The Ligandable Human Proteome

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Peptidase M12B, ADAM/reprolysin

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1ATS1A disintegrin and metalloproteinase with thrombospondin motifs 1Q9UHI8KIAA1346 METH1qhfAdamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS43q2h77.040.69
2ATS1A disintegrin and metalloproteinase with thrombospondin motifs 1Q9UHI8KIAA1346 METH1qgfAdamts1 in complex with a novel N-hydroxyformamide inhibitors3q2g77.053.5
3ATS4A disintegrin and metalloproteinase with thrombospondin motifs 4O75173KIAA06883pqCrystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)4wk787.4274.
4ATS4A disintegrin and metalloproteinase with thrombospondin motifs 4O75173KIAA06883puCrystal structure of human ADAMTS-4 in complex with inhibitor 5-chloro-N-{[(4R)-2,5-dioxo-4-(1,3-thiazol-2-yl)imidazolidin-4-yl]methyl}-1-benzofuran-2-carboxamide (compound 10)4wke85.328.
5ATS4A disintegrin and metalloproteinase with thrombospondin motifs 4O75173KIAA06883pwCrystal structure of human ADAMTS-4 in complex with inhibitor 5-CHLORO-N-{[(4S)-4-(1-METHYL-1H-IMIDAZOL-2-YL)-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}-1-BENZOFURAN-2-CARBOXAMIDE (compound 11)4wki80.285.
6ATS5A disintegrin and metalloproteinase with thrombospondin motifs 5Q9UNA0ADAMTS11 ADMP2098Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound3hy976.7917.
7ATS5A disintegrin and metalloproteinase with thrombospondin motifs 5Q9UNA0ADAMTS11 ADMP2099Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound3hyg79.9193.
8ATS5A disintegrin and metalloproteinase with thrombospondin motifs 5Q9UNA0ADAMTS11 ADMP2la3Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound3ljt78.28129.