Crystal structure of CDK2 in complex with inhibitor ICEC0942	5jq5	88.33	2341.
563	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	i73	Crystal structure of CDK2 in complex with inhibitor ICEC0943	5jq8	89.7	2000.
564	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6qb	Crystal Structure of CDK2 in complex with compound 22	5k4j	91.34	77.5
565	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1qk	CDK2 in complex with Dinaciclib	4kd1	91.83	no data
566	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	1qk	The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.	5l2w	93.42	210.
567	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	6zk	Structure of phopsho-CDK2-cyclin A in complex with an ATP-competitive inhibitor	5lmk	74.8	37.
568	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6o	85.27	6.
569	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw9	79.42	8.9
570	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR	2iw8	82.78	103.
571	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102	4eor	83.18	500.
572	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102	4eok	84.01	8600.
573	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	4sp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102	1h1s	81.92	6.
574	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	8qt	CCT068127 in complex with CDK2	5mhq	89.81	no data
575	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	9z2	Cdk2(F80C, C177A) covalent adduct with C37 at F80C	5oo1	88.08	no data
576	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	aeq	Cdk2(F80C, C177A) with covalent adduct at C80	5osm	92.88	no data
577	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	pdy	Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor	3wbl	82.13	23000.
578	CDK2	Cyclin-dependent kinase 2	P24941	CDKN2	x07	CDK2 in complex with inhibitor L1	3qqf	80.77	no data
579	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDKN5	alh	Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.	1ung	77.68	160.
580	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDKN5	rrc	Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.	1unl	87.17	200.
581	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	6zv	The X-ray co-crystal structure of human CDK6 and Abemaciclib.	5l2s	72.35	83.
582	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	lqq	The X-ray co-crystal structure of human CDK6 and Palbociclib.	5l2i	79.08	40.1
583	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	lqq	X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991	2euf	81.04	15.
584	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	ap9	X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol	2f2c	77.16	450.
585	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	3nu	CDK6 (monomeric) in complex with inhibitor	3nup	83.84	no data
586	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	3nv	CDK6 (monomeric) in complex with inhibitor	3nux	74.35	no data
587	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	fse	Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin	1xo2	93.45	850.
588	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	0rs	CDK6 (monomeric) in complex with inhibitor	4ez5	69.39	300.
589	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	24v	Crystal structure of a CDK6/Vcyclin complex with inhibitor bound	4tth	79	no data
590	CDK6	Cyclin-dependent kinase 6	Q00534	CDKN6	6zz	The X-ray co-crystal structure of human CDK6 and Ribociclib.	5l2t	81.5	650.
591	CDK8	Cyclin-dependent kinase 8	P49336		bax	Crystal Structure of human CDK8/CycC	3rgf	94.57	no data
592	CDK8	Cyclin-dependent kinase 8	P49336		0st	Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea)	4f70	87.13	1820.
593	CDK8	Cyclin-dependent kinase 8	P49336		4tv	CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one	5bnj	79.47	2.
594	CDK8	Cyclin-dependent kinase 8	P49336		5xg	CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one	5fgk	83.47	1.7
595	CDK8	Cyclin-dependent kinase 8	P49336		5y8	CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one	5hbj	86.65	2.3
596	CDK8	Cyclin-dependent kinase 8	P49336		6a6	CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone	5idp	90.36	45.
597	CDK8	Cyclin-dependent kinase 8	P49336		6a7	CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone	5idn	93.73	2.6
598	CDK8	Cyclin-dependent kinase 8	P49336		69z	CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone	5icp	93.53	3.8
599	CDK8	Cyclin-dependent kinase 8	P49336		68u	CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide	5i5z	85.79	0.9
600	CDK8	Cyclin-dependent kinase 8	P49336		66x	CDK8/CYCC IN COMPLEX WITH COMPOUND 20	5hvy	93.74	17.4
601	CDK8	Cyclin-dependent kinase 8	P49336		62m	CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone	5hnb	93.27	no data
602	CDK8	Cyclin-dependent kinase 8	P49336		5y7	CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide	5hbh	84.03	49.2
603	CDK8	Cyclin-dependent kinase 8	P49336		5y6	CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one	5hbe	86.98	2.3
604	CDK8	Cyclin-dependent kinase 8	P49336		50r	Crystal structure of CDK8:Cyclin C complex with compound 22	5cei	88.37	5.3
605	CDK8	Cyclin-dependent kinase 8	P49336		0sw	Crystal structure of human CDK8/CYCC in the DMG-in conformation	4f7s	87.49	no data
606	CDK8	Cyclin-dependent kinase 8	P49336		0sr	Crystal structure of human CDK8/CYCC in complex with compound 5 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea)	4f6u	97.93	700.
607	CDK9	Cyclin-dependent kinase 9	P50750	CDC2L4 TAK	t7z	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bch	80.47	22.
608	CDK9	Cyclin-dependent kinase 9	P50750	CDC2L4 TAK	cpb	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol	3blr	89.17	6.4
609	CDK9	Cyclin-dependent kinase 9	P50750	CDC2L4 TAK	slq	Structure of CDK9/CyclinT in complex with S-CR8	3lq5	75.76	110.
610	CDK9	Cyclin-dependent kinase 9	P50750	CDC2L4 TAK	rfz	Structure of CDK9/cyclinT1 in complex with DRB	3my1	88.01	3580.
611	CDK9	Cyclin-dependent kinase 9	P50750	CDC2L4 TAK	adn	crystal structure of P-TEFb complex with AFF4 and Tat	4ogr	83.6	no data
612	CDKL1	Cyclin-dependent kinase-like 1	Q00532		d15	CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN	4agu	86.43	no data
613	CDKL2	Cyclin-dependent kinase-like 2	Q92772		tc0	CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312	4bbm	81.15	no data
614	CDKL2	Cyclin-dependent kinase-like 2	Q92772		dki	Crystal structure of the human CDKL2 kinase domain	4aaa	88.27	no data
615	CDKL3	Cyclin-dependent kinase-like 3	Q8IVW4	NKIAMRE	38r	Crystal structure of the human CDKL3 kinase domain	3zdu	95.34	no data
616	CDKL5	Cyclin-dependent kinase-like 5	O76039	STK9	38r	Crystal structure of the human CDKL5 kinase domain	4bgq	95.39	no data
617	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	a58	Crystal Structure of the CHK1	4fsn	72.39	no data
618	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	a58	Structure of h-CHK1 complexed with AA582939	2e9o	71.34	20.
619	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	76a	Structure of h-CHK1 complexed with A767085	2e9n	68.46	6.2
620	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	5cv	Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design	5dls	70.15	4.4
621	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	38m	Crystal structure of chk1 kinase in complex with inhibitor 38	3f9n	62.95	1300.
622	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	2hk	Crystal Structure of the CHK1	4ftn	77.6	no data
623	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	199	Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor	1zys	70.84	no data
624	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	pfp	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2br1	71.25	7200.
625	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	pfq	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brb	78.9	13700.
626	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	dfy	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brg	77.59	6100.
627	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	dfw	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brh	75.03	22900.
628	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	df1	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brn	81.6	5500.
629	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	df2	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2bro	81.71	1400.
630	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3d3	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening	2cgx	86.37	15600.
631	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	77a	Structure of h-CHK1 complexed with A771129	2e9p	88.19	no data
632	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	a25	Structure of h-CHK1 complexed with A780125	2e9u	87.91	7.94
633	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	85a	Structure of h-CHK1 complexed with A859017	2e9v	73.48	12.59
634	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	12c	4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors	2gdo	89.51	0.32
635	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	710	crystal structure of Chek1 in complex with inhibitor 20	2hog	74.31	0.3
636	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	422	crystal structure of Chek1 in complex with inhibitor 1	2hxl	66.68	12.
637	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	373	crystal structure of Chek1 in complex with inhibitor 2	2hxq	65.29	144.
638	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	306	crystal structure of chek1 in complex with inhibitor 22	2hy0	70.81	0.65
639	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	7cs	crystal structure of Chek1 in complex with inhibitor 2a	2qhm	85.08	660.
640	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	m54	Crystal Structure of Chek1 in Complex with Inhibitor 54	2r0u	82.1	1.
641	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	zyq	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmq	80.83	no data
642	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	zyr	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmr	86.74	52000.
643	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	zyv	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmv	82.67	9200.
644	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	zyw	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmw	77.51	390.
645	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	zy6	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmx	74.83	860.
646	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	x8e	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration	2x8e	78.18	14.
647	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	x8i	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration	2x8i	82.36	190.
648	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ydi	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydi	62.07	150.
649	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ydk	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydk	82.54	7.
650	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ym3	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym3	74.44	1000.
651	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	4ym	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym4	85.81	1500.
652	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ym5	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym5	81.06	430.
653	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ym6	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym6	83.65	880.
654	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ym8	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym8	84.59	13.
655	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	agx	Characterization of the Chk1 allosteric inhibitor binding site	3jvr	64.46	1890.
656	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	5be	Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death	3nlb	75.71	35.
657	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	22k	X-ray crystal structure of compound 22k bound to human Chk1 kinase domain	3ot3	85.1	5.
658	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	mi5	X-ray crystal structure of compound 17r bound to human Chk1 kinase domain	3ot8	82.71	9.
659	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	c70	X-ray crystal structure of compound 70 bound to human CHK1 kinase domain	3pa3	78	1.
660	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	c72	X-ray crystal structure of compound 2a bound to human CHK1 kinase domain	3pa4	77.2	3.
661	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	c73	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain	3pa5	79.39	2.
662	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	07s	Crystal structure of Chk1 in complex with inhibitor S01	3tkh	55.89	47.
663	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	s25	Crystal structure of Chk1 in complex with inhibitor S25	3tki	76.96	0.05
664	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	09h	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain	3u9n	90.28	100.
665	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk1	Crystal Structure of the CHK1	4fsm	80.85	no data
666	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk5	Crystal Structure of the CHK1	4fsu	79.05	no data
667	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk6	Crystal Structure of the CHK1	4fsw	75.55	no data
668	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk7	Crystal Structure of the CHK1	4fsy	82.53	no data
669	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk8	Crystal Structure of the CHK1	4fsz	72.46	no data
670	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk9	Crystal Structure of the CHK1	4ft0	80.07	no data
671	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	h1k	Crystal Structure of the CHK1	4ft3	82.29	no data
672	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	h2k	Crystal Structure of the CHK1	4ft5	85.01	no data
673	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	h7k	Crystal Structure of the CHK1	4fti	65.83	no data
674	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	h8k	Crystal Structure of the CHK1	4ftj	66.3	no data
675	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	h0k	Crystal Structure of the CHK1	4ftl	84.51	no data
676	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	1hk	Crystal Structure of the CHK1	4ftm	91.78	no data
677	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3hk	Crystal Structure of the CHK1	4fto	65.64	no data
678	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	4hk	Crystal Structure of the CHK1	4ftq	73.89	no data
679	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	6hk	Crystal Structure of the CHK1	4ftt	72.64	no data
680	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	7hk	Crystal Structure of the CHK1	4ftu	79.98	no data
681	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	hk0	Crystal Structure of the CHK1	4gh2	68.73	no data
682	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	1am	X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain	4hyh	86.65	1.
683	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	1ao	X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain	4hyi	91.6	3.
684	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	1ko	X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain	4jik	77.64	18.
685	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3dl	CHK1 kinase domain in complex with diarylpyrazine compound 1	4qye	84.44	1200.
686	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3dv	CHK1 kinase domain in complex with aminopyrazine compound 13	4qyf	84.49	no data
687	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3dw	CHK1 kinase domain in complex with diazacarbazole compound 14	4qyg	69.71	4.1
688	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	3x7	CHK1 kinase domain with diazacarbazole compound 19	4rvm	73.87	1.
689	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	ydj	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydj	78.68	5.
690	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	d4q	CHK1 KINASE IN COMPLEX WITH COMPOUND 13	6fc8	80.73	no data
691	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	d58	CHK1 KINASE IN COMPLEX WITH COMPOUND 44	6fcf	81.86	no data
692	CHK1	Serine/threonine-protein kinase Chk1	O14757	CHK1	d4z	CHK1 KINASE IN COMPLEX WITH COMPOUND 13	6fck	81.31	no data
693	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	yit	Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor	2yit	84.47	0.29
694	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	nxp	Crystal structure of checkpoint kinase 2 in complex with PV788	2ycs	87.09	1.36
695	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	hcw	Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976	2ycr	74.47	69.6
696	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	a9t	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR	4a9t	75.28	70.
697	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	vgm	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR	2wtc	79.03	310.
698	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	wti	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR	2wti	83.71	92.
699	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	wtj	CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR	2wtj	81.24	700.
700	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	xbj	Crystal Structure of Chk2 in complex with an inhibitor	2xbj	81.63	3.
701	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	lwh	Structure of a small molecule inhibitor with the kinase domain of Chk2	2xm9	90.96	9.
702	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	upx	Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115	2ycq	86.6	0.14
703	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	ru9	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR	4a9s	71.06	61.
704	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	a9u	CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR	4a9u	73.86	60.
705	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	odh	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)	4bdc	74.64	11700.
706	CHK2	Serine/threonine-protein kinase Chk2	O96017	CDS1 CHK2 RAD53	hau	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)	4bdi	64.83	227700.
707	CLK1	Dual specificity protein kinase CLK1	P49759	CLK	jwn	CLK1 Kinase domain with bound imidazopyridin inhibitor TP003	6raa	76.35	no data
708	CLK1	Dual specificity protein kinase CLK1	P49759	CLK	h3q	Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound VN316 (derivative of compound 12h)	6i5l	95.72	no data
709	CLK1	Dual specificity protein kinase CLK1	P49759	CLK	fg9	CLK1 with bound pyridoquinazoline	6q8k	79.95	no data
710	CLK1	Dual specificity protein kinase CLK1	P49759	CLK	3ng	Crystal structure of CLK1 in complex with CX-4945	6khd	85.65	no data
711	CLK1	Dual specificity protein kinase CLK1	P49759	CLK	5id	Crystal structure of CLK1 in complex with 5-iodotubercidin	6g33	95.06	no data
712	CLK2	Dual specificity protein kinase CLK2	P49760		3ng	Crystal structure of CLK2 in complex with CX-4945	6khe	84.46	no data
713	CLK2	Dual specificity protein kinase CLK2	P49760		3ng	X-ray structure of CLK2-KD(136-496)/CX-4945 at 1.95A	6fyl	83.03	no data
714	CLK2	Dual specificity protein kinase CLK2	P49760		8fy	Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine]	5unp	83.97	no data
715	CLK2	Dual specificity protein kinase CLK2	P49760		eaz	X-Ray structure of CLK2-KD(136-496)/Indazole1 at 2.39A	6fyk	83.06	no data
716	CLK3	Dual specificity protein kinase CLK3	P49761		jwn	Crystal structure of CLK3 in complex with T3-CLK	6rct	65.69	no data
717	CLK3	Dual specificity protein kinase CLK3	P49761		dki	Crystal Structure of the Human CLK3 in complex with DKI	2wu6	82.6	29.2
718	CLK3	Dual specificity protein kinase CLK3	P49761		3ng	Crystal structure of CLK3 in complex with CX-4945	6khf	81.61	no data
719	CLK3	Dual specificity protein kinase CLK3	P49761		3ng	X-RAY STRUCTURE OF CLK3-KD(GP-[275-632], NON-PHOS.)/CX-4945 AT 2.29A	6fyp	87.31	no data
720	CLK4	Dual specificity protein kinase CLK4	Q9HAZ1		3ng	X-RAY STRUCTURE OF CLK4-KD(146-480)/CX-4945 AT 2.46A	6fyv	83.72	no data
721	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	ixh	cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor	3bea	73.54	7.
722	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	bdy	Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R	3lcd	59.68	40.
723	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	64m	Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME	4hw7	92.4	62.
724	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	622	Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622	6n33	91.72	no data
725	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	6c3	c-FMS tyrosine kinase in complex with a quinolone inhibitor	2i0v	85.69	160.
726	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	5cn	cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor	2i0y	87.79	24.
727	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	8c5	cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor	3dpk	76.66	4.1
728	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	krj	cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide	3krj	75.83	1.1
729	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	krl	cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide	3krl	75.14	0.8
730	CSF1R	Macrophage colony-stimulating factor 1 receptor	P07333	FMS	sti	Crystal structure of FMS kinase domain with a small molecular inhibitor, GLEEVEC	4r7i	88	no data
731	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	awk	The crystal structure of CK2alpha in complex with compound 24	5ot5	87.93	no data
732	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	auw	The crystal structure of CK2alpha in complex with CAM4712 and compound 37	6ehk	88.99	no data
733	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	auw	The crystal structure of CK2alpha in complex with CAM4712	5oty	91.05	no data
734	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	at8	The crystal structure of CK2alpha in complex with an analogue of compound 22	5otp	87.18	no data
735	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	aqw	The crystal structure of CK2alpha in complex with compound 30	5oto	87.83	no data
736	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	aqt	The crystal structure of CK2alpha in complex with compound 29	5otl	85.16	no data
737	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	aq8	The crystal structure of CK2alpha in complex with compound 26	5oth	92.79	no data
738	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	aow	The crystal structure of CK2alpha in complex with compound 25	5otd	90.4	no data
739	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	aok	The crystal structure of CK2alpha in complex with compound 27	5oti	92.35	no data
740	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	a8q	The crystal structure of CK2alpha in complex with compound 4	5os7	98.64	no data
741	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	a8q	The crystal structure of CK2alpha in complex with compound 3	6gmd	98.64	no data
742	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	agi	Crystal structure of human CK2 alpha complexed with apigenin	3amy	89.13	no data
743	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	54p	Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound	5ct0	93.12	no data
744	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	54r	Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound	5ctp	84.68	no data
745	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	54s	Crystal Structure of CK2alpha with compound 10 bound	5cu3	93.44	no data
746	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	54s	Crystal Structure of CK2alpha with Compound 10 bound	5cu4	91.71	320.
747	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	jmb	Crystal Structure of CK2alpha with Compound 7 bound	5mmf	90.61	no data
748	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	4ih	Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound	5mo5	89.38	no data
749	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	yra	Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound	5mo7	89.04	no data
750	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	c98	Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound	5mo8	91.11	1640.
751	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	avz	The crystal structure of CK2alpha in complex with compound 20	5oue	91.1	no data
752	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	awn	The crystal structure of CK2alpha in complex with compound 22	5ouu	86.46	no data
753	CSK21	Casein kinase II subunit alpha	P68400	CK2A1	avk	The crystal structure of CK2alpha in complex with compound 21	5oum	87.36	no data
754	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	jl2	Human CSNK2A2 bound to a Pyrrolo[2,3-d]pyrimidinyl inhibitor	6qy9	84.76	no data
755	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	gdw	STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR AR18	6hmd	85.12	no data
756	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	fxb	STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27	6hmc	84.6	no data
757	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	3ng	STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 Gene product) IN COMPLEX WITH the inhibitor CX-4945 (Silmitasertib)	6hmb	87.78	no data
758	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	7fc	Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)	5m56	96.13	13.
759	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	7fc	ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)	5m4u	92.61	13000.
760	CSK22	Casein kinase II subunit alpha'	P19784	CK2A2	9ye	STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P	5ooi	90.41	no data
761	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	kc5	Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive, tight-binding dibenzofuran inhibitor TF85 (4a)	5n9n	83.09	no data
762	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	ght	Human protein kinase CK2 alpha in complex with boldine	6hny	84.2	no data
763	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	fxb	HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA/CSKN2A1 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27	6hbn	87.85	no data
764	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	fxb	LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA; CSNK2A1 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27	6hme	85.84	no data
765	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	fu9	Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279	3r0t	88.18	0.91
766	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	e8k	The Structure of CK2alpha with CCh507 bound	6fvg	75.14	no data
767	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	8qh	Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive dibenzofuran inhibitor TF (4b)	5n9l	87.05	no data
768	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	5id	Crystal structure of CK2a1 with 5-iodotubercidin	6jwa	74.78	no data
769	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	503	The Structure of CK2alpha with CCh503 bound	6fvf	75.63	no data
770	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	atk	Crystal structure of CK2alpha with pyradine derivative	3at3	82.9	9.2
771	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	cck	Crystal structure of CK2alpha with pyradine derivertive	3at4	81.76	8.
772	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	3ng	Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945	3pe1	85.04	0.223
773	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	3ng	Human CK2 catalytic domain in complex with CX-4945	3nga	86.8	10.
774	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	e1b	Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011	3pe2	84.96	0.175
775	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	lnh	Casein kinase 2 in complex with AZ-Inhibitor	3u4u	77.93	3.
776	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	lcd	Crystal structure of the CK2alpha/compound3 complex	3wil	80.54	no data
777	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	0xg	Casein kinase 2 (CK2) bound to inhibitor	4grb	75.46	no data
778	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	3g5	Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)	4uba	86.38	no data
779	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	3g5	High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond	4ub7	92.65	no data
780	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	hck	Crystal structure of the CK2a/benzoic acid derivative complex	5b0x	78.32	20.
781	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	5y2	Crystal structure of CK2 with compound 2	5h8b	86.28	0.00491
782	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	5y3	Crystal structure of CK2 with compound 7h	5h8e	88.36	0.00633
783	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	5y4	Crystal structure of CK2 with compound 7b	5h8g	85.94	0.0482
784	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	6xk	Crystal structure of CK2	5ku8	84.51	no data
785	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	6xt	Crystal structure of CK2	5kwh	81.93	no data
786	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	7ey	Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions	5m4c	82.76	40.
787	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	7ey	Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under high-salt conditions	5m44	91.62	40.
788	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	7fc	Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under low-salt conditions	5m4f	90.15	13.
789	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	7fc	Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions	5m4i	91.88	13.
790	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	9ye	LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P	5oni	86.2	no data
791	CSK23	Casein kinase II subunit alpha 3	Q8NEV1	CSNK2A1P	9ye	HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P	5omy	85.05	no data
792	DAPK1	Death-associated protein kinase 1	P53355	DAPK	que	Crystal structure of DAPK1 in complex with quercetin.	5auw	93.67	8900.
793	DAPK1	Death-associated protein kinase 1	P53355	DAPK	3gu	Crystal structure of DAPKL93G with N6-cyclopentyladenosine	3gu8	92.62	no data
794	DAPK1	Death-associated protein kinase 1	P53355	DAPK	gen	Crystal structure of DAPK1-genistein complex in the presence of bromide ions.	5av4	89.21	no data
795	DAPK1	Death-associated protein kinase 1	P53355	DAPK	gen	Crystal structure of DAPK1 in complex with genistein.	5auz	86.38	98000.
796	DAPK1	Death-associated protein kinase 1	P53355	DAPK	kmp	Crystal structure of DAPK1-kaempferol complex in the presence of iodide ions.	5av3	88.47	no data
797	DAPK1	Death-associated protein kinase 1	P53355	DAPK	kmp	Crystal structure of DAPK1-kaempferol complex in the presence of bromide ions.	5av2	88.54	no data
798	DAPK1	Death-associated protein kinase 1	P53355	DAPK	kmp	Crystal structure of DAPK1 in complex with kaempferol.	5aux	87.98	10000.
799	DAPK1	Death-associated protein kinase 1	P53355	DAPK	38g	Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor	4txc	85.19	240.
800	DAPK1	Death-associated protein kinase 1	P53355	DAPK	lu2	Crystal structure of DAPK1 in complex with luteolin.	5auu	96.16	21000.
801	DAPK1	Death-associated protein kinase 1	P53355	DAPK	agi	Crystal structure of DAPK1 in complex with apigenin.	5auv	87.22	31000.
802	DAPK1	Death-associated protein kinase 1	P53355	DAPK	mri	Crystal structure of DAPK1 in complex with morin.	5auy	94.47	1600.
803	DAPK1	Death-associated protein kinase 1	P53355	DAPK	47x	Crystal structure of DAPK1 in complex with 7,3',4'-trihydroxyisoflavone.	5av0	91.26	280000.
804	DAPK3	Death-associated protein kinase 3	O43293	ZIPK	4rb	Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with an imidazo-pyridazine ligand	3bqr	84.69	no data
805	DAPK3	Death-associated protein kinase 3	O43293	ZIPK	duk	Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)	5vja	82.63	no data
806	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	vx6	DDR1 bound to VX-680	6brj	74.87	no data
807	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	gkb	Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor	6hp9	85.43	no data
808	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	few	Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2	6gwr	83.1	no data
809	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	djw	DDR1, 1-(1H-indazole-5-carbonyl)-5'-methoxy-1'-[2-oxo-2-[(2S)-2-(trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-2'-one, 1.790A, P212121, Rfree=23.8%	6fiq	93.55	no data
810	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	djq	DDR1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1.670A, P1211, Rfree=22.8%	6fin	93.03	no data
811	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	djh	DDR1, 2-[1'-(1H-indazole-5-carbonyl)-4-methyl-2-oxospiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.990A, P6522, Rfree=27.7%	6fio	94.89	no data
812	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	di1	Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1	4ckr	88.77	105.
813	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	d6z	DDR1, 2-[4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.291A, P212121, Rfree=17.4%	6fex	94.81	no data
814	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	d6w	DDR1, 2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-methylacetamide, 1.730A, P212121, Rfree=24.5%	6fil	93.31	no data
815	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	d6w	DDR1, 2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-methylacetamide, 1.440A, P1211, Rfree=24.1%	6few	92.13	no data
816	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	5x1	Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.	5fdx	82.85	no data
817	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	5wr	Structure of DDR1 receptor tyrosine kinase in complex with D2099 inhibitor at 2.25 Angstroms resolution.	5fdp	82.75	309.
818	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	1n1	DDR1 bound to Dasatinib	6bsd	70.55	no data
819	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	1n1	Fragment-based discovery of potent and selective DDR1/2 inhibitors	5bvw	74.04	1.5
820	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	sti	Crystal structure of the human DDR1 kinase domain in complex with imatinib	4bkj	88.7	1.9
821	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	4vc	Fragment-based discovery of potent and selective DDR1/2 inhibitors	5bvk	93.69	100000.
822	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	4vd	Fragment-based discovery of potent and selective DDR1/2 inhibitors	5bvn	92.07	1.5
823	DDR1	Epithelial discoidin domain-containing receptor 1	Q08345	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	4ve	Fragment-based discovery of potent and selective DDR1/2 inhibitors	5bvo	94.71	5.
824	DDR2	Discoidin domain-containing receptor 2	Q16832	NTRKR3 TKT TYRO10	d6q	Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide	6fer	94.48	no data
825	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	9ol	Crystal structure of human DYRK1A in complex with compound 32	6a1g	75.82	no data
826	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	2c3	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor	4mq1	85.16	12.
827	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	d15	Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide	2wo6	78.4	no data
828	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	d15	Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A	2vx3	88.67	no data
829	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	ehb	human DYRK1A/inhibitor complex	3anq	86.95	180.
830	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	2c4	The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor	4mq2	86.66	97.
831	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	4e1	Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j	4ylj	85.87	6.
832	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	4e2	Crystal structure of DYRK1A in complex with 10-Chloro-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5s	4ylk	89.42	180.
