The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	PAR10	Protein mono-ADP-ribosyltransferase PARP10	Q53GL7		78p	Human PARP10 (ARTD10), catalytic fragment in complex with PARP inhibitor Veliparib	5lx6	82.19	1900.
2	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	ee5	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6	6fzm	76.16	no data
3	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	ebb	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK1	6fym	94.26	no data
4	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	94z	Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor	5nqe	91.99	700.
5	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	91v	crystal structure of PARP14 bound to N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine inhibitor	5v7t	50.78	610.
6	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	egw	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72	6g0w	73.97	no data
7	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	91j	Crystal structure of human PARP14 bound to 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one inhibitor	5v7w	72.57	76.
8	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	7ag	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H5	5lxp	46.97	760.
9	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	xl2	Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2	4py4	56.16	1690.
10	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	0rz	Human Artd8 (Parp14, Bal2) - catalytic domain in complex with A16(E)	4f1q	67.98	11200.
11	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	0ry	Human Artd8 (Parp14, Bal2) - catalytic domain in complex with inhibitor A16(Z)	4f1l	96.01	7600.
12	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	fdr	Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor	3smj	83.72	no data
13	PAR14	Protein mono-ADP-ribosyltransferase PARP14	Q460N5	BAL2 KIAA1268	qdr	Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a quinazoline inhibitor	3smi	74.68	no data
14	PAR15	Protein mono-ADP-ribosyltransferase PARP15	Q460N3	BAL3	0ru	Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102	4f0e	84.93	no data
15	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	kyy	Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT57	6nrg	75.03	no data
16	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	kyv	Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT103	6nrf	68.38	no data
17	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	kyp	Crystal Structure of human PARP-1 ART domain bound inhibitor UTT63	6nrh	67.06	no data
18	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	kym	Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83	6nri	63.31	no data
19	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	kyj	Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT93	6nrj	81.44	no data
20	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	aai	PARP complexed with A620223	2rcw	85.81	8.
21	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	7u6	Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor	5ws0	81.83	no data
22	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	4yr	Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor	5wry	86.57	no data
23	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	6x2	Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor	5kpq	87.08	no data
24	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	09l	Crystal structure of constitutively active PARP-1	5ds3	78.67	no data
25	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	fsu	Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor	4zzz	88.31	87.
26	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	2yq	HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB	4und	86.01	1.1
27	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	l3l	PARP complexed with A906894	3l3l	82.36	33.
28	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	3gn	PARP complexed with A861696	3gn7	83.05	5.
29	PARP1	Poly [ADP-ribose] polymerase 1	P09874	ADPRT PPOL	78p	PARP complexed with A861695	2rd6	80.36	5.
30	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	8me	Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0355	4gv0	88.59	no data
31	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	5me	Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354	4gv2	87.6	no data
32	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	1va	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0368	4l7l	80.38	1000.
33	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	1vb	Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542	4l7n	84.98	14400.
34	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	m95	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0395	4l7p	75.52	no data
35	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	m00	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400	4l7r	80.83	9600.
36	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	1vc	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0398	4l7u	84.34	2200.
37	PARP3	Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	ADPRT3 ADPRTL3	ku8	Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor KU0058948	3c49	81.5	70.
38	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	k4f	Co-crystal structure of TNKS1 with compound 18 [4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-(quinolin-8-yl)benzamide]	4k4f	87.23	200.
39	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	jkn	Human TNKS1 in complex with 6,8-Difluoro-2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-quinazolin-4-one	6qxu	89.7	no data
40	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	iw8	Crystal structure of Tankyrase 1 with IWR-8	4tor	77.32	no data
41	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	5n8	Tankyrase 1 with Phthalazinone 2	5ebt	90.81	no data
42	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	355	Crystal structure of Tankyrase 1 with 355	4tos	92.38	no data
43	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	1xq	TANKYRASE-1 complexed with small molecule inhibitor 2-[4-(4-fluorobenzoyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-N-(thiophen-2-ylmethyl)acetamide	4li8	87.51	7.5
44	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2iw	Crystal structure of Tankyrase 1 with IWR2	4dvi	89.51	192.
45	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	k4e	Co-crystal structure of tnks1 with compound 52 [N~2-(5-chloro-2-methoxyphenyl)-N-[trans-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)cyclohexyl]glycinamide]	4k4e	87.54	24.
46	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2c8	Co-crystal structure of tankyrase 1 with compound 34	4msk	92.57	63.
47	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2gv	Co-crystal structure of tankyrase 1 with compound 3 [(4S)-3-{4-[6-amino-5-(pyrimidin-2-yl)pyridin-3-yl]phenyl}-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one]	4n4t	84.07	49.
48	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2gy	Co-crystal structure of tankyrase 1 with compound 4 [(4S)-3-{trans-4-[6-amino-5-(pyrimidin-2-yl)pyridin-3-yl]cyclohexyl}-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one]	4n4v	83.23	2.
