The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	jdg	GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form	6mbp	79.06	no data
2	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	e72	Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72	3mo5	69.13	136.
3	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	e67	human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67	3mo2	71.63	244.
4	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	90p	Crystal structure of catalytic domain of GLP with MS0105	5v9j	78.05	no data
5	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	7kz	Crystal structure of catalytic domain of GLP with MS012	5ttg	73.6	no data
6	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	q4a	G9a-like protein lysine methyltransferase inhibition by BIX-01294	3fpd	64.06	700.
7	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	e11	Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11	3mo0	87.39	154.
8	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	7l6	Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124	5tuz	76.62	40.
9	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	9hj	Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 13	5vsd	80.84	57.
10	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	9hg	Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 17	5vsf	77.22	94.
11	EHMT1	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EUHMTASE1 GLP KIAA1876 KMT1D	jdg	GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form	6mbo	33.79	no data
12	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	ciq	Crystal structure of histone lysine methyltransferase g9a with an inhibitor	3rjw	70.11	27.
13	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	90p	Crystal structure of catalytic domain of G9a with MS0105	5v9i	76.91	no data
14	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	7kz	Crystal structure of catalytic domain of G9a with MS012	5ttf	81.04	no data
15	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	dxq	Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a	3k5k	76.16	23.
16	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	2od	Human G9a in Complex with Inhibitor A-366	4nvq	91.94	3.3
17	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	7l6	Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124	5tuy	77.92	445.
18	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	9hj	Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13	5vsc	76.94	510.
19	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	BAT8 C6orf30 G9A KMT1C NG36	9hg	Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine	5vse	77.92	1070.
20	KMT5A	N-lysine methyltransferase KMT5A	Q9NQR1	PRSET7 SET07 SET8 SETD8	75p	human SETD8 in complex with MS2177	5t5g	61.53	no data
21	KMT5B	Histone-lysine N-methyltransferase KMT5B	Q4FZB7	SUV420H1	539	The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity	5cpr	84.3	27.5
22	PRDM9	Histone-lysine N-methyltransferase PRDM9	Q9NQV7	PFM6	ks7	Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor	6nm4	62.51	no data
23	SETD7	Histone-lysine N-methyltransferase SETD7	Q8WTS6	KIAA1717 KMT7 SET7 SET9	0n6	SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine	4e47	75.21	no data
24	SMYD2	N-lysine methyltransferase SMYD2	Q9NRG4	KMT3C	ew4	Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975	6cby	81.78	no data
25	SMYD2	N-lysine methyltransferase SMYD2	Q9NRG4	KMT3C	a4m	SET and MYND Domain Containing protein 2	5wcg	80.09	no data
26	SMYD2	N-lysine methyltransferase SMYD2	Q9NRG4	KMT3C	ew1	Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497	6cbx	84.17	no data
27	SUV92	Histone-lysine N-methyltransferase SUV39H2	Q9H5I1	KMT1B	nm4	Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor	6p0r	77.99	no data

The Ligandable Human Proteome

SET domain