833	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b5t	DYRK1A in complex with XMD7-117	6eif	75.43	no data
834	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b5z	DYRK1A in complex with HG-8-60-1	6eij	73.35	no data
835	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b6b	DYRK1A in complex with XMD8-49	6eil	80.98	no data
836	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b7b	DYRK1A in complex with XMD8-62e	6eip	82.53	no data
837	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b6z	DYRK1A in complex with XMD14-124	6eiq	71.16	no data
838	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b6h	DYRK1A in complex with XMD15-27-2	6eir	64.33	no data
839	DYR1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	DYRK MNB MNBH	b6q	DYRK1A in complex with JWD-065	6eiv	74.67	no data
840	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q92630		irb	Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand	3kvw	76.07	130.
841	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q92630		7aa	Crystal structure of DYRK2 in complex with EHT 5372 (Compound 1)	5lxc	88.06	10.8
842	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	3z4	Co-crystal Structure of PERK bound to 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor	4x7l	94.05	9.
843	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	3z3	Co-crystal Structure of PERK bound to 4-{2-amino-3-[5-fluoro-2-(methylamino)quinazolin-6-yl]-4-methylbenzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor	4x7k	93.88	4.
844	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	3z2	Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor	4x7h	89.4	42.
845	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	3z1	Co-crystal Structure of PERK with 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide inhibitor	4x7j	93.36	41.
846	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	0wh	Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution	4g31	94.92	0.4
847	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	924	Crystal Structure of GSK6924 Bound to PERK (R587-R1092, delete A660-T867) at 2.70 A Resolution	4g34	94.03	11.7
848	E2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Q9NZJ5	PEK PERK	3z6	Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor	4x7o	93.69	2.
849	E2AK4	eIF-2-alpha kinase GCN2	Q9P2K8	GCN2 KIAA1338	kav	Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents	6n3l	92.92	no data
850	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	w32	EGFR kinase domain complexed with compound 20a	3w32	85.44	75.
851	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	w2r	EGFR kinase domain with compound4	3w2s	91.47	6.9
852	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	w2r	EGFR Kinase domain T790M/L858R mutant with compound 4	3w2r	90.49	19.
853	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	w2p	EGFR Kinase domain T790M/L858R mutant with compound 2	3w2p	72.05	8100.
854	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	w19	EGFR kinase domain complexed with compound 19b	3w33	89.29	36.
855	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	o44	Crystal structure of EGFR kinase domain in complex with a sulfonyl fluoride probe XO44	5u8l	75.51	no data
856	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	l0q	Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19g	6s89	54.25	no data
857	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	l0n	Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19h	6s8a	66.47	no data
858	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	kjv	Crystal structure of EGFR kinase domain in complex with compound 4c	4jrv	79.83	29.
859	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	kjq	Crystal structure of EGFR kinase domain in complex with compound 2a	4jq7	81.86	393.
860	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	kj8	Crystal structure of EGFR kinase domain in complex with compound 4b	4jq8	80.92	8.
861	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	jbj	EGFR with an allosteric inhibitor	6duk	95.1	no data
862	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	iti	EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor	3lzb	84.21	63.
863	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	hki	EGFR kinase domain T790M/L858R mutant with HKI-272	3w2q	74.93	66.
864	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	fmm	EGFR kinase domain complexed with a quinazoline inhibitor- GW572016	1xkk	86.64	3.
865	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	f62	Crystal structure of EGFR 696-1022 T790M in complex with XTF-262	5gmp	66.13	0.8
866	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	81c	Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39	5gtz	70.26	no data
867	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xu	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(6)	5x28	69.36	no data
868	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xu	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)	5x2f	71.05	no data
869	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xr	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(5)	5x27	73.2	no data
870	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xr	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(5)	5x2c	72.92	no data
871	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	60e	EGFR kinase domain mutant ""TMLR"" with 3-azetidinyl azaindazole compound 21	5hcz	77.3	no data
872	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	60d	EGFR kinase domain mutant ""TMLR"" with 3-carboxamide azaindole compound 13	5hcy	79.39	1.2
873	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5x4	EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor.	5fed	73.27	no data
874	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5x4	EGFR kinase domain T790M mutant in complex with a covalent aminobenzimidazole inhibitor.	5fee	75.66	no data
875	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	1c9	Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)	4i23	82.57	no data
876	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	1c9	Structure of T790M EGFR kinase domain co-crystallized with dacomitinib	4i24	84.7	no data
877	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	03p	EGFR Kinase domain complexed with tak-285	3poz	88.11	23.
878	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	03p	EGFR Kinase domain T790M/L858R Mutant with TAK-285	3w2o	75.48	8400.
879	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	aee	Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788	2itt	73.52	1.7
880	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	ire	Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib	4i22	72.92	no data
881	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	ire	1.85 angstrom structure of EGFR kinase domain with gefitinib	4wkq	74.71	no data
882	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	ire	Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib	3ug2	63.45	5.6
883	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	ire	Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa	2itz	74.57	2.6
884	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	hyz	Structure of EGFR in complex with hydrazone, a potent dual inhibitor	2rgp	88.09	30.
885	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	pox	X-ray structure of EGFR in complex with oxime inhibitor	3bel	84.59	14.
886	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	djk	Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab	2j5f	86.38	no data
887	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	djk	EGFR L858R in complex with PD168393	4lqm	83.12	no data
888	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	0wn	Crystal structure of EGFR kinase in complex with BIBW2992	4g5j	73.94	no data
889	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	aq4	Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib	1m17	73.62	no data
890	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	aq4	Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib	4hjo	79.25	no data
891	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	kjr	Crystal structure of EGFR kinase domain in complex with compound 3g	4jr3	81.92	218.
892	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	3qs	EGFR kinase (T790M/L858R) with inhibitor compound 8	4rj8	82.01	17.
893	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	3qw	EGFR kinase (T790M/L858R) with inhibitor compound 6	4rj4	77.37	16.
894	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	3r0	EGFR kinase (T790M/L858R) with inhibitor compound 4	4rj6	75.78	76.
895	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	3r1	EGFR kinase (T790M/L858R) with inhibitor compound 1	4rj7	78.6	22.
896	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	yy3	AZD9291 complex with wild type EGFR	4zau	59.15	no data
897	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4yv	EGFR kinase domain mutant ""TMLR"" with compound 1	5c8k	82.18	20.
898	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4yw	EGFR kinase domain mutant ""TMLR"" with compound 17	5c8m	82.92	64.
899	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4yx	EGFR kinase domain mutant ""TMLR"" with compound 23	5c8n	78.92	28.
900	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4z8	EGFR kinase domain mutant ""TMLR"" with compound 24	5cal	86.88	22.
901	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zb	EGFR kinase domain mutant ""TMLR"" with compound 27	5can	86	124.
902	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zg	EGFR kinase domain mutant ""TMLR"" with compound 29	5cao	86.45	38.
903	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zh	EGFR kinase domain mutant ""TMLR"" with compound 30	5cap	87.95	52.
904	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zj	EGFR kinase domain mutant ""TMLR"" with compound 33	5caq	82.54	2.7
905	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zr	EGFR kinase domain mutant ""TMLR"" with compound 41b	5cau	81.04	1.6
906	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zq	EGFR kinase domain mutant ""TMLR"" with compound 41a	5cas	81.29	1.4
907	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	4zq	EGFR kinase domain with compound 41a	5cav	80.31	216.
908	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	57n	EGFR kinase domain in complex with mutant selective allosteric inhibitor	5d41	97.87	no data
909	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5n3	EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine	5edq	83.9	2.
910	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5n4	EGFR kinase (T790M/L858R) with inhibitor compound 27: ~{N}-(1~{H}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine	5edr	82.23	34.3
911	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5q2	EGFR kinase domain mutant ""TMLR"" with pyridone compound 2: 4-[2-(4-chlorophenyl)ethylamino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide	5em5	70.99	262.
912	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5q3	EGFR kinase domain mutant ""TMLR"" with pyridone compound 19: 4-[(2-azanylpyrimidin-4-yl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide	5em6	72.26	4.
913	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5q4	EGFR kinase domain mutant ""TMLR"" with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide	5em7	71.61	19.
914	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	5q4	EGFR kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide	5em8	65.82	1090.
915	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	80u	Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34	5gnk	95.1	5.3
916	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	60b	EGFR kinase domain mutant ""TMLR"" with azabenzimidazole compound 7	5hcx	88.53	4.1
917	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	633	EGFR (L858R, T790M, V948R) in complex with N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	5hg5	67.08	2.
918	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	630	EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988)	5hg7	78.61	4.
919	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	634	EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide	5hg8	77.54	3.
920	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	63a	EGFR (L858R, T790M, V948R) in complex with 1-[(3R,4R)-3-[({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one	5hg9	79.84	35.
921	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	63m	EGFR kinase domain mutant ""TMLR"" with a pyrazolopyrimidine inhibitor	5hib	88.48	no data
922	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	63n	EGFR kinase domain mutant ""TMLR"" with a imidazopyridinyl-aminopyrimidine inhibitor	5hic	91.11	no data
923	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	6hl	EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b	5j9y	85.34	58.
924	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	6hj	EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a	5j9z	85.23	16.
925	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	8bp	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide	5ug8	82.53	2.
926	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	8am	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide	5ug9	81.49	8.
927	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	8bm	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	5uga	69.3	161.
928	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	8bm	Crystal structure of the EGFR kinase domain in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	5ugb	65.44	161.
929	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	8bs	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide	5ugc	79.43	13.
930	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xo	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)	5x26	73.42	no data
931	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	7xo	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(3)	5x2a	77.75	no data
932	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	0un	Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002	3ika	67.75	14.
933	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	1e8	Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib	5yu9	86.98	180.
934	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	9ll	Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045	5zwj	93	no data
935	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	fzp	Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor	6d8e	75.09	no data
936	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	0wm	Crystal structure of EGFR kinase in complex with BIBW2992	4g5j	36.5	no data
937	EGFR	Epidermal growth factor receptor	P00533	ERBB ERBB1 HER1	aee	Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788	2itp	74.56	11.3
938	EPHA2	Ephrin type-A receptor 2	P29317	ECK	zzl	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with MLN8054	5ia1	71.76	530.
939	EPHA2	Ephrin type-A receptor 2	P29317	ECK	p17	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with PD173955	5ia3	80.43	46.
940	EPHA2	Ephrin type-A receptor 2	P29317	ECK	gv0	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with golvatinib (E7050)	5ia5	83.07	25.
941	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g0q	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT055	6het	90.62	no data
942	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g0n	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT058	6heu	90.18	no data
943	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g0k	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT061	6hev	93.47	no data
944	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g0h	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT050	6hes	90.2	no data
945	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g0e	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT069	6hew	91.24	no data
946	EPHA2	Ephrin type-A receptor 2	P29317	ECK	g02	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATMM006	6hex	90.69	no data
947	EPHA2	Ephrin type-A receptor 2	P29317	ECK	fzw	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATNK002	6hey	89.34	no data
948	EPHA2	Ephrin type-A receptor 2	P29317	ECK	dxh	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with NVP-BHG712	6fnf	92.4	no data
949	EPHA2	Ephrin type-A receptor 2	P29317	ECK	dwt	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with an isomer of NVP-BHG712	6fng	91.57	no data
950	EPHA2	Ephrin type-A receptor 2	P29317	ECK	db8	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with bosutinib (SKI-606)	5i9x	70.64	30.
951	EPHA2	Ephrin type-A receptor 2	P29317	ECK	a5b	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237)	5ia0	78.55	187.
952	EPHA2	Ephrin type-A receptor 2	P29317	ECK	91h	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2g	5nka	69.31	3500.
953	EPHA2	Ephrin type-A receptor 2	P29317	ECK	912	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e	5nk9	70.25	724.
954	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90z	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2f	5nk8	69.08	229.
955	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90w	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2d	5nk6	71.48	158.
956	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90k	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1m	5nk5	70.3	no data
957	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90e	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2c	5nk4	68.03	2.
958	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90b	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 3a	5nke	68.74	no data
959	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zw	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 4b	5nki	73.45	19.
960	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zt	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 4a	5nkb	70.43	0.76
961	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zn	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 3b	5nkf	71.92	no data
962	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zk	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 3d	5nkg	72.77	21.
963	EPHA2	Ephrin type-A receptor 2	P29317	ECK	88z	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with foretinib (XL880)	5ia4	81.59	52.
964	EPHA2	Ephrin type-A receptor 2	P29317	ECK	1n1	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with dasatinib	5i9y	76.61	2.8
965	EPHA2	Ephrin type-A receptor 2	P29317	ECK	627	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358)	5i9z	68.49	9.
966	EPHA2	Ephrin type-A receptor 2	P29317	ECK	l66	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with compound 66	5ia2	83.61	19.
967	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zh	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1g	5njz	70.84	16.
968	EPHA2	Ephrin type-A receptor 2	P29317	ECK	91e	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1j	5nk0	69.78	no data
969	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90n	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1k	5nk1	68.72	no data
970	EPHA2	Ephrin type-A receptor 2	P29317	ECK	92q	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1l	5nk3	74.17	38.
971	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zz	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2b	5nk2	67.28	182.
972	EPHA2	Ephrin type-A receptor 2	P29317	ECK	8zz	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2a	5nk7	70.58	468.
973	EPHA2	Ephrin type-A receptor 2	P29317	ECK	90t	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2h	5nkc	76.43	19.
974	EPHA2	Ephrin type-A receptor 2	P29317	ECK	91k	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2i	5nkd	72.59	26.
975	EPHA2	Ephrin type-A receptor 2	P29317	ECK	dxk	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine fragment of NVP-BHG712	6fnh	84.77	no data
976	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	q7m	Human EphA3 Kinase domain in complex with quinoxaline derivatives	4p5z	89.93	39.3
977	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	b96	Human EphA3 Kinase domain in complex with Birb796	4twn	89.92	no data
978	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	c07	Human EphA3 kinase domain in complex with compound 7	4g2f	85.07	160.
979	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	l87	Human EphA3 Kinase domain in complex with ligand 87	4gk3	87.47	56.
980	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	l90	Human EphA3 Kinase domain in complex with ligand 90	4gk4	85.63	14.
981	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	q0b	Human EphA3 Kinase domain in complex with quinoxaline derivatives	4p5q	76.34	no data
982	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	37w	Human EphA3 Kinase domain in complex with compound 164	4two	78.73	no data
983	EPHA3	Ephrin type-A receptor 3	P29320	ETK ETK1 HEK TYRO4	l66	Human EphA3 Kinase domain in complex with ligand 66	4gk2	86.58	1.6
984	EPHA4	Ephrin type-A receptor 4	P54764	HEK8 SEK TYRO1	q9g	Crystal structure of EphA4 kinase domain in complex with VUF 12058	2xyu	84.45	4500.
985	EPHA4	Ephrin type-A receptor 4	P54764	HEK8 SEK TYRO1	1n1	Crystal structure of EphA4 kinase domain in complex with Dasatinib.	2y6o	73.03	25.
986	EPHA7	Ephrin type-A receptor 7	Q15375	EHK3 HEK11	ihz	Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7	3dko	91.42	no data
987	EPHB1	Ephrin type-B receptor 1	P54762	ELK EPHT2 HEK6 NET	7o3	Kinase domain of human EphB1, G703C mutant, covalently bound to a quinazoline-based inhibitor	5mjb	88.71	3.
988	EPHB1	Ephrin type-B receptor 1	P54762	ELK EPHT2 HEK6 NET	7o3	Kinase domain of human EphB1 bound to a quinazoline-based inhibitor	5mja	83.61	220.
989	EPHB3	Ephrin type-B receptor 3	P54753	ETK2 HEK2 TYRO6	6p6	EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 3)	5l6o	93.81	6.
990	EPHB3	Ephrin type-B receptor 3	P54753	ETK2 HEK2 TYRO6	6p8	EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 6)	5l6p	87.37	55.
991	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	dxh	Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with NVP-BHG712	6fni	95.94	no data
992	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	dwt	Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with an isomer of NVP-BHG712	6fnj	91.18	no data
993	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	as6	ephB4 kinase domain inhibitor complex	2xvd	75.92	2.
994	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x1	ephB4 kinase domain inhibitor complex	2vwu	68.84	350.
995	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	30k	Complex of the EphB4 kinase domain with an oxindole inhibitor	4aw5	71.45	765.
996	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x3	ephB4 kinase domain inhibitor complex	2vwv	67.61	16000.
997	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x2	ephB4 kinase domain inhibitor complex	2vww	76.25	240.
998	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x4	ephB4 kinase domain inhibitor complex	2vwx	75.88	40.
999	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x5	ephB4 kinase domain inhibitor complex	2vwy	76.85	90.
1000	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x6	ephB4 kinase domain inhibitor complex	2vwz	74.68	794.
1001	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x7	ephB4 kinase domain inhibitor complex	2vx0	73.84	580.
1002	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	7x8	ephB4 kinase domain inhibitor complex	2vx1	77.97	220.
1003	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	x9f	ephB4 kinase domain inhibitor complex	2x9f	78.79	61.
1004	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	1n1	Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib	6fnm	71.32	no data
1005	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	32w	ephB4 kinase domain inhibitor complex	4bb4	69.3	190.
1006	EPHB4	Ephrin type-B receptor 4	P54760	HTK MYK1 TYRO11	dxk	Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine fragment of NVP-BHG712	6fnk	77.51	no data
1007	ERBB2	Receptor tyrosine-protein kinase erbB-2	P04626	HER2 MLN19 NEU NGL	03q	Crystal Structure of the Kinase domain of Human HER2 (erbB2).	3pp0	96.58	11.
1008	ERBB3	Receptor tyrosine-protein kinase erbB-3	P21860	HER3	db8	HER3 pseudokinase domain bound to bosutinib	6op9	68.41	no data
1009	ERBB4	Receptor tyrosine-protein kinase erbB-4	Q15303	HER4	gw7	ErbB4 kinase domain complexed with a thienopyrimidine inhibitor	2r4b	95.3	66.
1010	ERBB4	Receptor tyrosine-protein kinase erbB-4	Q15303	HER4	fmm	crystal structure of the ErbB4 kinase in complex with lapatinib	3bbt	90.39	700.
1011	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	O75460	IRE1	gxk	IRE1 ALPHA IN COMPLEX WITH imidazo[1,2-b]pyridazin-8-amine compound 2	6hx1	92.57	no data
1012	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	O75460	IRE1	guk	IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33	6hv0	94.37	no data
1013	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	O75460	IRE1	4k7	Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A)	4yz9	96.47	20.
1014	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	O75460	IRE1	4l5	Crystal structure of human IRE1 cytoplasmic kinase-RNase region - complex with imidazopyridine compound 3	4z7h	93.22	218.
1015	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	yam	Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor	3bz3	87.35	1.5
1016	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	vg8	Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor	2jkq	73.67	7.7
1017	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	kao	FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea	4kao	84.81	770.
1018	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	h82	Crystal structure of PTK2 in complex with BI-4464.	6i8z	74.04	no data
1019	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	euw	Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor	6gcx	70.42	no data
1020	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	euw	Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor	6gcr	71.44	no data
1021	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	euq	Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor	6gcw	72.86	no data
1022	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	bii	Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor	2jkm	74.97	17.76
1023	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	bij	Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor	2jko	79.29	7.7
1024	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	kgw	Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor	4brx	76.5	320.
1025	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	5ri	Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor	4c7t	81.39	400.
1026	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	bi9	Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor	2jkk	78.5	6.24
1027	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	10n	FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-N-methyl-methanesulfonamide	4gu6	83.4	44.
1028	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	4gu	Focal adhesion kinase catalytic domain in complex with (2-Fluoro-phenyl)-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine	4gu9	85.44	43000.
1029	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	1bq	Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound.	4i4e	70.53	500.
1030	FAK1	Focal adhesion kinase 1	Q05397	FAK FAK1	7py	Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative	2etm	74.55	212.
1031	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	yam	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency	5tob	72.93	1.5
1032	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	b96	Crystal Structure of PYK2 complexed with BIRB796	3fzs	81.84	1500.
1033	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	3jz	Crystal structure of PYK2 complexed with PF-431396	3fzr	73.72	11.
1034	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	349	Crystal structure of PYK2 complexed with PF-2318841	3et7	70.05	17.
1035	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	4jz	Crystal structure of PYK2 complexed with PF-4618433	3fzt	91.5	637.
1036	FAK2	Protein-tyrosine kinase 2-beta	Q14289	FAK2 PYK2 RAFTK	p1e	Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog	3h3c	80.43	140.
1037	FES	Tyrosine-protein kinase Fes/Fps	P07332	FPS	9fc	Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4	6jmf	84.66	no data
1038	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	yy7	FGFR1 kinase complex with inhibitor SN36985	6c19	77.88	no data
1039	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	yy5	FGFR1 kinase complex with inhibitor SN37115	6c18	75.85	no data
1040	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	yy4	FGFR1 kinase complex with inhibitor SN37118	6c1b	76.85	no data
1041	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	xoj	FGFR1 ligand complex	5a4c	78.57	5.7
1042	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	xl6	FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide	6nvl	86.8	no data
1043	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	tz0	TAS-120 covalent complex with FGFR1	6mzw	87.14	no data
1044	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	tz0	TAS-120 in reversible binding mode with FGFR1	6mzq	83.6	no data
1045	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	pd1	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074	2fgi	69.2	45.2
1046	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	o21	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11.	6p69	76.94	no data
1047	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	o1y	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.	6p68	80.27	no data
1048	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	gql	Crystal Structure of activated receptor tyrosine kinase in complex with substrates	3gql	81.5	no data
1049	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	9k8	Human FGF in complex with a covalent inhibitor	5o4a	70.19	no data
1050	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	9k5	Human FGF in complex with a covalent inhibitor	5o49	74.86	no data
1051	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	9es	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527	5vnd	72.89	no data
1052	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	0li	FGFR1 in complex with ponatinib (co-crystallisation).	4v01	89.84	7.7
1053	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	0li	FGFR1 in complex with ponatinib.	4v04	92.57	7.7
1054	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	07j	Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)	3tt0	73.13	0.9
1055	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	su2	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR	1agw	64.34	20000.
1056	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	su1	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR	1fgi	85.18	10000.
1057	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	c4f	FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole	3c4f	97.15	1900.
1058	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	3rh	Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069	3rhx	89.87	840.
1059	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	lev	FGFR-1 in complex with ligand lenvatinib	5zv2	94.69	no data
1060	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	0s7	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1	4f63	75.79	500.
1061	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	0s8	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 6	4f64	82.1	63.1
1062	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	0s9	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 8	4f65	88.6	2.5
1063	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	2k5	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1	4nk9	90.41	3.1
1064	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	2k7	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2	4nka	81.1	311.4
1065	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	2m2	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3	4nks	82.46	67.9
1066	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	66t	FGFR1 in complex with AZD4547.	4v05	79.61	0.2
1067	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	66t	Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)	4rwj	76.18	2.
1068	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	66t	Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE (AZD4547)	4rwk	67.81	64.
1069	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	66t	Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom	4wun	76.81	no data
1070	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	4ut	Crystal structure of FGFR1 kinase domain in complex with 7n	4zsa	72.9	15.
1071	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	38o	FGFR1 in complex with dovitinib	5a46	64.85	22.
1072	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	38o	Native FGFR1 with an inhibitor	5am6	65.09	185.
1073	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	38o	FGFR1 mutant with an inhibitor	5am7	64.62	64.5
1074	FGFR1	Fibroblast growth factor receptor 1	P11362	BFGFR CEK FGFBR FLG FLT2 HBGFR	jvt	Fibroblast growth factor receptor 1 kinase in complex with JK-P5	4uwb	61.45	no data
1075	FGFR2	Fibroblast growth factor receptor 2	P21802	BEK KGFR KSAM	9wx	The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold	6agx	87.6	no data
1076	FGFR2	Fibroblast growth factor receptor 2	P21802	BEK KGFR KSAM	aa2	FGFr2 kinase domain	1oec	64.45	no data
1077	FGFR2	Fibroblast growth factor receptor 2	P21802	BEK KGFR KSAM	3rh	Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069	3ri1	88.49	5000.
1078	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	xl9	FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide	6nvk	82.83	no data
1079	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	xl8	FGFR4 complex with N-(3,5-dichloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)phenyl)acrylamide	6nvg	79.44	no data
1080	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	xl7	FGFR4 complex with N-(3-chloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-5-fluorophenyl)acrylamide	6nvi	80.89	no data
1081	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	xl6	FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide	6nvh	82.48	no data
1082	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	xl5	FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-fluorophenyl)acrylamide	6nvj	83.41	no data
1083	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	fgf	Crystal structure of FGF401 in complex of FGFR4	6jpj	67.49	no data
1084	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	40m	Crystal Structure of FGFR4 with an Irreversible Inhibitor	4xcu	81.74	6.
1085	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	0li	FGFR4 in complex with Ponatinib	4uxq	89.18	16.
1086	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	0li	Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib	4qrc	92.68	452.
1087	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	0li	Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase	4tyj	87.39	no data
1088	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	9ct	FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA159527	5nwz	89.93	no data
1089	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	6lf	The crystal structure of FGFR4 kinase domain in complex with LY2874455	5jkg	79.6	no data
1090	FGFR4	Fibroblast growth factor receptor 4	P22455	JTK2 TKF	6lf	Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550L)	5xff	75.48	no data
1091	FLT3	Receptor-type tyrosine-protein kinase FLT3	P36888	CD135 FLK2 STK1	f6m	Crystal structure of the FLT3 kinase domain bound to the inhibitor FF-10101	5x02	64.7	no data
1092	GAK	Cyclin-G-associated kinase	O14976		49j	Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor	4y8d	80.58	8.9
1093	GRK5	G protein-coupled receptor kinase 5	P34947	GPRK5	sgv	Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with Sangivamycin	4tnb	85.8	no data
1094	GRK5	G protein-coupled receptor kinase 5	P34947	GPRK5	453	Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022	4wnk	91.12	380.
1095	GRK6	G protein-coupled receptor kinase 6	P43250	GPRK6	sgv	Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin	3nyn	89.83	1000.
1096	GSK3B	Glycogen synthase kinase-3 beta	P49841		kdi	GSK3b in complex with inhibitor	4ach	71.22	22.
1097	GSK3B	Glycogen synthase kinase-3 beta	P49841		gr9	GSK3b in complex with inhibitor	4acd	76.03	4.9
1098	GSK3B	Glycogen synthase kinase-3 beta	P49841		g8e	Crystal structure of GSK-3B in complex with pyrazine inhibitor C22	6hk4	85.25	no data
1099	GSK3B	Glycogen synthase kinase-3 beta	P49841		g8b	Crystal structure of GSK-3B in complex with pyrazine inhibitor C44	6hk3	80.45	no data
1100	GSK3B	Glycogen synthase kinase-3 beta	P49841		fkb	Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor	6h0u	85.81	no data
1101	GSK3B	Glycogen synthase kinase-3 beta	P49841		f1b	Crystal Structure of Glycogen Synthase Kinase-3 beta in Complex with BI-91BS	6gjo	86.44	no data
1102	GSK3B	Glycogen synthase kinase-3 beta	P49841		7yg	GSK3b in complex with inhibitor	4acc	70.82	20.
1103	GSK3B	Glycogen synthase kinase-3 beta	P49841		6vm	Glycogen Synthase Kinase 3 beta Complexed with BRD3731	5kpm	78.98	no data
1104	GSK3B	Glycogen synthase kinase-3 beta	P49841		6vl	Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia	5t31	79.7	no data
1105	GSK3B	Glycogen synthase kinase-3 beta	P49841		6lq	GSK3b in complex with inhibitor	4acg	77.54	0.22
1106	GSK3B	Glycogen synthase kinase-3 beta	P49841		679	GSK-3 Beta complexed with Inhibitor I-5	1q4l	90.2	40.
1107	GSK3B	Glycogen synthase kinase-3 beta	P49841		tmu	crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor	1q5k	74.71	38.
