The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	PYGL	Glycogen phosphorylase, liver form	P06737	rbf	Human liver glycogen phosphorylase a complexed with riboflavin, N-Acetyl-beta-D-Glucopyranosylamine and CP-403,700	1l5r	69.89	17000.
2	PYGM	Glycogen phosphorylase, muscle form	P11217	z57	Glycogen phosphorylase complexed with 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-bromo-benzene	3npa	95.83	136400.
3	PYGM	Glycogen phosphorylase, muscle form	P11217	z16	Glycogen phosphorylase complexed with 2,5-dihydroxy-3-(beta-D-glucopyranosyl)-chlorobenzene and 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-chlorobenzene	3np7	99.28	no data
4	PYGM	Glycogen phosphorylase, muscle form	P11217	z15	The crystal structure of glycogen phosphorylase b in complex with 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-chlorobenzene	3s0j	95.65	169900.
5	PYGM	Glycogen phosphorylase, muscle form	P11217	h53	Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal	2fet	95.02	no data
6	PYGM	Glycogen phosphorylase, muscle form	P11217	h53	Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal	2ff5	94.73	no data
7	PYGM	Glycogen phosphorylase, muscle form	P11217	f58	Rabbit muscle glycogen phosphorylase b in complex with N- cyclohexancarbonyl-N-beta-D-glucopyranosyl urea determined at 1.83 A resolution	3zcp	88.7	no data
8	PYGM	Glycogen phosphorylase, muscle form	P11217	f55	Glycogen Phosphorylase in complex with N-4-chlorobenzoyl-N-beta-D-glucopyranosyl urea	2qn3	91.05	4400.
9	PYGM	Glycogen phosphorylase, muscle form	P11217	7ls	A potent fluorescent inhibitor of glycogen phosphorylase as a catalytic site probe.	5mem	97.74	no data
10	PYGM	Glycogen phosphorylase, muscle form	P11217	12e	Glycogen phosphorylase complexed with 4-pyridinecarboxaldehyde-4-(beta-D-glucopyranosyl) thiosemicarbazone	3mrt	68.24	200000.
11	PYGM	Glycogen phosphorylase, muscle form	P11217	htp	COOPERATIVITY BETWEEN HYDROGEN-BONDING AND CHARGE-DIPOLE INTERACTIONS IN THE INHIBITION OF BETA-GLYCOSIDASES BY AZOLOPYRIDINES: EVIDENCE FROM A STUDY WITH GLYCOGEN PHOSPHORYLASE B	1axr	99.87	540000.
12	PYGM	Glycogen phosphorylase, muscle form	P11217	cr1	STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN	1fu7	94.27	no data
13	PYGM	Glycogen phosphorylase, muscle form	P11217	ntf	Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase	1ww3	93.92	no data
14	PYGM	Glycogen phosphorylase, muscle form	P11217	ox2	Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole,-benzothiazole, and-benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.	1xl0	94.45	no data
15	PYGM	Glycogen phosphorylase, muscle form	P11217	7gp	Crystal Structure of the glycogen phosphorylase B / ethyl-N-(beta-D-glucopyranosyl)oxamate complex	2f3s	94.28	no data
16	PYGM	Glycogen phosphorylase, muscle form	P11217	dl6	Crystallographic studies on N-azido-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine	2ffr	93.1	no data
17	PYGM	Glycogen phosphorylase, muscle form	P11217	g27	The crystal structure of glycogen phosphorylase in complex with (3R,4R,5R)-5-hydroxymethyl-1-(3-phenylpropyl)-piperidine-3,4-diol and phosphate	2g9u	93.05	840.
18	PYGM	Glycogen phosphorylase, muscle form	P11217	g27	The crystal structure of glycogen phosphorylase b in complex with (3R,4R,5R)-5-hydroxymethyl-1-(3-phenylpropyl)-piperidine-3,4-diol	2g9r	93.64	840.
19	PYGM	Glycogen phosphorylase, muscle form	P11217	cpb	Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site	1e1y	61.28	2500.
20	PYGM	Glycogen phosphorylase, muscle form	P11217	cpb	FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE	1c8k	64.42	1000.
21	PYGM	Glycogen phosphorylase, muscle form	P11217	cpb	Glycogen Phosphorylase b/flavopiridol complex	3ebp	64.67	1240.
22	PYGM	Glycogen phosphorylase, muscle form	P11217	que	Crystal structure of Gpb in complex with QUERCETIN	4mra	79.11	33500.
