| Index | Gene Name Primary | Protein Name | Uniprot ID | Gene Name Synonym | Ligand Name | Structure | PDB Code | ligand desolvation | Ligand Structure | Compound Affinity nM |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9bn | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-acetylcyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 16) | 5nvz | 67.03 | | 170. |
| 2 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9bk | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-acetamidocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 17) | 5nw0 | 66.76 | | 300. |
| 3 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9bh | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclobutanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 18) | 5nw1 | 69.11 | | 250. |
| 4 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9b8 | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-3,3-dimethyl-2-(oxetane-3-carboxamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 19) | 5nw2 | 69.27 | | 320. |
| 5 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 6z3 | pVHL:EloB:EloC in complex with VH298 | 5lli | 68.51 | | 90. |
| 6 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 4yy | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 10) | 5nvx | 70.28 | | 90. |
| 7 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jo | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3-phenylpropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 14) | 4w9k | 63.87 | | 291. |
| 8 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jj | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15) | 4w9l | 67.56 | | 9520. |
| 9 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jh | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13) | 4w9j | 66.61 | | 588. |
| 10 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | l8b | pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound | 3zrc | 67.99 | | 5400. |
| 11 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | tr0 | pVHL54-213-EloB-EloC complex _ (2S,4R)-N-((1,1'-biphenyl)-4-ylmethyl)- 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2- carboxamide | 3ztc | 67.95 | | 27700. |
| 12 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | ztd | pVHL54-213-EloB-EloC complex _ methyl 4-(((2S,4R)-4-hydroxy-1-(2-(3- methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamido)methyl)benzoate | 3ztd | 67.35 | | 96200. |
| 13 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | zun | pVHL54-213-EloB-EloC complex_(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol- 5-yl)acetyl)-N-(4-nitrobenzyl)pyrrolidine-2-carboxamide bound | 3zun | 67.32 | | no data |
| 14 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | uck | pVHL-EloB-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound | 4b95 | 67.64 | | 52000. |
| 15 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | tg0 | pVHL-ELOB-ELOC complex_(2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide bound | 4b9k | 67.12 | | 670. |
| 16 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | x6c | von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-1-ethanoyl-N-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | 4bks | 70.34 | | 150000. |
| 17 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | qd0 | von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-N-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide | 4bkt | 63.51 | | 240000. |
| 18 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jg | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 2) | 4w9c | 64.87 | | 22200. |
| 19 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jk | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methyloxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) | 4w9d | 69.81 | | 10200. |
| 20 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jt | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4) | 4w9e | 65.98 | | 7090. |
| 21 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3ju | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 5) | 4w9f | 64.64 | | 3270. |
| 22 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jv | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(3-methyl-4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6) | 4w9g | 65.07 | | 5530. |
| 23 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3jf | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) | 4w9h | 71.94 | | 185. |
| 24 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 3js | pVHL:EloB:EloC in complex with (2S,4R)-1-((2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carbonyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 10) | 4w9i | 67.93 | | 1100. |
| 25 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9bt | pVHL:EloB:EloC in complex with (2S,4R)-4-hydroxy-1-((S)-2-(2-hydroxyacetamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) | 5nvv | 70.75 | | 200. |
| 26 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9bw | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6) | 5nvw | 71.16 | | 170. |
| 27 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | 9b5 | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamidopropanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl) pyrrolidine-2-carboxamide (ligand 11) | 5nvy | 70.35 | | 760. |
| 28 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | dv2 | pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-oxopropan-2-yl)acetamide (ligand 2) | 6fmi | 66.96 | | no data |
| 29 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | dv5 | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-Acetamidopropanethioyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl) benzyl)pyrrolidine-2-carboxamide (ligand 3) | 6fmj | 69.32 | | no data |
| 30 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | dv8 | pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) | 6fmk | 67.57 | | no data |
| 31 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | exh | pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a) | 6gfy | 71.01 | | no data |
| 32 | VHL | von Hippel-Lindau disease tumor suppressor | P40337 | | exe | pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b) | 6gfz | 70.78 | | no data |