The Ligandable Human Proteome

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Receptor, ligand binding region

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1GABR1Gamma-aminobutyric acid type B receptor subunit 1Q9UBS5GPRC3A2c0Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist baclofen4ms497.36no data
2GRM2Metabotropic glutamate receptor 2Q14416GPRC1B MGLUR26ysMetabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid5kzq74.115.3
3GRM2Metabotropic glutamate receptor 2Q14416GPRC1B MGLUR252qmGlur2 with glutamate analog5cnj94.02144.
4GRM3Metabotropic glutamate receptor 3Q14832GPRC1C MGLUR3cwyStructure of mGluR3 with an agonist6b7h97.91no data
5GRM3Metabotropic glutamate receptor 3Q14832GPRC1C MGLUR352qmGluR3 complexed with glutamate analog5cnm65.23156.
6GRM8Metabotropic glutamate receptor 8O00222GPRC1H MGLUR8hvghuman mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)6e5v91.55no data