The Ligandable Human Proteome

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WD40 repeat

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1CDC20Cell division cycle protein 20 homologQ12834wr7Crystal structure of Cdc20 and apcin complex4n1465.62no data
2EEDPolycomb protein EEDO75530l9wEED in complex with a methyl-thiazole6sfc75.6no data
3EEDPolycomb protein EEDO75530l9kEED in complex with a triazolopyrimidine6sfb74.55no data
4EEDPolycomb protein EEDO7553082gPolycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine5u8f77.0611.
5EEDPolycomb protein EEDO7553073kCrystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound5wuk72.4214.
6EEDPolycomb protein EEDO7553073kEED in complex with an allosteric PRC2 inhibitor5gsa74.1182.
7EEDPolycomb protein EEDO75530lqeEED in complex with PRC2 allosteric inhibitor EED2105h1775.48890.
8EEDPolycomb protein EEDO75530lqfEED in complex with PRC2 allosteric inhibitor EED1625h1976.01320.
9EEDPolycomb protein EEDO755306puTargeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED5k0m69.52no data
10EEDPolycomb protein EEDO75530lqdEED in complex with PRC2 allosteric inhibitor EED7095h1576.451570.
11EEDPolycomb protein EEDO75530lqdPolycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine5u6978.24600.
12EEDPolycomb protein EEDO755307xgPolycomb protein EED in complex with inhibitor: 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide5u6d70.672.6
13EEDPolycomb protein EEDO7553082dPolycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine5u8a77.8613.
14EEDPolycomb protein EEDO755307wdCrystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine5u6287.231300.
15EEDPolycomb protein EEDO755307w7Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide5u5t88.423900.
16EEDPolycomb protein EEDO755307vvCrystal structure of EED in complex with 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine5u5h77.441300.
17FBW1AF-box/WD repeat-containing protein 1AQ9Y297BTRCP FBW1A FBXW1Aj91Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex6m9065.78no data
18WDR5WD repeat-containing protein 5P61964BIG3hlsDisplacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity6e2274.97no data
19WDR5WD repeat-containing protein 5P61964BIG3hlmDiscovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design6e1y82.26no data
20WDR5WD repeat-containing protein 5P61964BIG3hljDisplacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity6e2386.06no data
21WDR5WD repeat-containing protein 5P61964BIG3hhmWDR5 in complex with a WIN site inhibitor6dya76.55no data
22WDR5WD repeat-containing protein 5P61964BIG3hh7WDR5 in complex with a WIN site inhibitor6dy781.13no data
23WDR5WD repeat-containing protein 5P61964BIG3g2jDiscovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design6dar75.76no data
24WDR5WD repeat-containing protein 5P61964BIG3g2dDiscovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design6das81.78no data
25WDR5WD repeat-containing protein 5P61964BIG35moCrystal structure of human WDR5 in complex with compound 9e5eap87.54no data
26WDR5WD repeat-containing protein 5P61964BIG35mlCrystal structure of human WDR5 in complex with compound 9h5eal84.04no data
27WDR5WD repeat-containing protein 5P61964BIG335qCrystal structure of human WDR5 in complex with compound OICR-94294ql171.9993.
28WDR5WD repeat-containing protein 5P61964BIG3np7Crystal structure of human WD repeat domain 5 with compound3smr84.74no data
29WDR5WD repeat-containing protein 5P61964BIG30bwCrystal structure of human WD repeat domain 5 with compound3ur488.05no data
30WDR5WD repeat-containing protein 5P61964BIG3ia9Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide4ia990no data
31WDR5WD repeat-containing protein 5P61964BIG35mqCrystal structure of human WDR5 in complex with compound 9d5ear84.46no data
32WDR5WD repeat-containing protein 5P61964BIG3g2vDiscovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design6dai88.31no data
33WDR5WD repeat-containing protein 5P61964BIG3g1yDiscovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design6dak77.46no data