The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zye	Human BACE-1 in complex with 1-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-4-(2-oxo-1- pyrrolidinyl)-1H-indole-6-carboxamide	2wez	85.31	23.
2	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zy4	Human BACE-1 in complex with 6-ethyl-1-methyl-N-((1S)-2-oxo-1-(phenylmethyl)-3-(tetrahydro-2H-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide	2wf4	87.57	13.
3	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zy3	Human BACE-1 in complex with 6-(ethylamino)-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-1, 3,4,5-tetrahydro-2,1-benzothiazepine-8-carboxamide 2,2-dioxide	2wf3	86.58	19.
4	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zy2	Human BACE-1 in complex with 8-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1H,6H-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide	2wf2	84.47	26.
5	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zy1	Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4- dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2- dioxide	2wf1	85.08	2.
6	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zpx	Crystal structure of BACE1 with its inhibitor	3uqu	87.18	no data
7	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	xfi	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide	2xfi	83.06	15.
8	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg6	Human BACE-1 in complex with 3-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide	2vj7	87.76	40.
9	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg5	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl)benzamide	2vj6	89.05	13.
10	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg5	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl)benzamide	2xfj	88.8	13.
11	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg4	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(2-oxo- 1-pyrrolidinyl)-5-(propyloxy)benzamide	2viz	89.01	605.
12	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg3	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide	2viy	83.43	1800.
13	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg0	Human BACE-1 in complex with N-((1S,2R)-1-benzyl-2-hydroxy-3-((1,1,5- trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl) benzamide	2vie	89.07	33.
14	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	sii	Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor	3fkt	80.87	2800.
15	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	sc7	Structure of BACE Bound to SCH734723	2qp8	79.23	8.
16	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	sc6	Structure of BACE Bound to SCH745966	2qmg	87.34	0.7
17	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	rvi	Structure of Bace-1 (Beta-Secretase) in Complex with 2-((2-Amino-6-o-tolylquinolin-3-yl)methyl)-N-(cyclohexylmethyl)pentanamide	3rvi	86.73	11.
18	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	rtn	Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Amino-6-o-tolylquinolin-3-yl)-N-cyclohexylpropanamide	3rtn	86.37	74.
19	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	qud	human Bace (beta secretase) in complex with Cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4H-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide	2wjo	86.05	no data
20	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	qin	Crystal Structure of Human Beta Secretase Complexed with inhibitor	2oah	86.82	11.
21	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	qbh	Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors	3qbh	88.63	150.
22	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	pb8	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3-isoquinolinyl)ethyl)-4-phenylbutanamide	3skg	76.54	8.
23	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	pb7	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with (2S)-2-((3S)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1-yl)-N-((2S,3R)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2-yl)-4-phenylbutanamide	3skf	79.74	5.
24	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	pb0	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with BMS-693391 AKA (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2R,4R)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide	3r2f	78.42	1.4
25	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	p6j	co-crystal structure of BACE with inhibitor AM-6494	6pz4	81.05	no data
26	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	mr0	Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1	2p83	83.36	11.
27	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	m7d	Structure of BACE-1 in complex with Ligand 13	6od6	77.73	no data
28	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	l3j	BACE1 in complex with a macrocyclic inhibitor	6nv7	85.61	no data
29	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	l01	BACE (Beta Secretase) in complex with a nanomolar non-peptidic inhibitor	1w51	88.2	500.
30	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	l00	Crystal structure of Human Bace-1 bound to inhibitor	2ntr	82.92	no data
31	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	i6x	Design and Synthesis of BACE1 Inhibitors with In Vivo Brain Reduction of beta-Amyloid Peptides (COMPOUND (R)-41)	4b00	83.43	2.44
32	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	i03	Crystal structure of human Beta-secretase complexed with inhibitor	2is0	89.36	200.
33	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	i02	Crystal structure of human Beta-secretase complexed with inhibitor	2irz	89.09	12.
34	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	hrv	Structure of Bace-1 in complex with Ligand 8	6e3z	79.83	no data
35	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	frp	Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor	2fdp	87.43	26.
36	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1n	Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide	2zjn	78.11	no data
37	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1m	Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide	2zjm	85.64	no data
38	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	dwd	Crystal structure of BACE1 in complex with aminooxazoline xanthene 11a	4frk	80.72	8.