1108	GSK3B	Glycogen synthase kinase-3 beta	P49841		dfn	Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor	1r0e	92.13	no data
1109	GSK3B	Glycogen synthase kinase-3 beta	P49841		brw	GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME	1uv5	88.63	5.
1110	GSK3B	Glycogen synthase kinase-3 beta	P49841		553	Crystal structure of GSK-3 beta in complex with NMS-869553A	3du8	83.64	146.
1111	GSK3B	Glycogen synthase kinase-3 beta	P49841		z48	Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor	3i4b	85.68	7.
1112	GSK3B	Glycogen synthase kinase-3 beta	P49841		z92	3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3	3l1s	89.55	2.
1113	GSK3B	Glycogen synthase kinase-3 beta	P49841		55e	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors	3q3b	78.42	17.2
1114	GSK3B	Glycogen synthase kinase-3 beta	P49841		zrm	Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors	3zrm	74.59	130.
1115	GSK3B	Glycogen synthase kinase-3 beta	P49841		sjj	5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors	4afj	84.43	398.
1116	GSK3B	Glycogen synthase kinase-3 beta	P49841		0kd	Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor	4dit	81.59	no data
1117	GSK3B	Glycogen synthase kinase-3 beta	P49841		2we	Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b	4ptc	84.27	1.1
1118	GSK3B	Glycogen synthase kinase-3 beta	P49841		2wf	Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b	4pte	85.33	74.
1119	GSK3B	Glycogen synthase kinase-3 beta	P49841		2wg	Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b	4ptg	85.94	5.9
1120	GSK3B	Glycogen synthase kinase-3 beta	P49841		3uo	Crystal structure of GSK3b in complex with Compound 15: 2-[(cyclopropylcarbonyl)amino]-N-(4-methoxypyridin-3-yl)pyridine-4-carboxamide	5f94	86.98	3.4
1121	GSK3B	Glycogen synthase kinase-3 beta	P49841		3up	Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide	5f95	86.85	9.8
1122	GSK3B	Glycogen synthase kinase-3 beta	P49841		65a	X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937	5hlp	81.54	54.
1123	GSK3B	Glycogen synthase kinase-3 beta	P49841		6qh	Crystal structure of GSK-3beta complexed with PF-04802367, a highly selective brain-penetrant kinase inhibitor	5k5n	85.82	9.
1124	GSK3B	Glycogen synthase kinase-3 beta	P49841		6vl	Glycogen Synthase Kinase 3 beta Complexed with BRD0705	5kpl	79.91	no data
1125	GSK3B	Glycogen synthase kinase-3 beta	P49841		65c	Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor	6b8j	81.39	5.
1126	HCK	Tyrosine-protein kinase HCK	P08631		vse	Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	5zj6	77.19	no data
1127	HCK	Tyrosine-protein kinase HCK	P08631		vse	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	3vs3	77.13	0.43
1128	HCK	Tyrosine-protein kinase HCK	P08631		vsb	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	3vs2	82.31	no data
1129	HCK	Tyrosine-protein kinase HCK	P08631		oov	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,N,4-trimethylpentanamide	5h0h	73.7	686.
1130	HCK	Tyrosine-protein kinase HCK	P08631		oou	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,4-dimethylpentanamide	5h0g	75.29	111.
1131	HCK	Tyrosine-protein kinase HCK	P08631		oos	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanamide	5h0e	74.6	210.
1132	HCK	Tyrosine-protein kinase HCK	P08631		ooq	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid	5h0b	76.07	11.
1133	HCK	Tyrosine-protein kinase HCK	P08631		ooo	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-ethyl2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate	5h09	72.38	1323.
1134	HCK	Tyrosine-protein kinase HCK	P08631		l3g	Src family kinase Hck with bound inhibitor A-641359	2c0t	80.75	no data
1135	HCK	Tyrosine-protein kinase HCK	P08631		l2g	Src family kinase Hck with bound inhibitor A-770041	2c0o	76.14	1220.
1136	HCK	Tyrosine-protein kinase HCK	P08631		l1g	Src family kinase Hck with bound inhibitor A-420983	2c0i	79.43	no data
1137	HCK	Tyrosine-protein kinase HCK	P08631		1bm	Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247	2hk5	83.99	46.
1138	HCK	Tyrosine-protein kinase HCK	P08631		que	SRC FAMILY KINASE HCK-QUERCETIN COMPLEX	2hck	79.59	no data
1139	HCK	Tyrosine-protein kinase HCK	P08631		b43	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	3vry	90.87	7.7
1140	HCK	Tyrosine-protein kinase HCK	P08631		vrz	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	3vrz	90.48	no data
1141	HCK	Tyrosine-protein kinase HCK	P08631		vs0	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	3vs0	88.47	no data
1142	HCK	Tyrosine-protein kinase HCK	P08631		vsa	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	3vs1	88.7	no data
1143	HCK	Tyrosine-protein kinase HCK	P08631		vsf	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	3vs4	89.44	no data
1144	HCK	Tyrosine-protein kinase HCK	P08631		vsg	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	3vs5	87	no data
1145	HCK	Tyrosine-protein kinase HCK	P08631		sk8	Crystal Structure of HCK in complex with the fluorescent compound SKF86002	4lud	84.37	no data
1146	HIPK2	Homeodomain-interacting protein kinase 2	Q9H2X6		3ng	HIPK2 kinase domain bound to CX-4945	6p5s	78.8	no data
1147	IGF1R	Insulin-like growth factor 1 receptor	P08069		ozn	IGFR-1R complex with a pyrimidine inhibitor.	5fxs	70.2	no data
1148	IGF1R	Insulin-like growth factor 1 receptor	P08069		741	Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor	3f5p	70.99	140.
1149	IGF1R	Insulin-like growth factor 1 receptor	P08069		66a	Structure of NVP-AEW541 in complex with IGF-1R kinase	5hzn	92.19	61.
1150	IGF1R	Insulin-like growth factor 1 receptor	P08069		bmi	Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor	2oj9	79.3	390.
1151	IGF1R	Insulin-like growth factor 1 receptor	P08069		d94	Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP	3d94	85.94	157.
1152	IGF1R	Insulin-like growth factor 1 receptor	P08069		ebi	Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]	3i81	87.66	13.
1153	IGF1R	Insulin-like growth factor 1 receptor	P08069		lgx	Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11B)	3nw5	76.77	8400.
1154	IGF1R	Insulin-like growth factor 1 receptor	P08069		lgw	Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11A)	3nw6	91.95	7.
1155	IGF1R	Insulin-like growth factor 1 receptor	P08069		lgv	Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34)	3nw7	90.25	5.3
1156	IGF1R	Insulin-like growth factor 1 receptor	P08069		dyk	Human IGF in complex with a Dyrk1B inhibitor	4d2r	61.33	3300.
1157	IGF1R	Insulin-like growth factor 1 receptor	P08069		gd5	IGFR-1R complex with a pyrimidine inhibitor.	5fxq	72.57	no data
1158	IGF1R	Insulin-like growth factor 1 receptor	P08069		8ln	IGFR-1R complex with a pyrimidine inhibitor.	5fxr	74.9	no data
1159	IGF1R	Insulin-like growth factor 1 receptor	P08069		575	Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor	2zm3	67.05	614.
1160	INSR	Insulin receptor	P06213		gs3	Insulin receptor kinase complexed with an inhibitor	3ekn	68.24	4.
1161	INSR	Insulin receptor	P06213		gs2	Insulin receptor kinase complexed with an inhibitor	3ekk	70.44	no data
1162	INSR	Insulin receptor	P06213		5ja	The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578	5e1s	70.9	12.
1163	INSR	Insulin receptor	P06213		351	Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor	3eta	84.56	14.
1164	INSR	Insulin receptor	P06213		ir1	Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1	4ibm	88.98	1800.
1165	INSR	Insulin receptor	P06213		60o	Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.	5hhw	86.17	no data
1166	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		t20	Crystal Structure of IRAK-4	4rmz	82.52	no data
1167	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		t12	Crystal structure of IRAK-4	2nru	80.05	no data
1168	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		lty	Structure of the IRAK4 kinase domain with compound 5	6o9d	88.75	no data
1169	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		lsv	Structure of the IRAK4 kinase domain with compound 41	6o95	87.15	no data
1170	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		ls7	Crystal structure of IRAK4 in complex with compound 23	6o8u	86.68	no data
1171	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		lrs	Structure of the IRAK4 kinase domain with compound 17	6o94	90.73	no data
1172	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		kfd	IRAK4 bound to benzoxazole compound	6n8g	88.78	no data
1173	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		k1h	IRAK4 IN COMPLEX WITH inhibitor	6rfi	77.97	no data
1174	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		k1e	IRAK4 IN COMPLEX WITH inhibitor	6rfj	70.42	no data
1175	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		jx4	Crystal structure of human Interleukin-1 receptor associated Kinase 4 (IRAK 4, CID 100300) in complex with compound NCC00371481 (BSI 107591)	6mom	89.34	no data
1176	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		j8a	IRAK4 in complex with a type II inhibitor	6ega	87.75	no data
1177	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		76q	Irak4 kinase - compound 1 co-structure	5t1s	81.38	84.
1178	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		4s2	Irak4-inhibitor co-structure	4ztm	84.06	25.
1179	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		0li	IRAK4 in complex with Ponatinib	6eg9	85.02	no data
1180	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		42p	Irak4-inhibitor co-structure	4xs2	84.98	1520.
1181	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		xpy	Crystal structure of IRAK4 kinase domain with inhibitor	4y73	91.06	0.3
1182	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		4gd	Irak4-inhibitor co-structure	4yo6	88.93	2200.
1183	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		4gf	Irak4-inhibitor co-structure	4yp8	84.38	13.
1184	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		4s1	Irak4-inhibitor co-structure	4ztl	86.81	1200.
1185	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		4s3	Irak4-inhibitor co-structure	4ztn	85.25	19.
1186	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6qy	IRAK4 in complex with Compound 21	5k72	80.45	no data
1187	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6qx	IRAK4 in complex with Compound 1	5k75	82.99	no data
1188	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6r1	IRAK4 in complex with Compound 28	5k76	77.24	5.
1189	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6r0	IRAK4 in complex with AZ3862	5k7g	72.1	no data
1190	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6qz	IRAK4 in complex with AZ3864	5k7i	73.38	no data
1191	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		6ye	Irak4-inhibitor co-structure	5kx8	91.9	38.
1192	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		8by	Crystal structure of IRAK4 in complex with compound 11	5uir	89.11	71.9
1193	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		8c1	Crystal structure of IRAK4 in complex with compound 12	5uis	92.57	146.
1194	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		8cd	Crystal structure of IRAK4 in complex with compound 14	5uit	95.46	4.6
1195	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		8cg	Crystal structure of IRAK4 in complex with compound 30	5uiu	93.91	0.2
1196	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		9yy	CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 4)	5w84	86.88	360.
1197	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		9ys	CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 9)	5w85	83.25	10.
1198	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		cjt	IRAK4 IN COMPLEX WITH inhibitor	6f3d	80.21	no data
1199	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		cjq	IRAK4 IN COMPLEX WITH inhibitor	6f3e	85.28	no data
1200	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		cjn	IRAK4 IN COMPLEX WITH inhibitor	6f3g	77.19	no data
1201	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3		ckn	IRAK4 IN COMPLEX WITH inhibitor	6f3i	71.61	no data
1202	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	mjg	X-ray crystal structure of ITK complexed with inhibitor BMS-509744	3mj2	71.94	15.
1203	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	g7k	Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor	4l7s	71.27	no data
1204	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	3p6	ITK kinase domain in complex with compound 1 N-{1-[(1,1-dioxo-1-thian-2-yl)(phenyl)methyl]-1H- pyrazol-4-yl}-5,5-difluoro-5a-methyl-1H,4H,4aH,5H,5aH,6H-cyclopropa[f]indazole-3-carboxamide	4rfm	68.29	0.09
1205	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	18r	Crystal structure of ITK in complex with compound 52	4hct	87.69	73.
1206	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	13l	Crystal structure of ITK in complext with compound 40	4hcu	84.58	10.
1207	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	13j	Crystal structure of ITK in complex with compound 53	4hcv	84.72	400.
1208	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	614	X-ray crystal structure of ITK complexed with inhibitor RO5191614	3mj1	66.58	15.
1209	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	iaq	Crystal structure of BTK mutant (F435T,K596R) complexed with Imidazo[1,5-a]quinoxaline	3t9t	82.99	1.93
1210	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	0f2	Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 090	3v5j	69.15	10.9
1211	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	g5k	Kinase domain mutant of human Itk in complex with a covalently-binding inhibitor	4kio	78.41	501.
1212	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	b49	X-ray crystal structure of ITK complexed with sunitinib	3miy	66.77	21.
1213	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	m0z	Crystal structure of ITK in complex with compound 5 {4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide}	4m0z	99.24	6400.
1214	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	1yz	Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]	4m12	99.68	900.
1215	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	1e0	Crystal structure of ITK in complex with compound 8 [4-(carbamoylamino)-1-(7-propoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]	4m13	99.45	200.
1216	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	qws	Crystal structure of ITK in complex with compound 9 [4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide] and ADP	4m15	98.98	no data
1217	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	29y	ITK kinase domain in complex with benzothiazole inhibitor 12b (1S,2S)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-N-[6-(1H-PYRAZOL-4-YL)-1,3-BENZOTHIAZOL-2-YL]CYCLOPROPANECARBOXAMIDE	4mf1	65.21	0.7
1218	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	2vt	ITK kinase domain with compound 1 (N-[1-(3-CYANOBENZYL)-1H-PYRAZOL-4-YL]-2H-INDAZOLE-3-CARBOXAMIDE)	4pp9	75.99	43.
1219	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	2vv	ITK kinase domain with compound 28 (N-{1-[(1S)-3-(DIMETHYLAMINO)-1-PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE)	4ppb	70.8	0.1
1220	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	2vw	ITK kinase domain with compound 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1-PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE)	4ppc	70.36	0.93
1221	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	2w6	ITK kinase domain with compound GNE-9822	4pqn	64.75	0.7
1222	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	EMT LYK	2vu	ITK kinase domain with compound 11 (N-[1-(3-CYANOBENZYL)-1H-PYRAZOL-4-YL]-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE)	4ppa	78.55	0.8
1223	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kf4	Structure of the human JAK1 kinase domain with compound 54	6n7d	96.48	no data
1224	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kf1	Structure of the human JAK1 kinase domain with compound 56	6n7c	87.66	no data
1225	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	key	Structure of the human JAK1 kinase domain with compound 38	6n7b	94.48	no data
1226	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kev	Structure of the human JAK1 kinase domain with compound 39	6n7a	85.83	no data
1227	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kes	Structure of the human JAK1 kinase domain with compound 20	6n79	97.26	no data
1228	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kep	Structure of the human JAK1 kinase domain with compound 21	6n78	94.73	no data
1229	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	kej	Structure of the human JAK1 kinase domain with compound 15	6n77	85.86	no data
1230	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	gyq	HUMAN JAK1 IN COMPLEX WITH LASW1393	6hzu	92.06	no data
1231	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	eyq	Human jak1 kinase domain in complex with inhibitor	6ggh	84.05	no data
1232	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	bfk	Human jak1 kinase domain in complex with compound 7	6elr	82.67	no data
1233	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	mi1	Crystal structures of JAK1 and JAK2 inhibitor complexes	3eyg	94.07	1.6
1234	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	0nt	JAK1 kinase (JH1 domain) in complex with compound 26	4e5w	87.61	22.
1235	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	0q2	JAK1 kinase (JH1 domain) in complex with compound 20	4ei4	90.61	1.8
1236	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	1j6	JAK1 kinase (JH1 domain) in complex with the inhibitor (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE	4ivc	91.12	0.1
1237	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	15t	JAK1 kinase (JH1 domain) in complex with compound 34	4ivd	88.65	0.3
1238	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	1q3	The Jak1 kinase domain in complex with compound 37	4k6z	93.66	2.
1239	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	1q4	JAK1 kinase (JH1 domain) in complex with compound 6	4k77	90.36	235.
1240	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	5jg	Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution	5e1e	82.12	22.
1241	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	66p	Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one	5hx8	89.56	0.1
1242	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	b7v	JAK1 complexed with compound 28	5wo4	86.87	0.1
1243	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	9t6	Crystal structure of JAK1 in complex with peficitinib	6aah	93.66	no data
1244	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	d7d	Crystal Structure of JAK1 in complex with compound 25	6bbu	93.27	no data
1245	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1A JAK1B	g4j	Jak1 with compound 23	6dbn	87.81	no data
1246	JAK2	Tyrosine-protein kinase JAK2	O60674		ekt	Crystal Structure of JAK2-V617F pseudokinase domain in complex with Compound 2	6g3c	84.67	no data
1247	JAK2	Tyrosine-protein kinase JAK2	O60674		bjg	Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors	4d1s	74.75	22.
1248	JAK2	Tyrosine-protein kinase JAK2	O60674		7gs	Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin	5tq8	70.72	23.1
1249	JAK2	Tyrosine-protein kinase JAK2	O60674		3yt	JAK2 JH2 in complex with PRT062607	5ut2	71.12	no data
1250	JAK2	Tyrosine-protein kinase JAK2	O60674		1m3	JAK2 kinase (JH1 domain) in complex with TG101209	4ji9	77.93	no data
1251	JAK2	Tyrosine-protein kinase JAK2	O60674		046	Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594	3ugc	89.31	947.
1252	JAK2	Tyrosine-protein kinase JAK2	O60674		az5	Inhibitors of Jak2 Kinase domain	2xa4	86.39	3.
1253	JAK2	Tyrosine-protein kinase JAK2	O60674		1p5	2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2	3io7	88.81	17.
1254	JAK2	Tyrosine-protein kinase JAK2	O60674		1p6	2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2	3iok	90.38	11.
1255	JAK2	Tyrosine-protein kinase JAK2	O60674		jzh	Janus Kinase 2 Inhibitors	3jy9	88.25	1.
1256	JAK2	Tyrosine-protein kinase JAK2	O60674		nvb	Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor	3lpb	82.52	42.
1257	JAK2	Tyrosine-protein kinase JAK2	O60674		mi1	Crystal structures of JAK1 and JAK2 inhibitor complexes	3fup	94.84	21.7
1258	JAK2	Tyrosine-protein kinase JAK2	O60674		j2i	Structure of Janus kinase 2 with a pyrrolotriazine inhibitor	3q32	83.96	1.8
1259	JAK2	Tyrosine-protein kinase JAK2	O60674		17p	Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor	3rvg	74.16	5.
1260	JAK2	Tyrosine-protein kinase JAK2	O60674		0tp	Co-crystal structure of jak2 with thienopyridine 8	3tjc	86.36	31.
1261	JAK2	Tyrosine-protein kinase JAK2	O60674		6tp	co-crystal structure of Jak2 with thienopyridine 19	3tjd	85.11	1.
1262	JAK2	Tyrosine-protein kinase JAK2	O60674		3o4	Aminoalkylpyrimidine Inhibitor Complexes with JAK2	4bbe	77.41	3.6
1263	JAK2	Tyrosine-protein kinase JAK2	O60674		o19	Aminoalkylpyrimidine Inhibitor Complexes with JAK2	4bbf	78.8	2.2
1264	JAK2	Tyrosine-protein kinase JAK2	O60674		lmm	Inhibitors of Jak2 Kinase domain	4c61	80.34	4.
1265	JAK2	Tyrosine-protein kinase JAK2	O60674		xww	Inhibitors of Jak2 Kinase domain	4c62	76.7	no data
1266	JAK2	Tyrosine-protein kinase JAK2	O60674		953	Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors	4d0x	88.72	8.
1267	JAK2	Tyrosine-protein kinase JAK2	O60674		0nv	JAK2 kinase (JH1 domain) triple mutant in complex with compound 12	4e6q	91.69	4.4
1268	JAK2	Tyrosine-protein kinase JAK2	O60674		0x2	JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE	4gfm	91.53	60.
1269	JAK2	Tyrosine-protein kinase JAK2	O60674		0x5	JAK2 kinase (JH1 domain) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE	4gmy	73.47	28.
1270	JAK2	Tyrosine-protein kinase JAK2	O60674		15v	JAK2 kinase (JH1 domain) in complex with compound 8	4hge	90.54	11.9
1271	JAK2	Tyrosine-protein kinase JAK2	O60674		1k3	JAK2 kinase (JH1 domain) in complex with compound 9	4jia	64.66	0.6
1272	JAK2	Tyrosine-protein kinase JAK2	O60674		4hz	Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases	4ytf	87.03	7.
1273	JAK2	Tyrosine-protein kinase JAK2	O60674		467	Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases	4yth	85.71	2.
1274	JAK2	Tyrosine-protein kinase JAK2	O60674		vjk	Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease	4yti	87.22	13.
1275	JAK2	Tyrosine-protein kinase JAK2	O60674		4ok	CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH A 9H-CARBAZOLE-1-CARBOXAMIDE INHIBITOR	4zim	72.94	2.4
1276	JAK2	Tyrosine-protein kinase JAK2	O60674		50y	CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE	5cf4	85.98	40.
1277	JAK2	Tyrosine-protein kinase JAK2	O60674		50w	CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.02,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE	5cf5	81.06	2.5
1278	JAK2	Tyrosine-protein kinase JAK2	O60674		50o	CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE	5cf6	84.79	8.2
1279	JAK2	Tyrosine-protein kinase JAK2	O60674		50v	CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE	5cf8	83.67	1.1
1280	JAK2	Tyrosine-protein kinase JAK2	O60674		5bs	JAK2 JH2 in complex with XMU-MP-1	6brw	75.68	no data
1281	JAK2	Tyrosine-protein kinase JAK2	O60674		4sp	JAK2 JH2 in complex with NU6102	6bss	69.84	no data
1282	JAK2	Tyrosine-protein kinase JAK2	O60674		35r	JAK2 JH2 in complex with AT9283	5ut0	65.05	1323.
1283	JAK2	Tyrosine-protein kinase JAK2	O60674		35r	JAK2 Pseudokinase in complex with AT9283	5wim	69.54	no data
1284	JAK2	Tyrosine-protein kinase JAK2	O60674		7gy	Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin	5tq4	88	4.2
1285	JAK2	Tyrosine-protein kinase JAK2	O60674		7gx	Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin	5tq5	80.64	58.8
1286	JAK2	Tyrosine-protein kinase JAK2	O60674		7gv	Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin	5tq6	90.25	123.6
1287	JAK2	Tyrosine-protein kinase JAK2	O60674		7gt	Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin	5tq7	80.39	21.2
1288	JAK2	Tyrosine-protein kinase JAK2	O60674		ik1	JAK2 JH2 in complex with IKK-2 Inhibitor VI	5ut3	73.08	no data
1289	JAK2	Tyrosine-protein kinase JAK2	O60674		dqx	Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor	3krr	79.8	0.48
1290	JAK2	Tyrosine-protein kinase JAK2	O60674		dqx	JAK2 JH2 in complex with NVP-BSK805	5ut4	68.34	42000.
1291	JAK2	Tyrosine-protein kinase JAK2	O60674		2hb	Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634	4p7e	80.28	17500.
1292	JAK2	Tyrosine-protein kinase JAK2	O60674		2hb	JAK2 JH2 in complex with GLPG0634	5ut5	74.78	no data
1293	JAK2	Tyrosine-protein kinase JAK2	O60674		7dz	JAK2 JH2 in complex with BI-D1870	5ut1	77.98	no data
1294	JAK2	Tyrosine-protein kinase JAK2	O60674		9zs	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model	5wev	72.01	150.
1295	JAK2	Tyrosine-protein kinase JAK2	O60674		aqg	JAK2 Pseudokinase in complex with NU6140	5wij	64.38	no data
1296	JAK2	Tyrosine-protein kinase JAK2	O60674		584	JAK2 Pseudokinase in complex with BI-D1870	5wik	81.69	no data
1297	JAK2	Tyrosine-protein kinase JAK2	O60674		ydj	JAK2 Pseudokinase in complex with AZD7762	5wil	78.5	no data
1298	JAK2	Tyrosine-protein kinase JAK2	O60674		ske	JAK2 JH1 in complex with JNJ-7706621 (Crystal Form 2)	6drw	79.21	no data
1299	JAK2	Tyrosine-protein kinase JAK2	O60674		ske	JAK2 JH1 in complex with JNJ-7706621	5usy	71.25	31.
1300	JAK2	Tyrosine-protein kinase JAK2	O60674		ske	JAK2 JH2 in complex with JNJ-7706621	5usz	74.23	106.
1301	JAK2	Tyrosine-protein kinase JAK2	O60674		ske	JAK2 Pseudokinase in complex with JNJ7706621	5win	75.11	no data
1302	JAK2	Tyrosine-protein kinase JAK2	O60674		9t6	Crystal structure of JAK2 in complex with peficitinib	6aaj	86.45	no data
1303	JAK2	Tyrosine-protein kinase JAK2	O60674		d7d	Crystal Structure of JAK2 in complex with compound 25	6bbv	94.19	no data
1304	JAK2	Tyrosine-protein kinase JAK2	O60674		l0i	Structure determination of Aurora Kinase in complex with inhibitor	2w1i	70.94	1.2
1305	JAK3	Tyrosine-protein kinase JAK3	P52333		z3a	Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor	6ny4	80.73	no data
1306	JAK3	Tyrosine-protein kinase JAK3	P52333		hb4	JAK3 with cyanamide CP12	6dud	87.51	no data
1307	JAK3	Tyrosine-protein kinase JAK3	P52333		gyw	HUMAN JAK3 IN COMPLEX WITH LASW959 PROTEIN IN COMPLEX WITH LIGAND	6hzv	89.26	no data
1308	JAK3	Tyrosine-protein kinase JAK3	P52333		g9b	JAK3 in complex with a covalent EGFR inhibitor	4v0g	73.06	no data
1309	JAK3	Tyrosine-protein kinase JAK3	P52333		g54	JAK3 with Cyanamide CP23	6db3	92.01	no data
1310	JAK3	Tyrosine-protein kinase JAK3	P52333		g4y	JAK3 with Cyanamide CP34	6db4	88.68	no data
1311	JAK3	Tyrosine-protein kinase JAK3	P52333		g4v	JAK3 with Cyanamide CP10	6da4	83.75	no data
1312	JAK3	Tyrosine-protein kinase JAK3	P52333		f3w	Crystal structure of JAK3 in complex with Compound 10 (FM475)	6gl9	85.51	no data
1313	JAK3	Tyrosine-protein kinase JAK3	P52333		4lh	Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide	4z16	72.01	4.8
1314	JAK3	Tyrosine-protein kinase JAK3	P52333		mi1	Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6	3lxk	95.16	0.16
1315	JAK3	Tyrosine-protein kinase JAK3	P52333		vfc	Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor	3zc6	88.2	0.6
1316	JAK3	Tyrosine-protein kinase JAK3	P52333		1nx	Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor	3zep	75.19	22.
1317	JAK3	Tyrosine-protein kinase JAK3	P52333		933	JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide	4hvd	85.58	1.4
1318	JAK3	Tyrosine-protein kinase JAK3	P52333		19q	JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide	4hvg	86.69	17.
