The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	x8u	Crystal structure of BCL-XL in complex with inhibitor (Compound 6)	3zlo	83.69	1.5
2	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	x0d	Crystal structure of Bcl-xL in complex with benzoylurea compound (39b)	4c52	75.5	2100.
3	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	x0b	Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)	3zlr	83.4	0.55
4	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	h0y	Crystal structure of BCL-XL in complex with inhibitor (Compound 3)	3zln	88.39	3.4
5	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	b50	Crystal Structure of Bcl-xL bound to BM501	3spf	52.32	138000.
6	B2CL1	Bcl-2-like protein 1	Q07817	BCL2L BCLX	0q5	Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide	4ehr	70.62	13.
7	BCL2	Apoptosis regulator Bcl-2	P10415		dro	Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex	2w3l	65.47	30.
8	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	n0s	Crystal structure of Mcl1 with inhibitor 9	6oqc	83.2	no data
9	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	n0p	Crystal structure of Mcl1 with inhibitor 7	6oqn	80.08	no data
10	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	n0m	Crystal structure of Mcl1 with inhibitor 8	6oqd	78.41	no data
11	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	n0j	Co-crystal structure of Mcl1 with inhibitor 10	6oqb	76.56	no data
12	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	loj	Co-crystal structure of Mcl1 with inhibitor	6o6g	83.92	no data
13	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	lod	Co-crystal structure of Mcl1 with inhibitor	6o6f	84.1	no data
14	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	lc3	Crystal structure of Mcl-1 in complex with compound 4	3wix	76.39	540.
15	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jlk	Structure of Mcl-1 in complex with compound 8d	6qzb	73.51	no data
16	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jlh	Structure of MBP-Mcl-1 in complex with compound 18a	6qyo	63.36	no data
17	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jle	Structure of Mcl-1 in complex with compound 8b	6qz6	72.82	no data
18	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jle	Structure of Mcl-1 in complex with compound 8a	6qz5	72.77	no data
19	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jle	Structure of MBP-Mcl-1 in complex with compound 8b	6qz7	70.59	no data
20	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jle	Structure of MBP-Mcl-1 in complex with compound 8a	6qyl	70.22	no data
21	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jlb	Structure of MBP-Mcl-1 in complex with compound 7a	6qyk	73.85	no data
22	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jl8	Structure of Mcl-1 in complex with compound 10d	6qz8	73.94	no data
23	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jl8	Structure of MBP-Mcl-1 in complex with compound 10d	6qyn	71.26	no data
24	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jl5	Structure of Mcl-1 in complex with compound 13	6qyp	63.28	no data
25	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	jkq	Structure of MBP-Mcl-1 in complex with compound 6a	6qxj	72.43	no data
26	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	j1n	Structure of human Mcl-1 in complex with thienopyrimidine inhibitor	6qgd	77.66	no data
27	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	e4q	MCL1 in complex with an indole acid ligand	6fs1	74.47	no data
28	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	cn7	Crystal structure of MCL-1 in complex with a BIM competitive inhibitor	6b4u	70.93	21.
29	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	cjy	Crystal structure of MCL-1 in complex with a BIM competitive inhibitor	6b4l	86.48	340.
30	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	865	STRUCTURE OF MBP-MCL1 BOUND TO ligand 1 AT 2.35A	4wmt	69.07	no data
31	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	865	STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A	4wmr	74.99	no data
32	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	5x2	Mcl-1 complexed with small molecule inhibitor	5fdo	88.67	361.
33	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	4m7	Mcl-1 complexed with small molecules	4zbf	83.59	74.
34	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	4m6	Mcl-1 complexed with small molecules	4zbi	85.28	310.
35	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	2uu	Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid	4oq5	98.87	500.
36	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	19h	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design	4hw2	94.13	55.
37	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	19h	STRUCTURE OF MBP-MCL1 BOUND TO ligand 2 AT 1.55A	4wmu	86.83	180.
38	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	19g	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design	4hw3	86.76	320.
39	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	2uv	Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid	4oq6	89.95	3300.
40	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	BCL2L3	5wl	Mcl-1 complexed with small molecule inhibitor	5fc4	82.44	no data

The Ligandable Human Proteome

Blc2 family