The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	RASK	GTPase KRas	P01116	KRAS2 RASK2	o67	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.	6p8w	83.14	no data
2	RASK	GTPase KRas	P01116	KRAS2 RASK2	o5y	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.	6p8y	72.62	no data
3	RASK	GTPase KRas	P01116	KRAS2 RASK2	o5v	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.	6p8x	93.74	no data
4	RASK	GTPase KRas	P01116	KRAS2 RASK2	o5s	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor	6p8z	74.59	no data
5	RASK	GTPase KRas	P01116	KRAS2 RASK2	k9m	Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C	6n2j	93.22	no data
6	RASK	GTPase KRas	P01116	KRAS2 RASK2	k9j	Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C	6n2k	86.36	no data
7	RASK	GTPase KRas	P01116	KRAS2 RASK2	94f	Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739	5yy1	97.02	no data
8	RASK	GTPase KRas	P01116	KRAS2 RASK2	91g	KRAS G12C inhibitor	5v9o	84.24	no data
9	RASK	GTPase KRas	P01116	KRAS2 RASK2	91d	KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder	5v9l	64.78	no data
10	RASK	GTPase KRas	P01116	KRAS2 RASK2	21f	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C	4lyh	81.23	no data
11	RASK	GTPase KRas	P01116	KRAS2 RASK2	21f	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group	4lyj	81.82	no data
12	RASK	GTPase KRas	P01116	KRAS2 RASK2	20g	Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C	4luc	86.92	no data
13	RASK	GTPase KRas	P01116	KRAS2 RASK2	20h	Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C	4lv6	87.67	no data
14	RASK	GTPase KRas	P01116	KRAS2 RASK2	21c	Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C	4lyf	78.42	no data
15	RASK	GTPase KRas	P01116	KRAS2 RASK2	5ut	Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C	5f2e	96.45	no data
16	RASK	GTPase KRas	P01116	KRAS2 RASK2	8yd	Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C	5v6s	94.82	no data
17	RASK	GTPase KRas	P01116	KRAS2 RASK2	8ya	Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C	5v6v	85.55	no data
18	RASK	GTPase KRas	P01116	KRAS2 RASK2	91s	Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C	5v9u	96.71	no data
19	RASK	GTPase KRas	P01116	KRAS2 RASK2	94c	Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484	5yxz	86.26	no data
20	RASK	GTPase KRas	P01116	KRAS2 RASK2	c8g	Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C	6b0v	92.22	no data
21	RASK	GTPase KRas	P01116	KRAS2 RASK2	8zg	KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder	5v71	76.23	no data
22	RASK	GTPase KRas	P01116	KRAS2 RASK2	8zg	Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C	6b0y	92.17	no data
23	RASN	GTPase NRas	P01111	HRAS1	f8q	KRAS-169 Q61H GPPNHP + CH-3	6gqy	66.41	no data
24	RASN	GTPase NRas	P01111	HRAS1	f6e	KRAS-169 Q61H GPPNHP + PPIN-1	6gom	62.32	no data
25	RASN	GTPase NRas	P01111	HRAS1	f0k	CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852	6gj8	50.88	no data
26	RASN	GTPase NRas	P01111	HRAS1	f0b	CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 22	6gj7	52.98	no data
27	RASN	GTPase NRas	P01111	HRAS1	ezz	CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 18	6gj6	75.41	no data
28	RASN	GTPase NRas	P01111	HRAS1	d1z	Antibody derived (Abd-6) small molecule binding to KRAS.	6fa3	59.77	no data
29	RASN	GTPase NRas	P01111	HRAS1	0qw	Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation	4ept	75.02	no data
30	RASN	GTPase NRas	P01111	HRAS1	0qr	Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation	4epx	75.5	no data
31	RASN	GTPase NRas	P01111	HRAS1	0qy	Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation	4epy	59.32	340000.
32	RASN	GTPase NRas	P01111	HRAS1	9rk	Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.	5oco	67.62	no data
33	RASN	GTPase NRas	P01111	HRAS1	d2z	Antibody derived (Abd-4) small molecule binding to KRAS.	6fa1	45.51	no data
34	RASN	GTPase NRas	P01111	HRAS1	d2w	Antibody derived (Abd-5) small molecule binding to KRAS.	6fa2	53.67	no data
35	RASN	GTPase NRas	P01111	HRAS1	d1w	Antibody derived (Abd-7) small molecule binding to KRAS.	6fa4	69.02	no data

The Ligandable Human Proteome

Small GTPase