1319	JAK3	Tyrosine-protein kinase JAK3	P52333		19r	JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-hydroxy-1,2-dimethyl-propyl	4hvh	86.26	19.
1320	JAK3	Tyrosine-protein kinase JAK3	P52333		19s	JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide	4hvi	89.02	68.9
1321	JAK3	Tyrosine-protein kinase JAK3	P52333		1dt	JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide	4i6q	83.4	30.
1322	JAK3	Tyrosine-protein kinase JAK3	P52333		3c9	JAK3 kinase domain in complex with 1-[(3S)-1-isobutylsulfonyl-3-piperidyl]-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)urea	4qt1	86.66	7.
1323	JAK3	Tyrosine-protein kinase JAK3	P52333		3qx	Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor	4rio	86.93	1.
1324	JAK3	Tyrosine-protein kinase JAK3	P52333		79t	Crystal structure of JAK3 in complex with Compound 4 (FM381)	5lwm	76.26	1.34
1325	JAK3	Tyrosine-protein kinase JAK3	P52333		79r	Crystal structure of JAK3 in complex with Compound 5 (FM409)	5lwn	88.07	17.
1326	JAK3	Tyrosine-protein kinase JAK3	P52333		79s	Crystal structure of JAK3 in complex with Compound 5 (FM409)	5lwn	90.74	no data
1327	JAK3	Tyrosine-protein kinase JAK3	P52333		7h4	JAK3 with covalent inhibitor PF-06651600	5toz	81.35	0.346
1328	JAK3	Tyrosine-protein kinase JAK3	P52333		7ku	Jak3 with covalent inhibitor 4	5tts	80.63	56.
1329	JAK3	Tyrosine-protein kinase JAK3	P52333		7kv	Jak3 with covalent inhibitor 7	5ttu	90.33	47.
1330	JAK3	Tyrosine-protein kinase JAK3	P52333		7kx	Jak3 with covalent inhibitor 6	5ttv	81.5	29.
1331	JAK3	Tyrosine-protein kinase JAK3	P52333		9j4	CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE INHIBITOR	5vo6	81.19	0.9
1332	JAK3	Tyrosine-protein kinase JAK3	P52333		9yv	CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 7)	5w86	69.22	2.
1333	JAK3	Tyrosine-protein kinase JAK3	P52333		9z4	THE JAK3 KINASE DOMAIN IN COMPLEX WITH A COVALENT INHIBITOR	5wfj	85.6	1.3
1334	JAK3	Tyrosine-protein kinase JAK3	P52333		9t6	Crystal structure of JAK3 in complex with peficitinib	6aak	81.99	no data
1335	JAK3	Tyrosine-protein kinase JAK3	P52333		f48	Crystal structure of JAK3 in complex with Compound 20 (FM484)	6glb	84.68	no data
1336	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	ss5	PKA structures of indazole-pyridine series of AKT inhibitors	2uzv	78.08	1360.
1337	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r96	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh7	91.25	150.
1338	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r94	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh6	91.43	48.
1339	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r69	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh4	93.51	34.
1340	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r69	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh9	93.49	17.
1341	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r68	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xha	91.38	no data
1342	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r68	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh5	91.21	3400.
1343	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	r55	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh8	91.44	1700.
1344	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	j0p	Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor	6e9l	85.26	no data
1345	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	ee4	Crystal structure of cAMP-dependent protein kinase Calpha subunit bound with N46	6c0u	89.18	no data
1346	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	b8l	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8	1rek	88.44	200.
1347	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	9d4	Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors	5vi9	78.65	no data
1348	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	gvk	Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine	2uw0	92.61	20.
1349	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	gvo	Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine	2uw6	88.02	280.
1350	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	l9m	Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18	3l9m	93.71	50.
1351	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	vx6	Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680	3amb	80.98	660.
1352	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	35r	Protein kinase A mutants as surrogate model for Aurora B with AT9283 inhibitor	5n23	89.63	no data
1353	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	ske	Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621	3ama	88.79	297.
1354	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	9cy	Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitor	5vhb	86.42	no data
1355	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	47v	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2,5-dimethyl-N-pyridin-4-ylfuran-3-carboxamide	5n1l	91.25	no data
1356	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	8et	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-quinolin-5-ylpyridine-3-carboxamide	5n1f	85.45	no data
1357	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	9nt	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-(1,3-benzodioxol-5-yl)-2-piperidin-1-ylacetamide	5n1e	90.51	no data
1358	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	nvx	PKAB3 in complex with pyrrolidine inhibitor 34a	4z84	91.6	1500.
1359	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	8bq	Protein Kinase A in complex with an Inhibitor	4ujb	90.29	10.
1360	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	4l7	Protein Kinase A in complex with an Inhibitor	4uja	93.99	0.9
1361	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	s3n	Protein Kinase A in complex with an Inhibitor	4uj9	93.52	2.
1362	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	nvv	Protein Kinase A in complex with an Inhibitor	4uj2	89.32	80.
1363	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	nvx	Protein Kinase A in complex with an Inhibitor	4uj1	89.5	300.
1364	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	ptv	Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone	4ij9	91.1	no data
1365	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	pzx	Bovine PKA C-alpha in complex with 3-pyridylmethyl-5-methyl-1H-pyrazole-3-carboxylate	4ie9	89.55	no data
1366	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	nu3	PKA-S6K1 Chimera with compound 1 (NU1085) bound	4c35	92.92	560.
1367	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	s69	human cAMP-dependent protein kinase in complex with an inhibitor	3poo	93.66	no data
1368	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	4sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3p0m	85.82	no data
1369	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	3sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3oxt	91.42	no data
1370	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	2sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3owp	88.32	no data
1371	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	xfe	Human cyclic AMP-dependent protein kinase PKA inhibitor complex	3mvj	95.49	3200.
1372	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	l9n	crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27	3l9n	94.54	8.6
1373	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	l9l	Crystal structure of pka with compound 36	3l9l	94.19	167.
1374	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	b99	Structure of PKA with a protein Kinase B-selective inhibitor.	3kkv	85.76	no data
1375	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	m05	Structure of PKA-PKB chimera complexed with 4-(4-Chlorobenzyl)-1-(7H- pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine	2vo6	94.49	no data
1376	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	m04	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine	2vo3	93.89	no data
1377	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	m01	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine	2vnw	92.82	no data
1378	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	l20	PKA structures of indazole-pyridine series of AKT inhibitors	2uzu	84.92	no data
1379	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	gvq	Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine	2uw8	88.53	77000.
1380	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	gvn	Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine	2uw5	93.15	31.
1381	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	gvj	Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine	2uvz	90.86	no data
1382	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	l20	Structure of cAMP-dependent protein kinase complexed with A-443654	2jds	86.19	6.3
1383	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	796	Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies	2gu8	92.26	2.6
1384	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	2ea	PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine	2f7e	84.98	no data
1385	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	b1l	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1	1rej	90.02	5.
1386	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	bd2	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2	1re8	91.5	0.3
1387	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	y27	The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632	1q8t	87.89	17500.
1388	KAPCA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PKACA	adn	CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE	1fmo	96.73	no data
1389	KC1A	Casein kinase I isoform alpha	P48729		lci	Crystal structure of Human CSNK1A1 with A86	6gzd	82.55	no data
1390	KC1D	Casein kinase I isoform delta	P48730	HCKID	d5q	Crystal structure of human Casein Kinase I delta in complex with 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide	5mqv	78.74	8.
1391	KC1D	Casein kinase I isoform delta	P48730	HCKID	cg5	Crystal structure of human Casein Kinase I delta in complex with compound 31a	6f1w	91.35	no data
1392	KC1D	Casein kinase I isoform delta	P48730	HCKID	c9z	Crystal structure of human Casein Kinase I delta in complex with compound 31b	6f26	65.1	no data
1393	KC1D	Casein kinase I isoform delta	P48730	HCKID	386	Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation	4tw9	84.97	20.
1394	KC1D	Casein kinase I isoform delta	P48730	HCKID	37j	2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4- carboxamide derivatives as potent inhibitors of CK1d/e	4twc	85.49	40.
1395	KC1D	Casein kinase I isoform delta	P48730	HCKID	0ck	crystal structure of ck1d with PF670462 from P1 crystal form	3uyt	89.56	14.
1396	KC1D	Casein kinase I isoform delta	P48730	HCKID	0ck	crystal structure of ck1d with PF670462 from P21 crystal form	3uzp	89.77	13.
1397	KC1D	Casein kinase I isoform delta	P48730	HCKID	15g	Crystal structure of ck1d with compound 13	4hgt	90.15	40.
1398	KC1D	Casein kinase I isoform delta	P48730	HCKID	16w	Crystal structure of ck1d in complex with pf4800567	4hnf	83.37	711.
1399	KC1D	Casein kinase I isoform delta	P48730	HCKID	1qn	CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANAMINE ligand	4kb8	88.04	12.9
1400	KC1D	Casein kinase I isoform delta	P48730	HCKID	1qm	CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine inhibitor	4kba	87.8	6.
1401	KC1D	Casein kinase I isoform delta	P48730	HCKID	1qg	CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine inhibitor	4kbk	82.68	6.6
1402	KC1D	Casein kinase I isoform delta	P48730	HCKID	pfo	CK1d in complex with inhibitor	4tn6	82.82	no data
1403	KC1D	Casein kinase I isoform delta	P48730	HCKID	9xk	Crystal structure of human Casein Kinase I delta in complex with IWP-2	5okt	60.35	no data
1404	KC1D	Casein kinase I isoform delta	P48730	HCKID	9wg	Identification and Profiling of a Selective and Brain Penetrant Radioligand for In Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors	5w4w	84.13	8.
1405	KC1E	Casein kinase I isoform epsilon	P49674		16w	crystal structure of ck1e in complex with PF4800567	4hni	86.07	32.
1406	KC1G2	Casein kinase I isoform gamma-2	P78368	CK1G2	5id	Structure of casein kinase 1 gamma 2	2c47	75	no data
1407	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		dki	Structure of casein kinase 1 gamma 3	2chl	81.49	no data
1408	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		brq	Structure of casein kinase gamma 3 in complex with inhibitor	2izs	88.37	no data
1409	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		0vm	Crystal structure of ck1g3 with 2-[(4-{[3-(TRIFLUOROMETHYL)PYRIDIN2-YL]OXY}PHENYL)AMINO]-1H-BENZIMIDAZOLE-6-CARBONITRILE	4g16	80.62	140.
1410	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		p01	Structure of casein kinase gamma 3 in complex with inhibitor	2izu	81.03	no data
1411	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		23d	Structure of casein kinase gamma 3 in complex with inhibitor	2izt	79.09	no data
1412	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		0yo	Crystal structure of ck1g3 with compound 1	4hgl	86.13	8.
1413	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		15g	Crystal structure of ck1gs with compound 13	4hgs	86	5.
1414	KC1G3	Casein kinase I isoform gamma-3	Q9Y6M4		f92	Human CSNK1G3 bound to SB-223133	6gro	87.56	no data
1415	KCC1D	Calcium/calmodulin-dependent protein kinase type 1D	Q8IU85	CAMKID	qpp	Crystal structure of human calmodulin-dependent protein kinase 1D	2jc6	74.33	no data
1416	KCC1G	Calcium/calmodulin-dependent protein kinase type 1G	Q96NX5	CLICK3 VWS1	j60	Crystal structure of human calmodulin-dependent protein kinase I G	2jam	60.63	no data
1417	KCC2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMKD	d0s	The structure of human CamKII with bound inhibitor	6bab	87.24	no data
1418	KCC2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMKD	9ej	The structure of human CamKII with bound inhibitor	5vlo	76.51	no data
1419	KCC2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMKD	k88	Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin	2wel	75.99	no data
1420	KCC2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMKD	gvd	Crystal Structure of Human Calcium Calmodulin dependent Protein Kinase II delta isoform 1, CAMKD	2vn9	79.8	no data
1421	KCC2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMKD	c2v	The structure of human CamKII with bound inhibitor	6ayw	84.54	no data
1422	KCC4	Calcium/calmodulin-dependent protein kinase type IV	Q16566	CAMK CAMK-GR CAMKIV	dki	Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)	2w4o	68.12	no data
1423	KGP1	cGMP-dependent protein kinase 1	Q13976	PRKG1B PRKGR1A PRKGR1B	ee4	Crystal structure of cGMP-dependent protein kinase Ialpha (PKG Ialpha) catalytic domain bound with N46	6c0t	84.5	no data
1424	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	jwy	Crystal structure of KIT1 in complex with DP2976 via co-crystallization	6mob	95.84	no data
1425	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	g4e	Structure of c-Kit with allosteric inhibitor 3G8	6hh1	94.51	no data
1426	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	0li	Crystal structure of KIT in complex with ponatinib	4u0i	88.5	6.
1427	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	sti	STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE	1t46	90.81	370.
1428	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	b49	KIT kinase domain in complex with sunitinib	3g0e	85.76	20.
1429	KIT	Mast/stem cell growth factor receptor Kit	P10721	SCFR	b49	KIT kinase domain mutant D816H in complex with sunitinib	3g0f	81.97	22.
1430	KKCC1	Calcium/calmodulin-dependent protein kinase kinase 1	Q8N5S9	CAMKKA	h1n	Crystal Structure of the Human CAMKK1A in complex with Hesperadin	6ccf	70.21	no data
1431	KKCC1	Calcium/calmodulin-dependent protein kinase kinase 1	Q8N5S9	CAMKKA	dxv	Crystal Structure of the Human CAMKK1A in complex with GSK650394	6cd6	92.73	no data
1432	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	su6	Structure of CaMKK2-inhibitor complex	5yvc	83.7	no data
1433	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	r78	Crystal Structure of the Human CAMKK2B in complex with BI2526	6bqq	61.49	no data
1434	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	f6j	Human CAMKK2 with GSK650393	6cmj	89.74	no data
1435	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	dxv	Crystal Structure of the Human CAMKK2B bound to GSK650394	6bku	91.31	no data
1436	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	92c	Structure of CaMKK2-inhibitor complex	5yvb	90.19	no data
1437	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	91x	Structure of CaMKK2-inhibitor complex	5yva	89.82	no data
1438	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	91o	Structure of CaMKK2-inhibitor complex	5yv9	85.11	no data
1439	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	91l	Structure of CaMKK2-inhibitor complex	5yv8	97.37	no data
1440	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	8r7	Crystal Structure of the Human CAMKK2B	5uyj	94.28	no data
1441	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	8r4	Crystal Structure of the Human CAMKK2B	5uy6	89.95	no data
1442	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	bi9	Crystal Structure of the Human CAMKK2B in complex with TAE-226	6bql	74.06	no data
1443	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	9js	Crystal Structure of the Human CAMKK2B bound to a thiadiazinone benzamide inhibitor	5vt1	76.77	no data
1444	KKCC2	Calcium/calmodulin-dependent protein kinase kinase 2	Q96RR4	CAMKKB KIAA0787	34u	Crystal Structure of the Human CAMKK2B in complex with CP673451	6ble	82.96	no data
1445	KPCA	Protein kinase C alpha type	P17252	PKCA PRKACA	lw4	Crystal structure of PKC alpha in complex with NVP-AEB071	3iw4	88.83	2.1
1446	KPCA	Protein kinase C alpha type	P17252	PKCA PRKACA	3kz	Crystal Structure of Human Protein Kinase C Alpha in Complex with Compound 28 ((R)-6-((3S,4S)-1,3-Dimethyl-piperidin-4-yl)-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)	4ra4	77.25	no data
1447	KPCB	Protein kinase C beta type	P05771	PKCB PRKCB1	pds	Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor	2i0e	84.87	2.
1448	KPCI	Protein kinase C iota type	P41743	DXS1179E	c58	A novel small molecule aPKC inhibitor	3zh8	82.79	341.
1449	KPCL	Protein kinase C eta type	P24723	PKCL PRKCL	07u	PKC eta kinase in complex with a naphthyridine	3txo	91.72	9.
1450	KPCT	Protein kinase C theta type	Q04759	PRKCT	5vs	Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one	5f9e	94.28	0.46
1451	KPCT	Protein kinase C theta type	Q04759	PRKCT	pzw	Human Protein Kinase C Theta in Complex with Compound35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)	4q9z	91.49	55.
1452	KPCT	Protein kinase C theta type	Q04759	PRKCT	lg8	The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.	2jed	89.26	no data
1453	KS6A1	Ribosomal protein S6 kinase alpha-1	Q15418	MAPKAPK1A RSK1	p01	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A	2z7s	73	no data
1454	KS6A3	Ribosomal protein S6 kinase alpha-3	P51812	ISPK1 MAPKAPK1B RSK2	2nr	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8	4nw5	77.72	20.
1455	KS6A3	Ribosomal protein S6 kinase alpha-3	P51812	ISPK1 MAPKAPK1B RSK2	0jg	Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate	4d9t	79.94	no data
1456	KS6A3	Ribosomal protein S6 kinase alpha-3	P51812	ISPK1 MAPKAPK1B RSK2	2nk	Rsk2 N-terminal kinase in complex with LJH685	4nus	75.57	5.
1457	KS6A3	Ribosomal protein S6 kinase alpha-3	P51812	ISPK1 MAPKAPK1B RSK2	2ns	Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27	4nw6	78.34	4.
1458	KS6A3	Ribosomal protein S6 kinase alpha-3	P51812	ISPK1 MAPKAPK1B RSK2	584	Rsk2 N-terminal Kinase in Complex with BI-D1870	5d9k	78.73	4.
1459	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	fs7	Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate	3wf9	86.68	567.
1460	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	f76	Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate	3wf8	86.56	232.
1461	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	fz8	Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine	3wf5	87.18	81.
1462	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	fs9	Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide	3wf7	87.39	206.
1463	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1-PIF	4l42	88.43	no data
1464	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole	3we4	88.18	15.
1465	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1 kinase domain	4l3j	88.86	no data
1466	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1 kinase domain (Zinc anomalous)	4l3l	89.6	no data
1467	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1-T389E	4l45	94.16	no data
1468	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1-T389A (form II)	4l44	91.01	no data
1469	KS6B1	Ribosomal protein S6 kinase beta-1	P23443	STK14A	5fi	Crystal structures of human p70S6K1-T389A (form I)	4l43	92.72	no data
1470	KSYK	Tyrosine-protein kinase SYK	P43405		s19	Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor	3srv	85.75	31.6
1471	KSYK	Tyrosine-protein kinase SYK	P43405		p5c	Crystal structure of spleen tyrosine kinase complexed with YM193306	3fqe	87.54	5.
1472	KSYK	Tyrosine-protein kinase SYK	P43405		gdh	CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR	6hm7	81.04	no data
1473	KSYK	Tyrosine-protein kinase SYK	P43405		fpx	Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide	3tud	89.99	no data
1474	KSYK	Tyrosine-protein kinase SYK	P43405		fpw	Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide	3tuc	87.23	no data
1475	KSYK	Tyrosine-protein kinase SYK	P43405		cg4	Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor	4pv0	72.11	0.85
1476	KSYK	Tyrosine-protein kinase SYK	P43405		7cu	Crystal structure of SYK kinase domain with inhibitor	5tiu	83.08	5.
1477	KSYK	Tyrosine-protein kinase SYK	P43405		50j	Crystal structure of SYK in complex with compound 2	5c27	73.92	no data
1478	KSYK	Tyrosine-protein kinase SYK	P43405		3yx	SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor2	4rx8	90.45	35.
1479	KSYK	Tyrosine-protein kinase SYK	P43405		3yv	SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor	4rx7	87.9	5.
1480	KSYK	Tyrosine-protein kinase SYK	P43405		3yt	SYK Catalytic Domain Complexed with a Potent Pyrimidine Inhibitor	4rx9	79.77	13.
1481	KSYK	Tyrosine-protein kinase SYK	P43405		2x6	SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor	4px6	84.75	4.
1482	KSYK	Tyrosine-protein kinase SYK	P43405		0xf	Crystal structure of spleen tyrosine kinase complexed with r9021	4gfg	82.94	no data
1483	KSYK	Tyrosine-protein kinase SYK	P43405		0vh	Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide	4fz7	88.96	no data
1484	KSYK	Tyrosine-protein kinase SYK	P43405		0vf	Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid	4fyo	74.1	47.
1485	KSYK	Tyrosine-protein kinase SYK	P43405		685	Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)	3emg	79.85	9.
1486	KSYK	Tyrosine-protein kinase SYK	P43405		057	Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole	3fqh	72.58	570.
1487	KSYK	Tyrosine-protein kinase SYK	P43405		sti	Crystal structure of the syk tyrosine kinase domain with Gleevec	1xbb	60.69	5000.
1488	KSYK	Tyrosine-protein kinase SYK	P43405		fpu	Crystal structure of SYK kinase domain with 1-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1R,2S)-2-phenylcyclopropyl)urea	3tub	93.21	no data
1489	KSYK	Tyrosine-protein kinase SYK	P43405		0je	Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416	3vf8	74.23	150.
1490	KSYK	Tyrosine-protein kinase SYK	P43405		0k0	Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor	4dfl	80.78	670.
1491	KSYK	Tyrosine-protein kinase SYK	P43405		0k1	Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor	4dfn	86.06	20.
1492	KSYK	Tyrosine-protein kinase SYK	P43405		0ve	Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol	4fyn	69.81	no data
1493	KSYK	Tyrosine-protein kinase SYK	P43405		0vg	Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine	4fz6	72.04	127.
1494	KSYK	Tyrosine-protein kinase SYK	P43405		1b4	Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide	4i0r	75.25	14.
1495	KSYK	Tyrosine-protein kinase SYK	P43405		1b5	Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide	4i0s	85.03	36.
1496	KSYK	Tyrosine-protein kinase SYK	P43405		1b6	Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide	4i0t	90.13	26.
1497	KSYK	Tyrosine-protein kinase SYK	P43405		4mg	Crystal structure of tyrosine-protein kinase SYK with an inhibitor	4rss	78.57	1.7
1498	KSYK	Tyrosine-protein kinase SYK	P43405		3rt	SYK catalytic domain in complex with a potent triazolopyridine inhibitor	4wnm	72.56	26.
1499	KSYK	Tyrosine-protein kinase SYK	P43405		x3g	Crystal structure of an inhibitor-bound Syk	4xg3	77.24	17.5
1500	KSYK	Tyrosine-protein kinase SYK	P43405		x4g	Crystal structure of an inhibitor-bound Syk	4xg4	72.02	21.5
1501	KSYK	Tyrosine-protein kinase SYK	P43405		x6g	Crystal structure of an inhibitor-bound Syk	4xg6	83.95	9.7
1502	KSYK	Tyrosine-protein kinase SYK	P43405		x7g	Crystal structure of an inhibitor-bound Syk	4xg7	78.13	32.6
1503	KSYK	Tyrosine-protein kinase SYK	P43405		x8g	Crystal structure of an inhibitor-bound Syk	4xg8	85.3	1.9
1504	KSYK	Tyrosine-protein kinase SYK	P43405		x9g	Crystal structure of an inhibitor-bound Syk	4xg9	82.32	0.7
1505	KSYK	Tyrosine-protein kinase SYK	P43405		4dk	SYK kinase domain in complex with inhibitor GTC000224	4yjq	86.99	no data
1506	KSYK	Tyrosine-protein kinase SYK	P43405		4dt	THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000250	4yjv	83.75	no data
1507	KSYK	Tyrosine-protein kinase SYK	P43405		50h	Crystal structure of SYK in complex with compound 1	5c26	77.15	170.
1508	KSYK	Tyrosine-protein kinase SYK	P43405		55m	SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor	5cxh	86.17	5.
1509	KSYK	Tyrosine-protein kinase SYK	P43405		55u	SYK catalytic domain complexed with naphthyridine inhibitor	5cxz	74.83	552.
1510	KSYK	Tyrosine-protein kinase SYK	P43405		55y	SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor	5cy3	87.82	16.
1511	KSYK	Tyrosine-protein kinase SYK	P43405		x5g	Crystal structure of an inhibitor-bound Syk	5ghv	69.13	12.1
1512	KSYK	Tyrosine-protein kinase SYK	P43405		6zg	HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR	5lma	80.91	250.
1513	KSYK	Tyrosine-protein kinase SYK	P43405		6zf	HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR	5lmb	79.35	15.8
1514	KSYK	Tyrosine-protein kinase SYK	P43405		77v	Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine	5t68	74.87	23.
1515	KSYK	Tyrosine-protein kinase SYK	P43405		7kg	Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)	5tr6	86.53	3.2
1516	KSYK	Tyrosine-protein kinase SYK	P43405		7kf	Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)	5tt7	82.84	13.
1517	KSYK	Tyrosine-protein kinase SYK	P43405		8or	Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor	5y5t	75.3	no data
1518	KSYK	Tyrosine-protein kinase SYK	P43405		8ou	Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor	5y5u	79.67	no data
1519	KSYK	Tyrosine-protein kinase SYK	P43405		585	Crystal structure of spleen tyrosine kinase complexed with R406	3fqs	66.02	41.
1520	LCK	Tyrosine-protein kinase Lck	P06239		odj	Tyrosine-protein kinase LCK bound to Compound 11	6pdj	89.6	no data
1521	LCK	Tyrosine-protein kinase Lck	P06239		lhl	Structure of human LCK kinase with a small molecule inhibitor	3kmm	65.31	0.2
1522	LCK	Tyrosine-protein kinase Lck	P06239		kzm	Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ac5	75.31	no data
1523	LCK	Tyrosine-protein kinase Lck	P06239		kzl	Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ac4	57.82	no data
1524	LCK	Tyrosine-protein kinase Lck	P06239		kzi	Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK, (Auto-phosphorylated on TYR394)	3ac1	63.81	no data
1525	LCK	Tyrosine-protein kinase Lck	P06239		ksk	Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ac8	77.52	no data
1526	LCK	Tyrosine-protein kinase Lck	P06239		kse	Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ac2	62.59	no data
1527	LCK	Tyrosine-protein kinase Lck	P06239		am9	X-Ray co-crystal structure of 2-amino-6-phenylpyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one 25 bound to Lck	3byo	68.19	7.
1528	LCK	Tyrosine-protein kinase Lck	P06239		am5	co-crystal structure of Lck and aminopyrimidine amide 10b	3bys	81.23	0.5
1529	LCK	Tyrosine-protein kinase Lck	P06239		am0	X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck	3bym	74.96	6.
1530	LCK	Tyrosine-protein kinase Lck	P06239		925	The complex crystal structure of LCK with a probe molecule w259	3kxz	70.94	35.
