The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	9v8	Crystal structure of autotaxin in complex with BI-2545	5ohi	84.03	no data
2	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	7nb	Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity	5mhp	84.61	15.
3	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	7hr	Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity	5m7m	83.22	357.
4	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	6xn	Crystal structure of murine autotaxin in complex with a small molecule inhibitor	5lia	93.65	no data
5	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	4ny	Structural basis for inhibition of human autotaxin by four novel compounds	4zg6	89.06	472.
6	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	dwv	Crystal Structure of Autotaxin in Complex with Compound 10	3wav	84.69	180.
7	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	dww	Crystal Structure of Autotaxin in Complex with 2BoA	3waw	81.89	580.
8	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	4o3	Structural basis for inhibition of human autotaxin by four novel compounds	4zga	93.33	20.
9	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	6zm	Crystal Structure of Autotaxin and Compound 1	5l0b	89.56	no data
10	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	6zo	crystal structure of autotaxin in complex with PF-8380	5olb	87.44	no data
11	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	7cr	Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors	5m0e	89.56	no data
12	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	dwy	Crystal Structure of Autotaxin in Complex with 4BoA	3way	85.41	22.
13	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q13822	ATX PDNP2	dwx	Crystal Structure of Autotaxin in Complex with 3BoA	3wax	85.56	13.

The Ligandable Human Proteome

Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase