The Ligandable Human Proteome

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Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1PDK1[Pyruvate dehydrogenaseQ15118PDHK1azxStructure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD75452q8g67.7587.
2PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells4v2673.28no data
3PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells4v2571.6no data
4PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase5m4m68.01no data
5PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase5m4p74.23no data
6PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase5m4n72.28no data
7PDK2[Pyruvate dehydrogenaseQ15119PDHK2tf3Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase5m4k68.48no data