The Ligandable Human Proteome

Home

Dihydroorotate dehydrogenase domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1PYRDDihydroorotate dehydrogenaseQ02127m0bHuman DHODH bound to inhibitor IPP/CNRS-A0176syp78.65no data
2PYRDDihydroorotate dehydrogenaseQ02127jtuCrystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue4jtu96.14no data
3PYRDDihydroorotate dehydrogenaseQ02127jjeCrystal structure of human DHODH in complex with BAY 24022346qu797.31no data
4PYRDDihydroorotate dehydrogenaseQ02127ilhdual binding modes of a novel series of DHODH inhibitors2fqi95.07no data
5PYRDDihydroorotate dehydrogenaseQ02127ilfDual binding mode of a novel series of DHODH inhibitors2fpy93.76no data
6PYRDDihydroorotate dehydrogenaseQ02127ilbDual Binding Mode of a Novel Series of DHODH inhibitors2fpt95.81no data
7PYRDDihydroorotate dehydrogenaseQ02127f54Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 436cjf96.67no data
8PYRDDihydroorotate dehydrogenaseQ02127cihHuman dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 23fj693.87no data
9PYRDDihydroorotate dehydrogenaseQ02127breHUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG1d3g99.74no data
10PYRDDihydroorotate dehydrogenaseQ02127b5xCrystal structure of human DHODH in complex with inhibitor 12916j3c95.43no data
11PYRDDihydroorotate dehydrogenaseQ02127b5oCrystal structure of human DHODH in complex with inhibitor 12896j3b96.19no data
12PYRDDihydroorotate dehydrogenaseQ021279bxStructure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)5zfb95.43no data
13PYRDDihydroorotate dehydrogenaseQ021279buStructure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr5zfa94.95no data
14PYRDDihydroorotate dehydrogenaseQ021279boStructure of human dihydroorotate dehydrogenase in complex with 277-11-OAc5zf896.46no data
15PYRDDihydroorotate dehydrogenaseQ021279auCrystal structure of human DHODH in complex with ferulenol6idj96.63no data
16PYRDDihydroorotate dehydrogenaseQ02127951Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution3kvm94.87no data
17PYRDDihydroorotate dehydrogenaseQ021273x2Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A3124ls194.48no data
18PYRDDihydroorotate dehydrogenaseQ021273v1Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A3674rr478.35no data
19PYRDDihydroorotate dehydrogenaseQ021273rvCrystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A3564rk894.98no data
20PYRDDihydroorotate dehydrogenaseQ021273ftDual binding mode of a novel series of DHODH inhibitors2bxv94.49no data
21PYRDDihydroorotate dehydrogenaseQ02127238The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site2prh99.75no data
22PYRDDihydroorotate dehydrogenaseQ021271eaHigh resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog4igh95.1no data
23PYRDDihydroorotate dehydrogenaseQ02127ilcDual binding mode of a novel series of DHODH inhibitors2fpv95.45no data
24PYRDDihydroorotate dehydrogenaseQ02127r2cThe structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site2prl99.37no data
25PYRDDihydroorotate dehydrogenaseQ02127vgnComplex of human dihydroorotate dehydrogenase with the inhibitor 2212902wv899.83no data
26PYRDDihydroorotate dehydrogenaseQ021271x5Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution3kvj94.34no data
27PYRDDihydroorotate dehydrogenaseQ021276x1Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 641 at 2.05A resolution3kvk96.05no data
28PYRDDihydroorotate dehydrogenaseQ021277z5Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 715 at 1.85A resolution3kvl95.21no data
29PYRDDihydroorotate dehydrogenaseQ0212703uDihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor3u2o95.82no data
30PYRDDihydroorotate dehydrogenaseQ02127w7aStructure of Human dihydroorotate dehydrogenase in complex with mii-4-0973w7r99.84no data
31PYRDDihydroorotate dehydrogenaseQ02127avqStructure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor3zws96.37no data
32PYRDDihydroorotate dehydrogenaseQ02127kfzStructure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor3zwt96.68no data
33PYRDDihydroorotate dehydrogenaseQ021273ryCrystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A3474rka95.33no data
34PYRDDihydroorotate dehydrogenaseQ021274r5Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A3384zmg92.89no data
35PYRDDihydroorotate dehydrogenaseQ02127mljCrystal structure of human dihydroorotate dehydrogenase with ML3905k9c93.26no data
36PYRDDihydroorotate dehydrogenaseQ02127hytCrystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds5mut95.15no data
37PYRDDihydroorotate dehydrogenaseQ02127y9bCrystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds5mvc94.76no data
38PYRDDihydroorotate dehydrogenaseQ02127u91Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds5mvd94.95no data
39PYRDDihydroorotate dehydrogenaseQ02127chwStructure of human dihydroorotate dehydrogenase in complex with 277-9-OH5zf796.29no data
40PYRDDihydroorotate dehydrogenaseQ02127f51Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 466cjg98.39no data
41PYRDDihydroorotate dehydrogenaseQ02127sdvHUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR6et497.65no data
42PYRDDihydroorotate dehydrogenaseQ02127duhTargeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold6fmd98.22no data