The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	HXK4	Glucokinase	P35557	tk1	Human glucokinase in complex with a synthetic activator	3h1v	90.21	no data
2	HXK4	Glucokinase	P35557	hkm	Crystal structure of Glucokinase in complex with compound 6	6e0e	89.38	no data
3	HXK4	Glucokinase	P35557	hkg	Crystal structure of Glucokinase in complex with compound 72	6e0i	71.31	no data
4	HXK4	Glucokinase	P35557	b84	Crystal Structure of human glucokinase in complex with a synthetic activator	3imx	90.36	no data
5	HXK4	Glucokinase	P35557	aji	Human glucokinase in complex with a synthetic activator	3a0i	90.14	no data
6	HXK4	Glucokinase	P35557	ajb	Human glucokinase in complex with 2-amino benzamide activator	3fr0	88.25	no data
7	HXK4	Glucokinase	P35557	loi	Human glucokinase in complex with a synthetic activator	3goi	86.05	no data
8	HXK4	Glucokinase	P35557	mrk	Crystal structure of human glucokinase	1v4s	93.11	no data
9	HXK4	Glucokinase	P35557	mrk	Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap	3f9m	93.23	no data
10	HXK4	Glucokinase	P35557	mrk	Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP	3id8	90.62	no data
11	HXK4	Glucokinase	P35557	0h4	Glucokinase in complex with an activator and glucose	3vev	82.89	no data
12	HXK4	Glucokinase	P35557	0h5	glucokinase in complex with glucose and ATPgS	3vey	89.78	no data
13	HXK4	Glucokinase	P35557	0h6	Glucokinase in complex with glucose and activator	3vf6	84.43	no data
14	HXK4	Glucokinase	P35557	s41	Glucokinase in complex with activator and glucose	3s41	81.67	no data
15	HXK4	Glucokinase	P35557	s41	Crystal structure of human glucokinase in complex with glucose and activator	4dhy	81.82	no data
16	HXK4	Glucokinase	P35557	1fw	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide	4ise	93.68	no data
17	HXK4	Glucokinase	P35557	1fx	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide	4isf	92.33	no data
18	HXK4	Glucokinase	P35557	1fy	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide	4isg	92.7	no data
19	HXK4	Glucokinase	P35557	1j9	Crystals structure of Human Glucokinase in complex with small molecule activator	4iwv	95.2	no data
20	HXK4	Glucokinase	P35557	1jd	Crystal structure of Human Glucokinase in complex with a small molecule activator.	4ixc	94.76	no data
21	HXK4	Glucokinase	P35557	926	Crystal structure of glucokinase-activator complex	4l3q	93.71	no data
22	HXK4	Glucokinase	P35557	vo1	Human Glucokinase in Complex with Novel Amino Thiazole Activator	4mle	89.03	no data
23	HXK4	Glucokinase	P35557	vo2	Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator	4mlh	88.49	no data
24	HXK4	Glucokinase	P35557	2n8	Human Glucokinase in complex with a nanomolar activator.	4no7	92.77	no data
25	HXK4	Glucokinase	P35557	3lz	Discovery of 2-Pyridyl Ureas as Glucokinase Activators	4rch	87.47	no data
26	HXK4	Glucokinase	P35557	8wj	Human glucokinase in complex with novel pyrazole activator.	5v4x	80.18	no data

The Ligandable Human Proteome

Hexokinase, C-terminal