39	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	cs9	Structure of BACE Bound to SCH735310	2qmf	84.32	3.
40	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	cs5	Structure of BACE1 bound to SCH626485	2qk5	82.48	8.
41	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	cs5	Structure of BACE Bound to SCH589432	3l58	82.04	8.
42	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c83	Crystal Structure of BACE1 in complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide	6jt3	83.52	no data
43	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c7x	Crystal Structure of BACE1 in complex with N-(3-((4S,5S)-2-amino-4-methyl-5-phenyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide	6jsf	90.09	no data
44	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c7o	Crystal Structure of BACE1 in complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide	6jsn	74.4	no data
45	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c6u	Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-chloropyridine-2-carboxamide	6jsg	83.89	no data
46	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c6r	Crystal Structure of BACE1 in complex with N-(3-((4S,5R)-2-amino-4-methyl-5-phenyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide	6jse	91.45	no data
47	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c6a	Design and synthesis of hydroxyethylamine (hea) BACE-1 inhibitors: prime side chromane-containing inhibitors	3qi1	86.56	22.
48	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bxq	Crystal Structure of Human Beta Secretase in Complex with NVP-BXQ490	4d88	86.52	49.
49	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bxd	Crystal Structure of Human Beta Secretase in Complex with NVP-BXD552, derived from a co-crystallization experiment	4d8c	81.52	2.
50	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bxd	Crystal Structure of Human Beta Secretase in Complex with NVP-BXD552, derived from a soaking experiment	4d89	82.64	2.
51	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	buh	Crystal Structure of Human BACE-1 in Complex with CNP520	6eqm	78.65	no data
52	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bjc	Human bace-1 complex with bjc060	3k5g	84.98	2.5
53	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdw	Structure of BACE Bound to SCH736062	3l5e	77.87	27.
54	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	ayh	Human BACE-1 COMPLEX WITH AYH011	3k5f	87.71	3700.
55	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	aa9	Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)(phenyl)amino)benzamide	2xfk	84.41	3.
56	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	957	SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors	4i0i	83.17	no data
57	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	957	BACE-1 in complex with ELN475957	3nsh	83.17	470.
58	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	916	Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors	4exg	86.72	8.5
59	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	879	Bace1 in complex with the aminopyridine Compound 44	3l38	78.72	100.
60	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	74a	Structure of BACE bound to SCH743813	3lnk	71.47	1150.
61	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	712	Crystal Structure of Human Beta Secretase Complexed with inhibitor	2ph6	89.26	27.
62	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	6bs	Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide	5ie1	81.4	140.
63	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	68m	Crystal structure of BACE1 in complex with aminoquinoline compound 1	5i3v	86.71	16.
64	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	68j	Crystal structure of BACE1 in complex with aminoquinoline inhibitor 6	5i3x	85.18	8.
65	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	625	Bace-1 with the aminopyridine Compound 32	3l3a	81.22	420.
66	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5ha	Crystal structure of BACE1 complexed with an inhibitor	3tpr	76.96	19.9
67	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5ha	Crystal structure of BACE1 complexed with an inhibitor	3tpp	91.82	15.
68	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5ha	Crystal structure of human beta secretase complexed with inhibitor	2b8l	90.01	15.
69	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	508	Discovery of Pyrrolidine-based b-Secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency	3ufl	88.61	150.
70	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4qf	BACE1 in complex with 8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one	4zpg	86.28	55.
71	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4qd	BACE1 in complex with 8-(3-((1-aminopropan-2-yl)oxy)benzyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one	4zpf	83.26	180.
72	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4qa	BACE1 in complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one	4zpe	86.42	450.
73	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	411	X-ray structure of Bace-1 in complex with compound 6g	2ze1	78.09	600.
74	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ut	Crystal structure of BACE1 in complex with 2-aminooxazoline 3-aza-4-fluoro-xanthene inhibitor 22	4wtu	83.58	0.3
75	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3rs	Structure of Bace-1 (Beta-Secretase) in complex with (R)-3-(2-amino-6-o-tolylquinolin-3-yl)-N-((R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-methylpropanamide	3rsv	86.97	0.7
76	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3mr	Structure of BACE complexed to compound 3a	2q15	81.97	11.
77	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3lo	Crystal structure of BACE1 in complex with 2-aminooxazoline 4-fluoroxanthene inhibitor 49	4rcf	83.85	4.
