The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	os3	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol	6dz0	85.11	no data
2	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	os2	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol	6dyz	90.2	no data
3	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	fmc	STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A	1sd1	91.53	no data
4	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	7a6	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-A	5tc6	93.91	no data
5	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	5s7	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate	5eub	92.76	no data
6	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	mta	STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION	1cg6	93.37	no data
7	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	tdi	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A	5tc8	94.08	no data
8	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	mth	STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-METHYLTHIOTUBERCIDIN	1sd2	93.36	no data
9	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	mth	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom	5tc7	94.24	no data
10	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	4ct	Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA	3ozc	88.93	no data
11	MTAP	S-methyl-5'-thioadenosine phosphorylase	Q13126	MSAP	4ct	Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA	3ozd	81.76	no data
12	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate	1rt9	95.26	0.056
13	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H	2oc4	92.31	86.
14	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H	2oc9	91.5	11.
15	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH IMMUCILLIN H	1pf7	94.13	0.072
16	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H	2on6	91.94	172.
17	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate	1rr6	94.24	0.056
18	PNPH	Purine nucleoside phosphorylase	P00491	NP	imh	Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H	2q7o	91.61	12.
19	PNPH	Purine nucleoside phosphorylase	P00491	NP	im5	Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG	3phb	99.79	no data
20	PNPH	Purine nucleoside phosphorylase	P00491	NP	im5	Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate	5ugf	99.8	no data
21	PNPH	Purine nucleoside phosphorylase	P00491	NP	gmp	Crystal Structure of Human Purine Nucleoside Phosphorylase Complexed with Guanosine	1rfg	95.44	no data
22	PNPH	Purine nucleoside phosphorylase	P00491	NP	22a	Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H	3k8q	93.17	0.0052
23	PNPH	Purine nucleoside phosphorylase	P00491	NP	2fd	Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine	3ggs	93.31	no data
24	PNPH	Purine nucleoside phosphorylase	P00491	NP	dih	Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate	3bgs	93.53	0.38
25	PNPH	Purine nucleoside phosphorylase	P00491	NP	dih	Structure of human purine nucleoside phosphorylase H257D mutant	2a0y	93.39	no data
26	PNPH	Purine nucleoside phosphorylase	P00491	NP	dih	Structure of human purine nucleoside phosphorylase H257F mutant	2a0x	93.79	no data
27	PNPH	Purine nucleoside phosphorylase	P00491	NP	dih	Structure of human purine nucleoside phosphorylase H257G mutant	2a0w	91.88	no data
28	PNPH	Purine nucleoside phosphorylase	P00491	NP	msg	Crystal structure of human PNP complexed with MESG	1yry	95.87	no data
29	PNPH	Purine nucleoside phosphorylase	P00491	NP	3dg	Crystal Structure of human PNP complexed with 3-deoxyguanosine	1v45	94.61	no data
30	PNPH	Purine nucleoside phosphorylase	P00491	NP	2di	Structure of human PNP complexed with DDI	1v3q	91.58	no data
31	PNPH	Purine nucleoside phosphorylase	P00491	NP	dih	Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate	1rsz	95.14	no data
32	PNPH	Purine nucleoside phosphorylase	P00491	NP	nos	Crystal structure of Human purine nucleoside phosphorylase complexed with INOSINE	1rct	96.57	no data
33	PNPH	Purine nucleoside phosphorylase	P00491	NP	ac2	CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR	1pwy	94.68	90000.
34	UPP2	Uridine phosphorylase 2	O95045		bau	Structure of hUPP2 in an inactive conformation with bound 5-benzylacyclouridine	3p0f	79.37	no data
35	UPP2	Uridine phosphorylase 2	O95045		bau	Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine	3p0e	99.02	no data

The Ligandable Human Proteome

Nucleoside phosphorylase domain