The Ligandable Human Proteome

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Actin family

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1ACTSActin, alpha skeletal muscleP68133ACTAlabLokiProfilin2/Rabbit Actin Complex5zzb85.55no data
2ACTSActin, alpha skeletal muscleP68133ACTAlabOdinProfilin/Rabbit Actin Complex5zza78.78no data
3ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of ArhGAP12 bound to G-Actin6gvc84.92no data
4ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of Pectenotoxin-2 and Latrunculin B Bound to Actin2q0u81.83no data
5ACTSActin, alpha skeletal muscleP68133ACTAlabStructures of actin-bound WH2 domains of Spire and the implication for filament nucleation3mn579.26no data
6ACTSActin, alpha skeletal muscleP68133ACTAlabCrystal structure of LokiProfilin1/Rabbit Actin Complex5yee83.88no data
7ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of MAL-RPEL1 complexed to actin2v5183.29no data
8ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of MAL-RPEL2 complexed to G-actin2v5286.64no data
9ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of the Phactr1 RPEL-2 bound to G-actin4b1x84.19no data
10ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of the Phactr1 RPEL-3 bound to G-actin4b1y84.27no data
11ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of the Phactr1 RPEL-N domain bound to G-actin4b1v86.07no data
12ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of the Phactr1 RPEL-2 domain bound to actin4b1w87.97no data
13ACTSActin, alpha skeletal muscleP68133ACTAlabStructure of the Phactr1 RPEL domain and RPEL motif directed assemblies with G-actin reveal the molecular basis for actin binding cooperativity.4b1u82.42no data
14ACTSActin, alpha skeletal muscleP68133ACTAlarActin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer1rdw85.57no data
15ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal Structure of a Cross-linked Actin Dimer2a5x73.66no data
16ACTSActin, alpha skeletal muscleP68133ACTAlarActin Dimer Cross-linked Between Residues 41 and 3742q1n75.78no data
17ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of ia-bTAD-actin complex3buz77.45no data
18ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP-Latrunculin A3sjh83.77no data
19ACTSActin, alpha skeletal muscleP68133ACTAlarActin Dimer Cross-linked Between Residues 41 and 374 and proteolytically cleaved by subtilisin between residues 47 and 48.2q3176.2no data
20ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of NAD+-Ia-actin complex4h0388.22no data
21ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of NAD+-Ia(E380A)-actin complex4h0x81.64no data
22ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of Ia-ADPR-actin complex4h0t84.56no data
23ACTSActin, alpha skeletal muscleP68133ACTAlarTHE X-RAY CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RABBIT SKELETAL MUSCLE ACTIN AND LATRUNCULIN A AT 2.85 A RESOLUTION1ijj79.78no data
24ACTSActin, alpha skeletal muscleP68133ACTAlarCOMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 11esv78.5no data
25ACTSActin, alpha skeletal muscleP68133ACTAlarCRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN1sqk82.95no data
26ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of NAD+-Ia(E380S)-actin complex4h0y85.01no data
27ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of NAD+-Ia(E378S)-actin complex4h0v82.95no data
28ACTSActin, alpha skeletal muscleP68133ACTAlarCrystal structure of apo-Ia-actin complex4gy281.63no data
29ACTSActin, alpha skeletal muscleP68133ACTAlarActin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer1rfq77.19no data