1531	LCK	Tyrosine-protein kinase Lck	P06239		242	crystal structure of aminoquinazoline 1 bound to Lck	2ofv	95.63	0.2
1532	LCK	Tyrosine-protein kinase Lck	P06239		1n8	crystal structure of aminoquinazoline 36 bound to Lck	2og8	81.33	0.5
1533	LCK	Tyrosine-protein kinase Lck	P06239		547	crystal structure of furanopyrimidine 8 bound to lck	2of2	71.29	210.
1534	LCK	Tyrosine-protein kinase Lck	P06239		979	crystal structure of furanopyrimidine 1 bound to lck	2of4	67.32	81.
1535	LCK	Tyrosine-protein kinase Lck	P06239		ksf	Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	2zm1	84.69	220.
1536	LCK	Tyrosine-protein kinase Lck	P06239		ksm	Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)	2zm4	77.79	no data
1537	LCK	Tyrosine-protein kinase Lck	P06239		pp2	STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS	1qpe	85.21	20.
1538	LCK	Tyrosine-protein kinase Lck	P06239		ksl	Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	2zyb	83.83	20.
1539	LCK	Tyrosine-protein kinase Lck	P06239		ksh	Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ac3	58.36	no data
1540	LCK	Tyrosine-protein kinase Lck	P06239		ksc	Crystal structure of Pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)	3ad6	60.56	no data
1541	LCK	Tyrosine-protein kinase Lck	P06239		5lk	LCK complexed with a pyrazolopyrimidine	3mpm	76.05	30.
1542	LCK	Tyrosine-protein kinase Lck	P06239		sti	LCK bound to imatinib	2pl0	86.26	62.
1543	LIMK1	LIM domain kinase 1	P53667	LIMK	9db	LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736	5nxc	82.68	no data
1544	LIMK2	LIM domain kinase 2	P53671		9d8	LIM Domain Kinase 2 (LIMK2) In Complex With TH-300	5nxd	98.08	no data
1545	LIMK2	LIM domain kinase 2	P53671		35h	Crystal Structure of the Human LIMK2 Kinase Domain In Complex With a Non-ATP Competitive Inhibitor	4tpt	94.35	92.
1546	LYN	Tyrosine-protein kinase Lyn	P07948	JTK8	pp2	Lyn Tyrosine Kinase Domain-PP2 complex	2zv9	87.88	9.
1547	LYN	Tyrosine-protein kinase Lyn	P07948	JTK8	1n1	Lyn Tyrosine Kinase Domain-Dasatinib complex	2zva	69.16	11.
1548	LYN	Tyrosine-protein kinase Lyn	P07948	JTK8	8h0	Crystal structure of Lyn kinase domain in complex with N-(1H-indazol-6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine	5xy1	76.73	no data
1549	M3K12	Mitogen-activated protein kinase kinase kinase 12	Q12852	ZPK	50f	DLK in complex with inhibitor 2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile	5ceq	68.67	42.
1550	M3K12	Mitogen-activated protein kinase kinase kinase 12	Q12852	ZPK	9fs	DLK in complex with compound 10 (5-(1-isopropyl-5-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine)	5vo1	69.12	7.
1551	M3K12	Mitogen-activated protein kinase kinase kinase 12	Q12852	ZPK	9fv	DLK in complex with inhibitor 5-(1-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine (compound 7)	5vo2	71.1	154.
1552	M3K12	Mitogen-activated protein kinase kinase kinase 12	Q12852	ZPK	50e	DLK in complex with inhibitor N-(1-isopropyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine	5cep	78.26	145.
1553	M3K12	Mitogen-activated protein kinase kinase kinase 12	Q12852	ZPK	50d	DLK in complex with inhibitor 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile	5ceo	66.33	0.5
1554	M3K14	Mitogen-activated protein kinase kinase kinase 14	Q99558	NIK	13v	Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)	4idv	94.53	40.
1555	M3K20	Mitogen-activated protein kinase kinase kinase 20	Q9NYL2	MLTK ZAK	032	Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib	5hes	93.56	29.
1556	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	9e1	Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 6)	5vil	88.71	no data
1557	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	im6	Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor	3vw6	72.75	14.
1558	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	bh9	Crystal Structures of Ask1-inhibitor Complexes	4bhn	70.38	6.31
1559	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	ieo	Crystal Structures of Ask1-inhibitor Complexes	4bib	89.88	250.
1560	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	ie8	Crystal Structures of Ask1-inhibitor Complexes	4bid	89.7	7.94
1561	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	ie6	Crystal Structures of Ask1-inhibitor Complexes	4bie	86.95	250.
1562	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	8gv	Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure	5uor	78.92	6.31
1563	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	8gy	Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure	5uox	80.36	5.01
1564	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	8gs	Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure	5up3	88.19	12.59
1565	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	8v7	Structure-based drug design of novel ASK1 inhibitors using a fully integrated lead optimization strategy	5v24	88.35	400.
1566	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	9e4	Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13)	5vio	84.47	no data
1567	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	kk7	ASK1 kinase domain complex with inhibitor	6e2m	86.52	no data
1568	M3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	ASK1 MAPKKK5 MEKK5	kk8	ASK1 kinase domain complex with inhibitor	6e2n	81.85	no data
1569	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	ng2	Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1	4o91	87.99	149.
1570	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6v5	Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 4	5gjg	76.77	610.
1571	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6v4	Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 3	5gjf	80	260.
1572	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6v3	Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 2	5gjd	89.48	12.
1573	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	yiy	Crystal structure of compound 8 bound to TAK1-TAB	2yiy	91.34	no data
1574	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	1fm	Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol	4gs6	88.41	71.
1575	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	1ul	Crystal Structure of 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethan-1-one bound to TAK1-TAB1	4l52	73.91	4.
1576	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	1uo	Crystal Structure of (1R,4R)-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}cyclohexan-1-ol bound to TAK1-TAB1	4l53	74.27	28.
1577	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	adn	Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1	2eva	90.08	no data
1578	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	5kw	Crystal structure of TL10-81 bound to TAK1-TAB1	5e7r	72.33	25.
1579	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6h3	Crystal structure of SM1-71 bound to TAK1-TAB1	5j7s	73.65	50.
1580	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6h4	Crystal structure of TL11-113 bound to TAK1-TAB1	5j8i	70.23	5.1
1581	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6hf	Crystal structure of CPT1691 bound to TAK1-TAB1	5j9l	73.45	34.
1582	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6kc	Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 11c	5jga	73.49	2.3
1583	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6jv	Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 10	5jgb	57.64	13.
1584	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	t92	Crystal structure of TL10-92 bound to TAK1-TAB1	5jh6	72.4	3.3
1585	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	6l4	Crystal structure of TL11-128 bound to TAK1-TAB1	5jk3	76.18	7.3
1586	M3K7	Mitogen-activated protein kinase kinase kinase 7	O43318	TAK1	edh	Crystal structure of Takinib bound to TAK1	5v5n	82.68	9.5
1587	M4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Q92918	HPK1	f97	Crystal structure of HPK1 in complex an inhibitor G1858	6cqf	72.39	no data
1588	M4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Q92918	HPK1	b49	Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with sunitinib in the inactive state.	6ng0	72.38	no data
1589	M4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Q92918	HPK1	b49	Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.	6nfz	75.6	no data
1590	M4K3	Mitogen-activated protein kinase kinase kinase kinase 3	Q8IVH8	RAB8IPL1	6g2	GLK co-crystal structure with aminopyrrolopyrimidine inhibitor	5j5t	78.55	110.
1591	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	6hh	MAP4K4 in complex with inhibitor	5j95	81.8	no data
1592	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	2qt	MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE	4obq	79.09	65.
1593	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3xm	MAP4K4 in complex with a pyridin-2(1H)-one derivative	4rvt	85.19	1900.
1594	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3c8	MAP4K4 Bound to inhibitor compound 1	4u41	93.78	no data
1595	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3c8	MAP4K4 T181E Mutant Bound to inhibitor compound 1	4u42	94.43	no data
1596	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3d8	MAP4K4 in complex with inhibitor (compound 6)	4u43	93.76	48000.
1597	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3dc	MAP4K4 in complex with inhibitor (compound 25)	4u45	87.42	10.
1598	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	4p4	MAP4K4 in complex with inhibitor GNE-495	4zk5	83.35	3.7
1599	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	5df	MAP4K4 in complex with an inhibitor	5di1	89.58	21.
1600	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	9x4	MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide)	5w5q	95.36	no data
1601	M4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	HGK KIAA0687 NIK	3d9	MAP4K4 in complex with inhibitor (compound 16)	4u44	86.55	8.
1602	MAPK2	MAP kinase-activated protein kinase 2	P49137		b18	Structure of MK2 Complexed with Compound 76	2pzy	67.89	34.
1603	MAPK2	MAP kinase-activated protein kinase 2	P49137		mk3	MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thiophene-2-carboxamide	3ka0	71.38	no data
1604	MAPK2	MAP kinase-activated protein kinase 2	P49137		l8i	Crystal structure of MAPKAK kinase 2 (MK2) complexed with a spiroazetidine-tetracyclic ATP site inhibitor	3m2w	82.65	3.
1605	MAPK2	MAP kinase-activated protein kinase 2	P49137		hgf	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor	3m42	81.48	no data
1606	MAPK2	MAP kinase-activated protein kinase 2	P49137		05b	MK2 kinase bound to Compound 5b	3r2b	84.05	4.
1607	MAPK2	MAP kinase-activated protein kinase 2	P49137		yrz	Crystal structure of MAPKAP Kinase-2 (MK2) in complex with non-selective inhibitor	3wi6	85.76	4700.
1608	MAPK3	MAP kinase-activated protein kinase 3	Q16644		f10	High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex	3fxw	89.59	1100.
1609	MAPK3	MAP kinase-activated protein kinase 3	Q16644		05b	MK3 kinase bound to Compound 5b	3r1n	83	no data
1610	MAPK3	MAP kinase-activated protein kinase 3	Q16644		i85	Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series	3she	79.81	no data
1611	MARK2	Serine/threonine-protein kinase MARK2	Q7KZI7	EMK1	24r	Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties	5eak	81.37	0.5
1612	MARK4	MAP/microtubule affinity-regulating kinase 4	Q96L34	KIAA1860 MARKL1	5rc	CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR	5es1	82.52	4.6
1613	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	xin	Crystal structure of MELK in complex with an inhibitor	5maf	70.47	no data
1614	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	tak	Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)	6gvx	70.35	no data
1615	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	h91	Structure of Maternal Embryonic Leucine Zipper Kinase	5twl	83.6	no data
1616	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	b5s	Structure of MELK in complex with inhibitors	4umq	83.51	4200.
1617	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	82b	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor	4bky	78.11	12.
1618	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	7my	Structure of Maternal Embryonic Leucine Zipper Kinase	5tx3	84.82	no data
1619	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	7lv	Structure of Maternal Embryonic Leucine Zipper Kinase	5tvt	79.26	no data
1620	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	7kd	Crystal structure of MELK in complex with an inhibitor	5mah	79.79	no data
1621	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	6pv	MELK in complex with NVS-MELK5	5k00	87.03	7.
1622	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	5u5	Crystal structure of MELK in complex with an inhibitor	5mai	76.37	no data
1623	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	1ws	Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor	4bkz	75.99	27.
1624	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	3i7	Structure of MELK in complex with inhibitors	4d2t	85.83	1000.
1625	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	qbb	Structure of MELK in complex with inhibitors	4umr	74.94	160000.
1626	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	47w	Structure of MELK in complex with inhibitors	4umt	92.41	720.
1627	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	6bf	MELK in complex with NVS-MELK8A	5ih9	69.84	2.
1628	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	6be	MELK in complex with NVS-MELK8F	5iha	69.61	9.
1629	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	6bb	MELK in complex with NVS-MELK12B	5ihc	80.24	13.
1630	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	7kc	Crystal structure of MELK in complex with an inhibitor	5mag	74.08	no data
1631	MELK	Maternal embryonic leucine zipper kinase	Q14680	KIAA0175	7ly	Structure of Maternal Embryonic Leucine Zipper Kinase	5twy	68.69	no data
1632	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	k0x	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541	5k0x	70.45	4.4
1633	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	7ae	Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate	5td2	75.97	2.2
1634	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	4mh	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817	4mha	67.45	5.2
1635	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	olp	Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor C52	3bpr	73.1	11300.
1636	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	ckj	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569	3tcp	72.33	4.3
1637	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	24k	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917	4m3q	81.08	17.
1638	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	mh7	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896	4mh7	78.62	5900.
1639	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	6q1	Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434	5k0k	65.05	no data
1640	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	79y	Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate	5tc0	85.38	25.
1641	MERTK	Tyrosine-protein kinase Mer	Q12866	MER	7ys	Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor	5u6c	80.42	0.05
1642	MET	Hepatocyte growth factor receptor	P08581		q6w	Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor	3q6w	71.48	27.
1643	MET	Hepatocyte growth factor receptor	P08581		mt4	Structure of c-Met with pyrimidone inhibitor 50	3efk	91	14.
1644	MET	Hepatocyte growth factor receptor	P08581		m61	Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog	3r7o	71.47	4.4
1645	MET	Hepatocyte growth factor receptor	P08581		dwf	Crystal structure of CMET in complex with novel inhibitor	4mxc	92.99	6.7
1646	MET	Hepatocyte growth factor receptor	P08581		dfq	human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor	3a4p	80.73	28.
1647	MET	Hepatocyte growth factor receptor	P08581		ckk	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor	3c1x	87.33	45.
1648	MET	Hepatocyte growth factor receptor	P08581		am7	x-ray structure of c-Met with inhibitor.	2rfn	74.16	5.
1649	MET	Hepatocyte growth factor receptor	P08581		88z	Crystal structure of D1228V cMET bound by foretinib	6sdc	81.07	no data
1650	MET	Hepatocyte growth factor receptor	P08581		88z	Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)	3lq8	78.26	0.4
1651	MET	Hepatocyte growth factor receptor	P08581		88z	Crystal structure of wild-type cMET bound by foretinib	6sd9	76.56	no data
1652	MET	Hepatocyte growth factor receptor	P08581		75h	Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor	5t3q	85.06	no data
1653	MET	Hepatocyte growth factor receptor	P08581		66l	Crystal structure of c-Met kinase domain in complex with LXM108	5hti	81.41	no data
1654	MET	Hepatocyte growth factor receptor	P08581		63k	CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD.	5ho6	59.41	204.
1655	MET	Hepatocyte growth factor receptor	P08581		63k	Crystal structure of c-Met-M1250T in complex with SAR125844.	5hor	60.22	6.
1656	MET	Hepatocyte growth factor receptor	P08581		63k	Crystal structure of c-Met L1195V in complex with SAR125844	5hoa	59.78	64.
1657	MET	Hepatocyte growth factor receptor	P08581		62e	Crystal structure of c-Met mutant Y1230H in complex with compound 14	5hlw	64.73	23.
1658	MET	Hepatocyte growth factor receptor	P08581		5b4	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157	5dg5	92.64	no data
1659	MET	Hepatocyte growth factor receptor	P08581		3eh	Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor	4r1y	76.36	400.
1660	MET	Hepatocyte growth factor receptor	P08581		353	Crystal structure of D1228V cMET bound by BMS-777607	6sdd	92.63	no data
1661	MET	Hepatocyte growth factor receptor	P08581		353	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide	3f82	94.65	4.6
1662	MET	Hepatocyte growth factor receptor	P08581		1jc	Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog	4iwd	77.36	1.
1663	MET	Hepatocyte growth factor receptor	P08581		044	Crystal structure of c-Met in complex with pyrazolone inhibitor 58a	3u6i	91.72	1.
1664	MET	Hepatocyte growth factor receptor	P08581		03x	Crystal structure of c-Met in complex with pyrazolone inhibitor 26	3u6h	90.74	1.
1665	MET	Hepatocyte growth factor receptor	P08581		lkg	X-ray structure of c-Met with triazolopyridazine inhibitor.	3ccn	90.9	120.
1666	MET	Hepatocyte growth factor receptor	P08581		l5g	X-ray Structure of c-Met with triazolopyridazine Inhibitor.	3cd8	89.91	9.
1667	MET	Hepatocyte growth factor receptor	P08581		1fn	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor	3ce3	91.17	1.8
1668	MET	Hepatocyte growth factor receptor	P08581		319	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor	3cth	95.76	110.
1669	MET	Hepatocyte growth factor receptor	P08581		320	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor	3ctj	90.87	35.
1670	MET	Hepatocyte growth factor receptor	P08581		mt3	Structure of c-Met with pyrimidone inhibitor 7	3efj	92.79	39.
1671	MET	Hepatocyte growth factor receptor	P08581		ihx	Human c-Met Kinase in complex with quinoxaline inhibitor	3f66	72.8	900.
1672	MET	Hepatocyte growth factor receptor	P08581		b2d	Crystal structure of c-Met with triazolopyridazine inhibitor 13	3i5n	89.35	14.
1673	MET	Hepatocyte growth factor receptor	P08581		l8v	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor	3l8v	96.12	8.
1674	MET	Hepatocyte growth factor receptor	P08581		3qt	c-Met Kinase in Complex with NVP-BVU972	3qti	90.43	14.
1675	MET	Hepatocyte growth factor receptor	P08581		df6	Crystal structure of human c-Met kinase domain with its inhibitor	3vw8	92.09	no data
1676	MET	Hepatocyte growth factor receptor	P08581		6xe	X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.	3zbx	89.85	6.
1677	MET	Hepatocyte growth factor receptor	P08581		w9z	X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline.	3zc5	91.14	74.
1678	MET	Hepatocyte growth factor receptor	P08581		5tf	X-ray Structure of c-Met kinase in complex with inhibitor (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3- b)pyridazin-6-amine	3zcl	91.47	10.1
1679	MET	Hepatocyte growth factor receptor	P08581		6xp	Crystal structure of C-MET kinase domain in complex with N'-((3Z)-4- chloro-7-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4- hydroxyphenyl)propanohydrazide	3zze	92.62	1.3
1680	MET	Hepatocyte growth factor receptor	P08581		4k0	Crystal structure of C-MET kinase domain in complex with 4-(3-((1H- pyrrolo(2,3-b)pyridin-3-yl)methyl)-(1,2,4)triazolo(4,3-b)(1,2,4) triazin-6-yl)benzonitrile	4aoi	86.89	4.
1681	MET	Hepatocyte growth factor receptor	P08581		f47	Crystal structure of C-MET kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol	4ap7	90.5	11.
1682	MET	Hepatocyte growth factor receptor	P08581		vgh	X-ray Structure of PF-02341066 bound to the kinase domain of c-Met	2wgj	78.4	2.
1683	MET	Hepatocyte growth factor receptor	P08581		0jj	Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2	4deg	89.85	6.
1684	MET	Hepatocyte growth factor receptor	P08581		0jk	Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3	4deh	87.2	612.
1685	MET	Hepatocyte growth factor receptor	P08581		0jl	Crystal structure of c-Met in complex with triazolopyridinone inhibitor 24	4dei	84.62	1.
1686	MET	Hepatocyte growth factor receptor	P08581		0j3	Crystal structure of CMET in complex with novel inhibitor	4gg5	80	0.93
1687	MET	Hepatocyte growth factor receptor	P08581		0j8	Crystal structure of cMET in complex with novel inhibitor	4gg7	73	6.3
1688	MET	Hepatocyte growth factor receptor	P08581		1ru	C-Met in complex with OSI ligand	4knb	76.9	47.
1689	MET	Hepatocyte growth factor receptor	P08581		3e8	Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors	4r1v	75.3	1.
1690	MET	Hepatocyte growth factor receptor	P08581		44x	Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole	4xyf	82.62	1.
1691	MET	Hepatocyte growth factor receptor	P08581		5sz	Crystal structure of c-Met in complex with naphthyridinone inhibitor 5	5eyc	90.63	3.
1692	MET	Hepatocyte growth factor receptor	P08581		5t1	Crystal structure of c-Met in complex with AMG 337	5eyd	82.81	1.
1693	MET	Hepatocyte growth factor receptor	P08581		63b	CRYSTAL STRUCTURE OF CMET WT with compound 3	5hni	72.92	no data
1694	MET	Hepatocyte growth factor receptor	P08581		84m	MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody	5uab	82.73	no data
1695	MET	Hepatocyte growth factor receptor	P08581		84p	MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody	5uaf	82.15	no data
1696	MET	Hepatocyte growth factor receptor	P08581		84p	MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody	5uad	82.15	no data
1697	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	zas	Crystal structure of ERK2 in complex with an adenosine derivative	6frp	83.85	no data
1698	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	n0v	phosphorylated ERK2 with SCH-CPD336	6opi	85.61	no data
1699	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	g17	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor	4i5h	96	2.
1700	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	f8v	Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology	6cpw	85.42	no data
1701	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	f3z	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6gdm	88.85	no data
1702	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	evq	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6ge0	86.99	no data
1703	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	esw	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9m	81.14	no data
1704	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	esn	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9n	87.75	no data
1705	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	esk	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9k	88.23	no data
1706	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	erk	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9j	91.93	no data
1707	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek6	Crystal Structure of the ERK2 complexed with EK6	4fv3	79.53	no data
1708	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek6	A multiconformer ligand model of EK6 bound to ERK2	6dmg	81.34	no data
1709	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek3	Crystal Structure of the ERK2 complexed with EK3	4fv0	84.29	no data
1710	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e94	Crystal Structure of the ERK2 complexed with E94	4fv7	87.62	no data
1711	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e63	Crystal Structure of the ERK2 complexed with E63	4fv8	80.27	no data
1712	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e2k	Crystal structure of ERK2 in complex with an adenosine derivative	6fq7	83.47	no data
1713	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	du8	Crystal structure of ERK2 in complex with an adenosine derivative	6fma	87.48	no data
1714	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	dkw	Crystal structure of ERK2 in complex with an adenosine derivative	6fjz	76.88	no data
1715	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	dj2	Crystal structure of ERK2 in complex with an adenosine derivative	6fi3	80.98	no data
1716	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	aoc	Crystal structure of ERK2 in complex with an adenosine derivative	6fjb	78.08	no data
1717	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	a3n	Crystal structure of ERK2 in complex with an adenosine derivative	6fj0	78.83	no data
1718	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6ts	In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor	5lcj	54.2	230.
1719	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6qb	phosphorylated ERK2 with GDC-0994	6oph	86.68	no data
1720	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6h3	Crystal structure of ERK2 covalently bound to SM1-71	6g54	75.34	no data
1721	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	390	Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE	4qte	86.66	no data
1722	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	390	Phosphorylated ERK2 with Vertex-11e	6opk	87.24	no data
1723	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	38z	Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide	5hd4	86.82	no data
1724	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	38z	Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide	5hd7	86.42	no data
1725	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	38z	Structure of human ERK2 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket	4qta	88.74	200.
1726	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	olo	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE	4erk	75.55	27000.
1727	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	82a	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide	2ojj	89.07	2.
1728	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	s91	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid	2z7l	76.73	no data
1729	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	sb4	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025	3erk	78.31	18000.
1730	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	z48	Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide	3i5z	86.57	2.
1731	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e86	Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide	3i60	86.75	2.
1732	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	z8b	Crystal structure of ERK2 in complex with an inhibitor	3qyz	85.66	no data
1733	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e75	Crystal Structure of the ERK2 complexed with E75	4fux	77.53	no data
1734	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek5	Crystal Structure of the ERK2 complexed with EK5	4fv2	83.95	no data
1735	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek7	Crystal Structure of the ERK2 complexed with EK7	4fv4	86.61	no data
1736	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek9	Crystal Structure of the ERK2 complexed with EK9	4fv5	89.43	no data
1737	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e57	Crystal Structure of the ERK2 complexed with E57	4fv6	88.06	no data
1738	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	ek0	Crystal Structure of the ERK2	4g6n	82.79	no data
1739	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	e28	Crystal Structure of the ERK2	4g6o	79.59	no data
1740	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	1fm	The structure of ERK2 in complex with FR148083	3w55	89.51	80.
1741	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	2h1	A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor	4n4s	93.77	133.
1742	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	2sh	Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2	4o6e	81.25	1.
1743	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	36q	Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol	4qp3	77.78	no data
1744	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	35x	Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine	4qp9	90.71	71.
1745	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	35w	Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine	4qpa	85.69	37.
1746	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	3g7	Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State	4qyy	87.86	50.
1747	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	41b	Crystal structure of ERK2 in complex with an inhibitor 14K	4xj0	80.68	0.3
1748	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	cq6	Human ERK2 in complex with an irreversible inhibitor	4zzm	78.36	no data
1749	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	cq8	Human ERK2 in complex with an inhibitor	4zzn	81.4	no data
1750	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	cq3	Human ERK2 in complex with an irreversible inhibitor	4zzo	85.7	no data
1751	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	5id	Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.	5ax3	87.63	1200.
1752	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4v8	ERK2 complexed with N-benzylpyridone tetrahydroazaindazole	5bue	87.14	3.
1753	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4v9	ERK2 complexed with 2-pyridiyl tetrahydroazaindazole	5bui	94	89.
1754	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4vb	ERK2 complexed with a N-H tetrahydroazaindazole	5buj	95.37	5.
1755	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4vf	Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase	5bvd	90.24	0.16
1756	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4vg	Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase	5bve	88.66	0.01
1757	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	4vj	Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase	5bvf	86.93	0.19
1758	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6qb	Crystal Structure of ERK2 in complex with compound 22	5k4i	89.35	3.1
1759	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6s9	Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers	5ke0	84.82	0.2
1760	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	6tt	A Clickable Covalent ERK 1/2 Inhibitor	5lck	85.5	8.
1761	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8x2	Human Erk2 with an Erk1/2 inhibitor	5ngu	75.45	36.
1762	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8x5	Human Erk2 with an Erk1/2 inhibitor	5nhf	81.96	0.32
1763	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8xh	Human Erk2 with an Erk1/2 inhibitor	5nhh	91.86	1.13
1764	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8xe	Human Erk2 with an Erk1/2 inhibitor	5nhj	88.93	5.4
1765	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8xb	Human Erk2 with an Erk1/2 inhibitor	5nhl	83.7	0.3
1766	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8xn	Human Erk2 with an Erk1/2 inhibitor	5nho	87.17	0.3
1767	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8xk	Human Erk2 with an Erk1/2 inhibitor	5nhp	83.86	23.
1768	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	8qb	Human Erk2 with an Erk1/2 inhibitor	5nhv	88.02	2.8
1769	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	eu2	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g93	81.68	no data
1770	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	eqz	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g97	88.12	no data
1771	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	esq	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9a	79	no data
1772	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	er8	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9d	87.36	no data
1773	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	erw	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6g9h	85.23	no data
1774	MK01	Mitogen-activated protein kinase 1	P28482	ERK2 PRKM1 PRKM2	evk	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2	6gdq	86.13	no data
1775	MK03	Mitogen-activated protein kinase 3	P27361	ERK1 PRKM3	ewh	Crystal structure of ERK1 covalently bound to SM1-71	6ges	43.63	no data
1776	MK03	Mitogen-activated protein kinase 3	P27361	ERK1 PRKM3	6h3	Crystal structure of ERK1 covalently bound to SM1-71	6ges	77.61	no data
1777	MK03	Mitogen-activated protein kinase 3	P27361	ERK1 PRKM3	38z	Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket	4qtb	87.43	200.
1778	MK03	Mitogen-activated protein kinase 3	P27361	ERK1 PRKM3	5id	Structural dissection of human mitogen-activated kinase ERK1	2zoq	94.44	900.
1779	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	g9e	Crystal structure of Compound 35 with ERK5	6hkn	95.69	no data
1780	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	4qx	MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR	4zsg	80.56	10000.
1781	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	4r0	MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR	4zsj	78.32	2300.
1782	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	4qz	MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR	4zsl	72.84	10000.
1783	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	4wg	ERK5 IN COMPLEX WITH SMALL MOLECULE	5byy	69.94	98.
1784	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	4we	ERK5 in complex with small molecule	5byz	81.14	42.
1785	MK07	Mitogen-activated protein kinase 7	Q13164	BMK1 ERK5 PRKM7	9n8	ERK5 in complex with a pyrrole inhibitor	5o7i	80.42	no data
1786	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	myu	Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor	3v3v	88.99	4600.