78	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ln	Crystal structure of BACE1 in complex with aminooxazoline xanthene inhibitor 2	4rce	81.62	2.
79	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3kw	BACE-1 in complex with 2-(((1R,3S)-3-(((R)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium	4r95	73.35	14.
80	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3hf	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with bms-655295 aka n~3~-((1s,2r)-1- benzyl-2-hydroxy-3-((3-methoxybenzyl)amino)propyl)-n~1~, n~1~-dibutyl-1h-indole-1,3-dicarboxamide	3ohf	80.77	94.
81	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3bn	Crystal structure of human Beta-secretase complexed with L-L000430,469	2b8v	87.16	98.
82	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	32p	Crystal structure of human Beta secretase complexed with inhibitor	1tqf	83.45	1400.
83	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	318	Structure of BACE Bound to SCH726222	3cid	84.28	5.
84	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	316	Structure of BACE Bound to SCH709583	3cic	83.73	3.
85	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	2li	Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents	3ivi	92.87	12.
86	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1yu	Crystal Structure of Human Beta Secretase in Complex with compound 12a	4lxm	82.07	88.
87	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1yt	Crystal Structure of Human Beta Secretase in Complex with compound 11d	4lxk	82.87	4.
88	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1ys	Crystal Structure of Human Beta Secretase in Complex with Compound 11a	4lxa	84.15	2.
89	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1r8	Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13	4ke0	87.4	17.
90	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1r6	Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19	4ke1	85.67	2.5
91	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1qu	Bace-1 inhibitor complex	4k9h	86.85	76.
92	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1qt	Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity	4k8s	87.03	36.
93	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1li	Design and Synthesis of Potent BACE-1 Inhibitors with Cellular Activity: Structure-Activity Relationship of P1 Substituents	3ivh	84.71	47.
94	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1bl	SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.	4i0h	82.08	no data
95	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1be	Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors	4i1c	85.9	8.
96	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1bc	Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors	4i12	79.45	406.
97	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1b8	Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors	4i0e	78.57	no data
98	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1b7	Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors	4i0d	86.44	610.
99	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0xa	BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571	4gmi	89.95	no data
100	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0n1	BACE-1 in complex with HEA-macrocyclic inhibitor, MV078512	4dpi	89.28	78.
101	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0kn	Structure of Bace-1 (Beta-Secretase) in Complex with (2R)-N-((2S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((S)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)-2-methoxypropanamide	4dh6	86.48	16.8
102	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0k9	Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37	4di2	84.45	5.5
103	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0gu	Crystal Structure of Human Beta Secretase in Complex with NVP-BVI151	4d85	89.86	140.
104	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0gt	Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a soaking experiment	3vg1	86.74	55.
105	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0gt	Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment	4d83	87.38	55.
106	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0gs	Crystal Structure of Human Beta Secretase in Complex with NVP-BQQ711	3vf3	85.16	1370.
107	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0go	Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326	3veu	84.44	55.
108	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0bi	Human BACE-1 complex with NB-216	3k5c	83.77	17.
109	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	012	Crystal structure of BACE-1 in complex with inhibitor	3ckp	81.5	449.
110	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	009	Crystal structure of BACE-1 in complex with inhibitor	3ckr	77.52	5001.
111	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	cmz	X-ray crystal structure of beta secretase complexed with compound 5	2of0	73.76	no data
112	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	9ip	X-ray crystal structure of beta secretase complexed with compound 6b	2ohs	76	40000.
113	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	xx4	Structure of BACE complexed to compound 1	2q11	79.09	900.
114	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	251	BACE1 with Compound 1	2qu2	75.09	3700.
115	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	462	BACE1 with Compound 2	2qu3	79.42	590.
116	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c8c	X-ray crystal structure of beta secretase complexed with compound 8c	2va5	72.49	86000.
117	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vg7	Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide	2vj9	88.62	180.
118	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1h	Crystal structure of the human BACE1 catalytic domain in complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide	2zjh	74.83	no data
119	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1i	Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide	2zji	75.76	no data
120	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1k	Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide	2zjk	75.57	no data
121	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1l	Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide	2zjl	82.77	no data
122	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	aed	BACE-1 complexed with compound 4	3buh	73.98	220000.
123	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	b35	Discovery of aminoheterocycles as a novel beta-secretase inhibitor class	3h0b	86.37	3200.
