The Ligandable Human Proteome

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NADP-dependent oxidoreductase domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11uv8Crystal structure of human AKR1B10 complexed with NADP+ and the synthetic retinoid UVI20085m2f83.68no data
2AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11mk4Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK1845lix94.07no data
3AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11fidHuman AKR1B10 mutant V301L complexed with NADP+ and fidarestat4gab87.42no data
4AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11flfCrystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid4i5x88.03no data
5AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11tolCrystal Structure Of AKR1B10 Complexed With NADP+ And Tolrestat1zua90.89no data
6AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11388Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor IDD3885liu87.57no data
7AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11suzCrystal structure of human AKR1B10 complexed with NADP+ and sulindac4wev84.24no data
8AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11zstCrystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat4jii91.02no data
9AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11w8xCrystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK1815lik87.53no data
10AK1BAAldo-keto reductase family 1 member B10O60218AKR1B111wxCrystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK3195liw98.64no data
11AK1BAAldo-keto reductase family 1 member B10O60218AKR1B11qapCrystal structure of AKR1B10 complexed with NADP+ and Caffeic acid phenethyl ester4gq084.87no data
12AK1BAAldo-keto reductase family 1 member B10O60218AKR1B118qlCrystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol5y7n83.03no data
13AK1C1Aldo-keto reductase family 1 member C1Q04828DDH DDH1jmsCrystal Structure of AKR1C1 complexed with meclofenamic acid6ijx97.61no data
14AK1C1Aldo-keto reductase family 1 member C1Q04828DDH DDH19s0AKR1C1 complexed with new inhibitor with novel scaffold6a7a94.66no data
15AK1C1Aldo-keto reductase family 1 member C1Q04828DDH DDH1strCrystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone1mrq81.97no data
16AK1C1Aldo-keto reductase family 1 member C1Q04828DDH DDH15p3Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid3nty99.22no data
17AK1C1Aldo-keto reductase family 1 member C1Q04828DDH DDH1gbmCrystal Structure of AKR1C1 complexed with glibenclamide4yvp76.12no data
18AK1C2Aldo-keto reductase family 1 member C2P52895DDH2iu5Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate1ihi72.56no data
19AK1C2Aldo-keto reductase family 1 member C2P52895DDH25sdCrystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one4xo679.86no data
20AK1C2Aldo-keto reductase family 1 member C2P52895DDH2aoxCrystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one4xo677.19no data
21AK1C2Aldo-keto reductase family 1 member C2P52895DDH2strCrystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 in Complex with NADP+ and Progesterone4l1w76.63no data
22AK1C2Aldo-keto reductase family 1 member C2P52895DDH2strCrystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone4l1x77.61no data
23AK1C2Aldo-keto reductase family 1 member C2P52895DDH2ffaCrystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone2ipj77.07no data
24AK1C2Aldo-keto reductase family 1 member C2P52895DDH2tesHuman 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone1j9675.04no data
25AK1C2Aldo-keto reductase family 1 member C2P52895DDH2flpAKR1C2 complex with flurbiprofen4jtq82.95no data
26AK1C2Aldo-keto reductase family 1 member C2P52895DDH2ibpAKR1C2 complex with ibuprofen4jtr85.96no data
27AK1C2Aldo-keto reductase family 1 member C2P52895DDH2suzAKR1C2 complex with sulindac4jq281.53no data
28AK1C2Aldo-keto reductase family 1 member C2P52895DDH2imnAKR1C2 complex with indomethacin4jq487.77no data
29AK1C2Aldo-keto reductase family 1 member C2P52895DDH2id8AKR1C2 complex with mefenamic acid4jqa86.28no data
30AK1C2Aldo-keto reductase family 1 member C2P52895DDH2npsAKR1C2 complex with naproxen4jq187.28no data
31AK1C2Aldo-keto reductase family 1 member C2P52895DDH2zomAKR1C2 complex with zomepirac4jq378.22no data
32AK1C2Aldo-keto reductase family 1 member C2P52895DDH2asdCrystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one4xo781.39no data
33AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSffwCrystal structure of Aldo-Keto Reductase 1C3 (AKR1C3) complexed with inhibitor.6gxk96.93no data
34AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS9s0AKR1C3 complexed with new inhibitor with novel scaffold6a7b91.76no data
35AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSpg2Structure of prostaglandin F synthase with prostaglandin D21ry087.76no data
36AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSe04Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM14041zq590.75no data
37AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS15mCrystal structure of prostaglandin F synathase containing bimatoprost2f3890.86no data
38AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSizpAKR1C3 complex with ibuprofen3r8g97.81no data
39AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSsuzAKR1C3 complex with sulindac3r7m79.48no data
40AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSflrAKR1C3 complex with flurbiprofen3r9497.95no data
41AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSnpxAKR1C3 complex with R-naproxen3ufy99.25no data
42AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSimnAKR1C3 complex with indomethacin at pH 7.53ug896.46no data
43AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSimnAKR1C3 complex with indomethacin at pH 6.83ugr99.36no data
44AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSimnCrystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin1s2a98.96no data
45AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS511Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 2'-desmethyl-indomethacin4dbw97.64no data
46AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS0t0Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80)4fal97.89no data
47AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS0szCrystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid (17)4fam98.42no data
48AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSid8AKR1C3 complexed with mefenamic acid3r4397.85no data
49AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSnpsAKR1C3 complex with naproxen3r5897.94no data
50AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSzomAKR1C3 complex with zomepirac3r8h94.59no data
51AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSasdCrystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) complexed with delta4-androstene-3,17-dione and NADP1xf093.98no data
52AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSjmsAKR1C3 complex with meclofenamic acid3r6i96.51no data
53AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSwdu17beta-HSD5 in complex with 4-chloro-N-(4-chlorobenzyl)-5-nitro-1H-pyrazole-3-carboxamide4wdu93.65no data
54AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSwdx17beta-HSD5 in complex with [4-(2-hydroxyethyl)piperidin-1-yl](5-methyl-1H-indol-2-yl)methanone4wdx98.05no data
55AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSwdv17beta-HSD5 in complex with 4-nitro-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)phenol4xvd96.46no data
56AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSwds17beta-HSD5 in complex with 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one4xve91.73no data
57AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSgmrCrystal structure of AKR1C3 complexed with glimepiride4yvx87.46no data
58AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSgczCrystal structure of AKR1C3 complexed with glicazide4zfc81.29no data
59AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSqapCrystal Structure of AKR1C3 complexed with CAPE5hnt90.38no data
60AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFS6nyCrystal structure of AKR1C3 complexed with a pro-drug5jm560.72no data
61AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFSgbmCrystal structure of AKR1C3 complexed with glibenclamide4yvv82.59no data
62AK1C3Aldo-keto reductase family 1 member C3P42330DDH1 HSD17B5 KIAA0119 PGFScj2Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid6f2u91.16no data
63AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1strCrystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A.3cot88.28no data
64AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1ci2Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione3cav80.83no data
65AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1tesCrystal structure of Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and TESTOSTERONE. RESOLUTION: 1.62 A.3bur98.57no data
66AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1tesCrystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and delta4-androstenedione3uzz87.46no data
67AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1bdtCrystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and 5beta-dihydrotestosterone3uzy82.91no data
68AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1pdnCrystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A.3cmf86.93no data
69AK1D1Aldo-keto reductase family 1 member D1P51857SRD5B1asdCrystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 4-androstenedione3cas97.34no data
70ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2sfiCrystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide3rx475.33no data
71ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2litHuman aldose reductase complexed with nitrofuryl-oxadiazol inhibitor at 1.55 A2ikh95.83no data
72ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2itbHuman Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)2nvd79.98no data
73ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2itaHuman Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)2nvc78.94no data
74ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR23t4Human aldose reductase in complex with a nitrile-containing IDD inhibitor3t4291.76no data
75ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2i84HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR1el362.74no data
76ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zesCRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.1iei90.58no data
77ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2bfiCrystal structure of human Aldose Reductase complexed with NADP and Minalrestat1pwl92.94no data
78ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidHuman aldose reductase double mutant S302R-C303D complexed with fidarestat.2pdy85.32no data
79ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidHuman aldose reductase mutant C303D complexed with fidarestat.2pdw85.31no data
80ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidHuman aldose reductase mutant V47I complexed with fidarestat.2pd985.39no data
81ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidAldose Reductase Mutant Leu 300 Pro complexed with Fidarestat2agt85.97no data
82ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.2pev94.84no data
83ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidFIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE1ef385.38no data
84ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.2pf896.12no data
85ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.2pfh96.13no data
86ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2fidCrystal structure of human Aldose Reductase complexed with NADP and Fidarestat1pwm85.11no data
87ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2id5Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 51t4092.56no data
88ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2id5Crystal structure of human aldose reductase complexed with NADP and IDD5521t4193.84no data
89ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2firCrystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S)1x9786.67no data
90ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR23naHuman aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom1z3n92.74no data
91ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2tolHuman aldose reductase complexed with tolrestat at 1.08 A resolution.2fzd89.92no data
92ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2tolHuman Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.2fzb99.89no data
93ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2tolHuman aldose reductase mutant L301M complexed with tolrestat.2pdl89.63no data
94ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human Aldose Reductase mutant T113V in complex with IDD393 crystallized in spacegroup P13mc591.35no data
95ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase complexed with nitro-substituted IDD-type inhibitor2ikj91.37no data
96ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase mutant S302R complexed with IDD 393.2pdp91.58no data
97ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase mutant C303D complexed with IDD393.2pdu91.27no data
98ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase mutant L300A complexed with IDD393.2pdj89.17no data
99ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase mutant F121P complexed with IDD393.2pdc91.34no data
100ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393Human aldose reductase mutant T113V complexed with IDD3933m6491.46no data
101ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2393The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant2pzn91.27no data
102ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2q74Human aldose reductase complexed with IDD 740 inhibitor3g5e91.59no data
103ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase mutant T113V complexed with IDD5943lz591.72no data
104ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtPerdeuterated alr2 in complex with idd5942qxw91.58no data
105ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman Aldose Reductase structure2r2493.38no data
106ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman Aldose Reductase mutant T113A complexed with IDD 5943lql91.73no data
107ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase mutant T113C complexed with IDD5943lbo91.56no data
108ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.2pev94.7no data
109ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage.3ght91.36no data
110ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. First stage of radiation damage3ghr91.32no data
111ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K2i1791.16no data
112ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K2i1691.36no data
113ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom1us091.23no data
114ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage.3ghu91.49no data
115ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage.3ghs91.24no data
116ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.2pf893.85no data
117ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtComplex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.2pfh94.2no data
118ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ldtHuman aldose reductase mutant T113S complexed with IDD5943ld591.82no data
119ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2388Human Aldose Reductase mutant T113V complexed with IDD3883m4h91.12no data
120ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2388Human aldose reductase complexed with halogenated IDD-type inhibitor2iki91.14no data
121ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2doyNovel Benzothiazepine Inhibitor in Complex with human Aldose Reductase3p2v86.52no data
122ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2suzAldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution3u2c81.92no data
123ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2suzCrystal Structure of Human Aldose Reductase Complexed with Sulindac3rx373.48no data
124ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2sloCrystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone3rx273.61no data
125ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2tltCrystal Structure of Human Aldose Reductase Complexed with Tolmetin3s3g67.09no data
126ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2ntiAldose reductase complexed with a nitro compound3v3582.15no data
127ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR22x9Complex of Aldose Reductase with inhibitor IDD 12194gca94.63no data
128ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose reductase complexed with inhibitor zopolrestat at 1.48 A(1 day soaking).2fz892.42no data
129ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase double mutant S302R-C303D complexed with zopolrestat.2pdx92.12no data
130ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase mutant L300A complexed with zopolrestat at 1.55 A.2pdi90.53no data
131ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase mutant S302R complexed with zopolrestat.2pdm92.1no data
132ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase mutant F121P complexed with zopolrestat.2pdb92.39no data
133ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase mutant L300P complexed with zopolrestat.2pdf90.47no data
134ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman aldose reductase mutant V47I complexed with zopolrestat2pd592.69no data
135ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase complexed with inhibitor zopolrestat after 3 days soaking (3days_soaked_2)2duz91.83no data
136ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstCrystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)2dux92.35no data
137ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase mutant T113S complexed with Zopolrestat3len93no data
138ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst)2hvo92.17no data
139ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase-zopolrestat complex obtained by cocrystallisation after one day (1day_cocryst)2hvn92.11no data
140ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase complexed with inhibitor zopolrestat after three days soaking (3days_soaked_3)2hv592.3no data
141ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)2dv092.15no data
142ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase mutant T113V in complex with Zopolrestat3m0i92.83no data
143ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase complexed with inhibitor zopolrestat after six days soaking.2fz992.26no data
144ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2zstHuman Aldose Reductase mutant T113A complexed with Zopolrestat3mb993.11no data
145ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2w8xCrystal structure of human AR complexed with NADP+ and {2-[(4-bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid4lau91.72no data
146ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR21wwCrystal structure of human AR complexed with NADP+ and {5-chloro-2-[(4-iodobenzyl)carbamoyl]phenoxy}acetic acid4laz91.66no data
147ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2m15Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid4lb392.14no data
148ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR21wxCrystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid4lb492.06no data
149ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR24o9Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid4lbr92.33no data
150ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR24o8Crystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid4lbs92.13no data
151ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR22wrHuman Aldose Reductase complexed with a ligand with an IDD structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic acid) at 1.14 A4puu84.17no data
152ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR22wqHuman Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A4puw84.99no data
153ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR22yzHuman Aldose Reductase complexed with a ligand with an IDD structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid) at 1.19 A4q7b91.1no data
154ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR230lHuman Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A4qbx91.91no data
155ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR237vHuman Aldose Reductase complexed with a ligand with an IDD structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic acid) at 1.05 A4qr692.53no data
156ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2i98Crystal structure of human AR complexed with NADP+ and AK1984qxi91.3no data
157ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR23uhHuman Aldose Reductase complexed with a ligand with an IDD structure at 1.20 A (1)4rpq85.98no data
158ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR24g7Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.4ys168.52no data
159ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2av5Crystal structure of human AKR1B1 complexed with NADP+ and compound 375ou079.47no data
160ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2aw8Crystal structure of human AKR1B1 complexed with NADP+ and compound 395ouj75.79no data
161ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2avtCrystal structure of human AKR1B1 complexed with NADP+ and compound 415ouk75.01no data
162ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2wy1Human Aldose Reductase in Complex with NADP+ and WY14643 in Space Group P2121215ha763.91no data
163ALDRAldo-keto reductase family 1 member B1P15121ALDR1 ALR2lpaCrystal Structure of Aldose Reductase complexed with Lipoic Acid2iqd81.03no data
164KCAB2Voltage-gated potassium channel subunit beta-2Q13303KCNA2B KCNK2pdnVoltage-dependent K+ channel beta subunit (W121A) in complex with cortisone3eb355.23no data
165KCAB2Voltage-gated potassium channel subunit beta-2Q13303KCNA2B KCNK2pdnVoltage-dependent K+ channel beta subunit (I211R) in complex with cortisone3eb461.04no data
166KCAB2Voltage-gated potassium channel subunit beta-2Q13303KCNA2B KCNK2pdnVoltage-dependent K+ channel beta subunit in complex with cortisone3eau61.61no data