The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	DCK	Deoxycytidine kinase	P27707	2y1	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 9 {2-{[(1R)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}	4q1d	84.48	16.6
2	DCK	Deoxycytidine kinase	P27707	2xn	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 12R {N-{2-[5-(4-{(1R)-1-[(4,6-diaminopyrimidin-2-yl)sulfanyl]ethyl}-5-methyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide}	4q1f	83.41	9.2
3	DCK	Deoxycytidine kinase	P27707	2xm	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 8 {2,2'-[{4-[(2R)-4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-2,3-dihydro-1,3-thiazol-2-yl]benzene-1,2-diyl}bis(oxy)]diethanol}	4q1c	80.02	2.
4	DCK	Deoxycytidine kinase	P27707	1qc	Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor	4kcg	80.69	5.
5	DCK	Deoxycytidine kinase	P27707	ac2	Human dCK complex with Acyclic Nucleoside	3mjr	85.71	no data
6	DCK	Deoxycytidine kinase	P27707	3d1	C4S dCK variant of dCK in complex with D-dA+UDP	2zi6	93.02	no data
7	DCK	Deoxycytidine kinase	P27707	3d1	C4S-E247A dCK variant of dCK in complex with D-dA+ADP	2zi3	99.19	no data
8	DCK	Deoxycytidine kinase	P27707	cfb	Crystal structure of human dCK complexed with clofarabine and ADP	2a7q	99.59	no data
9	DCK	Deoxycytidine kinase	P27707	mcy	Human dCK complex with 5-Me dC and ADP	3kfx	97.39	no data
10	DCK	Deoxycytidine kinase	P27707	etv	C4S dCK variant of dCK in complex with FTC+ADP	2no6	98.56	no data
11	DCK	Deoxycytidine kinase	P27707	ldc	C4S dCK variant of dCK in complex with L-dC+ADP	2no7	98.39	no data
12	DCK	Deoxycytidine kinase	P27707	ltt	The structure of deoxycytidine kinase complexed with troxacitabine and ADP.	2no9	98.82	no data
13	DCK	Deoxycytidine kinase	P27707	3tc	The structure of deoxycytidine kinase complexed with lamivudine and ADP.	2noa	98.95	no data
14	DCK	Deoxycytidine kinase	P27707	geo	C4S dCK variant of dCK in complex with gemcitabine+ADP	2no0	98.22	no data
15	DCK	Deoxycytidine kinase	P27707	geo	Structure of human dCK complexed with gemcitabine and ADP-MG	1p62	96.34	no data
16	DCK	Deoxycytidine kinase	P27707	3l1	C4S dCK variant of dCK in complex with L-dA+ADP	2zi4	99.89	no data
17	DCK	Deoxycytidine kinase	P27707	3l1	C4S dCK variant of dCK in complex with L-dA+UDP	2zi5	93.27	no data
18	DCK	Deoxycytidine kinase	P27707	cl9	C4S-E247A dCK variant of dCK in complex with cladribine+ADP	2zi9	98.82	no data
19	DCK	Deoxycytidine kinase	P27707	cl9	C4S dCK variant of dCK in complex with cladribine+UDP	2zia	98.54	no data
20	DCK	Deoxycytidine kinase	P27707	b86	X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor	3ipx	97.39	120.
21	DCK	Deoxycytidine kinase	P27707	b87	X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor	3ipy	88.93	510.
22	DCK	Deoxycytidine kinase	P27707	5bt	S74E dCK in complex with 5-bromodeoxycytidine and UDP	3qen	92.94	no data
23	DCK	Deoxycytidine kinase	P27707	llt	Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP	3hp1	98.93	no data
24	DCK	Deoxycytidine kinase	P27707	llt	S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP	3qeo	87.85	no data
25	DCK	Deoxycytidine kinase	P27707	1nn	Human dCK C4S-S74E mutant in complex with UDP and the F2.3.1 inhibitor (2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)	4jlm	92.84	22.7
26	DCK	Deoxycytidine kinase	P27707	18v	Human dCK C4S-S74E mutant in complex with UDP and the F2.4.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-PROPYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)	4jln	84.48	16.7
27	DCK	Deoxycytidine kinase	P27707	1ux	Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor	4l5b	81.99	no data
28	DCK	Deoxycytidine kinase	P27707	gng	C4S dCK variant of dCK in complex with D-dG+UDP	2zi7	98.86	no data
29	DCK	Deoxycytidine kinase	P27707	2xl	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 5 {5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL}	4q19	85.84	8.9
30	DCK	Deoxycytidine kinase	P27707	2xz	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 6 {2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethanol}	4q1a	82.31	0.5
31	DCK	Deoxycytidine kinase	P27707	2y0	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 7 {N-(2-(3-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)phenoxy)ethyl)methanesulfonamide}	4q1b	80.87	1.9
32	DCK	Deoxycytidine kinase	P27707	2y7	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}	4q1e	72.86	6.8
33	DCK	Deoxycytidine kinase	P27707	2y8	Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine}	4q1e	90.82	6.8
34	DCK	Deoxycytidine kinase	P27707	dcz	C4S dCK variant of dCK in complex with D-dC+ADP	2no1	97.96	no data
35	DCK	Deoxycytidine kinase	P27707	dcz	Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21	1p60	97.83	no data
36	DCK	Deoxycytidine kinase	P27707	dcz	Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group	1p61	97.15	no data
37	DCK	Deoxycytidine kinase	P27707	1no	Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)	4jlk	91.49	no data

The Ligandable Human Proteome

Deoxynucleoside kinase domain