124	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	454	Bace-1 with Compound 3	3igb	69.65	38000.
125	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	472	Bace1 with Compound 30	3in3	78.87	60.
126	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bx2	Bace1 with Compound 38	3in4	73.28	30.
127	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	593	Bace1 with the aminohydantoin Compound 29	3ind	77.23	1530.
128	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	x17	Bace1 with the aminohydantoin Compound S-34	3ine	75.54	170.
129	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	x45	Bace1 with the aminohydantoin Compound 37	3inf	76.27	40.
130	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	569	Bace1 with the aminohydantoin Compound R-58	3inh	80.14	20.
131	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	g00	Structure of BACE bound to SCH346572	3kmx	87.85	15000.
132	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	d8y	Structure of BACE bound to SCH12472	3kmy	80.2	32000.
133	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdj	Structure of BACE Bound to SCH710413	3l59	70.04	200000.
134	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdo	Structure of BACE Bound to SCH713601	3l5b	62.04	123000.
135	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdq	Structure of BACE Bound to SCH723871	3l5c	55.16	7000.
136	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdv	Structure of BACE Bound to SCH723873	3l5d	61.47	78000.
137	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bdx	Structure of BACE Bound to SCH736201	3l5f	80.15	605.
138	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	z81	Bace1 in complex with the aminohydantoin Compound 4g	3lhg	74.51	20.
139	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	ev4	Fragment Based Discovery and Optimisation of BACE-1 Inhibitors	3msk	69.34	26000.
140	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	842	SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors	4i0j	86.52	no data
141	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	842	BACE-1 in complex with ELN380842	3n4l	86.35	59.
142	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	zoo	Bace1 in complex with the aminohydantoin Compound 102	3ooz	83.19	14.
143	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	rtm	Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide	3rtm	68	38400.
144	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ru	Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-(cyclohexylmethyl)propanamide	3ru1	81.3	14200.
145	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	591	Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors	3s7l	78.53	80.
146	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	532	Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors	3s7m	80.86	10.
147	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	b00	Crystal Structure of beta secetase in complex with 2-amino-3-methyl-6-((1S, 2R)-2-phenylcyclopropyl)pyrimidin-4(3H)-one	3vv6	74.25	157000.
148	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0b1	Crystal Structure of beta secetase in complex with 2-amino-6-((1S,2R)-2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3H)-one	3vv7	76.31	4600.
149	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	b02	Crystal structure of beta secetase in complex with 2-amino-3-methyl-6-((1S,2R)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(3H)-one	3vv8	78.31	17100.
150	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0b3	Crystal Structure of beta secetase in complex with 2-amino-3,6-dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-one	3wb4	72.29	36600.
151	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0b4	Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one	3wb5	74.9	26800.
152	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	6t9	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Ethoxy-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j0t	80.95	184.
153	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	wzv	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND	3zov	80.83	60.
154	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	32d	Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease	4b05	86	26.1
155	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	6t6	New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain	4b1e	76.26	no data
156	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	kgg	Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab- lowering in Brain	4b78	78.03	10000.
157	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	8t3	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND	4bfd	85.27	96.
158	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0kk	Structure of BACE Bound to 2-imino-3-methyl-5,5-diphenylimidazolidin-4-one	4dju	73.77	3600.
159	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0kp	Structure of BACE Bound to 2-imino-3-methyl-5-phenyl-5-(3-(pyridin-3-yl)phenyl)imidazolidin-4-one	4djw	77.52	530.
160	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0kq	Structure of BACE Bound to 5-(3-(5-chloropyridin-3-yl)phenyl)-5-cyclopropyl-2-imino-3-methylimidazolidin-4-one	4djx	79.44	59.
161	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0mp	Structure of Bace-1 (Beta-Secretase) in complex with N-((2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)butan-2-yl)acetamide	4dus	85.08	5.
162	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	996	Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors	4ewo	86.65	44.
163	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0up	Crystal Structure of BACE with Compound 14g	4fm7	78.59	57.
164	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0uq	Crystal Structure of BACE with Compound 12a	4fm8	79.3	1060.
165	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0va	crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide	4fse	86.24	40.