1787	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	38z	Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode	4qtd	71.46	1080.
1788	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	0nr	Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor	4e73	65.29	no data
1789	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	893	Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors	2h96	78.31	230.
1790	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	gs7	Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.	3elj	79.08	5000.
1791	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	cfk	JNK1 in complex with inhibitor	3pze	84.66	no data
1792	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	aq2	Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.	4awi	79	1000.
1793	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	g1w	Crystal structure of JNK1 in complex with JIP1 peptide and 7-Fluoro-3-[4-(2-hydroxy-ethanesulfonyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester	4g1w	71.74	no data
1794	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	1bj	Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan	4hys	70.39	55.
1795	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	1bk	Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan	4hyu	72.24	6.2
1796	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	1j2	Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan	4izy	71.7	3.
1797	MK08	Mitogen-activated protein kinase 8	P45983	JNK1 PRKM8 SAPK1 SAPK1C	1v5	Co-crystal Structure of JNK1 and AX13587	4l7f	86.02	160.
1798	MK09	Mitogen-activated protein kinase 9	P45984	JNK2 PRKM9 SAPK1A	b96	Crystal structure of JNK2 complexed with BIRB796	3npc	95.29	4.6
1799	MK09	Mitogen-activated protein kinase 9	P45984	JNK2 PRKM9 SAPK1A	35f	Crystal Structure of JNK2	3e7o	71.52	120.
1800	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	jbi	Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury	3ttj	83.73	210.
1801	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	j88	JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one	3g9n	83.28	1800.
1802	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	j67	JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one	3g9l	83.89	740.
1803	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	bz9	Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine	3da6	89.01	2.
1804	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	aiz	inhibitor complex of JNK3	2b1p	68.02	3.
1805	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	984	Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor	1pmn	81.98	7.1
1806	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	880	THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR	4z9l	89.1	1.6
1807	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	46c	Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor	2zdt	80.66	9.6
1808	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	446	Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor	2zdu	73.26	no data
1809	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	3el	Crystal structure of human JNK3 in complex with a benzenesulfonamide inhibitor.	4u79	81.03	400.
1810	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	255	c-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor	2r9s	77.45	150.
1811	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	1rq	The crystal structure of inhibitor-bound JNK3	4kkh	76.8	no data
1812	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	jnk	Inhibitor complex of JNK3	2exc	77.04	235.
1813	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	c0m	Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide	2o0u	73.35	3200.
1814	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	738	Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide	2o2u	92.27	400.
1815	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	j07	Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors	2p33	76.61	57.
1816	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	snb	Crystal structure of human Jnk3 complexed with a 1-aryl-3,4- dihydroisoquinoline inhibitor	2waj	87.81	398.
1817	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	jno	IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding	3cgo	74.25	3000.
1818	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	jk3	JNK3 bound to piperazine amide inhibitor, SR2774.	3fv8	88.78	160.
1819	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	j72	JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one	3g90	82.1	440.
1820	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	syy	Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases	3oxi	82.36	2200.
1821	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	932	Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor	3ptg	78.37	25.
1822	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	34i	Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration	3rtp	80.1	7.
1823	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	kbi	Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor	3tti	84.97	6.
1824	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	cqq	Discovery of potent and selective covalent inhibitors of JNK	3v6r	73.97	709.
1825	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	0f0	Discovery of potent and selective covalent inhibitors of JNK	3v6s	75.52	0.75
1826	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	3h8	JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide	4w4v	79.93	115.
1827	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	3hn	JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide	4w4x	79.31	102.8
1828	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	3nl	Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives	4whz	71.68	1.
1829	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	3wh	The MAP kinase JNK3 as target for halogen bonding	4x21	77.51	36.
1830	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	4f2	Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors	4y46	64.6	11.
1831	MK10	Mitogen-activated protein kinase 10	P53779	JNK3 JNK3A PRKM10 SAPK1B	519	Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors	4y5h	63.54	15.
1832	MK11	Mitogen-activated protein kinase 11	Q15759	PRKM11 SAPK2 SAPK2B	nil	Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib	3gp0	89.91	36.
1833	MK11	Mitogen-activated protein kinase 11	Q15759	PRKM11 SAPK2 SAPK2B	b45	The structure of p38beta C162S in complex with a dihydroquinazolinone	3gc8	87.51	no data
1834	MK11	Mitogen-activated protein kinase 11	Q15759	PRKM11 SAPK2 SAPK2B	b45	The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor	3gc9	87.74	no data
1835	MK13	Mitogen-activated protein kinase 13	O15264	PRKM13 SAPK4	n61	MAPK13 Complex with inhibitor	4eyj	94.9	620.
1836	MK13	Mitogen-activated protein kinase 13	O15264	PRKM13 SAPK4	0rx	MAPK13 complex with inhibitor	4eym	90.16	98747.
1837	MK13	Mitogen-activated protein kinase 13	O15264	PRKM13 SAPK4	n58	Crystal structure of MAPK13 complex with inhibitor	5ekn	90.71	1900.
1838	MK13	Mitogen-activated protein kinase 13	O15264	PRKM13 SAPK4	n17	Crystal structure of MAPK13 complex with inhibitor	5eko	89.31	15785.
1839	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	z86	Human p38 MAP Kinase in Complex with RL99	3lfc	89.7	no data
1840	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	z84	Human p38 MAP Kinase in Complex with RL116	3lfe	89.07	no data
1841	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	yiw	triazolopyridine inhibitors of p38 kinase	2yiw	91.16	0.8
1842	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	t75	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors	6anl	86.07	no data
1843	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	t75	X-ray structure of p38alpha bound to TAK-715	3zsg	81.86	no data
1844	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Fragments KCL_615 and KCL_802 in complex with MAP kinase p38-alpha	6sov	90.05	no data
1845	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Fragment KCL615 in complex with MAP kinase p38-alpha	6spl	90.91	no data
1846	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Fragment KCL802 in complex with MAP kinase p38-alpha	6sp9	89.99	no data
1847	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p7c	p38 inhibitor-bound	3p7c	84.31	22.
1848	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p39	Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2	3bv3	88.33	0.46
1849	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p38	Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30	3bv2	93.95	0.44
1850	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	mih	p38 kinase Crystal structure in complex with small molecule inhibitor	3mw1	80.13	0.82
1851	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lo8	Fragment RZ132 in complex with MAP kinase p38-alpha	6so4	59.47	no data
1852	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lo5	Fragment N13569a in complex with MAP kinase p38-alpha	6so1	73.68	no data
1853	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lie	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717	2gtn	95.5	no data
1854	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lid	Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579	2gtm	94.21	no data
1855	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lgf	P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds	2qd9	73.39	13.
1856	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lbe	MAPK14 with bound inhibitor SR-318	6sfo	94.07	no data
1857	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lbb	Crystal structure of p38 alpha in complex with compound 77 (MCP41)	6sfj	92.57	no data
1858	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lb8	Crystal structure of p38 alpha in complex with compound 81 (MCP42)	6sfk	89.18	no data
1859	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lb5	Crystal structure of p38 alpha in complex with compound 75 (MCP33)	6sfi	94.48	no data
1860	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	kq7	Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide	3kq7	84.47	no data
1861	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	j9g	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10	6m9l	86.03	no data
1862	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	j8s	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1	6m95	93.18	no data
1863	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	ipk	Human p38 MAP Kinase in Complex with an Imidazo-pyridine	3iw7	88.37	2300.
1864	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	i2o	p38 kinase crystal structure in complex with small molecule inhibitor	3rin	97.89	1.3
1865	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	hb9	Dibenzosuberone inhibitor 8e in complex with p38 MAPK	5mty	78.73	1.3
1866	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	gxh	Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31)	6hwt	77.16	no data
1867	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	g2g	Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea	2puu	88.63	no data
1868	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fss	P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one	3fsf	61.07	no data
1869	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fs8	Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative	3uvq	78.86	17.
1870	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fko	P38 kinase crystal structure in complex with RO3668	3fko	91.95	no data
1871	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fji	Dibenzooxepinone inhibitor 12b in complex with p38 MAPK	5mtx	69.52	17.7
1872	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	f46	Human p38 MAP kinase in complex with a Dibenzoxepinone	4l8m	81.45	1.
1873	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	dqo	Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor	1m7q	82.55	2.6
1874	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	dg7	Human p38 MAP Kinase in Complex with RL182	3pg3	91.16	no data
1875	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	df3	Human p38 MAP Kinase in Complex with an Indole Derivative	3iw5	90.03	839.
1876	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bw1	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9j	5n66	95.59	no data
1877	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bff	Human p38 MAP Kinase in Complex with CP-547632	3l8s	80.78	99.
1878	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	b96	Human p38 MAP Kinase in Complex with BIRB 796	1kv2	90.78	0.1
1879	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	b96	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9j	5n66	89.04	no data
1880	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	b45	The structure of p38alpha in complex with a dihydroquinazolinone	3gc7	77.25	0.6
1881	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	aqz	p38alpha MAP kinase bound to MPAQ	2bak	79.06	37.
1882	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	aqz	P38ALPHA MAP KINASE BOUND TO CMPD 8	4a9y	79.06	no data
1883	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	aa0	P38ALPHA MAP KINASE BOUND TO CMPD 2	4aa0	84.22	35.
1884	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	a17	P38 complex with a phthalazine inhibitor	3ds6	96.54	0.8
1885	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	9y8	p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12	5omg	97.17	no data
1886	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	9o5	Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C	5o8u	90.87	no data
1887	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	9o2	Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C	5o8v	84.82	no data
1888	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	8ow	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9c	5n63	95.36	no data
1889	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	8en	P38 ALPHA MUTANT C162S IN COMPLEX WITH CMPD2 [N-(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl)benzamide]	5mz3	87.69	220.
1890	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	79q	Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1	5tco	71.18	6.46
1891	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	6sh	Crystal structure of p38 alpha MAPK14 in complex with VPC00628	5lar	94.02	no data
1892	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	6np	Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor	1yqj	88.28	7.3
1893	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	469	X-ray structure of p38alpha bound to SCIO-469	3zsh	75.21	no data
1894	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	469	Human p38 MAP Kinase in Complex with Scios-469	3hub	78.71	8.2
1895	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	358	The structure of p38 alpha in complex with a dihydroquinolinone	1ove	89.47	0.74
1896	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1vi	Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b	5ml5	69.47	10.
1897	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1r9	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE	4kip	90.84	7.
1898	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1pp	p38alpha bound to pyrazolourea	2baj	94.37	4.
1899	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1m8	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE	4kin	91.33	4.8
1900	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	094	The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor	1ouy	80.96	4.3
1901	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	084	The structure of p38 alpha in complex with a pyridinylimidazole inhibitor	1ouk	81.99	0.13
1902	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	048	Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone	3uvp	87.28	35.
1903	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb6	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995	1bl6	79.59	160.
1904	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb5	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655	1bmk	80.95	25.
1905	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	msq	THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di9	77.47	5000.
1906	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fph	P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR	1oz1	81.73	no data
1907	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	l10	p38 Kinase crystal structure in complex with small molecule inhibitor	1w82	95.44	196.
1908	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	l11	p38 Kinase crystal structure in complex with small molecule inhibitor	1w83	91.52	65.
1909	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	l09	fragment based p38 inhibitors	1wbn	92.12	350.
1910	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	li2	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbs	93.53	630.
1911	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	wbt	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbt	93.88	340.
1912	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	pgj	Mutated Mus Musculus P38 Kinase (mP38)	1yw2	88.39	141.
1913	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	li9	Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor	1ywr	82.77	13.
1914	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bi5	Human P38 MAP Kinase in Complex with Inhibitor 1a	1zyj	81.29	1500.
1915	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	b11	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes	1zz2	82.82	6000.
1916	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	tzy	Crystal structure of P38 with triazolopyridine	1zzl	95.7	5.
1917	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	pqa	p38alpha MAP kinase bound to pyrazoloamine	2bal	76.71	490.
1918	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	pqb	P38 Kinase Crystal Structure in complex with RO3201195	2gfs	83.85	700.
1919	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	pqb	p38alpha bound to Ro3201195	2baq	84.89	no data
1920	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lib	Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743	2ghl	85.39	no data
1921	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	lic	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449	2ghm	84.42	no data
1922	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	279	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B	2rg5	87.58	3.1
1923	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	yix	Triazolopyridine Inhibitors of p38	2yix	97.35	3.3
1924	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	gk4	Crystal structure of P38 in complex with biphenyl amide inhibitor	2zb1	93.09	480.
1925	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1n1	Human p38 MAP Kinase in Complex with Dasatinib	3lfa	58.03	no data
1926	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	304	P38 alpha map kinase complexed with BMS-640994	3bx5	97.1	3.5
1927	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	gk5	Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor	3d7z	94.35	12.
1928	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	gk6	Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor	3d83	84.78	4.4
1929	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p40	P38 Complexed with a quinazoline inhibitor	3dt1	80.43	2.4
1930	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	19b	Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor	3e93	83.77	no data
1931	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)	4loo	88.56	7.
1932	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)	4lop	89.37	7.
1933	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025	1bl7	80.61	19.
1934	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)	4loq	88.34	7.
1935	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb4	Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide.	5o90	86.63	no data
1936	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fi4	P38 kinase crystal structure in complex with RO4499	3fi4	88.09	no data
1937	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fkl	P38 kinase crystal structure in complex with RO9552	3fkl	88.78	no data
1938	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fl4	P38 kinase crystal structure in complex with RO5634	3fl4	90.49	no data
1939	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	3fn	P38 kinase crystal structure in complex with R1487	3fln	84.85	no data
1940	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	891	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin	3flq	73.61	no data
1941	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fls	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one	3fls	78.72	no data
1942	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	flw	P38 kinase crystal structure in complex with pamapimod	3flw	83.1	no data
1943	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fly	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one	3fly	82.2	no data
1944	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	flz	P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3flz	80.03	no data
1945	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	533	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3fmh	81.33	no data
1946	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fmj	P38 kinase crystal structure in complex with 4-(5-Methyl-3-phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine	3fmj	86.17	no data
1947	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fmk	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((S)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3fmk	88.35	no data
1948	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	fml	P38 kinase crystal structure in complex with RO6224	3fml	79.63	no data
1949	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	xi2	P38 kinase crystal structure in complex with RO6226	3fmm	91.4	no data
1950	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	530	P38 kinase crystal structure in complex with RO2530	3fmn	80.68	no data
1951	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	ro6	P38 kinase crystal structure in complex with RO6257	3fsk	80.55	no data
1952	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	Dual binding mode of pyridinylimidazole to MAP kinase p38	2ewa	79.38	11.5
1953	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding	3obg	75.22	no data
1954	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580	1a9u	73.54	48.
1955	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3mpa	71.48	no data
1956	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	Structural basis for kinase selectivity of three clinical p38alpha inhibitors	3zs5	77.25	no data
1957	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb2	Human P38 MAP Kinase in Complex with SB203580	3gcp	79.32	15.
1958	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bax	P38 in complex with Sorafenib	3heg	91.33	180.
1959	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bax	Human P38 MAP kinase in complex with Sorafenib	3gcs	90.51	56.
1960	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p37	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor	3gfe	84.24	3.2
1961	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	i47	Crystal Structure of Human p38alpha complexed with SD-0006	3hl7	80.45	23.
1962	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	i39	p38 kinase Crystal structure in complex with small molecule inhibitor	3hrb	86.76	21.
1963	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	g97	Human p38 MAP Kinase in Complex with RL40	3huc	73.12	1030.
1964	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	r39	Human p38 MAP Kinase in Complex with RL39	3hv6	89.67	2300.
1965	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	g11	Crystal structure of p38 in complex with a biphenylamide inhibitor	3iph	87.8	25.1
1966	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p66	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor	3itz	95.05	1.4
1967	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	pp0	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol	3iw6	85.47	3290.
1968	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	hiz	Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea	3iw8	90.43	13400.
1969	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	f4c	P38alpha bound to novel DFG-out compound PF-00416121	3k3j	89.05	12500.
1970	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	l9g	Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound	3kf7	83.75	40.
1971	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	n4d	P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor	3l8x	88.73	10.
1972	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	z83	Human p38 MAP Kinase in Complex with RL166	3lff	90.35	no data
1973	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1gk	Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor	3mpt	83.02	251.
1974	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sti	P38 in complex with Imatinib	3hec	85.03	34000.
1975	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	38p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K	3mvl	89.54	13.
1976	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	39p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V	3mvm	87.18	3.9
1977	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	edb	Crystal structure of P38 alpha in complex with DP1376	3nnu	90.91	48.
1978	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	edd	Crystal structure of phosphorylated P38 alpha in complex with DP802	3nnx	92.5	11.
1979	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	edd	Crystal structure of P38 alpha in complex with DP802	3nnw	91.51	9.
1980	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	3nw	P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor	3nww	85.75	7.
1981	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding	3obj	91.49	no data
1982	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3oc1	90.34	no data
1983	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	p38 MAP Kinase in Complex with Inhibitor 1	1kv1	91.08	1160.
1984	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3o8u	92.72	no data
1985	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	Conformational plasticity of p38 MAP kinase DFG-motif mutants in response to inhibitor binding	3o8t	90.82	no data
1986	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3o8p	93.63	350.
1987	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	ocg	P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor	3ocg	89.7	3.
1988	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p5k	P38 inhibitor-bound	3p5k	88.99	76.
1989	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p78	P38 inhibitor-bound	3p78	88.43	110.
1990	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p79	P38 inhibitor-bound	3p79	87.06	2300.
1991	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p7b	p38 inhibitor-bound	3p7b	88.19	18.
1992	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	3ff	Human p38 MAP Kinase in Complex with Skepinone-L	3que	83.89	1.5
1993	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	cq0	p38 kinase crystal structure in complex with small molecule inhibitor	3s3i	89.15	16.
1994	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	nk0	P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor	3s4q	90.69	4.
1995	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	09j	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor	3u8w	89.96	1.
1996	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	2a8	Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone	3zya	95.19	100.
1997	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	nar	Human p38 MAP kinase in complex with NP-F2 and RL87	4eh3	92.93	292000.
1998	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	qc0	P38ALPHA MAP KINASE BOUND TO CMPD 22	4aa4	81.36	9.
1999	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	nqb	P38ALPHA MAP KINASE BOUND TO CMPD 33	4aa5	79.2	16.
2000	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	aav	P38ALPHA MAP KINASE BOUND TO CMPD 29	4aac	81.18	6.7
2001	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F10 and RL87	4ehv	96.77	no data
2002	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F2 and RL87	4eh3	95.74	no data
2003	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F5 and RL87	4eh6	95.82	no data
2004	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F6 and RL87	4eh7	93.46	no data
2005	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F1 and RL87	4eh2	92.69	no data
2006	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F3 and RL87	4eh4	96.19	no data
2007	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F7 and RL87	4eh8	93.94	no data
2008	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F11 and RL87	4eh9	92.77	no data
2009	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with NP-F4 and RL87	4eh5	93.43	no data
2010	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	irg	Human p38 MAP kinase in complex with RL87	4dli	94.46	2400.
2011	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	0ok	Human p38 MAP kinase in complex with NP-F1 and RL87	4eh2	76.64	692000.
2012	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	0om	Human p38 MAP kinase in complex with NP-F4 and RL87	4eh5	81.59	818000.
2013	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	sb0	Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063	4fa2	88.38	no data
2014	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	1ra	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE	4kiq	93.26	23.
2015	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	3gf	Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate	4r3c	83.44	101.
2016	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	8oh	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9g	5n64	95.79	no data
2017	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	8on	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9l	5n67	81.15	no data
2018	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	8ok	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9m	5n68	84.71	no data
2019	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	aqy	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors	5wjj	89.36	no data
2020	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	ftz	The structure of p38 alpha in complex with a triazol inhibitor	5xyx	83.23	no data
2021	MK14	Mitogen-activated protein kinase 14	Q16539	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	p0f	The structure of p38 alpha in complex with a triazol inhibitor	5xyy	83.5	no data
2022	MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1	Q9BUB5	MNK1	7ux	Structure of Mnk1 in complex with DS12881479	5wvd	80.14	no data
2023	MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2	Q9HBH9	GPRK7 MNK2	f4g	Crystal Structure of Mnk2-D228G in Complex With Inhibitor	6cj5	87.77	no data
2024	MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2	Q9HBH9	GPRK7 MNK2	f67	Co-crytsal Structure of MNK2 in Complex With an Inhibitor	6ck3	90.99	no data
2025	MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2	Q9HBH9	GPRK7 MNK2	fzj	Co-crystal structure of MNK2 in Complex With Inhibitor	6cki	93.36	no data
2026	MLKL	Mixed lineage kinase domain-like protein	Q8NB16		6ux	Pseudokinase Domain of MLKL bound to Compound 1.	5knj	83.85	116.
2027	MLKL	Mixed lineage kinase domain-like protein	Q8NB16		6uy	Pseudokinase Domain of MLKL bound to Compound 4.	5ko1	90.16	230.
2028	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	vra	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP	3e8n	90.2	19.
2029	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	mek	MEK1 with PF-04622664 Bound	3dv3	94.41	no data
2030	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	lcj	Crystal structure of BRAF:MEK1 complex	6pp9	95.59	no data
2031	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	izg	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP	3pp1	93.63	3.2
2032	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	eui	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an2	94.39	0.9
2033	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	eui	Crystal Structure of MEK1 kinase bound to GDC0973	4lmn	90.94	0.05
2034	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	chu	Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP	3wig	91.58	2.3
2035	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	bbm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	1s9j	91.05	no data
2036	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	77d	Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP	3sls	86.76	no data
2037	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	5u5	MEK1 IN COMPLEX WITH BI 847325	5eym	79.55	25.
2038	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3or	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP	3orn	96.24	0.24
2039	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	mra	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	2p55	94.73	no data
2040	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	1cx	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	3dy7	95.19	no data
2041	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P	3eqc	94.34	no data
2042	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	4bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP	3vvh	94.99	no data
2043	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	4bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P	3eqg	92.99	no data
2044	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	lsg	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP	3mbl	93.58	18.
2045	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3os	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP	3os3	95.16	235.
2046	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3v0	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v01	94.37	25.
2047	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	v04	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v04	94.86	13.
2048	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	5ez	Crystal structure of MEK1 in complex with fragment 18	3zlx	90.13	157000.
2049	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	22t	Crystal structure of MEK1 in complex with fragment 1	3zm4	93.1	1100.
2050	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	5y0	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an3	94.77	0.6
2051	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	2p7	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an9	92.81	44.
2052	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	yqy	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4anb	94.24	6.6
2053	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	m3k	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP	4ark	91.06	63.
2054	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	573	Crystal structure of the BRAF:MEK1 complex	4mne	97.08	no data
2055	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3ew	Mitogen-Activated Protein Kinase Kinase (MEK1) bound to G805	4u7z	93.31	no data
2056	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3ex	MEK 1 kinase bound to G799	4u80	95.37	no data
2057	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	3ey	MEK1 Kinase bound to small molecule inhibitor G659	4u81	95.33	no data
2058	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MEK1 PRKMK1	e62	Mek1 adopts DFG-out conformation when bound to an analog of E6201.	5hze	94.06	no data
2059	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	j3n	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1m	6qhr	87.22	no data
2060	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	j3h	Dual specificity mitogen-activated protein kinase kinase 7 in complex with pyrazolopyrimidine 1a	6qho	86.16	no data
2061	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	j0e	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine inhibitor 1h	6qg4	83.65	no data
2062	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	j0b	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b	6qft	87.27	no data
2063	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	h8z	The structure of MKK7 in complex with the covalent 4-amino-pyrazolopyrimidine 3a	6ib0	84.79	no data
2064	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	862	The structure of MKK7 in complex with the covalent 4-amino-pyrazolopyrimidine 4a	6ib2	85.16	no data
2065	MP2K7	Dual specificity mitogen-activated protein kinase kinase 7	O14733	JNKK2 MEK7 MKK7 PRKMK7 SKK4	6hl	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k	6qg7	87.39	no data
2066	MRCKA	Serine/threonine-protein kinase MRCK alpha	Q5VT25	KIAA0451	22e	Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)	4aw2	71.64	no data
2067	MRCKB	Serine/threonine-protein kinase MRCK beta	Q9Y5S2	KIAA1124	3fv	MRCK beta in complex with BDP00005290	4ual	90.04	4.
2068	MRCKB	Serine/threonine-protein kinase MRCK beta	Q9Y5S2	KIAA1124	nm7	MRCK beta in complex with TPCA-1	3qfv	83.36	1690.
2069	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	wgz	Structure of NEK2 bound to CCT	2xnm	75.54	160.
2070	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	wcx	Structure of Nek2 bound to CCT244858	2xnp	76.65	360.
2071	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	jup	NEK2-EDE bound to CCT248662	4a4x	76.97	59.
2072	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	ed8	Structure of Nek2 bound to CCT243779	2xno	72.18	1180.
2073	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	430	Structure of Nek2 bound to CCT242430	2xnn	76.61	50000.
2074	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	5z5	Human Kinase with pyrrole-indolinone ligand	2jav	76.01	no data
2075	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	vgk	STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950	2wqo	74.73	no data
2076	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	xk3	Structure of Nek2 bound to Aminopyrazine compound 35	2xk3	82.89	2100.
2077	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	ol2	Structure of Nek2 bound to aminopyrazine compound 17	2xk4	76.14	16900.
2078	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	eqh	Structure of Nek2 bound to aminopyrazine compound 36	2xk6	78.98	1600.
2079	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	30e	Structure of Nek2 bound to aminopyrazine compound 23	2xk7	74.81	1500.
2080	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	5r1	Structure of Nek2 bound to aminopyrazine compound 15	2xk8	81.31	2400.
2081	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	4vq	Structure of Nek2 bound to aminopyrazine compound 14	2xkc	72.12	2600.
2082	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	t3m	Structure of Nek2 bound to aminopyrazine compound 12	2xkd	76.49	2300.
2083	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	wi2	Structure of Nek2 bound to Aminipyrazine Compound 5	2xke	78.96	4200.
2084	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	bx1	Structure of Nek2 bound to aminopyrazine compound 2	2xkf	76.98	870.
2085	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	ggy	Nek2 bound to hybrid compound 21	4afe	79.44	73.
2086	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	nu6	Nek2 bound to arylaminopurine compound 8	5m51	76.4	19000.
2087	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	7gj	Nek2 bound to arylaminopurine inhibitor 11	5m53	78.67	620.
2088	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	4sp	Nek2 bound to arylaminopurine 6	5m57	73.59	12000.
2089	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	f9n	Nek2 bound to purine inhibitor	6h0o	64.52	no data
2090	NEK2	Serine/threonine-protein kinase Nek2	P51955	NEK2A NLK1	7gg	Nek2 bound to arylaminopurine 71	5m55	68.98	240.
2091	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	ymx	THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB	5kvt	79.78	no data
2092	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	oom	TRK-A IN COMPLEX WITH LIGAND 1a	6pl2	88.35	no data
2093	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	ooj	TRK-A IN COMPLEX WITH LIGAND 1B	6pl1	89.52	no data
2094	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	ood	TRK-A IN COMPLEX WITH LIGAND 2a	6pl3	85.08	no data
2095	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	l0p	TRK-A IN COMPLEX WITH LIGAND 9	6nsp	81.89	no data
2096	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	gxa	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3.	6dkw	89.7	no data
2097	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	go7	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 13b.	6dkg	86.26	no data
2098	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	fky	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10b.	6dkb	86.3	no data
2099	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	69c	TrkA with (6~{R})-3-methylsulfanyl-6-phenyl-1-(1~{H}-pyrazol-3-yl)-6,7-dihydro-5~{H}-thieno[3,4-c]pyridin-4-one	5i8a	82.41	no data
2100	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	31x	The structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid	4pms	91.84	7.9
2101	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	31w	The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea	4pmp	93.19	400.