23	PYGM	Glycogen phosphorylase, muscle form	P11217	57d	Glycogen Phosphorylase b/Chrysin complex	3ebo	80.29	19010.
24	PYGM	Glycogen phosphorylase, muscle form	P11217	dkx	Crystal Structure of Glycogen Phosphorylase DK1 complex	3l79	93.19	3.46e+006
25	PYGM	Glycogen phosphorylase, muscle form	P11217	dkz	Crystal Structure of Glycogen Phosphorylase DK3 complex	3l7b	92.97	4.01e+006
26	PYGM	Glycogen phosphorylase, muscle form	P11217	dk4	Crystal Structure of Glycogen Phosphorylase DK4 complex	3l7c	93.72	3.67e+006
27	PYGM	Glycogen phosphorylase, muscle form	P11217	z2t	Glycogen phosphorylase complexed with 3-(beta-D-glucopyranosyl)-2-hydroxy-5-methoxy-chlorobenzene	3np9	97.74	39800.
28	PYGM	Glycogen phosphorylase, muscle form	P11217	gpk	Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil	3syr	94.21	7900.
29	PYGM	Glycogen phosphorylase, muscle form	P11217	gpq	Glycogen phosphorylase b in complex with GlcClU	3t3e	94.65	1020.
30	PYGM	Glycogen phosphorylase, muscle form	P11217	gpu	Glycogen Phosphorylase b in complex with GlcBrU	3t3g	95.31	3270.
31	PYGM	Glycogen phosphorylase, muscle form	P11217	gpv	Glycogen Phosphorylase b in complex with GlcIU	3t3h	95.01	1940.
32	PYGM	Glycogen phosphorylase, muscle form	P11217	gpw	Glycogen Phosphorylase b in complex with GlcCF3U	3t3i	95.4	17000.
33	PYGM	Glycogen phosphorylase, muscle form	P11217	d1f	Crystal structure of GPb in complex with DK10	4ej2	91.28	3.204e+006
34	PYGM	Glycogen phosphorylase, muscle form	P11217	d1i	Crystal structure of GPb in complex with DK11	4eke	92.26	33400.
35	PYGM	Glycogen phosphorylase, muscle form	P11217	d1j	Crystal structure of GPb in complex with DK15	4eky	94.6	303000.
36	PYGM	Glycogen phosphorylase, muscle form	P11217	d1k	Crystal structure of GPb in complex with DK16	4el0	94.02	32400.
37	PYGM	Glycogen phosphorylase, muscle form	P11217	d1m	Crystal structure of GPb in complex with DK12	4el5	95.72	4300.
38	PYGM	Glycogen phosphorylase, muscle form	P11217	26r	Crystal structure of Gpb in complex with SUGAR (N-{(2R)-2-METHYL-3-[4-(PROPAN-2-YL)PHENYL]PROPANOYL}-BETA-D-GLUCOPYRANOSYLAMINE) (S21)	4mi3	91.05	75290.
39	PYGM	Glycogen phosphorylase, muscle form	P11217	26v	Crystal structure of Gpb in complex with SUGAR (N-[4-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)BUTANOYL]-BETA-D-GLUCOPYRANOSYLAMINE)	4mi6	95	48680.
40	PYGM	Glycogen phosphorylase, muscle form	P11217	26w	Crystal structure of Gpb in complex with SUGAR (N-[(3R)-3-(4-ETHYLPHENYL)BUTANOYL]-BETA-D-GLUCOPYRANOSYLAMINE) (S20)	4mi9	94.13	376870.
41	PYGM	Glycogen phosphorylase, muscle form	P11217	26y	Crystal structure of Gpb in complex with SUGAR (N-{(2E)-3-[4-(PROPAN-2-YL)PHENYL]PROP-2-ENOYL}-BETA-D-GLUCOPYRANOSYLAMINE) (S6)	4mic	91.36	4980.
42	PYGM	Glycogen phosphorylase, muscle form	P11217	thm	Glucogen Phosphorylase complex with thymidine	3bcu	61.5	no data
43	PYGM	Glycogen phosphorylase, muscle form	P11217	azz	Glycogen Phosphorylase b in complex with AZT	3bcr	55.47	no data

The Ligandable Human Proteome

Glycosyl transferase, family 35