49	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2xs	Crystal structure of Tankyrase1 in complex with IWR1	4oa7	92.28	no data
50	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	k56	Crystal Structure of human Tankyrase-1 bound to K-756	5ety	77.13	31.
51	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	5n2	Tankyrase 1 with Phthalazinone 1	5ece	88.14	9.
52	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	3j5	Human Tankyrase 1 with small molecule inhibitor	4w6e	68.68	no data
53	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	3j1	Tankyrase in complex with compound	4w5s	88.04	no data
54	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	t40	X-ray crystal structure of human TNKS in complex with a small molecule inhibitor	4uuh	90.91	17.
55	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	3dn	X-ray crystal structure of human TNKS in complex with a small molecule inhibitor	4u6a	86.51	no data
56	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2gu	Co-crystal structure of tankyrase 1 with compound 2 (5-(2-aminoquinazolin-6-yl)-N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-fluorobenzamide)	4n3r	92.2	150.
57	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2d6	Co-crystal structure of tankyrase 1 with compound 49	4mt9	86.64	0.1
58	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	2c6	Crystal structure of tankyrase 1 with compound 22	4msg	93.44	0.1
59	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	1xp	TANKYRASE-1 complexed with small molecule inhibitor 4-chloro-5-cyano-N-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-methoxybenzamide	4li7	90.72	770.
60	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	1xo	TANKYRASE-1 Complexed with small molecule inhibitor N-[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]-3-phenyl-N-(thiophen-2-ylmethyl)propanamide	4li6	94.42	106.
61	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	1sx	Tankyrase-1 complexed with small molecule inhibitor	4krs	85.93	299.
62	TNKS1	Poly [ADP-ribose] polymerase tankyrase-1	O95271	PARP5A PARPL TIN1 TINF1 TNKS1	1dy	Crystal structure of tankyrase 1 with compound 4	4i9i	91.05	8.
63	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	kc8	Crystal structure of TNKS2 in complex with 2-[4-(4-methyl-2-oxoimidazolidin-4-yl)phenyl]-3,4-dihydroquinazolin-4-one	5ows	89.04	no data
64	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	a64	Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone	4bs4	93.15	6.
65	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	cnq	Crystal Structure of human Tankyrase 2 in complex with 3,4-CPQ-5-C.	4tju	75.64	3600.
66	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	iwr	Crystal structure of human tankyrase 2 in complex with a selective inhibitor	3ua9	89.09	56.
67	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	28c	Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854	4m7b	88.25	200.
68	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	33c	Crystal Structure of human Tankyrase 2 in complex with IWR-1.	4tkf	89.39	285.
69	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	cdj	Crystal structure of human tankyrase 2 in complex with 5-amino-3-(4- chlorophenyl)-1,2-dihydroisoquinolin-1-one	4uvn	94.33	no data
70	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	sgw	Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-methoxy-1,2- dihydroisoquinolin-1-one	4uvy	93.42	5.5
71	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	3gx	Crystal structure of human tankyrase 2 in complex with 1-methyl-7-phenyl-1,2,3,4,5,6-hexahydro-1,6- naphthyridin-5-one	4w5i	95.27	no data
72	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	a95	Crystal structure of human tankyrase 2 in complex with JW55	5adq	88.97	2010.
73	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	qs5	Crystal structure of human tankyrase 2 in complex with OD38	5adr	89.5	2300.
74	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	qns	Crystal structure of human tankyrase 2 in complex with OD39	5ads	90.5	2150.
75	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	1tc	Crystal structure of human tankyrase 2 in complex with OD73	5adt	90.05	2230.
76	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	8ir	Crystal structure of human tankyrase 2 in complex with OD332	5aeh	88.42	37.
77	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	92t	Crystal structure of human tankyrase 2 in complex with OD336	5nob	83.35	6.3
78	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f37	Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione	5owt	89.98	no data
79	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	9a8	Crystal structure of TNKS2 in complex with 2-[4-(propan-2-yloxy)phenyl]-3,4-dihydroquinazolin-4-one	5nut	90.91	no data
80	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	q28	Crystal structure of human tankyrase 2 in complex with TA-92	5fpg	89.99	no data
81	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	59b	Tankyrase 2 complexed with a selective inhibitor	5dcz	83.88	0.5
82	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	jl9	Crystal structure of TNKS2 in complex with 2-(4-((pyridin-4-yl)methyl) piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one	5al5	86.7	71.
83	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	wlh	Crystal structure of TNKS2 in complex with 2-(4-methylpiperazin-1-yl)- 3,4,5,6,7,8-hexahydroquinazolin-4-one	5al4	94.1	300.
84	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	tgw	Crystal structure of TNKS2 in complex with 2-(2,4-dichlorophenyl)-1- methyl-1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one	5al3	95.46	11000.
85	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	o53	Crystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one	5al2	93.83	360.
86	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	gn5	Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1H, 2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one	5al1	92.37	53000.
87	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	nki	Crystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-one	5akw	95.04	410.
88	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	29f	Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1,2, 3,4-tetrahydroquinazolin-4-one	5aku	92.61	150.