166	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0vb	Crystal structure of beta-site app-cleaving enzyme 1 (BACE-DB-MUT) complex with N-(N-(4- acetamido-3-chloro-5-methylbenzyl)carbamimidoyl)-3-(4- methoxyphenyl)-5-methyl-4-isothiazolecarboxamide	4fsl	82.64	20.
167	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	10j	Structure of BACE-1 Bound to (7aR)-6-benzoyl-7a-(4-(3-cyanophenyl)thiophen-2-yl)-3-methyl-4-oxohexahydro-1H-pyrrolo[3,4-d]pyrimidin-2(3H)-iminium	4h1e	81.51	3.
168	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	10q	Structure of BACE Bound to 2-((7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)nicotinonitrile	4h3g	83.41	6.
169	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	10v	Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile	4h3i	72.12	3.
170	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	10w	Structure of BACE Bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile	4h3j	86.38	90.
171	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0za	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates	4hzt	85.17	750.
172	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1bf	Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors	4i0f	83.43	450.
173	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1b9	Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors	4i0g	83.89	no data
174	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1ch	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.	4i11	74.19	27200.
175	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vsi	Crystal structure of BACE1 with its inhibitor	4ivs	70.5	44.
176	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	vti	Crystal structure of BACE1 with its inhibitor	4ivt	81.12	1010.
177	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1h7	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j0v	80.83	28.
178	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1h6	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4R,5S)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j0y	81.97	435.
179	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1h5	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4S,5R)-2-amino-5-fluoro-4-fluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j0z	80.68	77.
180	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1ho	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((S)-2-amino-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1c	80.88	49.
181	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hm	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4S,6S)-2-amino-4-fluoromethyl-6-trifluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1e	78.62	19.
182	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hl	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4S,6S)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1f	79.05	12.
183	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hj	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4S,6R)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1h	76.51	776.
184	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hh	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4R,5R,6R)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1i	77.46	40.
185	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hg	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j1k	77.14	13.
186	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1m7	Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors	4jpe	76.63	48.
187	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1w1	Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)	4l7h	81.32	200000.
188	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1w2	Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)	4l7j	83.73	200000.
189	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1wp	Aminooxazoline inhibitor of BACE-1	4lc7	76.44	11800.
190	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	2ex	Discovery of 7-THP chromans: BACE1 inhibitors that reduce A-beta in the CNS	4n00	76.75	9.5
191	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3j9	8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors	4r5n	77.33	76.
192	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ko	BACE-1 in complex with (R)-4-(2-cyclohexylethyl)-4-(((R)-1-(2-cyclopentylacetyl)pyrrolidin-3-yl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium	4r8y	79.96	640.
193	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3kt	BACE-1 in complex with (R)-4-(2-cyclohexylethyl)-4-(((1S,3R)-3-(cyclopentylamino)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium	4r91	81.45	430.
194	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ku	BACE-1 in complex with (R)-4-(2-cyclohexylethyl)-4-(((1S,3R)-3-(isonicotinamido)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium	4r92	76.13	39.
195	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	779	BACE-1 in complex with (R)-4-(2-cyclohexylethyl)-1-methyl-5-oxo-4-(((1S,3R)-3-(3-phenylureido)cyclohexyl)methyl)imidazolidin-2-iminium	4r93	73.35	16.
196	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3uw	8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors	4rrn	75.35	48.
197	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ux	8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors	4rro	75.39	26.
198	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3uy	8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors	4rrs	76.01	210.
199	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3vo	Crystal structure of human BACE-1 bound to Compound 24B	4wy1	79.08	5100.
200	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3vp	Crystal structure of human BACE-1 bound to Compound 36	4wy6	78.65	1070.
201	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3wp	Crystal structure of human BACE-1 bound to Compound 6	4x2l	78.42	36000.
202	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	si5	Crystal structure of BACE1 with a pyrazole-substituted tetrahydropyran thioamidine	4xxs	86.84	52.
203	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5qv	Compound 18	5enk	75.02	8.
204	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5qu	Compound 10	5enm	73.17	70.
205	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60y	BACE-1 in complex with (7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5hd0	79.07	4.
206	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60w	BACE-1 incomplex with (7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5hdu	89.85	1.
207	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60v	BACE-1 incomplex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5hdv	73.65	15.
208	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60u	BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5hdx	75.94	48.
209	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	954	BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylthio)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5hdz	78.57	45.
210	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60t	BACE-1 in complex with (4aR,7aS)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5he4	81.63	20.
