The Ligandable Human Proteome

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Transthyretin/hydroxyisourate hydrolase domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1TTHYTransthyretinP02766PALBt33MECHANISM OF MOLECULAR RECOGNITION. STRUCTURAL ASPECTS OF 3,3'-DIIODO-L-THYRONINE BINDING TO HUMAN SERUM TRANSTHYRETIN1tha50.79no data
2TTHYTransthyretinP02766PALBmkuCrystal structure of V30M mutated transthyretin in complex with 3-isomangostin4y9g50.88no data
3TTHYTransthyretinP02766PALBmktCrystal structure of V30M mutated transthyretin in complex with gamma-mangostin4y9e60.38no data
4TTHYTransthyretinP02766PALBmktCrystal structure of V30M mutated transthyretin with bromide in complex with gamma-mangostin4y9f60.1no data
5TTHYTransthyretinP02766PALBmksCrystal structure of V30M mutated transthyretin with bromide in complex with alpha-mangostin4y9c54.55no data
6TTHYTransthyretinP02766PALBmksCrystal structure of V30M mutated transthyretin in complex with alpha-mangostin4y9b54.8no data
7TTHYTransthyretinP02766PALBjtkCrystal structure of transthyretin in complex with CHF4795, a flurbiprofen analogue6r6857.11no data
8TTHYTransthyretinP02766PALBjteCrystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue6r6756.21no data
9TTHYTransthyretinP02766PALBg24Wild type human transthyretin (TTR) complexed with GC-24 (TTRwt:GC-24)3neo47.741200.
10TTHYTransthyretinP02766PALBg24V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24)3nex48.231000.
11TTHYTransthyretinP02766PALBfq7Structure of human transthyretin complex with analgesic inhibitor6d0w46.87no data
12TTHYTransthyretinP02766PALBdz2Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide3eso54.39no data
13TTHYTransthyretinP02766PALBdesThe orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol1tt649.97no data
14TTHYTransthyretinP02766PALBd75Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: daidzein-7-O- glucuronide5al840.52no data
15TTHYTransthyretinP02766PALBa93Transthyretin in complex with a covalent small molecule kinetic stabilizer3hj048.221960.
16TTHYTransthyretinP02766PALB9crTRANSTHYRETIN COMPLEX WITH RETINOIC ACID1tyr48.19no data
17TTHYTransthyretinP02766PALB1w4Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide4l1s47.8no data
18TTHYTransthyretinP02766PALB1flStructure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal6e7346.42no data
19TTHYTransthyretinP02766PALB1flStructure of Wild Type Human Transthyretin in Complex with Diflunisal6e7058.71no data
20TTHYTransthyretinP02766PALB1flStructure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal6e7850.01no data
21TTHYTransthyretinP02766PALBdifCrystal structure of human wild-type transthyretin in complex with diclofenac3cfq52.24no data
22TTHYTransthyretinP02766PALBflfCrystal structure of human transthyretin variant A25T in complex with flufenamic acid.3ozl52.65no data
23TTHYTransthyretinP02766PALBmilSTRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX1tlm52.13no data
24TTHYTransthyretinP02766PALBfhiCrystal structure of transthyretin in complex with iododiflunisal1y1d42.99no data
25TTHYTransthyretinP02766PALB3caHuman transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID2b7741.11no data
26TTHYTransthyretinP02766PALBqueCrystal structure of Transthyretin-quercetin complex4wnj48.77no data
27TTHYTransthyretinP02766PALBlj5Human transthyretin (TTR) in complex with N-(3,5-Dibromo-4-hydroxyphenyl)benzamide3cn445.99no data
28TTHYTransthyretinP02766PALB57dCrystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR)4des53.971400.
29TTHYTransthyretinP02766PALBdz1Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide3esn50.82no data
30TTHYTransthyretinP02766PALBdz3Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-3,5-dimethyl-4-hydroxybenzamide3esp53.03no data
31TTHYTransthyretinP02766PALBifaCrystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe3fc852.384100.