89	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	h2w	Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-fluoro-1,2-dihydroisoquinolin-1-one	4uvx	94.16	11.
90	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	w8l	Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-methyl-1,2-dihydroisoquinolin-1-one	4uvv	94.37	32.
91	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	u1t	Crystal structure of human tankyrase 2 in complex with 1-((4-(5- methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)phenyl)methyl)pyrrolidin-1- ium	4uvu	86.4	1200.
92	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	5ww	Crystal structure of human tankyrase 2 in complex with 5-amino-3-(4- methoxyphenyl)-1,2-dihydroisoquinolin-1-one	4uvo	93.52	no data
93	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	sz5	Crystal structure of human tankyrase 2 in complex with TA-21	4uhg	95.44	540.
94	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	m3w	Crystal structure of human tankyrase 2 in complex with TA-13	4ufy	93.54	7.
95	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	2zi	Crystal structure of human tankyrase 2 in complex with TA-12	4ufu	93.03	10.
96	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	09l	Crystal Structure of human Tankyrase 2 in complex with AZD2281.	4tkg	90.16	140.
97	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	32z	Crystal Structure of human Tankyrase 2 in complex with DPQ.	4tk0	77.13	2800.
98	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	3gn	Crystal Structure of human Tankyrase 2 in complex with ABT-888.	4tjy	79.87	367.
99	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	aj5	Tankyrase 2 in complex with 3-chloro-N-(2-methoxyethyl)-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzamide	4j3l	75.23	16.
100	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	aj7	Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide	4j22	65.37	18.
101	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f37	Crystal structure of human tankyrase 2 in complex with 5-methyl-5-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)imidazolidine-2,4-dione	4buy	88.27	no data
102	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f35	Crystal structure of human tankyrase 2 in complex with 3-((4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenyl)methyl)imidazolidine-2,4-dione	4bux	85.57	no data
103	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f33	Crystal structure of human tankyrase 2 in complex with 2-(4-(2-oxo-1, 3-oxazolidin-3-yl)phenyl)-3,4-dihydroquinazolin-4-one	4buw	90.08	no data
104	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	16i	Crystal structure of human tankyrase 2 in complex with N-(4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenyl)thiophene-2-carboxamide	4buv	81.07	no data
105	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f38	Crystal structure of human tankyrase 2 in complex with (4-(4-oxo-3,4- dihydroquinazolin-2-yl)phenyl)methanesulfonamide	4buu	91.98	no data
106	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	31f	Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-3,4- dihydroquinazolin-2-yl)benzene-1-sulfonamide	4but	93.01	no data
107	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	32f	Crystal structure of human tankyrase 2 in complex with 2-(4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenoxy)acetic acid	4bus	89.03	no data
108	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	w2e	Crystal structure of human tankyrase 2 in complex with methyl 4-(4- oxo-3,4-dihydroquinazolin-2-yl)benzoate	4bui	92.12	no data
109	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f36	Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one	4buf	92.06	no data
110	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	jqf	Crystal structure of human tankyrase 2 in complex with 3-methyl-N-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)butanamide	4bue	82.07	no data
111	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	29f	Crystal structure of human tankyrase 2 in complex with 2-(4-tert- butylphenyl)-1,4-dihydroquinazolin-4-one	4bud	92.85	no data
112	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	91f	Crystal structure of human tankyrase 2 in complex with 2-(4-(methylsulfanyl)phenyl)-3,4-dihydroquinazolin-4-one	4bua	94.57	no data
113	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	08c	Crystal structure of human tankyrase 2 in complex with 2-(4- methoxyphenyl)-3,4-dihydroquinazolin-4-one	4bu9	92.97	no data
114	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	27f	Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-1,4- dihydroquinazolin-2-yl)benzonitrile	4bu8	94.07	no data
115	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	25f	Crystal structure of human tankyrase 2 in complex with 2-(4- bromophenyl)-3,4-dihydroquinazolin-4-one	4bu7	94.77	no data
116	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	rgk	Crystal structure of human tankyrase 2 in complex with 2-(4- aminophenyl)-3,4-dihydroquinazolin-4-one	4bu6	94.47	no data
117	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	3f4	Crystal structure of human tankyrase 2 in complex with 2-(4- hydroxyphenyl)-3,4-dihydroquinazolin-4-one	4bu5	94.71	no data
118	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	f40	Crystal structure of human tankyrase 2 in complex with 2-phenyl-3,4- dihydroquinazolin-4-one	4bu3	96.42	no data
119	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	rpb	Crystal structure of human tankyrase 2 in complex with Rucaparib	4bjc	70.09	14.
120	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	09l	Crystal structure of human tankyrase 2 catalytic domain in complex with olaparib	3u9y	90.53	no data
121	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	nnl	Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor	3p0q	85.53	no data
122	TNKS2	Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	PARP5B TANK2 TNKL	nnf	Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor	3p0p	89.88	no data

The Ligandable Human Proteome

Poly(ADP-ribose) polymerase, catalytic domain