The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	MMP1	Interstitial collagenase	P03956	CLG	rs2	CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID	966c	79.21	23.
2	MMP10	Stromelysin-2	P09238	STMY2	ngh	Crystal structure of the catalytic domain of human matrix metalloproteinase 10	1q3a	84.91	no data
3	MMP12	Macrophage metalloelastase	P39900	HME	hs5	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-hydroxyethyl)-N-(2-nitroso-2-oxoethyl)benzenesulfonamide	3f18	77	39.5
4	MMP12	Macrophage metalloelastase	P39900	HME	deo	Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid	1ros	81.17	1.7
5	MMP12	Macrophage metalloelastase	P39900	HME	b9z	Crystal structure of MMP12 in complex with inhibitor BE4.	6ela	79.82	no data
6	MMP12	Macrophage metalloelastase	P39900	HME	b9n	Crystal structure of MMP12 in complex with inhibitor BE7.	6ekn	76.66	no data
7	MMP12	Macrophage metalloelastase	P39900	HME	cp8	Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid	1utt	81.81	100000.
8	MMP12	Macrophage metalloelastase	P39900	HME	576	MMP12 complex with a beta hydroxy carboxylic acid	2woa	90	1150.
9	MMP12	Macrophage metalloelastase	P39900	HME	cgs	Crystal Structure Analysis of human Macrophage Elastase MMP-12	1jiz	66.42	2.
10	MMP12	Macrophage metalloelastase	P39900	HME	cgs	Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.	2w0d	84.5	2.
11	MMP12	Macrophage metalloelastase	P39900	HME	jt5	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(N-hydroxyethyl)biphenyl-4-ylsulfonamido)acetamide	3n2v	79.07	31.
12	MMP12	Macrophage metalloelastase	P39900	HME	nhk	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-Hydroxy-2-(N-(2-hydroxyethyl)4-methoxyphenylsulfonamido)acetamide	3nx7	78.7	7.88
13	MMP12	Macrophage metalloelastase	P39900	HME	z79	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor paramethoxy-sulfonyl-glycine hydroxamate	3lk8	87.26	19.7
14	MMP12	Macrophage metalloelastase	P39900	HME	0d2	MMP12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5-phenylhydantoin	3uvc	97.07	no data
15	MMP12	Macrophage metalloelastase	P39900	HME	ngh	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH	5lab	76.02	no data
16	MMP12	Macrophage metalloelastase	P39900	HME	ngh	Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A resolution	1rmz	76.11	10.
17	MMP12	Macrophage metalloelastase	P39900	HME	e37	Human MMP12 in complex with L-glutamate motif inhibitor	4efs	91.34	2.5
18	MMP12	Macrophage metalloelastase	P39900	HME	10b	Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor	4h76	77.7	no data
19	MMP12	Macrophage metalloelastase	P39900	HME	y38	Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.	4h84	95.62	no data
20	MMP12	Macrophage metalloelastase	P39900	HME	lpw	Crystal structure of MMP12 in complex with hydroxamate inhibitor LP168.	6enm	79.61	no data
21	MMP13	Collagenase 3	P45452		az6	Mmp13 in complex with a piperazine hydantoin ligand	4jpa	77.5	3.3
22	MMP13	Collagenase 3	P45452		az4	Mmp13 in complex with a reverse hydroxamate Zn-binder	4jp4	79.78	no data
23	MMP13	Collagenase 3	P45452		8om	Matrix metalloproteinase-13 complexed with selective inhibitor compound (S)-10a	5uwk	83.14	2.3
24	MMP13	Collagenase 3	P45452		518	MMP-13 in complex with a non zinc-chelating inhibitor	3i7i	76.64	620.
25	MMP13	Collagenase 3	P45452		3kr	Crystal structure of MMP-13 in complex with SC-78080	3kry	73.92	0.1
26	MMP13	Collagenase 3	P45452		24f	Crystal Structure of MMP-13 Complexed with Inhibitor 24f	3elm	78.87	0.19
27	MMP13	Collagenase 3	P45452		033	Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033	1ztq	77.18	1.3
28	MMP13	Collagenase 3	P45452		pb3	Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1xuc	90	72.
29	MMP13	Collagenase 3	P45452		pb4	Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1xud	90.19	8.
30	MMP13	Collagenase 3	P45452		pb5	Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1xur	91.85	6600.
31	MMP13	Collagenase 3	P45452		pfd	Crystal structure of the catalytic domain of MMP-13 complexed with a potent pyrimidinetrione inhibitor	1you	76.97	0.87