32TTHYTransthyretinP02766PALBifbCrystal structure of transthyretin in complex with iododiflunisal-betaAlaOH3fcb51.584900.
33TTHYTransthyretinP02766PALBgenV30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.53kgt54.743100.
34TTHYTransthyretinP02766PALBgenWild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.53kgu53.481200.
35TTHYTransthyretinP02766PALBft2CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-34abv53.5850.
36TTHYTransthyretinP02766PALBcjzHuman Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid3m1o48.43no data
37TTHYTransthyretinP02766PALBflpCRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH FLURBIPROFEN1dvt46.25no data
38TTHYTransthyretinP02766PALBb72V30M mutant human transthyretin (TTR) complexed with GC-1 (V30M:GC-1)3nes48.032400.
39TTHYTransthyretinP02766PALBb72Wild type human transthyretin (TTR) complexed with GC-1 (TTRwt:GC-1)3nee40.944600.
40TTHYTransthyretinP02766PALB3m3Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole3p3t51.7657.91
41TTHYTransthyretinP02766PALB3m4Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole3p3u53.44329.1
42TTHYTransthyretinP02766PALBtcwV122I Transthyretin structure in complex with Tolcalpone5a6i57.6556.
43TTHYTransthyretinP02766PALBimnCrystal structure of wild-type human transthyretin in complex with indomethacin4iki33.35no data
44TTHYTransthyretinP02766PALBimnCrystal structure of human transthyretin in complex with indomethacin4ik748.54no data
45TTHYTransthyretinP02766PALB16vThe Structure of V122I Mutant Transthyretin in Complex with AG104hiq56.636.2
46TTHYTransthyretinP02766PALB18aKinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide4hjt48.31no data
47TTHYTransthyretinP02766PALBlurCrystal structure of human transthyretin in complex with lumiracoxib4ik649.61no data
48TTHYTransthyretinP02766PALBlurCrystal structure of wild-type human transthyretin in complex with lumiracoxib4iiz41.82no data
49TTHYTransthyretinP02766PALBdiuCrystal structure of transthyretin in complex with 3,5-diiodosalicylic acid3b5653.7no data
50TTHYTransthyretinP02766PALBgbjCrystal structure of V30M mutant human transthyretin complexed with glabridin4n8746.21no data
51TTHYTransthyretinP02766PALBgbjCrystal structure of human transthyretin complexed with glabridin4n8646.64no data
52TTHYTransthyretinP02766PALBeszHuman transthyretin (TTR) complexed with 16-alpha-bromo-estradiol4pm148.42no data
53TTHYTransthyretinP02766PALBpwhCrystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester4pwh45.85no data
54TTHYTransthyretinP02766PALBroaCrystal structure of V30M mutant human transthyretin complexed with rosmarinic acid4pwi37.66no data
55TTHYTransthyretinP02766PALB30zCrystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid4pwj50.68no data
56TTHYTransthyretinP02766PALBkmpCrystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE)4det45.282100.
57TTHYTransthyretinP02766PALBlu2Crystal structure of human transthyretin variant V30M in complex with luteolin4qya46.6no data
58TTHYTransthyretinP02766PALBlu2CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION4qxv52.87no data
59TTHYTransthyretinP02766PALBagiCrystal structure of transthyretin in complex with apigenin4wo049.93no data
60TTHYTransthyretinP02766PALBagiCrystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API)4der48.04490.
61TTHYTransthyretinP02766PALBl57Human transthyretin (TTR) complexed with (Z)-((3,4-Dichloro-phenyl)-methyleneaminooxy)-acetic acid5e4o57.56no data
62TTHYTransthyretinP02766PALB1flHuman transthyretin (ttr) complexed with diflunisal3d2t51.5475.
63TTHYTransthyretinP02766PALBqapCrystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester4qrf53.03no data
64TTHYTransthyretinP02766PALB6b5Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution5ihh47.56390.
65TTHYTransthyretinP02766PALB6j3Crystal Structure of Human Transthyretin in Complex with Clonixin5l4i49.85260.
66TTHYTransthyretinP02766PALBxloWild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]benzoic Acid5u4d51.91470.