The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	P53	Cellular tumor antigen p53	P04637	P53	p96	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196	4agq	59.57	9700.
2	P53	Cellular tumor antigen p53	P04637	P53	p86	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086	4agm	61.28	105000.
3	P53	Cellular tumor antigen p53	P04637	P53	p74	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174	4ago	57.24	15500.
4	P53	Cellular tumor antigen p53	P04637	P53	p51	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176	4agp	59.2	20600.
5	P53	Cellular tumor antigen p53	P04637	P53	kmn	Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211	5a7b	59.71	271000.
6	P53	Cellular tumor antigen p53	P04637	P53	9h5	p53 cancer mutant Y220C in complex with compound MB240	5o1a	73.39	no data
7	P53	Cellular tumor antigen p53	P04637	P53	qc5	Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242	3zme	77.94	no data
8	P53	Cellular tumor antigen p53	P04637	P53	p84	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784	4agl	77.37	225000.
9	P53	Cellular tumor antigen p53	P04637	P53	nxg	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116	4agn	66.29	107000.
10	P53	Cellular tumor antigen p53	P04637	P53	92o	Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole	5ab9	78.33	470.
11	P53	Cellular tumor antigen p53	P04637	P53	ul7	Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149	5aba	60.12	1.04e+006
12	P53	Cellular tumor antigen p53	P04637	P53	y0v	Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid	5aoj	83.02	21000.
13	P53	Cellular tumor antigen p53	P04637	P53	fy8	Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883	5aom	79.75	1.27e+006
14	P53	Cellular tumor antigen p53	P04637	P53	9h2	p53 cancer mutant Y220C in complex with compound MB84	5o1b	84.47	no data
15	P53	Cellular tumor antigen p53	P04637	P53	9gz	p53 cancer mutant Y220C in complex with compound MB184	5o1c	82.17	no data
16	P53	Cellular tumor antigen p53	P04637	P53	9gw	p53 cancer mutant Y220C in complex with compound MB481	5o1d	85.01	no data
17	P53	Cellular tumor antigen p53	P04637	P53	9gt	p53 cancer mutant Y220C im complex with compound MB577	5o1e	86	no data
18	P53	Cellular tumor antigen p53	P04637	P53	9gq	p53 cancer mutant Y220C in complex with compound MB582	5o1f	83.5	no data
19	P53	Cellular tumor antigen p53	P04637	P53	9gk	p53 cancer mutant Y220C in complex with compound MB487	5o1g	77.81	no data
20	P53	Cellular tumor antigen p53	P04637	P53	9gn	p53 cancer mutant Y220C in complex with compound MB539	5o1h	84.25	no data
21	P53	Cellular tumor antigen p53	P04637	P53	9gh	p53 cancer mutant Y220C in complex with compound MB710	5o1i	79.11	no data

The Ligandable Human Proteome

p53, DNA-binding domain