211	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60s	BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium	5he5	78.98	336.
212	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	60x	BACE-1 in complex with (4aR,7aS)-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one	5he7	81.59	5.
213	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	6wd	(4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to BACE1	5kqf	70.05	310.
214	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	6we	(4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to BACE1	5kr8	72.75	150.
215	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	iii	BACE-1 IN COMPLEX WITH LIGAND 32397778	5mxd	75.77	no data
216	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	74b	Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality	5t1w	80.8	77.
217	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	p6u	Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality	5t1u	77.79	69.
218	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0b5	Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide	5ygx	81.16	no data
219	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	djs	BACE crystal structure with hydroxy pyrrolidine inhibitor	6bfd	89.73	5.
220	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	dk7	BACE crystal structure with hydroxy morpholine inhibitor	6bfw	82.45	220.
221	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	ej7	Structure of Bace-1 (Beta-Secretase) in complex with : N-(3-((1R,5S,6R)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide	6c2i	81.19	no data
222	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	b7e	BACE1 compound 28	6ej2	83.16	no data
223	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	b7t	BACE1 compound 23	6ej3	81.05	no data
224	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	d9w	Crystal Structure of Human BACE-1 in Complex with amino-1,4-oxazine compound 4	6fgy	82.63	no data
225	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	dkj	BACE crystal structure with hydroxy pyrrolidine inhibitor	6bfx	83.07	79.
226	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	djv	BACE crystal structure with hydroxy pyrrolidine inhibitor	6bfe	91.43	1400.
227	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0b6	Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide	5ygy	77.21	no data
228	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	7h3	CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME 1 COMPLEXED WITH N-(3-((4AS,7AS)-2-AMINO-4,4A,5,6-TETRAHYDRO-7AH-FURO[2,3-D][1,3]THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-BROMO-2-PYRIDINECARBOXAMIDE	5tol	81.67	33.
229	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	68l	Crystal structure of BACE1 in complex with 2-aminooxazoline-3-azaxanthene inhibitor 2	5i3w	87.53	0.6
230	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	66f	BACE1 in complex with (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide	5hu1	87.43	2.2
231	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	66h	BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium	5hu0	80.83	595.
232	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5t7	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH (1SR,2SR)-2-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-N-(3-chloroquinolin-8-yl)cyclopropanecarboxamide	5f01	79.41	420.
233	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	5t8	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-[3-[(3-chloro-8-quinolyl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine	5f00	79.57	250.
234	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	52k	1,4-Oxazine BACE1 inhibitors	5clm	81.71	44.
235	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4ry	BACE crystal structure with tricyclic aminothiazine inhibitor	4zsr	79.17	36100.
236	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4rx	BACE crystal structure with tricyclic aminothiazine inhibitor	4zsq	81.01	2250.
237	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	4rz	BACE crystal structure with bicyclic aminothiazine inhibitor	4zsp	79.5	1830.
238	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3ys	Crystal Structure of BACE with amino thiazine inhibitor LY2886721	4x7i	83.89	20.3
239	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1hq	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((S)-2-amino-4-difluoromethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j17	81.98	54.
240	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1h8	CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide	4j0p	81.08	51.
241	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1bs	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates	4i10	80.15	170.
242	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1bb	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates	4i0z	76.64	470.
243	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	10o	Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile	4h3f	83.74	1.
244	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	0kr	Structure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one	4djy	79.38	5.4
245	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	1b1	New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain	4b1c	84.89	79.
246	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	gmf	Lead Generation of BACE1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold	4b0q	85.67	no data
247	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	s8z	Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 23	4acx	89.33	77.6
248	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	qn7	Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14	4acu	84.92	40.7
249	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	09e	Crystal Structure of BACE with Compound 13	3udq	83.8	1000.
250	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	09d	Crystal Structure of BACE with Compound 12	3udp	85.4	6000.
251	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	18p	Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (BACE) Inhibitors	3u6a	79.83	324.
252	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	ev6	Fragment based discovery and optimisation of bace-1 inhibitors	3s2o	71.54	8900.
253	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3p5	Crystal Structure of Human Beta Secretase in Complex with BFG356	3pi5	86.54	950.
254	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	ev5	Fragment Based Discovery and Optimisation of BACE-1 Inhibitors	3msl	68.83	7000.