32	MMP13	Collagenase 3	P45452		gg1	MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid	2ozr	91.53	0.67
33	MMP13	Collagenase 3	P45452		347	Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344	2pjt	65.66	860.
34	MMP13	Collagenase 3	P45452		5el	MMP13 in complex with a novel selective non zinc binding inhibitor	2yig	75.66	79.4
35	MMP13	Collagenase 3	P45452		732	MMP-13 in complex with a non zinc-chelating inhibitor	3i7g	75.04	430.
36	MMP13	Collagenase 3	P45452		3ke	Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound	3kec	90.86	58.
37	MMP13	Collagenase 3	P45452		3ej	Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound	3kej	89.83	75.9
38	MMP13	Collagenase 3	P45452		3ek	Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound	3kek	89.49	4.4
39	MMP13	Collagenase 3	P45452		la3	Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound	3ljz	76.33	7.3
40	MMP13	Collagenase 3	P45452		whh	Crystal structure of the catalytic domain of MMP-13 complexed with 4-(2-((6-fluoro-2-((3-methoxybenzyl)carbamoyl)-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)benzoic acid	3wv1	92.27	0.0039
41	MMP13	Collagenase 3	P45452		wgg	Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide	3wv2	89.26	12.
42	MMP13	Collagenase 3	P45452		wll	Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide	3wv3	86.71	24.
43	MMP13	Collagenase 3	P45452		e41	MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor	3zxh	69.37	3.
44	MMP13	Collagenase 3	P45452		cbp	STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)	1cxv	80.77	no data
45	MMP13	Collagenase 3	P45452		cbp	CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID	456c	77.95	0.17
46	MMP13	Collagenase 3	P45452		3w4	MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22	4a7b	75.78	no data
47	MMP13	Collagenase 3	P45452		3w5	MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22	4a7b	74.85	39.8
48	MMP13	Collagenase 3	P45452		wnn	Crystal structure of the catalytic domain of MMP-13 complexed with 4-oxo-N-(3-(2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy)benzyl)-3,4-dihydroquinazoline-2-carboxamide	5b5p	83.05	0.2
49	MMP13	Collagenase 3	P45452		4uf	X-RAY Co-structure of MMP-13 with 4-[({5-[2-(ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}formamido)methyl]benzoate	5bpa	87.87	1.
50	MMP13	Collagenase 3	P45452		8oj	Matrix metalloproteinase-13 complexed with selective inhibitor compound (S)-17a	5uwl	85.67	9.4
51	MMP13	Collagenase 3	P45452		rs1	COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID	830c	79.19	0.52
52	MMP3	Stromelysin-1	P08254	STMY1	spc	CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR.	1d7x	87.97	3.
53	MMP3	Stromelysin-1	P08254	STMY1	n25	DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS	1bqo	71.95	18.4
54	MMP3	Stromelysin-1	P08254	STMY1	in7	X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXED WITH NON-PEPTIDE INHIBITORS: IMPLICATIONS FOR INHIBITOR SELECTIVITY	1b8y	88.3	14.
55	MMP3	Stromelysin-1	P08254	STMY1	s80	DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS	1biw	65.69	104.
56	MMP3	Stromelysin-1	P08254	STMY1	mm3	CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR.	1d5j	76.72	0.7
57	MMP3	Stromelysin-1	P08254	STMY1	hqq	X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin	1g4k	87.21	2000.
58	MMP3	Stromelysin-1	P08254	STMY1	in9	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372	1usn	61.35	18.
59	MMP3	Stromelysin-1	P08254	STMY1	ohl	catalytic domain of stromelysin-1 in complex with N-Hydroxy-2-(4-methoxy-N-(pyridine-3-ylmethyl)phenylsulfonamido)acetamide	3ohl	73.32	no data
60	MMP3	Stromelysin-1	P08254	STMY1	z79	catalytic domain of stromelysin-1 in complex with N-Hydroxy-2-(4-methylphenylsulfonamido)acetamide	3oho	85.51	no data
61	MMP7	Matrilysin	P09237	MPSL1 PUMP1	tqj	The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger	2y6d	72.49	79.
62	MMP7	Matrilysin	P09237	MPSL1 PUMP1	rss	MATRILYSIN COMPLEXED WITH CARBOXYLATE INHIBITOR	1mmp	64.76	850.
63	MMP7	Matrilysin	P09237	MPSL1 PUMP1	rrs	MATRILYSIN COMPLEXED WITH HYDROXAMATE INHIBITOR	1mmq	65.11	30.
64	MMP7	Matrilysin	P09237	MPSL1 PUMP1	srs	MATRILYSIN COMPLEXED WITH SULFODIIMINE INHIBITOR	1mmr	64.49	4000.
65	MMP8	Neutrophil collagenase	P22894	CLG1	axb	Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor	3dpf	85.71	57.
66	MMP8	Neutrophil collagenase	P22894	CLG1	axb	Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor	3dpe	85.72	57.
67	MMP8	Neutrophil collagenase	P22894	CLG1	bsi	CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909	1bzs	76.55	10.
68	MMP8	Neutrophil collagenase	P22894	CLG1	bsi	COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)	1i76	76.9	no data
69	MMP8	Neutrophil collagenase	P22894	CLG1	bbt	Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition	1jj9	70.46	1700.
70	MMP8	Neutrophil collagenase	P22894	CLG1	2ni	Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor	1zp5	80.7	1.2e+006
71	MMP8	Neutrophil collagenase	P22894	CLG1	axa	Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor	3dng	92.01	7.4
72	MMP9	Matrix metalloproteinase-9	P14780	CLG4B	10b	Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain	4h3x	92.01	no data
73	MMP9	Matrix metalloproteinase-9	P14780	CLG4B	e40	Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain	4wzv	87.09	0.43
74	MMP9	Matrix metalloproteinase-9	P14780	CLG4B	b9z	Crystal structure of MMP9 in complex with inhibitor BE4.	6esm	82.13	no data

The Ligandable Human Proteome

Peptidase M10, metallopeptidase