2102	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	v4z	Human TrkA in complex with the inhibitor AZ-23	4aoj	91.24	no data
2103	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	31y	The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine	4pmt	81.83	997.
2104	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6k0	Crystal structure of TrkA in complex with PF-00593174	5jfs	89.59	no data
2105	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6k1	Crystal structure of TrkA in complex with PF-05206283	5jfv	91.13	no data
2106	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6k2	Crystal structure of TrkA in complex with PF-05247452	5jfw	91.01	no data
2107	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6k4	Crystal structure of TrkA in complex with PF-06273340	5jfx	90.38	no data
2108	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6uh	TrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea	5kml	90.87	no data
2109	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6uk	TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea	5kmn	91.92	no data
2110	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	6um	TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea	5kmo	83.01	no data
2111	NTRK1	High affinity nerve growth factor receptor	P04629	MTC TRK TRKA	god	Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 19.	6dki	90.3	no data
2112	NTRK2	BDNF/NT-3 growth factors receptor	Q16620	TRKB	t6e	CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429	4at4	93.58	12.
2113	NTRK2	BDNF/NT-3 growth factors receptor	Q16620	TRKB	lti	CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH CPD5N	4at3	91.64	4.
2114	NTRK2	BDNF/NT-3 growth factors receptor	Q16620	TRKB	muj	CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580	4at5	93.42	38.
2115	NTRK3	NT-3 growth factor receptor	Q16288	TRKC	dzc	crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide	6kzc	81.23	no data
2116	NTRK3	NT-3 growth factor receptor	Q16288	TRKC	dz6	Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide	6kzd	79.47	no data
2117	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		xr1	Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor	4eqc	78.96	8.
2118	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		7kc	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors	4o0r	79.94	no data
2119	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		59u	Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036	5dfp	78.59	22.
2120	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		59n	Crystal structure of PAK1 in complex with an inhibitor compound 5	5dew	80.39	no data
2121	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4or	PAK1 in complex with (S)-N-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	4zjj	93.09	9.9
2122	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		2ol	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors	4o0t	86.43	2900.
2123	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		2k0	Crystal structure of the kinase domain of human PAK1 in complex with compound 15	4p90	73.32	64.
2124	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4oq	PAK1 in complex with 2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	4zji	91.75	340.
2125	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4pv	Serine/threonine-protein kinase PAK1 complexed with a dibenzodiazepine: identification of an allosteric site on PAK1	4zlo	85.92	12000.
2126	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4t5	Crystal Structure of p21-activated kinase 1 in complex with an inhibitor compound 17	4zy5	81.28	26.
2127	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		59t	Crystal structure of PAK1 in complex with an inhibitor compound G-5555	5dey	80.68	3.7
2128	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		6bz	Crystal structure of P21-activated kinase 1 (PAK1) in complex with compound 9	5ime	88.43	4.6
2129	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		ipw	Pak1 in complex with 7-azaindole inhibitor	5kbr	77.6	260.
2130	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		c7y	P21-activated kinase 1 in complex with a 4-azaindole inhibitor	6b16	76.72	32.
2131	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		ipv	Pak1 in complex with bis-anilino pyrimidine inhibitor	5kbq	79.35	100.
2132	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4t6	Crystal structure of P21-activated kinase 1 in complex with an inhibitor compound 29	4zy6	78.62	5.
2133	PAK1	Serine/threonine-protein kinase PAK 1	Q13153		4t3	Crystal structure of P21 activated kinase 1 in complex with an inhibitor compound 4	4zy4	74.21	22.
2134	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	n53	Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide	4app	75.19	64.
2135	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	9eo	Crystal Structure of PAK4 in complex with inhibitor CZg353	5zjw	89.65	no data
2136	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	981	PAK4 kinase domain in complex with FRAX486	5vee	74.7	779.
2137	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	7kc	Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309	2x4z	82.97	no data
2138	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	23d	CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH CGP74514A	2cdz	75.92	no data
2139	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	2ol	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors	4o0v	86.43	3.3
2140	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	2oq	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors	4o0x	91.64	68.
2141	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	2oo	Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors	4o0y	89.95	60.
2142	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	4t6	Crystal structure of P21-activated kinase 4 in complex with an inhibitor compound 29	5bms	78.52	455.
2143	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	8fu	Crystal Structure of PAK4 in complex with inhibitor CZH216	5xva	85	no data
2144	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	8fr	Crystal Structure of PAK4 in complex with inhibitor CZH062	5xvf	76.49	no data
2145	PAK4	Serine/threonine-protein kinase PAK 4	O96013	KIAA1142	8fx	Crystal Structure of PAK4 in complex with inhibitor CZH226	5xvg	85.45	no data
2146	PAK6	Serine/threonine-protein kinase PAK 6	Q9NQU5	PAK5	7kc	PAK6 kinase domain in complex with PF-3758309	4ks7	77.71	no data
2147	PAK6	Serine/threonine-protein kinase PAK 6	Q9NQU5	PAK5	b49	PAK6 kinase domain in complex with sunitinib	4ks8	63.57	no data
2148	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	mp7	PDK1 in complex with inhibitor MP7	3nax	97.5	no data
2149	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	mp7	PDK1 in complex with DFG-OUT inhibitor xxx	3qc4	97.46	2.
2150	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	mp6	PDK1 in complex with inhibitor MP6	3nay	90.6	no data
2151	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	mh4	Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor	2xck	68.88	713.
2152	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	li8	Crystal Structure Of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1	1z5m	78.6	30.
2153	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	3q4	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide	3qd0	84.05	3.16
2154	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	3q3	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide	3qcy	84.06	20.
2155	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	517	CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) {2-Oxo-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-2,3-dihydro-1H-indol-5-yl}-urea {BX-517} COMPLEX	2pe1	86.57	5.
2156	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	464	CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 3-{5-[2-Oxo-5-ureido-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrol-3-yl}-N-(2-piperidin-1-yl-ethyl)-benzamide COMPLEX	2pe2	76.47	4.
2157	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	ckg	Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor	2xch	79.9	374.
2158	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	9bd	Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9	3h9o	79.34	70.
2159	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	8h1	PDK1 in complex with Compound 8h	3ion	86.85	8.
2160	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	8i1	PDK-1 in complex with the inhibitor Compound-8i	3iop	83.49	17.
2161	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	abq	Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)	3rwp	93.54	0.6
2162	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	3rw	Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1)	3rwq	93.25	35.
2163	PDPK1	3-phosphoinositide-dependent protein kinase 1	O15530	PDK1	adn	Human PDK1 Kinase Domain in Complex with Adenosine Bound to the ATP-Binding Site	5lvn	84.28	20000.
2164	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	p47	Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket	3hrf	81.57	10300.
2165	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	j30	PDK1 mutant bound to allosteric disulfide fragment activator JS30	3otu	66.25	no data
2166	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	a06	Human PDK1 Kinase Domain in Complex with Allosteric Activator PS114 Bound to the PIF-Pocket	4a06	79.6	no data
2167	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	mjf	Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket	4aw0	78.93	no data
2168	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	rf4	Crystal structure of PDK1 in complex with ATP and the PIF-pocket ligand RF4	4xx9	76.5	8400.
2169	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	svq	Human PDK1 Kinase Domain in Complex with Allosteric Compound 7 Bound to the PIF-Pocket	5ack	65.21	no data
2170	PDPK2	Putative 3-phosphoinositide-dependent protein kinase 2	Q6A1A2	PDPK2	78w	Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket	5lvo	74.44	no data
2171	PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	P15735		b49	Structure of human phosphorylase kinase, gamma 2	2y7j	67.96	no data
2172	PIM1	Serine/threonine-protein kinase pim-1	P11309		rtz	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine	4iaa	81.94	no data
2173	PIM1	Serine/threonine-protein kinase pim-1	P11309		rtx	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives	4med	88.05	no data
2174	PIM1	Serine/threonine-protein kinase pim-1	P11309		od4	Human PIM1 bound to benzothiophene inhibitor 292	6pdn	74.9	no data
2175	PIM1	Serine/threonine-protein kinase pim-1	P11309		od1	Human PIM1 bound to benzothiophene inhibitor 354	6pdo	70.8	no data
2176	PIM1	Serine/threonine-protein kinase pim-1	P11309		ocj	Human PIM1 bound to benzothiophene inhibitor 224	6pdi	78.77	no data
2177	PIM1	Serine/threonine-protein kinase pim-1	P11309		oby	Human PIM1 bound to benzothiophene inhibitor 379	6pdp	70.73	no data
2178	PIM1	Serine/threonine-protein kinase pim-1	P11309		o97	Human PIM1 bound to benzothiophene inhibitor 213	6pcw	75.34	no data
2179	PIM1	Serine/threonine-protein kinase pim-1	P11309		myu	Crystal structure of Pim1 with Quercetagetin	2o64	92.26	340.
2180	PIM1	Serine/threonine-protein kinase pim-1	P11309		kuv	PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)	6no9	88.16	no data
2181	PIM1	Serine/threonine-protein kinase pim-1	P11309		9g5	Crystal structure of PIM1 kinase in complex with small-molecule inhibitor	5o13	70.35	no data
2182	PIM1	Serine/threonine-protein kinase pim-1	P11309		3u6	Crystal structure of human Pim-1 kinase in complex with a thiadiazolamine-indole inhibitor.	4wt6	88.03	12.
2183	PIM1	Serine/threonine-protein kinase pim-1	P11309		3ok	Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives	4rc4	86.48	no data
2184	PIM1	Serine/threonine-protein kinase pim-1	P11309		3oa	Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives	4rc3	74.46	no data
2185	PIM1	Serine/threonine-protein kinase pim-1	P11309		3o8	Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives	4rc2	79.64	no data
2186	PIM1	Serine/threonine-protein kinase pim-1	P11309		1oc	Structure of PIM-1 kinase bound to N-(5-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-((((3R,4R)-3-fluoropiperidin-4-yl)methyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide	4k1b	79.51	0.003
2187	PIM1	Serine/threonine-protein kinase pim-1	P11309		li7	Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE	1yxx	88.95	no data
2188	PIM1	Serine/threonine-protein kinase pim-1	P11309		xj1	Protein kinase Pim-1 in complex with small molecule inibitor	2xj1	91.43	28.
2189	PIM1	Serine/threonine-protein kinase pim-1	P11309		985	Crystal structure of human Pim-1 in complex with DAPPA	3f2a	90.61	57.
2190	PIM1	Serine/threonine-protein kinase pim-1	P11309		985	Protein kinase Pim-1 in complex with small molecule inhibitor	2xj2	89.85	66.
2191	PIM1	Serine/threonine-protein kinase pim-1	P11309		vx2	Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2	3bgq	86.62	11.
2192	PIM1	Serine/threonine-protein kinase pim-1	P11309		que	Crystal structure of Pim1 with Quercetin	2o3p	90.91	1100.
2193	PIM1	Serine/threonine-protein kinase pim-1	P11309		que	Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002)	4lmu	87.84	55.
2194	PIM1	Serine/threonine-protein kinase pim-1	P11309		jn5	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V	3cy3	87.46	no data
2195	PIM1	Serine/threonine-protein kinase pim-1	P11309		lxg	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors	3jxw	81.47	1.
2196	PIM1	Serine/threonine-protein kinase pim-1	P11309		lyg	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors	3jy0	77.29	5.
2197	PIM1	Serine/threonine-protein kinase pim-1	P11309		3ng	Crystal structure of PIM1 kinase in complex with small-molecule inhibitor	5o11	87.5	216.
2198	PIM1	Serine/threonine-protein kinase pim-1	P11309		55e	Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one	3dcv	85.43	3.
2199	PIM1	Serine/threonine-protein kinase pim-1	P11309		unm	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors	3r02	90.28	1.
2200	PIM1	Serine/threonine-protein kinase pim-1	P11309		unq	The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors	3r04	80.62	120.
2201	PIM1	Serine/threonine-protein kinase pim-1	P11309		3t9	Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution	3t9i	92.65	no data
2202	PIM1	Serine/threonine-protein kinase pim-1	P11309		596	Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one	3umw	82.65	3.
2203	PIM1	Serine/threonine-protein kinase pim-1	P11309		0f5	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design	3vbq	90.16	0.47
2204	PIM1	Serine/threonine-protein kinase pim-1	P11309		79o	Benzofuropyrimidinone Inhibitors of Pim-1	4alu	84.87	17.
2205	PIM1	Serine/threonine-protein kinase pim-1	P11309		r9p	Benzofuropyrimidinone Inhibitors of Pim-1	4alv	83.01	7.
2206	PIM1	Serine/threonine-protein kinase pim-1	P11309		hy7	Benzofuropyrimidinone Inhibitors of Pim-1	4alw	86.19	27.
2207	PIM1	Serine/threonine-protein kinase pim-1	P11309		ugx	Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor	4bzn	88.04	1441.
2208	PIM1	Serine/threonine-protein kinase pim-1	P11309		676	Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor	4bzo	84.37	13.
2209	PIM1	Serine/threonine-protein kinase pim-1	P11309		7li	Novel and selective pan-PIM kinase inhibitor	4dtk	88.99	3.
2210	PIM1	Serine/threonine-protein kinase pim-1	P11309		1n6	Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one	4jx7	78.83	123.
2211	PIM1	Serine/threonine-protein kinase pim-1	P11309		1oa	Structure of PIM-1 kinase bound to N-(4-fluorophenyl)-7-hydroxy-5-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	4k0y	87.19	15.
2212	PIM1	Serine/threonine-protein kinase pim-1	P11309		1ob	Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide	4k18	88.61	1.1
2213	PIM1	Serine/threonine-protein kinase pim-1	P11309		adn	Structure of Pim-1 bound to adenosine	1yi4	78.65	no data
2214	PIM1	Serine/threonine-protein kinase pim-1	P11309		sk8	Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002	4ll5	86.05	no data
2215	PIM1	Serine/threonine-protein kinase pim-1	P11309		q17	Crystal structure of Pim1 kinase in complex with small molecule inhibitor	3uix	90.75	151.
2216	PIM1	Serine/threonine-protein kinase pim-1	P11309		q17	Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002)	4lm5	94.1	150.
2217	PIM1	Serine/threonine-protein kinase pim-1	P11309		26k	Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors	4mbi	88.16	7.
2218	PIM1	Serine/threonine-protein kinase pim-1	P11309		26l	Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors	4mbl	87.59	2.9
2219	PIM1	Serine/threonine-protein kinase pim-1	P11309		2hv	Pim1 Complexed with a phenylcarboxamide	4n6y	85.51	92.
2220	PIM1	Serine/threonine-protein kinase pim-1	P11309		2hw	Pim1 Complexed with a pyridylcarboxamide	4n6z	95	16.
2221	PIM1	Serine/threonine-protein kinase pim-1	P11309		2hx	Pim1 Complexed with a pyridylcarboxamide	4n70	88.62	0.001
2222	PIM1	Serine/threonine-protein kinase pim-1	P11309		3u1	Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.	4wrs	85.64	0.4
2223	PIM1	Serine/threonine-protein kinase pim-1	P11309		hul	Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin	4xh6	85.67	2710.
2224	PIM1	Serine/threonine-protein kinase pim-1	P11309		3yr	PIM1 kinase in complex with Compound 1s	4xhk	86.98	5.
2225	PIM1	Serine/threonine-protein kinase pim-1	P11309		l20	Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors	5dgz	84.4	14.
2226	PIM1	Serine/threonine-protein kinase pim-1	P11309		5e6	PIM1 in complex with Cpd36 ((1S,3S)-N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)cyclohexane-1,3-diamine)	5dia	88.32	0.035
2227	PIM1	Serine/threonine-protein kinase pim-1	P11309		5h7	Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies	5dwr	88.62	0.006
2228	PIM1	Serine/threonine-protein kinase pim-1	P11309		6cb	Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold	5iis	88.44	1.
2229	PIM1	Serine/threonine-protein kinase pim-1	P11309		6s3	Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor	5kcx	65.48	200.
2230	PIM1	Serine/threonine-protein kinase pim-1	P11309		6yn	Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor.	5kzi	88.92	0.1
2231	PIM1	Serine/threonine-protein kinase pim-1	P11309		8et	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule N-quinolin-5-ylpyridine-3-carboxamide	5mzl	79.28	no data
2232	PIM1	Serine/threonine-protein kinase pim-1	P11309		7aj	Pim-1 kinase in complex with a 7-azaindole	5tel	73	no data
2233	PIM1	Serine/threonine-protein kinase pim-1	P11309		7au	Pim-1 kinase in complex with a 7-azaindole	5tex	78.65	400.
2234	PIM1	Serine/threonine-protein kinase pim-1	P11309		8gx	Pim1 Kinase in complex with a benzofuranone inhibitor	5vua	83.71	no data
2235	PIM1	Serine/threonine-protein kinase pim-1	P11309		8gu	Pim1 Kinase in complex with a benzofuranone inhibitor	5vub	82.89	no data
2236	PIM1	Serine/threonine-protein kinase pim-1	P11309		c2j	Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide	6ayd	90.56	500.
2237	PIM1	Serine/threonine-protein kinase pim-1	P11309		mvg	Human PIM1 kinase in complex with compound 12b	6bsk	89.61	no data
2238	PIM2	Serine/threonine-protein kinase pim-2	Q9P1W9		3yr	PIM2 kinase in complex with Compound 1s	4x7q	90.06	14.
2239	PKN1	Serine/threonine-protein kinase N1	Q16512	PAK1 PKN PRK1 PRKCL1	mi1	Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib	4oti	89.42	43.
2240	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	r78	Structure of PLK1 in complex with BI2536	2rku	73.23	5.
2241	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	937	Crystal structure of Polo-like kinase 1 in complex with NMS-P937	2yac	85.89	2.
2242	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	79d	Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor.	5ta6	72.11	1.5
2243	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	79c	Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor	5ta8	70.83	no data
2244	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	664	CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR	4a4o	86.27	9.
2245	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	1j4	Crystal structure of PLK1 in complex with TAK-960	4j53	70.65	2.
2246	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	1j3	Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor	4j52	70.75	3.
2247	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	626	Structure of the Catalytic Domain of Human Polo-like Kinase 1	2owb	81.23	440.
2248	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	071	Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor	3kb7	84.19	7.
2249	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	3ta	Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor	3thb	86.56	2.
2250	PLK1	Serine/threonine-protein kinase PLK1	P53350	PLK	939	CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO- PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR	4a4l	87.16	15.
2251	PLK2	Serine/threonine-protein kinase PLK2	Q9NYY3	SNK	r78	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain	4i5m	69.38	8.8
2252	PLK2	Serine/threonine-protein kinase PLK2	Q9NYY3	SNK	1d1	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain	4i5p	81.98	377.
2253	PLK2	Serine/threonine-protein kinase PLK2	Q9NYY3	SNK	11g	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain	4i6b	83.08	1170.
2254	PLK2	Serine/threonine-protein kinase PLK2	Q9NYY3	SNK	1c7	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain	4i6f	86.62	5.
2255	PLK2	Serine/threonine-protein kinase PLK2	Q9NYY3	SNK	1c8	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain	4i6h	87.78	5.
2256	PLK3	Serine/threonine-protein kinase PLK3	Q9H4B4	CNK FNK PRK	9zp	Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design	4b6l	81.13	no data
2257	PLK4	Serine/threonine-protein kinase PLK4	O00444	SAK STK18	631	Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)	4jxf	81.45	no data
2258	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	xzn	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Bosutinib isomer	5vcz	74.21	444.
2259	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	h8h	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB	5vcx	74.37	2817.
2260	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	h8h	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (de-phosphorylated) IN COMPLEX WITH SARACATINIB	5vd3	74.24	2817.
2261	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	db8	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB	5vcy	72.83	270.
2262	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	8x7	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH MK1775	5vd0	75.26	324.
2263	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	p48	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH PHA-848125	5vd1	73.13	990.
2264	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	1n1	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Dasatinib	5vcv	71.1	150.
2265	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Q99640	MYT1	93j	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Pelitinib	5vcw	76.18	1105.
2266	PRP4B	Serine/threonine-protein kinase PRP4 homolog	Q13523	KIAA0536 PRP4 PRP4H PRP4K	ond	Human PRPF4B bound to benzothiophene inhibitor 329	6pk6	72.11	no data
2267	PRP4B	Serine/threonine-protein kinase PRP4 homolog	Q13523	KIAA0536 PRP4 PRP4H PRP4K	ocj	Human PRPF4B bound to benzothiophene inhibitor 224	6pjj	65.98	no data
2268	PRP4B	Serine/threonine-protein kinase PRP4 homolog	Q13523	KIAA0536 PRP4 PRP4H PRP4K	1eh	Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine	4ijp	79.6	16.
2269	PTK6	Protein-tyrosine kinase 6	Q13882	BRK	fky	Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide	6cz4	88.63	no data
2270	PTK6	Protein-tyrosine kinase 6	Q13882	BRK	1n1	Crystal structure of PTK6 Kinase Domain complexed with Dasatinib	5h2u	77.93	7.
2271	PTK6	Protein-tyrosine kinase 6	Q13882	BRK	58v	Crystal structure of PTK6 Kinase domain with inhibitor	5da3	70.54	80.
2272	PTK6	Protein-tyrosine kinase 6	Q13882	BRK	flj	Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone	6cz3	71.06	no data
2273	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	zd6	Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor ZD6474	2ivu	76.72	375.
2274	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	xin	STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB	6nec	69.05	no data
2275	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	adn	Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine	4cki	85.54	1100.
2276	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	adn	Crystal structure of RET tyrosine kinase domain bound to adenosine	4ckj	89.22	14300.
2277	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	adn	Oncogenic point mutation of RET receptor tyrosine kinase	6fek	81.69	no data
2278	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	CDHF12 CDHR16 PTC RET51	dtq	The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors	5amn	90.19	4.5
2279	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	q1a	X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor	4neu	95.32	no data
2280	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	l8d	Structure of human RIPK1 kinase domain in complex with GNE684	6nyh	92.11	no data
2281	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	l4y	Structure of human RIPK1 kinase domain in complex with compound 11	6nw2	97.31	no data
2282	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	k8k	Crystal structure of RIP1 kinase in complex with GSK3145095	6rln	95.86	no data
2283	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	1hw	Crystal structure of RIP1 kinase in complex with necrostatin-3 analog	4iti	98.86	439.5
2284	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	1hx	Crystal structure of RIP1 kinase in complex with necrostatin-4	4itj	98.91	377.2
2285	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	65u	Crystal structure of RIP1 kinase with a benzo[b][1,4]oxazepin-4-one	5hx6	96.51	10.
2286	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	7mj	Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772	5tx5	96.81	16.
2287	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIP RIP1	ejp	Structure based design of RIP1 kinase inhibitors	6c4d	95.85	no data
2288	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	9xa	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.	5w5o	72.3	8.
2289	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	0li	Structure of the kinase domain of human RIPK2 in complex with ponatinib	4c8b	86.32	no data
2290	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	sb2	RIP2 Kinase Catalytic Domain (1 - 310) complex with SB-203580	5ar4	82.34	200.
2291	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	iq7	RIP2 Kinase Catalytic Domain (1 - 310) complex with Benzimidazole	5ar5	76.73	500.
2292	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	sr8	RIP2 Kinase Catalytic Domain (1 - 310) complex with Biaryl Urea	5ar7	97.53	320.
2293	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	9ws	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases	5w5j	92.77	1500.
2294	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	O43353	CARDIAK RICK RIP2	bw8	Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35	6es0	97.34	no data
2295	RIPK4	Receptor-interacting serine/threonine-protein kinase 4	P57078	ANKRD3 DIK	vx6	Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to tozasertib (VX-680)	5wnm	77.04	no data
2296	ROCK1	Rho-associated protein kinase 1	Q13464		j0p	Crystal structure of Rock1 with a pyridinylbenzamide based inhibitor	6e9w	88.27	no data
2297	ROCK1	Rho-associated protein kinase 1	Q13464		b4y	X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR	5wng	79.72	no data
2298	ROCK1	Rho-associated protein kinase 1	Q13464		b4v	X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR	5wnf	80.79	no data
2299	ROCK1	Rho-associated protein kinase 1	Q13464		b4j	X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR	5wne	81.13	no data
2300	ROCK1	Rho-associated protein kinase 1	Q13464		6u2	ROCK 1 bound to azaindole thiazole piperazine inhibitor	5kkt	80.59	no data
2301	ROCK1	Rho-associated protein kinase 1	Q13464		65r	Rho-associated protein kinase 1 (ROCK 1) in complex with a pyridine thiazole piperidine inhibitor	5hvu	78.24	no data
2302	ROCK1	Rho-associated protein kinase 1	Q13464		4tw	ROCK 1 bound to a pyridine thiazole inhibitor	5bml	83.11	10.
2303	ROCK1	Rho-associated protein kinase 1	Q13464		3j7	Crystal Structure of ROCK 1 bound to YB-15-QD37	4w7p	87.57	32.
2304	ROCK1	Rho-associated protein kinase 1	Q13464		07r	Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447	3twj	87.49	14.5
2305	ROCK1	Rho-associated protein kinase 1	Q13464		07q	Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342	3tv7	86.28	30.
2306	ROCK1	Rho-associated protein kinase 1	Q13464		3nc	X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor	3ncz	86.66	15.
2307	ROCK1	Rho-associated protein kinase 1	Q13464		y27	Crystal Structure of ROCK I bound to Y-27632	2etr	79.5	150.
2308	ROCK1	Rho-associated protein kinase 1	Q13464		hfs	Crystal Structure of ROCK 1 bound to hydroxyfasudil	2etk	81.86	150.
2309	ROCK2	Rho-associated protein kinase 2	O75116	KIAA0619	j0p	Crystal structure of Rock2 with a pyridinylbenzamide based inhibitor	6ed6	88.17	no data
2310	ROCK2	Rho-associated protein kinase 2	O75116	KIAA0619	3sg	ROCK2 IN COMPLEX WITH 1426382-07-1	4wot	84.31	no data
2311	ROS1	Proto-oncogene tyrosine-protein kinase ROS	P08922	MCF3 ROS	vgh	Structure of Human ROS1 Kinase Domain in Complex with Crizotinib	3zbf	71.78	30.
2312	ROS1	Proto-oncogene tyrosine-protein kinase ROS	P08922	MCF3 ROS	5p8	Structure of Human ROS1 Kinase Domain in Complex with PF-06463922	4uxl	80.49	0.025
2313	SGK1	Serine/threonine-protein kinase Sgk1	O00141	SGK	mmg	Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1	3hdm	79.78	40.