255	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	3to	Structure of BACE bound to SCH708236	3kn0	77.3	250000.
256	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	bav	Crystal structure of human beta-secretase in complex with NVP-BAV544	3dv5	86.16	22.
257	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	f1j	Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide	2zjj	92.4	no data
258	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	310	X-ray structure of Bace-1 in complex with compound 3.b.10	2zdz	80.59	700.
259	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	c27	X-ray crystal structure of beta secretase complexed with compound 27	2va7	78.71	200.
260	BACE1	Beta-secretase 1	P56817	BACE KIAA1149	8ip	X-ray crystal structure of beta secretase complexed with compound 6a	2ohr	72.92	100000.
261	BACE2	Beta-secretase 2	Q9Y5Z0	AEPLC ALP56 ASP21	c7o	BACE2 xaperone complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide	6jsz	72.77	no data
262	BACE2	Beta-secretase 2	Q9Y5Z0	AEPLC ALP56 ASP21	wzv	BACE2 XAPERONE COMPLEX WITH INHIBITOR	3zks	78.5	no data
263	BACE2	Beta-secretase 2	Q9Y5Z0	AEPLC ALP56 ASP21	wzv	BACE2 FAB INHIBITOR COMPLEX	3zkn	65.08	no data
264	BACE2	Beta-secretase 2	Q9Y5Z0	AEPLC ALP56 ASP21	wzv	BACE2 MUTANT STRUCTURE WITH LIGAND	3zki	78.57	1200.
265	BACE2	Beta-secretase 2	Q9Y5Z0	AEPLC ALP56 ASP21	6t9	BACE2 XAPERONE COMPLEX	3zlq	79.81	904.
266	RENI	Renin	P00797		s53	Structure-Based Optimization of Potent 4- and 6-Azaindole-3-Carboxamides as Renin Inhibitors	3sfc	91.78	3.
267	RENI	Renin	P00797		rx6	Clinically Useful Alkyl Amine Renin Inhibitors	3q5h	89.96	560.
268	RENI	Renin	P00797		rx5	Clinically Useful Alkyl Amine Renin Inhibitors	3q4b	89.13	0.47
269	RENI	Renin	P00797		rpf	crystal structure of renin-pf00257567 complex	2bkt	88.12	23.
270	RENI	Renin	P00797		r32	Human renin in complex with compound 18	3vsx	85.46	1.4
271	RENI	Renin	P00797		hhe	Human renin in complex with compound 5	3vuc	83.07	0.9
272	RENI	Renin	P00797		c41	Crystal Structure of Renin with Inhibitor 10 (Aliskiren)	2v0z	88.9	0.6
273	RENI	Renin	P00797		bfx	New Classes of Potent and Bioavailable Human Renin Inhibitors	3k1w	88.06	no data
274	RENI	Renin	P00797		9g7	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5vpm	86.38	1.6
275	RENI	Renin	P00797		90d	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5v8v	80	1.3
276	RENI	Renin	P00797		7ek	Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor	5tmg	95.09	no data
277	RENI	Renin	P00797		7ej	Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor	5tmk	87.96	no data
278	RENI	Renin	P00797		72x	Crystal structure of human renin complexed with a novel inhibitor	3gw5	89.09	0.47
279	RENI	Renin	P00797		6vs	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5kos	90.72	1.5
280	RENI	Renin	P00797		6ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g22	89.86	no data
281	RENI	Renin	P00797		4lg	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g27	88.33	no data
282	RENI	Renin	P00797		3zn	RENIN IN COMPLEXED WITH (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate INHIBITOR	4rz1	87.71	40.
283	RENI	Renin	P00797		3zk	RENIN IN COMPLEXED WITH 4-methoxy-3-(3-methoxypropoxy)-N-{[(3S,4S)-4-{[(4-methylphenyl)sulfonyl]amino}pyrrolidin-3-yl]methyl}-N-(propan-2-yl)benzamide INHIBITOR	4ryc	89.18	80.
