The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	hfy	Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	6dws	78.36	no data
2	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	h5v	Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine	6do2	94.51	no data
3	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	gba	Crystal structure of human GRP78 in complex with 8-bromoadenosine	6dfo	93.63	no data
4	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	3p1	Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with small molecule inhibitor	3ldp	76.27	2410.
5	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	3fd	Crystal structure of ATPase domain of Human GRP78 bound to Ver155008	6cz1	74.23	no data
6	BIP	Endoplasmic reticulum chaperone BiP	P11021	GRP78	3bh	Crystal structure of human GRP78 in complex with 8-aminoadenosine	6dfm	92.97	no data
7	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	sgv	HSP72 with adenosine-derived inhibitor	5aqz	83.12	3300.
8	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	gb8	HSP72 with adenosine-derived inhibitor	5ar0	80.32	720.
9	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	3fd	Crystal structure of human HSP70 complexed with 4-{(2R,3S,4R)-5-[(R)-6-Amino-8-(3,4-dichloro-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethyl}-benzonitrile	4io8	74.01	228.
10	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	adn	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqy	89.44	no data
11	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	3um	HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN WITH COVALENTLY LINKED NOVOLACTONE	4wv7	86.03	no data
12	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	5p7	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqw	90.75	no data
13	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	kc7	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqx	82.16	no data
14	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	ti8	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation	5mkr	70.26	17000.
15	HS71A	Heat shock 70 kDa protein 1A	P0DMV8	HSP72 HSPA1 HSX70	ti8	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation	5mks	66.77	17000.
16	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3p1	Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor	3ldq	62.34	4320.
17	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3fd	CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008	6h54	72.07	no data
18	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3fd	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors	3fzl	67.53	no data
19	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3f5	Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor	3m3z	83.69	1850.
20	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3bk	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors	3fzk	68.79	no data
21	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	3bh	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors	3fzh	83.86	no data
22	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	ux0	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqu	69.82	1.04e+006
23	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	kc7	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqv	75.5	370000.
24	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	5p7	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqt	74.78	310000.
25	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	zjb	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqg	75.46	31000.
26	HSP7C	Heat shock cognate 71 kDa protein	P11142	HSC70 HSP73 HSPA10	adn	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues	5aqf	87.19	165000.

The Ligandable Human Proteome

Heat shock protein 70 family