The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	C11B2	Cytochrome P450 11B2, mitochondrial	P19099		1ca	Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone	4dvq	95.67	no data
2	CP11A	Cholesterol side-chain cleavage enzyme, mitochondrial	P05108	CYP11A	hcd	Crystal structure of human CYP11A1 in complex with 20-hydroxycholesterol	3na1	95.54	no data
3	CP11A	Cholesterol side-chain cleavage enzyme, mitochondrial	P05108	CYP11A	hc9	Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol	3n9z	94.92	no data
4	CP11A	Cholesterol side-chain cleavage enzyme, mitochondrial	P05108	CYP11A	clr	Crystal structure of human CYP11A1 in complex with cholesterol	3n9y	94.82	no data
5	CP11A	Cholesterol side-chain cleavage enzyme, mitochondrial	P05108	CYP11A	2dc	Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol	3na0	96.15	no data
6	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	tok	Human Cytochrome P450 17A1 in complex with TOK-001	3swz	97.58	no data
7	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	aer	Human Cytochrome P450 CYP17A1 in complex with Abiraterone	3ruk	97.73	no data
8	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	aer	Human steroidogenic cytochrome P450 17A1 mutant A105L with inhibitor abiraterone	4nkv	98.57	no data
9	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	8qd	Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog	5uys	98.71	no data
10	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	3nr	Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 nitrile	6ciz	97.41	no data
11	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	3nq	Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 oxime	6cir	98.85	no data
12	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	plo	Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate pregnenolone	4nkw	98.78	no data
13	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	str	Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate progesterone	4nkx	98.41	no data
14	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	3qz	Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxyprogesterone	4nky	98.71	no data
15	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	6d7	Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel	5irq	96.29	no data
16	CP17A	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CYP17 S17AH	3nx	Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide	6chi	98.46	no data
17	CP19A	Aromatase	P11511	ARO1 CYAR CYP19	tes	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) COMPLEXED WITH TESTOSTERONE	5jkw	99.29	no data
18	CP19A	Aromatase	P11511	ARO1 CYAR CYP19	asd	Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione	3eqm	99.53	no data
19	CP19A	Aromatase	P11511	ARO1 CYAR CYP19	asd	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #2	5jl6	99.53	no data
20	CP19A	Aromatase	P11511	ARO1 CYAR CYP19	asd	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) AT 2.75 ANGSTROM WITH BOUND POLYETHYLENE GLYCOL	5jkv	99.53	no data
21	CP19A	Aromatase	P11511	ARO1 CYAR CYP19	asd	Human placental aromatase cytochrome P450 (CYP19A1) refined at 2.75 angstrom	3s79	99.52	no data
22	CP1A1	Cytochrome P450 1A1	P04798		hjj	Structure of Human Cytochrome P450 1A1 with Bergamottin	6dwm	98.17	no data
23	CP1A1	Cytochrome P450 1A1	P04798		aq4	Structure of Human Cytochrome P450 1A1 with Erlotinib	6dwn	97.32	no data
24	CP21A	Steroid 21-hydroxylase	P08686	CYP21 CYP21B	str	Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex	4y8w	99.89	no data
25	CP2A6	Cytochrome P450 2A6	P11509	CYP2A3	d1g	Microsomal P450 2A6 with the inhibitor N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound	2fdu	99.59	no data
26	CP2A6	Cytochrome P450 2A6	P11509	CYP2A3	9pl	Human Cytochrome P450 2A6 in complex with Pilocarpine	3t3r	100	no data
27	CP2A6	Cytochrome P450 2A6	P11509	CYP2A3	9pl	Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine	3t3q	99.42	no data
28	CP2AD	Cytochrome P450 2A13	Q16696		0qa	Human Cytochrome P450 2A13 in complex with two molecules of 4-(methylnitrosamino)-1-(3-puridyl)-1-butanone	4eji	99.87	no data
29	CP2AD	Cytochrome P450 2A13	Q16696		0qa	Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)	4ejh	99.86	no data
30	CP2AD	Cytochrome P450 2A13	Q16696		9pl	Human Cytochrome P450 2A13 in complex with Pilocarpine	3t3s	100	no data
31	CP2C8	Cytochrome P450 2C8	P10632		mtk	CYP2C8dH complexed with montelukast	2nni	91	no data
32	CP2C8	Cytochrome P450 2C8	P10632		9cr	CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid	2nnh	96.35	no data
33	CP2C8	Cytochrome P450 2C8	P10632		225	CYP2C8dH complexed with felodipine	2nnj	87.27	no data
34	CP2C8	Cytochrome P450 2C8	P10632		tdz	CYP2C8DH COMPLEXED WITH TROGLITAZONE	2vn0	89.32	no data
35	CP2C9	Cytochrome P450 2C9	P11712	CYP2C10	flp	Crystal Structure of P4502C9 with Flurbiprofen bound	1r9o	95.8	no data
36	CP2C9	Cytochrome P450 2C9	P11712	CYP2C10	lsn	Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules	5x24	90.52	no data
37	CP2C9	Cytochrome P450 2C9	P11712	CYP2C10	9w6	Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex	5w0c	86.21	no data
38	CP2C9	Cytochrome P450 2C9	P11712	CYP2C10	swf	Structure of human cytochrome P450 CYP2C9	1og5	88.64	no data
39	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	pn0	V308E mutant of cytochrome P450 2D6 complexed with prinomastat	6csd	98.38	no data
40	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	pn0	Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6	3tda	97.78	no data
