The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	7h9	Small Molecule inhibitors of IAP	5m6n	61.67	no data
2	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	2dy	Crystal structure of cIAP1 BIR3 bound to T3450325	4mu7	57.55	1.4
3	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	2dx	Crystal structure of cIAP1 BIR3 bound to T3258042	4mti	58.67	1.2
4	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	1yh	Crystal structure of clAP1 BIR3 bound to T3226692	4lgu	57.95	2.1
5	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	1y0	Crystal structure of clAP1 BIR3 bound to T3261256	4lge	58.43	3.5
6	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	1bg	Crystal structure of cIAP1 BIR3 bound to T3170284	4hy4	59.64	2.7
7	BIRC2	Baculoviral IAP repeat-containing protein 2	Q13490	API1 MIHB RNF48	1aq	Crystal structure of cIAP1 BIR3 bound to T3256336	4hy5	52.18	1.3
8	BIRC7	Baculoviral IAP repeat-containing protein 7	Q96CA5	KIAP LIVIN MLIAP RNF50	851	Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic	3gta	58.52	53000.
9	BIRC7	Baculoviral IAP repeat-containing protein 7	Q96CA5	KIAP LIVIN MLIAP RNF50	516	Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic	3gt9	58.01	110000.
10	BIRC7	Baculoviral IAP repeat-containing protein 7	Q96CA5	KIAP LIVIN MLIAP RNF50	419	Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic	3f7h	57.04	82.
11	BIRC7	Baculoviral IAP repeat-containing protein 7	Q96CA5	KIAP LIVIN MLIAP RNF50	618	Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic	2i3i	59.21	50.
12	BIRC7	Baculoviral IAP repeat-containing protein 7	Q96CA5	KIAP LIVIN MLIAP RNF50	g13	Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic	3f7i	58.79	46.
13	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	x23	Crystal Structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac010	3cm2	81.91	340.
14	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	smk	Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound	3eyl	56.33	250.
15	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	fue	Fragment Derived XIAP inhibitor	6h6r	65.94	no data
16	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	9jz	Crystal structure of XIAP BIR3 with CS3	3hl5	47.86	34000.
17	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	7h9	Small Molecule inhibitors of IAP	5m6l	65.31	no data
18	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	bi6	XIAP BIR3 bound to a Smac Mimetic	2jk7	57.9	67.
19	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	x22	Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac005	3clx	88.78	no data
20	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	4ye	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 7	5c7a	70.7	495000.
21	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	4yc	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 18	5c7c	74.16	5500.
22	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	4yf	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 17	5c7d	69.28	7700.
23	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	4yn	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 21	5c83	69.57	160.
24	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	4yl	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 20	5c84	70.87	640.
25	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	7ht	Small Molecule inhibitors of IAP	5m6e	69.18	no data
26	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	7hu	Small Molecule inhibitors of IAP	5m6f	62.22	220.
27	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	7j6	Small Molecule inhibitors of IAP	5m6h	63.68	150.
28	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	7h8	Small Molecule inhibitors of IAP	5m6m	64.81	44.
29	XIAP	E3 ubiquitin-protein ligase XIAP	P98170	API3 BIRC4 IAP3	c3t	Crystal structure of XIAP-BIR3 in complex with a cIAP1-selective SM	6ey2	86.03	no data

The Ligandable Human Proteome

BIR repeat