The Ligandable Human Proteome

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Peptidase M24

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1MAP11Methionine aminopeptidase 1P53582KIAA0094tn4Human methionine aminopeptidase type 1b (F309L mutant) in complex with TNP4705yr684.64no data
2MAP11Methionine aminopeptidase 1P53582KIAA0094tn4Human methionine aminopeptidase type 1b (F309M mutant) in complex with TNP4705yr485.9no data
3MAP11Methionine aminopeptidase 1P53582KIAA00941ayPyridinylpyrimidines selectively inhibit human methionine aminopeptidase-14hxx64.82no data
4MAP11Methionine aminopeptidase 1P53582KIAA0094hm2Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative2g6p80.97600.
5MAP11Methionine aminopeptidase 1P53582KIAA0094yz6Human MetAP1 with bengamide analog YZ6, in Mn form4fll78.335140.
6MAP11Methionine aminopeptidase 1P53582KIAA0094tfdCrystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine4iks63.137230.
7MAP11Methionine aminopeptidase 1P53582KIAA0094shxCrystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide4iku71.261790.
8MAP11Methionine aminopeptidase 1P53582KIAA0094tfvCrystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine4ikt73.92670.
9MAP11Methionine aminopeptidase 1P53582KIAA0094pvpCrystal structure of Type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol4ikr66.18590.
10MAP11Methionine aminopeptidase 1P53582KIAA0094hm5Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide2nq773.22900.
11MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2k4kCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 2-Oxo-1-phenyl-pyrrolidine-3-carboxylic acid (2-thiophen-2-yl-ethyl)-amide6qeg91.54no data
12MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2hzwCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR (S)-3-Hydroxy-2-oxo-1-phenyl-pyrrolidine-3-carboxylic acid 3-chloro-5-fluoro-benzylamide6qef92.72no data
13MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2hztCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR Thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2,4]triazol-3-ylmethyl)-amide6qej87.17no data
14MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2hzkCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR (S)-3-Hydroxy-2-oxo-1-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyrrolidine-3-carboxylic acid 3-chloro-5-fluoro-benzylamide6qed85.59no data
15MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2hzeCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR 5,6-Difluoro-3-(2-isopropoxy-4-piperazin-1-yl-phenyl)-1H-indole-2-carboxylic acid amide6qei68.23no data
16MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2fugHUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN1boa75.15no data
17MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2ao5Crystal Structure of MetAP2 complexed with A3573001r5876.89110.
18MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2ao1Crystal Structure of MetAP2 complexed with A3112631r5g85.2130.
19MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2ao2Crystal Structure of MetAP2 complexed with A3202821r5h88.29180.
20MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2a84h-MetAP2 complexed with A8495191yw981.36no data
21MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2f77h-MetAP2 complexed with A7738122ea290.5516.
22MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2f79h-MetAP2 complexed with A7978592ea490.1446.
23MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2i96Human Methionine Aminopeptidase-2 Complexed with SB-5870942oaz90.012.
24MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF2tn4HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-4701b6a79.89no data
25MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF252tStructure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31a5cls81.69220.
26MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF294aStructure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b5d6e82.9750000.
27MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF257rStructure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b5d6f78.4843000.
28MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF26koPotent, Reversible MetAP2 Inhibitors via FBDD5jhu75.81no data
29MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF27bhCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR 6-((R)-2-o-Tolyloxymethyl-pyrrolidin-1-yl)-9H-purine5lyw75.48700.
30MAP2Methionine aminopeptidase 2P50579MNPEP P67EIF27bfCRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX; WITH AN INHIBITOR 5-((R)-1-[1,2,4]Triazolo[1,5-a]pyrimidin-7-yl-pyrrolidin-2-ylmethoxy)-isoquinoline5lyx71.5438.