41	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	pn0	Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex	3qm4	96.99	no data
42	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	qi9	Human Cytochrome P450 2D6 Quinine Complex	4wnv	87.9	no data
43	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	si6	Human Cytochrome P450 2D6 BACE1 Inhibitor 6 Complex	4xrz	98.52	no data
44	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	si5	Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex	4xry	94.68	no data
45	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	p6m	Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex	5tfu	92.89	no data
46	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	p6u	Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex	5tft	89.57	no data
47	CP2D6	Cytochrome P450 2D6	P10635	CYP2DL1	qdn	Human Cytochrome P450 2D6 Quinidine Complex	4wnu	97.25	no data
48	CP2E1	Cytochrome P450 2E1	P05181	CYP2E	9pl	Human Cytochrome P450 2E1 in complex with pilocarpine	3t3z	99.86	no data
49	CP2R1	Vitamin D 25-hydroxylase	Q6VVX0		vd3	Crystal structure of CYP2R1 in complex with vitamin D3	3c6g	98.42	no data
50	CP2R1	Vitamin D 25-hydroxylase	Q6VVX0		v2h	Crystal structure of CYP2R1 in complex with 1-alpha-hydroxy-vitamin D2	3dl9	98.23	no data
51	CP2R1	Vitamin D 25-hydroxylase	Q6VVX0		d2v	Crystal structure of CYP2R1 in complex with vitamin D2	3czh	97.97	no data
52	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	tpf	Human CYP3A4 bound to an inhibitor fluconazole	6ma7	89.16	no data
53	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	myt	Human CYP3A4 bound to an inhibitor metyrapone	6ma6	86.39	no data
54	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	mwy	Human CYP3A4 bound to a drug substrate	6ooa	73.41	no data
55	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	mwv	Human CYP3A4 bound to a drug mibefradil	6oo9	95.59	no data
56	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	mws	Human CYP3A4 bound to a suicide substrate	6oob	92.1	no data
57	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	kln	Crystal structure of human P450 3A4 in complex with ketoconazole	2v0m	97.88	no data
58	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	dj1	Crystal structure of human CYP3A4 bound to an inhibitor	6bdk	89.98	no data
59	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	d81	Crystal structure of human CYP3A4 bound to an inhibitor	6bd8	89.58	no data
60	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	d0r	Crystal Structure of the complex between human cytochrome P450 3A4 and desthiazolylmethyloxycarbonyl ritonavir	3tjs	80.23	no data
61	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	8aw	Complex of human CYP3A4 with a desoxyritonavir analog	4k9x	83	no data
62	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	6aw	Complex of CYP3A4 with a desoxyritonavir analog	4k9v	89.85	no data
63	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	08y	Crystal structure of the cysteine depleted CYP3A4 bound to bromoergocryptine	5vcg	92.97	no data
64	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	08y	Crystal structure of the cytochrome P4503A4-bromoergocryptine complex	3ua1	93.47	no data
65	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	str	Crystal structure of cytochrome P450 3A4 bound to progesterone	5a1r	48.49	no data
66	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	str	Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate	5a1p	48.13	no data
67	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	str	Crystal structure of human cytochrome P450 3A4	1w0f	47.31	no data
68	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	myt	Crystal structure of human cytochrome P450 3A4	1w0g	76.83	no data
69	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	2qh	Crystal structure of CYP3A4 in complex with an inhibitor	4ny4	87.62	no data
70	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	08j	Crystal structure of the midazolam-bound human CYP3A4	5te8	89.89	no data
71	CP3A4	Cytochrome P450 3A4	P08684	CYP3A3	d7m	Crystal structure of human CYP3A4 bound to an inhibitor	6bd5	88.46	no data
72	CP46A	Cholesterol 24-hydroxylase	Q9Y6A2	CYP46	c3s	Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate	2q9f	98.09	no data
73	CP46A	Cholesterol 24-hydroxylase	Q9Y6A2	CYP46	vor	Voriconazole complex of Cytochrome P450 46A1	3mdt	94.82	no data
74	CP46A	Cholesterol 24-hydroxylase	Q9Y6A2	CYP46	fvx	Crystal Structure of Human Cytochrome P450 CYP46A1 with Fluvoxamine Bound	4enh	98.55	no data
75	CP51A	Lanosterol 14-alpha demethylase	Q16850	CYP51	vfv	HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP	4uhi	95.96	no data
76	CP51A	Lanosterol 14-alpha demethylase	Q16850	CYP51	kkk	Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole	3ld6	88.89	no data
77	CP51A	Lanosterol 14-alpha demethylase	Q16850	CYP51	ecn	Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole	3jus	93.14	no data
78	CP51A	Lanosterol 14-alpha demethylase	Q16850	CYP51	ecl	Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole	3jus	95.4	no data
79	CP7A1	Cholesterol 7-alpha-monooxygenase	P22680	CYP7	k2b	Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one	3sn5	97.96	no data
80	CP7A1	Cholesterol 7-alpha-monooxygenase	P22680	CYP7	0gv	Crystal structure of human CYP7A1 in complex with 7-ketocholesterol	3v8d	98.01	no data
81	PTGIS	Prostacyclin synthase	Q16647	CYP8 CYP8A1	mxd	Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil	3b6h	91.1	no data

The Ligandable Human Proteome

Cytochrome P450