2314	SLK	STE20-like serine/threonine-protein kinase	Q9H2G2	KIAA0204 STK2	guq	Human SLK bound to a maleimide inhibitor	6hvd	83.98	no data
2315	SLK	STE20-like serine/threonine-protein kinase	Q9H2G2	KIAA0204 STK2	dki	CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE	2jfl	78.93	no data
2316	SLK	STE20-like serine/threonine-protein kinase	Q9H2G2	KIAA0204 STK2	dki	Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide	2j51	74.52	no data
2317	SLK	STE20-like serine/threonine-protein kinase	Q9H2G2	KIAA0204 STK2	gvd	Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile	2uv2	77.29	no data
2318	SLK	STE20-like serine/threonine-protein kinase	Q9H2G2	KIAA0204 STK2	6ui	Human SLK with SB-440719	4usf	97.56	no data
2319	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	pd3	Crystal structure of c-Src in complex with pyrazolopyrimidine 3	3el7	91.13	480.
2320	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	o44	Crystal structure of c-SRC in complex with a covalent lysine probe	5k9i	74.98	no data
2321	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	i76	c-SRC kinase domain in complex with RM-1-176	4dgg	84.57	800.
2322	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	hvy	DGY-06-116, a novel and selective covalent inhibitor of SRC kinase	6e6e	79.36	no data
2323	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	h8h	Src kinase in complex with a quinazoline inhibitor	2h8h	70.69	2.7
2324	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	gut	Kinase domain of cSrc in complex with compound 29B	6hvf	62.05	no data
2325	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	db8	Src M314L T338M double mutant bound to kinase inhibitor bosutinib	4mxz	69.69	no data
2326	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	db8	Human Src A403T mutant bound to kinase inhibitor bosutinib	4mxx	69.07	no data
2327	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	db8	Src M314L T338M double mutant bound to kinase inhibitor bosutinib	4mxy	69.69	no data
2328	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	db8	human Src kinase bound to kinase inhibitor bosutinib	4mxo	70.85	no data
2329	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	72f	c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor	5sys	85.12	no data
2330	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	6h3	SRC kinase bound to covalent inhibitor	6ate	73.15	no data
2331	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	6g3	Src kinase in complex with a sulfonamide inhibitor	5j5s	90.82	no data
2332	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	4b7	C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase	4ybk	78.2	15.
2333	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	4a9	Type II Dasatinib Analog Crystallized with c-Src Kinase	4ybj	81.01	0.53
2334	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	mpz	Structure of unphosphorylated c-Src in complex with an inhibitor	1y57	61.1	1633.
2335	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	s03	Crystal structure of Src kinase domain in complex with CGP77675	1yol	77.23	no data
2336	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	p01	Crystal structure of Src kinase domain in complex with Purvalanol A	1yom	77.52	no data
2337	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	rbs	Crystal structure of Src kinase domain in complex with covalent inhibitor	2hwo	81.01	126.
2338	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	sr2	Crystal structure of drug resistant SRC kinase domain with irreversible inhibitor	2qq7	82.56	5710.
2339	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	pp2	Structural basis for the chemical rescue of Src kinase activity	3geq	89.24	no data
2340	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	1n1	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib	3qlg	72.29	no data
2341	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	1n1	Kinase domain of cSrc in complex with Dasatinib	3g5d	70.13	11.
2342	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	pd5	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5	3qlf	89.2	no data
2343	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	pd5	Crystal structure of c-Src in complex with pyrazolopyrimidine 5	3el8	88.57	25.
2344	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	ks4	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor	3en5	80.05	no data
2345	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	abj	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor	3en7	84.12	no data
2346	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	ihh	c-Src kinase domain in complex with small molecule inhibitor	3f6x	78.85	no data
2347	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	djk	Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393	2hwp	67.66	73.
2348	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	djk	Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393	3lok	78.01	120.
2349	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	sti	crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain complexed with imatinib	3oez	83.85	no data
2350	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	sti	Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.	2oiq	84.98	10000.
2351	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	vsp	Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9	3svv	91.03	114.
2352	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	bk5	c-SRC kinase domain in complex with BKI RM-1-89	3uqf	88	20000.
2353	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	b5a	c-SRC kinase domain in complex with bumpless BKI analog UW1243	3uqg	74.86	10000.
2354	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	ks1	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor	3en4	85.49	no data
2355	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	vgg	Structure of 3MB-PP1 bound to analog-sensitive Src kinase	4lgg	86.72	3.
2356	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	0jn	Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase	4lgh	86.35	2.
2357	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	11v	Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine	4o2p	77.59	200.
2358	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	563	Kinase domain of cSrc in complex with RL236	5d10	60.29	72.
2359	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	56g	Kinase domain of cSrc in complex with RL235	5d11	66.36	28.
2360	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	71d	c-Src V281C kinase domain in complex with Rao-IV-151	5swh	75.2	no data
2361	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	73a	c-Src kinase domain in complex with Rao-IV-151	5t0p	84.17	no data
2362	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	s56	c-Src V281C kinase domain in complex with Rao-IV-156	5teh	66.57	no data
2363	SRC	Proto-oncogene tyrosine-protein kinase Src	P12931	SRC1	g97	Kinase domain of cSrc in complex with RL40	5d12	58.54	43.
2364	ST17B	Serine/threonine-protein kinase 17B	O94768	DRAK2	que	Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin	3lm5	91.77	no data
2365	ST17B	Serine/threonine-protein kinase 17B	O94768	DRAK2	ebd	Crystal Structure of human Serine/Threonine Kinase 17B (STK17B)	3lm0	88.67	no data
2366	STK10	Serine/threonine-protein kinase 10	O94804	LOK	xzn	Crystal structure of human serine threonine kinase-10 bound to novel Bosutinib Isoform 1, previously thought to be Bosutinib	4bc6	73.46	no data
2367	STK10	Serine/threonine-protein kinase 10	O94804	LOK	r70	Human STK10 bound to a maleimide inhibitor	6hxf	81.27	no data
2368	STK10	Serine/threonine-protein kinase 10	O94804	LOK	r09	Human STK10 (LOK) with SB-633825	4use	76.73	no data
2369	STK10	Serine/threonine-protein kinase 10	O94804	LOK	g6i	Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7	4equ	82.22	no data
2370	STK10	Serine/threonine-protein kinase 10	O94804	LOK	db8	Human LOK (STK10) in complex with Bosutinib	5ajq	75.77	no data
2371	STK10	Serine/threonine-protein kinase 10	O94804	LOK	b96	Human STK10 bound to BIRB-796	6gtt	85.49	no data
2372	STK10	Serine/threonine-protein kinase 10	O94804	LOK	b6e	Human STK10 bound to GW683134A	6eim	88.84	no data
2373	STK10	Serine/threonine-protein kinase 10	O94804	LOK	88z	Human STK10 bound to Foretinib	6i2y	80.67	no data
2374	STK10	Serine/threonine-protein kinase 10	O94804	LOK	274	Crystal structure of human serine threonine kinase-10 bound to SU11274	2j7t	73.17	no data
2375	STK10	Serine/threonine-protein kinase 10	O94804	LOK	1n1	Human STK10 bound to dasatinib	5owr	64.75	no data
2376	STK10	Serine/threonine-protein kinase 10	O94804	LOK	38o	Human STK10 bound to dovitinib	5owq	72.72	no data
2377	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	h8h	MST3 in complex with SARACATINIB	4qmx	74.75	11000.
2378	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	h1n	MST3 in complex with HESPERADIN	4qmt	83.44	10.
2379	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	dki	MST3 IN COMPLEX WITH CDK1/2 INHIBITOR III, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE	4qmp	81.73	14.
2380	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	db8	MST3 in complex with BOSUTINIB	4qmn	71.55	3.
2381	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	1n1	MST3 in complex with DASATINIB	4qms	77.71	7400.
2382	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	ks1	MST3 IN COMPLEX WITH PP-121, 1-CYCLOPENTYL-3-(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE	4qmw	82.93	86.
2383	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	b49	MST3 IN COMPLEX WITH SUNITINIB	4qmz	68.62	210.
2384	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	3jb	Structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06645342)	4w8e	75.06	no data
2385	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	627	MST3 IN COMPLEX WITH Danusertib	4qo9	77.28	160.
2386	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	35r	MST3 IN COMPLEX WITH AT-9283, 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM	4qmm	76.81	460.
2387	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	34w	MST3 IN COMPLEX WITH PF-03814735, N-{2-[(1S,4R)-6-{[4-(CYCLOBUTYLAMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}-1,2,3,4-TETRAHYDRO-1,4-EPIMINONAPHTHALEN-9-YL]-2-OXOETHYL}ACETAMIDE	4qmv	75.42	23.
2388	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	ske	MST3 IN COMPLEX WITH JNJ-7706621, 4-({5-AMINO-1-[(2,6-DIFLUOROPHENYL)CARBONYL]-1H-1,2,4-TRIAZOL-3-YL}AMINO)BENZENESULFONAMIDE	4qmu	78.25	1300.
2389	STK24	Serine/threonine-protein kinase 24	Q9Y6E0	MST3 STK3	34u	MST3 in complex with CP-673451	4qmq	86.06	260.
2390	STK25	Serine/threonine-protein kinase 25	O00506	SOK1 YSK1	j60	Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1)	2xik	76.66	no data
2391	STK26	Serine/threonine-protein kinase 26	Q9P289	MASK MST4	gvd	Crystal structure of human Serine/threonine-protein kinase MST4 in complex with an quinazolin	3ggf	82.4	no data
2392	STK3	Serine/threonine-protein kinase 3	Q13188	KRS1 MST2	5bs	Crystal structure of MST2 in complex with XMU-MP-1	5dh3	90.75	38.1
2393	TBK1	Serine/threonine-protein kinase TBK1	Q9UHD2	NAK	bx7	Structure of Tank-Binding Kinase 1	4im2	71.56	no data
2394	TBK1	Serine/threonine-protein kinase TBK1	Q9UHD2	NAK	1fv	Crystal structure and mechanism of activation of TBK1	4iwq	75.7	no data
2395	TBK1	Serine/threonine-protein kinase TBK1	Q9UHD2	NAK	1fv	Structure of Tank-Binding Kinase 1	4im0	73.68	19.
2396	TBK1	Serine/threonine-protein kinase TBK1	Q9UHD2	NAK	1h4	Crystal structure and mechanism of activation of TBK1	4iwo	77.24	no data
2397	TBK1	Serine/threonine-protein kinase TBK1	Q9UHD2	NAK	su6	Crystal structure of mouse TBK1 bound to SU6668	4jlc	73.64	no data
2398	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	j2y	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(5-METHOXYPYRIDIN-2-YL)-1H-PYRROLO[3,2-B] PYRIDIN-2-YL]PYRIDIN-2-YL}ACETAMIDE	5qim	85.5	no data
2399	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	j2v	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2-YL]PYRIDIN-2-YL}ACETAMIDE	5qil	89.89	no data
2400	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	j2m	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide	5qik	90.45	no data
2401	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	580	Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor	1rw8	95.34	175.
2402	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	zzg	ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine	2wot	83.46	44.
2403	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	qig	ALK-5 kinase complex with GW857175	3gxl	91.79	25.
2404	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	855	Structure of Alk5 + GW855857	3hmm	92.79	25.
2405	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	jzo	Crystal structure of TGFbRI complexed with a pyrazolone inhibitor	3kcf	90.19	35.
2406	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	3wk	Selection of fragments for kinase inhibitor design: decoration is key	4x2g	84.82	no data
2407	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	3wn	Selection of fragments for kinase inhibitor design: decoration is key	4x2j	89.73	no data
2408	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	3wo	Selection of fragments for kinase inhibitor design: decoration is key	4x2k	89.73	no data
2409	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	5l4	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) IN COMPLEX WITH 3-AMINO-6- [4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE	5e90	81.04	no data
2410	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	5l4	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH 3-AMINO-6-[4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE	5e8z	79.7	1243.
2411	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	zuq	ALK5 in complex witha an N-(4-anilino-2-pyridyl)acetamide inhibitor.	5fri	87.4	no data
2412	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	8ly	ALK-5 kinase inhibitor complex	5usq	82.31	100.
2413	TGFR1	TGF-beta receptor type-1	P36897	ALK5 SKR4	d0a	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	6b8y	93.27	no data
2414	TGFR2	TGF-beta receptor type-2	P37173		j2v	TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE	5qin	92.67	no data
2415	TGFR2	TGF-beta receptor type-2	P37173		5l4	TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE	5e91	80.15	no data
2416	TIE2	Angiopoietin-1 receptor	Q02763	TIE2 VMCM VMCM1	raj	Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors	2oo8	77.03	1.
2417	TIE2	Angiopoietin-1 receptor	Q02763	TIE2 VMCM VMCM1	muh	Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors	2osc	86.31	17.
2418	TIE2	Angiopoietin-1 receptor	Q02763	TIE2 VMCM VMCM1	mr9	Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor	2p4i	88.78	10.
2419	TIE2	Angiopoietin-1 receptor	Q02763	TIE2 VMCM VMCM1	qq1	Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor	2wqb	78.53	540.
2420	TIE2	Angiopoietin-1 receptor	Q02763	TIE2 VMCM VMCM1	3wr	Selection of fragments for kinase inhibitor design: decoration is key	4x3j	87.08	no data
2421	TNIK	TRAF2 and NCK-interacting protein kinase	Q9UKE5	KIAA0551	58c	Crystal structure of the kinase domain of TRAF2 and NCK-interacting protein kinase with NCB-0846	5d7a	88.43	21.
2422	TTBK1	Tau-tubulin kinase 1	Q5TCY1	BDTK KIAA1855	f8e	TTBK1 in complex with inhibitor	4btm	77.68	4100.
2423	TTBK1	Tau-tubulin kinase 1	Q5TCY1	BDTK KIAA1855	2kc	Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol	4nfn	86.22	no data
2424	TTBK1	Tau-tubulin kinase 1	Q5TCY1	BDTK KIAA1855	dtq	TTBK1 in complex with inhibitor	4btk	82.05	240.
2425	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	n66	TTK kinase domain in complex with NTRC 0066-0	5n87	77.04	0.56
2426	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	ke7	Crystal structure of the human TTK in complex with an inhibitor	6n6o	72.72	no data
2427	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	cq7	TTK in Complex with Inhibitor	6b4w	88.38	5.
2428	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	c5n	Crystal structure of human Mps1 (TTK) in complex with Cpd-5	5mrb	74.68	471.
2429	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	8rh	TTK kinase domain in complex with BAY 1217389	5nad	92.97	1.1
2430	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	8qw	TTK kinase domain in complex with BAY 1161909	5n9s	83.75	2.4
2431	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	8qe	TTK kinase domain in complex with TC-Mps1-12	5n93	89.56	2.2
2432	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	2qk	Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)	4o6l	90.87	no data
2433	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	1pf	Crystal structure of TTK kinase domain with an inhibitor: 401348	4js8	93.89	no data
2434	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	052	Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor	4zeg	85.91	no data
2435	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	ad5	Crystal structure of human Mps1 (TTK) in complex with Reversine	5ljj	87.67	62.
2436	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	92m	Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand	3h9f	87.87	12.
2437	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	cx4	Crystal structure of human Mps1 catalytic domain in complex with a quinazolin ligand Compound 4	3hmp	85.3	3240.
2438	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o22	CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide	3vqu	88.24	37.
2439	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o43	CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(6-(cyclohexylamino)-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)imidazo[1,2-b]pyridazin-3-yl)-N-cyclopropylbenzamide	3wzj	83.01	6.6
2440	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o23	CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH N-cyclopropyl-4-(8-((thiophen-2-ylmethyl)amino)imidazo[1,2-a]pyrazin-3-yl)benzamide	3wzk	85.5	58.
2441	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	w2k	MPS1 kinase with 3-aminopyridin-2-one inhibitors	4cv9	68.74	no data
2442	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	wbi	MPS1 kinase with 3-aminopyridin-2-one inhibitors	4cva	71.23	no data
2443	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	dyk	Human TTK in complex with a Dyrk1B inhibitor	4d2s	69.72	20.
2444	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	au5	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap0	69.6	5.5
2445	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	au5	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap3	66.8	93.
2446	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o38	CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 6-((3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-2-(cyclohexylamino)nicotinonitrile	3wyx	82.44	4.3
2447	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o38	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap1	81.32	10.8
2448	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	o38	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap4	80.54	350.
2449	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	pwu	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap2	82.57	3.3
2450	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	pwu	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.	5ap6	83.88	13.3
2451	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	5nw	Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach	5eh0	80.41	18.
2452	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	5o1	Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach	5eho	83.9	no data
2453	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	5o7	Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach	5ei2	84.53	46.
2454	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	5oe	Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach	5ei8	79.68	8.
2455	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	8pt	TTK kinase domain in complex with MPI-0479605	5n7v	86.62	1.7
2456	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	8q5	TTK kinase domain in complex with Mps-BAY2b	5n84	81.74	11.
2457	TTK	Dual specificity protein kinase TTK	P33981	MPS1 MPS1L1	fmw	Introduction of a methyl group curbs metabolism of pyrido[3,4-d]pyrimidine MPS1 inhibitors and enables the discovery of the Phase 1 clinical candidate BOS172722.	6h3k	81.17	no data
2458	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		lb7	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE	6nzp	81.86	no data
2459	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		lb4	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE	6nzq	79.57	no data
2460	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		laj	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide	6nzr	87.45	no data
2461	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		l9a	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide	6nzh	86.44	no data
2462	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		l91	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE	6nzf	84.3	no data
2463	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		l8y	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE	6nze	83.98	no data
2464	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		mi1	Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6	3lxn	94.29	no data
2465	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		tz1	Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor	3nyx	93.09	32.
2466	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		0x2	TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE	4gfo	91.43	240.
2467	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		0x5	Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE	4gih	85.05	4.8
2468	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		0x6	Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	4gii	84.69	1.8
2469	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		0xh	Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	4gj2	85.53	2.5
2470	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		0xp	Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	4gj3	83.49	1.4
2471	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		3sm	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE	4wov	71.62	72.
2472	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		5u4	Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one	5f20	89.43	30.
2473	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		7gl	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE	5tkd	85.04	7.
2474	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		ik1	Human TYK2 pseudokinase domain bound to a kinase inhibitor	3zon	90.42	no data
2475	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		9zs	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model	5wal	85.76	1.7
2476	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		9t6	Crystal structure of TYK2 in complex with peficitinib	6aam	86.34	no data
2477	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		g5d	Tyk2 with compound 8	6dbk	76.92	no data
2478	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597		g4j	Tyk2 with compound 23	6dbm	87.89	no data
2479	TYRO3	Tyrosine-protein kinase receptor TYRO3	Q06418	BYK DTK RSE SKY TIF	lun	Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)	3qup	79.52	476.
2480	TYRO3	Tyrosine-protein kinase receptor TYRO3	Q06418	BYK DTK RSE SKY TIF	0t8	Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)	4feq	67.49	1100.
2481	UFO	Tyrosine-protein kinase receptor UFO	P30530	UFO	7ys	Structure of the Axl kinase domain in complex with a macrocyclic inhibitor	5u6b	80.26	0.13
2482	ULK1	Serine/threonine-protein kinase ULK1	O75385	KIAA0722	34w	Crystal structure of ULK1 in complexed with PF-03814735	6qas	81.97	no data
2483	ULK1	Serine/threonine-protein kinase ULK1	O75385	KIAA0722	3rf	Structure of ULK1 bound to an inhibitor	4wno	77.56	160.
2484	ULK1	Serine/threonine-protein kinase ULK1	O75385	KIAA0722	3rj	Structure of ULK1 bound to a potent inhibitor	4wnp	79.02	8.
2485	ULK1	Serine/threonine-protein kinase ULK1	O75385	KIAA0722	51w	Structure of ULK1 bound to a selective inhibitor	5ci7	69.42	120.
2486	ULK2	Serine/threonine-protein kinase ULK2	Q8IYT8	KIAA0623	hvh	Crystal structure of ULK2 in complexed with MRT68921	6qav	84.46	no data
2487	ULK2	Serine/threonine-protein kinase ULK2	Q8IYT8	KIAA0623	fe7	Crystal structure of ULK2 in complexed with hesperadin	6qat	78.08	no data
2488	ULK2	Serine/threonine-protein kinase ULK2	Q8IYT8	KIAA0623	1fv	Crystal structure of ULK2 in complexed with MRT67307	6qau	78.75	no data
2489	ULK3	Serine/threonine-protein kinase ULK3	Q6PHR2		c87	Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib	6fdz	78.34	no data
2490	VGFR1	Vascular endothelial growth factor receptor 1	P17948	FLT FRT VEGFR1	8st	Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide	3hng	95.82	180.
2491	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	xin	Structure of VEGFR2 kinase domain in complex with BIBF1120	3c7q	62.09	21.
2492	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	raj	Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor	3be2	83.56	2.
2493	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	lif	Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine	1ywn	81.97	no data
2494	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	k11	Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor	3ewh	89.3	69.
2495	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	gig	Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor	2oh4	84.81	3.5
2496	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	900	Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor	3b8q	88.63	0.5
2497	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	887	Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor	3b8r	88.16	0.6
2498	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	857	Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor	2qu6	88.68	3.
2499	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	2rl	Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor	2rl5	88.82	4.
2500	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	0ja	Crystal Structure of the Kinase domain of Human VEGFR2 with a [1,3]thiazolo[5,4-b]pyridine derivative	3vnt	90.29	2.2
2501	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	03x	Crystal structure of the VEGFR2 kinase domain in complex with a pyrazolone inhibitor	3u6j	89.33	6.2
2502	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	aax	Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor	1y6b	79.97	38.
2503	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	994	Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor	2p2h	75.04	68.
2504	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	608	Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor	2p2i	96.08	38.
2505	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	276	Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor	2qu5	94.09	8.7
2506	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	00j	Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)	2xir	77.14	no data
2507	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	kim	Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine	3cjg	74.53	no data
2508	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	c92	Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor	3cpb	94.4	25000.
2509	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	a96	Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor	3dtw	93.26	no data
2510	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	706	Crystal structure of the VEGFR2 kinase domain in complex with motesanib	3efl	95.63	no data
2511	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	bax	KDR in complex with ligand sorafenib	3wze	92.73	no data
2512	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	bax	Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with SORAFENIB (BAY 43-9006)	4asd	91.66	0.52
2513	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	42q	Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor.	3vhe	93.32	6.2
2514	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	0kf	Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative	3vo3	85.69	1.4
2515	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	lev	KDR in complex with ligand lenvatinib	3wzd	92.5	no data
2516	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	av9	CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951)	4ase	89.09	0.01
2517	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	b49	CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-diethylaminoethyl)-5-((Z)-(5- fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide)	4agd	63.6	3.9
2518	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	sav	Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine	3cjf	63.61	6.3
2519	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	axi	CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)	4ag8	84.85	1.1
2520	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	5t2	Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993	5ew3	94.86	1.2
2521	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	f82	Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 18)	6gqo	91.24	no data
2522	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	f88	Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 23)	6gqp	90.08	no data
2523	VGFR2	Vascular endothelial growth factor receptor 2	P35968	FLK1 VEGFR2	f8b	Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 35)	6gqq	88.97	no data
2524	VRK1	Serine/threonine-protein kinase VRK1	Q99986		kwj	Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor	6npn	83.97	no data
2525	VRK1	Serine/threonine-protein kinase VRK1	Q99986		reb	Human vaccinia-related kinase 1	3op5	85.75	no data
2526	VRK1	Serine/threonine-protein kinase VRK1	Q99986		7dz	Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870	5uvf	73.71	no data
2527	VRK1	Serine/threonine-protein kinase VRK1	Q99986		e8d	Crystal Structure of the Human vaccinia-related kinase bound to a phenyl-pteridinone inhibitor	6btw	76.3	no data
2528	VRK1	Serine/threonine-protein kinase VRK1	Q99986		ea7	Crystal Structure of the Human vaccinia-related kinase bound to a propynyl-pteridinone inhibitor	6cfm	79.41	no data
2529	VRK1	Serine/threonine-protein kinase VRK1	Q99986		f87	Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor	6cnx	86.52	no data
2530	VRK1	Serine/threonine-protein kinase VRK1	Q99986		f8y	Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor	6cqh	82.93	no data
2531	VRK2	Serine/threonine-protein kinase VRK2	Q86Y07		kjd	Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor	6ncg	68.28	no data
2532	VRK2	Serine/threonine-protein kinase VRK2	Q86Y07		7dz	Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to BI-D1870	5uu1	87.52	no data
2533	WEE1	Wee1-like protein kinase	P30291		xzn	Crystal structure of HUMAN WEE1 KINASE domain in complex with Bosutinib-isomer	5vc4	74.08	43.7
2534	WEE1	Wee1-like protein kinase	P30291		db8	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB	5vc3	74.15	77.5
2535	WEE1	Wee1-like protein kinase	P30291		99v	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue	5vd7	74.59	no data
2536	WEE1	Wee1-like protein kinase	P30291		99j	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-016, a MK1775 analougue	5vd4	73.61	no data
2537	WEE1	Wee1-like protein kinase	P30291		98m	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-099, a MK1775 analogue	5vd8	74.17	no data
2538	WEE1	Wee1-like protein kinase	P30291		96m	Crystal structure of human WEE1 kinase domain in complex with PD-166285	5vc5	75.05	11.
2539	WEE1	Wee1-like protein kinase	P30291		8x7	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH MK1775	5v5y	73.85	13.4
2540	WEE1	Wee1-like protein kinase	P30291		61e	Wee1 kinase complex with inhibitor PD331618	3biz	74.75	58.
2541	WEE1	Wee1-like protein kinase	P30291		396	Wee1 kinase complex with inhibitor PD352396	3bi6	75.81	15.
2542	WEE1	Wee1-like protein kinase	P30291		p48	crystal structure of human WEE1 kinase domain in complex with PHA-848125	5vc6	74.35	13.6
2543	WEE1	Wee1-like protein kinase	P30291		p91	Wee1 kinase complex with inhibitor PD074291	3cqe	84.8	no data
2544	WEE1	Wee1-like protein kinase	P30291		809	Wee1 kinase complex with inhibitor PD259_809	3cr0	88.56	no data
2545	WEE1	Wee1-like protein kinase	P30291		34w	crystal structure of human WEE1 kinase domain in complex with PF-03814735	5vd2	68.1	78.7
2546	WEE1	Wee1-like protein kinase	P30291		99m	CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-050, a MK1775 analougue	5vd5	77.96	no data
2547	WEE1	Wee1-like protein kinase	P30291		98g	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-097, a MK1775 analogue	5vd9	74.2	no data
2548	WEE1	Wee1-like protein kinase	P30291		98d	Crystal structure of human WEE1 kinase domain in complex with RAC-IV-101, a MK1775 analogue	5vda	74.78	no data
2549	WNK1	Serine/threonine-protein kinase WNK1	Q9H4A3	HSN2 KDP KIAA0344 PRKWNK1	a7y	Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl}-2-(3-methoxyphenyl)-N-methylquinoline-4-carboxamide (compound 8)	5we8	92.04	no data
2550	WNK1	Serine/threonine-protein kinase WNK1	Q9H4A3	HSN2 KDP KIAA0344 PRKWNK1	a6s	Crystal structure of WNK1 in complex with 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)pyridin-4-yl]-1H-indol-3-yl}methyl)methanamine (compound 6)	5wdy	86.99	no data
2551	WNK1	Serine/threonine-protein kinase WNK1	Q9H4A3	HSN2 KDP KIAA0344 PRKWNK1	7av	Crystal structure of WNK1 in complex with Mn2+AMPPNP and WNK476	5tf9	89.15	no data
2552	WNK3	Serine/threonine-protein kinase WNK3	Q9BYP7	KIAA1566 PRKWNK3	ks1	Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121	5o2b	89.72	no data

The Ligandable Human Proteome

Protein kinase domain