The Ligandable Human Proteome

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3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pfwStructure of PDE10-inhibitor complex3qpp74.0512.
2PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233jy7Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors6msc83.97no data
3PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2339g6Crystal structure of PDE10A catalytic domain complexed with LHB-65znl77.78no data
4PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2334xuPDE10 complexed with 6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine5c2h81.660.0082
5PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2332f4Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor4muw84.449.7
6PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2330t7Potent and Selective Phosphodiesterase 10A Inhibitors4fcb80.362.9
7PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233227Crystal structure of the catalytic domain of rat phosphodiesterase 10A2o8h60.525.
8PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pfhCrystal structure of the catalytic domain of rat phosphodiesterase 10A2ovv71.3312.
9PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233ev1Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals2wey81.2876.
10PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pf6Discovery of novel inhibitors of PDE10A3hqy82.9311.5
11PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pfrStructure of PDE10-inhibitor complex3qpo70.84247.
12PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233540Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors3sn783.920.7
13PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233546Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors3sni82.1411.
14PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233c1lDiscovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia3ui779.871.
15PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233x4cCrystal structure of PDE10A in complex with a benzimidazole inhibitor3ws877.36210.
16PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233lkfDiscovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia4bbx78.48no data
17PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2330jqPDE10a Crystal Structure Complexed with Novel Inhibitor4ddl66.584.9
18PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2330t6Potent and Selective Phosphodiesterase 10A Inhibitors4fcd80.940.28
19PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y23315hCrystal Structure of PDE10A with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol)4hf483.812.4
20PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2332f5Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor4mvh83.824.5
21PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2332w1Crystal Structure of PDE10A with 1H-benzimidazol-2-yl(4-((3-(tetrahydro-2H-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone4phw84.630.1
22PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2334lpCrystal structure of the catalytic domain of PDE10A complexed with highly potent and brain-penetrant PDE10A Inhibitor with 2-oxindole scaffold5axq71.940.08
23PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2336dwCrystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one5b4l78.560.76
24PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2334xyPDE10 complexed with 6-chloro-2-cyclopropyl-5-methyl-N-propyl-pyrimidin-4-amine5c2986.03880.
25PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2334y2PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine5c2a85.484.8
26PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2335ayPDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine5dh587.50.23
27PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2335m6human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A5ede73.32no data
28PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2336rcPDE10a with imidazopyrazine inhibitor5k9r77.08no data
29PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2338q7Crystal structure of human PDE10A in complex with inhibitor 16d5uwf81.9759.
30PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2338g3Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)et hyl]pyrazolo[1,5-a]pyrimidin-7-ol5xui82.66no data
31PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2335m9human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5%5edi84.10.3
32PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2335mfhuman PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7%5edh84.16no data
33PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2336dtCrystal structure of the catalytic domain of human PDE10A complexed with N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine5b4k85.130.46
34PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233490Crystal structure of PDE10A in complex with ASP94364xy278.388.
35PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y23315jCrystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol)4heu90.530.097
36PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233f03Identification and structural characterization of PDE10 fragment inhibitors4ajf83.68no data
37PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y2334hnPDE10A in complex with the inhibitor AZ54ael84.0912.
38PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pfkStructure of PDE10-inhibitor complex3qpn81.2117.
39PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pf9Discovery of novel inhibitors of PDE10A3hr186.360.37
40PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233axcTriazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation.2y0j75.6612.
41PDE10cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233pfjCrystal structure of the catalytic domain of rat phosphodiesterase 10A2ovy71.334.
42PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B4qjCrystal structure of human PDE1B with inhibitor 35b2579.330.058
43PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B0nkCrystal structure of human PDE1B bound to inhibitor 7A (6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine)4npv83.4735.
44PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B0nyPDE1b complexed with compound 3S5w6e90.26no data
45PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B0nyCrystal structure of human PDE1B bound to inhibitor 19A (7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine)4npw90.63no data
46PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B8hmCrystal structure of human PDE1B catalytic domain in complex with inhibitor 16j (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)5uoy82.8927.
47PDE1BCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BQ01064PDE1B1 PDES1B8hpCrystal structure of human PDE1B catalytic domain in complex with inhibitor 3 (6-(4-chlorobenzyl)-8,9,10,11-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)5up080.09460.
48PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408epvCrystal structure of human phosphodiesterase 2A with 1-(5-tert-butoxy-2-chloro-phenyl)-N-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7j79.74no data
49PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408eoyCrystal structure of human phosphodiesterase 2A with N-(1-adamantyl)-1-(2-chloro-5-isobutoxy-phenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7g77.65no data
50PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408eojCrystal structure of human phosphodiesterase 2A with N-(1-adamantyl)-1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7d76.22no data
51PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408dy1PDE2 complexed with 2-[6-fluoro-8-methylsulfonyl-9-[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid6blf84.13no data
52PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087ovCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluoro-3-iodophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5u0082.692.
53PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408ibmhPDE2A catalytic domain complexed with IBMX3itu85.3240000.
54PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408q2tPDE2a catalytic domain in complex with a brain penetrant inhibitor4d0885.6410.
55PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408788PDE2a catalytic domain in complex with a brain penetrant inhibitor4d0977.31.7
56PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004081l6Crystal structure of of PDE2-inhibitor complex4jib77.2445.
57PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087omCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX with [1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-N-(naphthalene-2-yl)piperidine-3-carboxamide5tz380.89140.
58PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087ogCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A WITH 3-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-1-[(naphthalene-2-yl)carbonyl]piperidine5tza81.511.
59PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087ojCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3-bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5tzz82.3714.
60PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087ojCrystal Structure of human PDE2a in complex with (5S)-1-[(3-bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5tzc82.248.
61PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087opCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5tzh80.38679.
62PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087p4CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3,4-difluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5tzw80.33987.
63PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087oyCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3-chloro-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine5tzx82.3852.
64PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO0040819fCrystal structure of PDE2 catalytic domain in complex with BAY60-75504htx85.34.7
65PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO0040819fPDE2 catalytic domain complexed with inhibitors5u7d84.390.5
66PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087xsPDE2 catalytic domain complexed with inhibitors5u7i77.2366.6
67PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087xvPDE2 catalytic domain complexed with inhibitors5u7j76.49389.6
68PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087y1PDE2 catalytic domain complexed with inhibitors5u7k87.837.1
69PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004087y4PDE2 catalytic domain complexed with inhibitors5u7l84.82423.
70PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004089gjDiscovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders5vp087.810.61
71PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO004089gaDiscovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders5vp184.30.51
72PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO0040887rCrystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide5xkm90.7724.
73PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408czvCrystal Structure of PDE2 in complex with compound 166b9687.7614.3
74PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408czyCrystal structure of PDE2 in complex with complex 96b9789.48237.
75PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408eogCrystal structure of human phosphodiesterase 2A with 1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7e79.99no data
76PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408eosCrystal structure of human phosphodiesterase 2A with 1-(2-chloro-5-isobutoxy-phenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7f83.6no data
77PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408ep7Crystal structure of human phosphodiesterase 2A with 1-(2-chloro-5-methoxy-phenyl)-N-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide6c7i77.68no data
78PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408fkvPDE2 in complex with compound 76cyb98.71no data
79PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408fkjPDE2 in complex with compound 56cyc98.36no data
80PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408fkgPDE2 in complex with compound 76cyd97.33no data
81PDE2AcGMP-dependent 3',5'-cyclic phosphodiesteraseO00408c6zPDE2 in complex with molecule 56ezf92.06no data
82PDE3BcGMP-inhibited 3',5'-cyclic phosphodiesterase BQ13370666CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR1so279.840.27
83PDE3BcGMP-inhibited 3',5'-cyclic phosphodiesterase BQ13370ibmCATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX1soj86.37242.
84PDE4AcAMP-specific 3',5'-cyclic phosphodiesterase 4AP27815DPDE20moCrystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone3i8v88.89no data
85PDE4AcAMP-specific 3',5'-cyclic phosphodiesterase 4AP27815DPDE2pnxThe structure of PDE4A with pentoxifylline at 2.84A resolution3tvx82.5172000.
86PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4zg2Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor3o5778.290.0794
87PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4viaCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil1xos85.6720000.
88PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4vdnCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil1xot76.233800.
89PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE46m5Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-0015laq73.98no data
90PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE419tSelective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-334myq91.4332.
91PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4066Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor3gwt84.080.00794
92PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4rolCatalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram1xn092.47570.
93PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4rolCatalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram1xmy87.9750.12
94PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4rolCrystal structure of PDE4B2B complexed with Rolipram (R & S)1ro689.41350.
95PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4filCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast1xlz83.2960.
96PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4pilCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast1xm489.890.041
97PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4rofCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast1xmu89.150.84
98PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4cioCatalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast1xlx89.0425.
99PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE420aCrystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor3d3p82.073.16
100PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4sk4Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor3frg84.813.98
101PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE40cpCrystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.3kkt93.74no data
102PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4z72Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor3ly287.745.
103PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4nvwCrystal structure of phosphodiesterase 4B in complex with compound 31e3w5e90.9111.
104PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4qpcCrystal structure of phosphodiesterase 4B in complex with compound 10f3wd991.378.3
105PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE42o5PDE4 catalytic domain4nw790.19237.
106PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE46qqHuman Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor5k6j86.66no data
107PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BQ07343DPDE4hbtCatalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene inhibitor3hmv91.8650.12
108PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3m99Crystal structure of PDE4D2 in complex with inhibitor L-8692992fm577.5443.
109PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3m98Crystal structure of PDE4D in complex with L-8692982fm077.960.4
110PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3krdCrystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-486njh92.77no data
111PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3kr4Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-496nji93.77no data
112PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ihmCrystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide3v9b83.430.5
113PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ffzCrystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-13356hwo78.64no data
114PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3e8hCrystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-0076fw377.25no data
115PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3e6zCrystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-0486ftw82.49no data
116PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d62Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-3566fe778.26no data
117PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d5zCrystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-10866feb76.94no data
118PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d5tCrystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-2266fdi75.88no data
119PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3akuCrystal structure of PDE4D complexed with a novel inhibitor6inm75.62no data
120PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3akuCrystal structure of PDE4D complexed with a novel inhibitor6ink74.64no data
121PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3akoCrystal structure of PDE4D complexed with a novel inhibitor6ind75.94no data
122PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ak0Crystal structure of PDE4D complexed with a novel inhibitor6imt77.73no data
123PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ajxCrystal structure of PDE4D complexed with a novel inhibitor6imr86.81no data
124PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ajlCrystal structure of PDE4D complexed with a novel inhibitor6imo78.19no data
125PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE36m5Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-0015lbo74.8no data
126PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rolCrystal structure of human phosphodiesterase 4d with rolipram3g4k91.53288.
127PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rolCatalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram1tbb88.36no data
128PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rolCrystal structure of PDE4D2 in complex with (R,S)-rolipram1oyn84.82550.
129PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rolThree dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity1q9m85.88330.
130PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3pilCatalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast1xon94.230.021
131PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rofCatalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast1xoq88.960.68
132PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3rofCrystal structure of human phosphodiesterase 4d with roflumilast3g4l88.675.8
133PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3cioCatalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast1xom87.0111.
134PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ev1Crystal structure of human phosphodiesterase 4d (PDE4d) with papaverine.3iak78.67no data
135PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d71Crystal structure of human phosphodiesterase 4d with d1558713g4i82.990.91
136PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE315xCrystal structure of human phosphodiesterase 4D with bound allosteric modulator3iad89.441.
137PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3ibmStructure of PDE4D2-IBMX1zkn75.5731000.
138PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE30moThe structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone3k4s86.23no data
139PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3j25Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d3sl577.2322.
140PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE33gjPDE4D complexed with inhibitor4w1o83.64no data
141PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE33kqPDE4 complexed with inhibitor4wcu88.83.
142PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE36ptPDE4 crystal structure in complex with small molecule inhibitor5k1i83.269.2
143PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE36q2PDE4D crystal structure in complex with small molecule inhibitor5k3292.05no data
144PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE37djCRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND5tkb78.3713.
145PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3r91Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-915wh589.98no data
146PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3akjCrystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)5wh689.95no data
147PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3e31Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN50046boj92.79no data
148PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3cv8Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b6f6u82.35no data
149PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3czkCrystal structure of the PDE4D catalytic domain in complex with GEBR-546f8r81.79no data
150PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3cztCrystal structure of the PDE4D catalytic domain in complex with GEBR-4a6f8t80.33no data
151PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3czqCrystal structure of the PDE4D catalytic domain in complex with GEBR-20b6f8u83.39no data
152PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d0bCrystal structure of the PDE4D catalytic domain in complex with GEBR-18b6f8v85.49no data
153PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d0eCrystal structure of the PDE4D catalytic domain in complex with GEBR-18a6f8w87.55no data
154PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d08Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g6f8x90.03no data
155PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3d5nCrystal structure of the PDE4D catalytic domain in complex with GEBR-32a6fdc78.52no data
156PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3dd5Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a6fdc79.27no data
157PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3jn7Crystal structure of the catalytic domain of PDE4D2 with compound 10o3sl872.45290.
158PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3jn8Crystal structure of the catalytic domain of PDE4D2 with compound 12c3sl674.15no data
159PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499DPDE3jn4Crystal structure of the catalytic domain of PDE4D2 with compound 10D3sl474.9827.
160PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5viaCrystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)1udt80.380.5
161PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5viaCrystal structure of PDE5 in complex with sildenafil2h4286.912.4
162PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5vdnCrystal Structure of PDE5A1 catalytic domain in complex with Vardenafil3b2r82.34no data
163PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5vdnCrystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra)1uho75.340.6
164PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE59t9Crystal structure of PDE5 in complex with inhibitor LW18056acb71.57no data
165PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE59m0Crystal structure of PDE5 in complex with inhibitor LW16345zz288.42no data
166PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE57caCrystal structure of PDE5A1 in complex with icarisid II2h4498.111700.
167PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55ioCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors4oew75.14152.
168PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55bbCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors4ia070.8577.
169PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE524eCrystal structure of PDE5 in complex with inhibitor 5R4md686.3317.
170PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5ciaCrystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)1udu88.280.9
171PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5wanCrystal structure of the PDE5A catalytic domain in complex with a novel inhibitor3bjc76.78110.
172PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5ibmCrystal structure of PDE5A1-IBMX1rkp87.16no data
173PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55foCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors3shy72.1290.9
174PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55coCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors3shz67.2235.9
175PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55boCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors3sie77.3613.3
176PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5ni0Crystal structure of PDE5A in complex with its inhibitor4g2w71.471.6
177PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55baCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors4i9z74.4918.2
178PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE55eoCrystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors4oex69.651450.
179PDE5AcGMP-specific 3',5'-cyclic phosphodiesteraseO76074PDE5ni5Crystal structure of PDE5A complexed with its inhibitor4g2y70.061000.
180PDE7AHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AQ13946ibmMultiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases1zkl82.718100.
181PDE7AHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AQ1394632vPDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivative4pm086.3645.
182PDE7AHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AQ13946epkCo-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A4y2b81.244.4
183PDE7AHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AQ13946tc8PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one3g3n76.02510.
184PDE8AHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AO60658ibmCrystal structure of PDE8A catalytic domain in complex with IBMX3ecn79.29698000.
185PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO760839q9Crystal structure of the PDE9 catalytic domain in complex with inhibitor 26a3n79.66no data
186PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083wtcHuman phosphodiesterase 9 in complex with inhibitor3jsi87.552.1
187PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083jarHuman PDE9 in complex with selective inhibitor3jsw78.5866.
188PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmCrystal structure of PDE9 in complex with IBMX2hd180.87500000.
189PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmCrystal structure of PDE9A (E406A) mutant in complex with IBMX3n3z86.78no data
190PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmCrystal structure of PDE9A(Q453E) in complex with IBMX3qi478.45117200.
191PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmhuman phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP3dyq69.95no data
192PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmhuman phosphodiestrase-5'GMP complex (EP), produced by soaking with 20mM cGMP+20 mM MnCl2+20 mM MgCl2 for 2 hours, and flash-cooled to liquid nitrogen temperature when substrate was still abudant.3dys74.07no data
193PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083pdbCrystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-66913qi384.55164200.
194PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083pdbCrystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-66913k3e84.5222.
195PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083byeCrystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-66913k3h83.5788.
196PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO760837rgHuman phosphodiesterase 9 in complex with inhibitors4e9074.2no data
197PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO760830wfHuman pde9 in complex with selective compound4g2j76.1411.
198PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO760830wlHuman PDE9 in complex with selective compound4g2l73.6932.
199PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083luoCrystal structure of the PDE9A catalytic domain in complex with inhibitor 284gh672.2221.
200PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO7608335ophosphodiesterase-9A in complex with inhibitor WYQ-C36D4qge76.560.5
201PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO7608349eCrystal structure of PDE9 in complex with racemic inhibitor C334y8677.62no data
202PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO7608349dCrystal structure of PDE9 in complex with racemic inhibitor C334y8685.54no data
203PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO7608349dCrystal structure of phosphodiesterase 9 in complex with (S)-C334y8c86.9411.
204PDE9AHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AO76083ibmCrystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX2yy275.07no data