284	RENI	Renin	P00797		3zj	RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR	4ryg	89.76	8.
285	RENI	Renin	P00797		22x	Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors	3km4	95.81	1.3
286	RENI	Renin	P00797		0qb	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bim	83.54	1.2
287	RENI	Renin	P00797		0n0	Crystal structure of renin in complex with NVP-BGQ311 (compound 12)	4gjd	86.26	3.
288	RENI	Renin	P00797		0lu	Crystal structure of renin in complex with PKF909-724 (compound 3)	4gj8	92.91	500000.
289	RENI	Renin	P00797		0iu	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bil	85.2	0.5
290	RENI	Renin	P00797		03d	HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS	1hrn	88.83	9.
291	RENI	Renin	P00797		1ig	Ketopiperazine-based renin inhibitors: Optimization of the ""C"" ring	2g1n	89.33	no data
292	RENI	Renin	P00797		5ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g1y	90.29	90.
293	RENI	Renin	P00797		7ig	Crystal Structure of Human Renin Complexed with Inhibitor	2iko	77.77	3571.
294	RENI	Renin	P00797		7ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g24	78	4000.
295	RENI	Renin	P00797		c40	Crystal Structure of Renin with Inhibitor 7	2v13	89.76	26.
296	RENI	Renin	P00797		c47	Crystal Structure of Renin with Inhibitor 3	2v16	86.81	6.
297	RENI	Renin	P00797		ssr	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oot	90.11	2.
298	RENI	Renin	P00797		s51	Crystal Structure Analysis of Renin-indole-piperazine inhibitor complexes	3oqf	88.84	91.
299	RENI	Renin	P00797		s52	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oqk	89.67	420.
300	RENI	Renin	P00797		rx0	Alkyl Amine Renin Inhibitors: Filling S1 from S3	3q3t	88.52	37.
301	RENI	Renin	P00797		vyd	Human renin in complex with inhibitor 6	3vyd	82.27	406.
302	RENI	Renin	P00797		vye	Human renin in complex with inhibitor 7	3vye	81.85	7.7
303	RENI	Renin	P00797		vyf	Human renin in complex with inhibitor 9	3vyf	85.89	1.6
304	RENI	Renin	P00797		0lt	Crystal structure of renin in complex with NVP-BCA079 (compound 12a)	4gj7	91.48	170.
305	RENI	Renin	P00797		0m3	Crystal structure of renin in complex with NVP-AYL747 (compound 5)	4gja	85.24	1200.
306	RENI	Renin	P00797		0me	Crystal structure of renin in complex with NVP-BBV031 (compound 6)	4gjb	84.54	100000.
307	RENI	Renin	P00797		0mj	Crystal structure of renin in complex with NVP-BCH965 (compound 9)	4gjc	85.02	90.
308	RENI	Renin	P00797		2xf	Crystal structure of renin in complex with compound4	4pyv	82.02	200.
309	RENI	Renin	P00797		2y9	Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors	4q1n	86.73	0.2
310	RENI	Renin	P00797		43t	Renin in complex with (S)-1-(3-fluoro-5-(((S)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4s1g	88.02	0.6
311	RENI	Renin	P00797		70x	Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4xx3	88.62	56.
312	RENI	Renin	P00797		6vr	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5koq	90.29	0.58
313	RENI	Renin	P00797		6vu	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5kot	94.95	no data
314	RENI	Renin	P00797		74y	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sz9	89.13	38000.
315	RENI	Renin	P00797		74z	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy3	97.95	43000.
316	RENI	Renin	P00797		74v	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy2	91.42	11000.
317	RENI	Renin	P00797		74u	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sxn	91.89	11000.
318	RENI	Renin	P00797		70y	Renin in complex with (4S)-4-isopropyl-4-methyl-6-oxo-1-(3-(2-oxo-4-phenylpyrrolidin-1-yl)benzyl)tetrahydropyrimidin-2(1H)-iminium	4xx4	86.75	44.
319	RENI	Renin	P00797		0m2	Crystal structure of renin in complex with GP055321 (compound 4)	4gj9	92.62	500000.
320	RENI	Renin	P00797		liy	Crystal Structure of Human Renin Complexed with Inhibitors	2iku	85.83	79.
321	RENI	Renin	P00797		ua4	Human renin/PF02342674 complex	2i4q	83.09	no data
322	RENI	Renin	P00797		l1b	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g21	91.44	no data
323	RENI	Renin	P00797		4ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring	2g1s	83.43	no data
324	RENI	Renin	P00797		3ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring	2g1r	89.41	20.
325	RENI	Renin	P00797		2ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g1o	90.56	no data

The Ligandable Human Proteome

Peptidase family A1 domain