The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	gce	Eg5-inhibitor complex	6hky	82	no data
2	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	gce	Eg5-inhibitor complex	6hkx	83.34	no data
3	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	g7x	The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib	4ap0	89.46	10.
4	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	g7x	Intermediate state of human kinesin Eg5 in complex with Ispinesib	4a5y	90.93	no data
5	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	6lx	Eg5(WT) complex	4bxn	83.65	10.
6	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	6lx	Eg5 complex 1	4as7	89.34	no data
7	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	5c5	Kinesin spindle protein Eg5 in complex with STLC-type inhibitor PVEI0138	5zo7	83.49	no data
8	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	2az	Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide	2gm1	88.55	100.
9	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	nat	Human Eg5 motor domain bound to Mg-ADP and monastrol	1x88	82.04	no data
10	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	nat	Crystal structure of the motor protein KSP in complex with ADP and monastrol	1q0b	81.15	6700.
11	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	l47	Crystal structure of KSP in complex with inhibitor 1	1yrs	90.48	450.
12	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	n2t	crystal structure of KSP in complex with inhibitor 13	2fky	78.99	2.6
13	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	n4t	crystal structure of KSP in complex with inhibitor 19	2fl2	85.37	2.
14	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	n5t	crystal structure of KSP in complex with inhibitor 6	2fl6	86.57	38.
15	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	3qc	Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide	2fme	87.7	104.
16	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	n9h	crystal structure of KSP in complex with inhibitor 9h	2g1q	82.28	44.
17	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	moy	Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer	2ieh	88.39	110.
18	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	k01	Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 15	2pg2	88.24	1700.
19	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	mkr	Crystal Structure of KSP in complex with Inhibitor 1	2q2y	68.03	1.6
20	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	mkk	Crystal Structure of KSP in Complex with Inhibitor 22	2q2z	72.47	2.
21	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	k02	Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33	2uyi	90	480.
22	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	k03	Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37	2uym	89.48	3100.
23	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	kz9	Crystal structure of human kinesin Eg5 in complex with (S)-enastron	2x7c	87.92	2000.
24	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	egb	Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron	2x7d	84.15	200.
25	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	x7e	Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol	2x7e	87.68	no data
26	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	k30	Crystal structure of KSP in complex with inhibitor 30	3cjo	76.02	2.2
27	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	l31	Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline	3k3b	87.47	200.
28	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	k5e	The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol.	3k5e	87.31	no data
29	KIF11	Kinesin-like protein KIF11	P52732	EG5 KNSL1 TRIP5	emq	X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085	3l9h	82.91	8.

The Ligandable Human Proteome

Kinesin motor domain