The Ligandable Human Proteome

SH2 domain

Index	Gene Name Primary	Protein Name	Gene Name Synonym	Uniprot ID
1	ABL1	Tyrosine-protein kinase ABL1	ABL JTK7	P00519
2	ABL2	Tyrosine-protein kinase ABL2	ABLL ARG	P42684
3	BCAR3	Breast cancer anti-estrogen resistance protein 3	NSP2 SH2D3B	O75815
4	BLK	Tyrosine-protein kinase Blk		P51451
5	BLNK	B-cell linker protein	BASH SLP65	Q8WV28
6	BMX	Cytoplasmic tyrosine-protein kinase BMX		P51813
7	BTK	Tyrosine-protein kinase BTK	AGMX1 ATK BPK	Q06187
8	CHN1	N-chimaerin	ARHGAP2 CHN	P15882
9	CHN2	Beta-chimaerin	ARHGAP3 BCH	P52757
10	CISH	Cytokine-inducible SH2-containing protein	G18	Q9NSE2
11	CLNK	Cytokine-dependent hematopoietic cell linker	MIST	Q7Z7G1
12	CRK	Adapter molecule crk		P46108
13	CRKL	Crk-like protein		P46109
14	CSK	Tyrosine-protein kinase CSK		P41240
15	DAPP1	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	BAM32	Q9UN19
16	FER	Tyrosine-protein kinase Fer	TYK3	P16591
17	FES	Tyrosine-protein kinase Fes/Fps	FPS	P07332
18	FGR	Tyrosine-protein kinase Fgr	SRC2	P09769
19	FRK	Tyrosine-protein kinase FRK	PTK5 RAK	P42685
20	FYN	Tyrosine-protein kinase Fyn		P06241
21	GRAP	GRB2-related adapter protein		Q13588
22	GRAP2	GRB2-related adapter protein 2	GADS GRB2L GRID	O75791
23	GRAPL	GRB2-related adapter protein-like		Q8TC17
24	GRB10	Growth factor receptor-bound protein 10	GRBIR KIAA0207	Q13322
25	GRB14	Growth factor receptor-bound protein 14		Q14449
26	GRB2	Growth factor receptor-bound protein 2	ASH	P62993
27	GRB7	Growth factor receptor-bound protein 7		Q14451
28	HCK	Tyrosine-protein kinase HCK		P08631
29	HSH2D	Hematopoietic SH2 domain-containing protein	ALX	Q96JZ2
30	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	SHIP SHIP1	Q92835
31	INPPL1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	SHIP2	O15357
32	ITK	Tyrosine-protein kinase ITK/TSK	EMT LYK	Q08881
33	JAK1	Tyrosine-protein kinase JAK1	JAK1A JAK1B	P23458
34	JAK2	Tyrosine-protein kinase JAK2		O60674
35	JAK3	Tyrosine-protein kinase JAK3		P52333
36	LCK	Tyrosine-protein kinase Lck		P06239
37	LCP2	Lymphocyte cytosolic protein 2		Q13094
38	LYN	Tyrosine-protein kinase Lyn	JTK8	P07948
39	MATK	Megakaryocyte-associated tyrosine-protein kinase	CTK HYL	P42679
40	NCK1	Cytoplasmic protein NCK1	NCK	P16333
41	NCK2	Cytoplasmic protein NCK2	GRB4	O43639
42	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	GRB1	P27986
43	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta		O00459
44	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma		Q92569
45	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1	P19174
46	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2		P16885
47	PTK6	Protein-tyrosine kinase 6	BRK	Q13882
48	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	PTP2C SHPTP2	Q06124
49	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	HCP PTP1C	P29350
50	RASA1	Ras GTPase-activating protein 1	GAP RASA	P20936
51	RIN1	Ras and Rab interactor 1		Q13671
52	RIN2	Ras and Rab interactor 2	RASSF4	Q8WYP3
53	RIN3	Ras and Rab interactor 3		Q8TB24
54	SH2B1	SH2B adapter protein 1	KIAA1299 SH2B	Q9NRF2
55	SH2B2	SH2B adapter protein 2	APS	O14492
56	SH2B3	SH2B adapter protein 3	LNK	Q9UQQ2
57	SH2D1A	SH2 domain-containing protein 1A	DSHP SAP	O60880
58	SH2D1B	SH2 domain-containing protein 1B	EAT2	O14796
59	SH2D2A	SH2 domain-containing protein 2A	SCAP TSAD VRAP	Q9NP31
60	SH2D3A	SH2 domain-containing protein 3A	NSP1	Q9BRG2
61	SH2D3C	SH2 domain-containing protein 3C	NSP3	Q8N5H7
62	SH2D4A	SH2 domain-containing protein 4A	PPP1R38 SH2A	Q9H788
63	SH2D4B	SH2 domain-containing protein 4B		Q5SQS7
64	SH2D5	SH2 domain-containing protein 5		Q6ZV89
65	SH2D6	SH2 domain-containing protein 6		Q7Z4S9
66	SH2D7	SH2 domain-containing protein 7		A6NKC9
67	SH3BP2	SH3 domain-binding protein 2	3BP2	P78314
68	SHB	SH2 domain-containing adapter protein B		Q15464
69	SHC1	SHC-transforming protein 1	SHC SHCA	P29353
70	SHC2	SHC-transforming protein 2	SCK SHCB	P98077
71	SHC3	SHC-transforming protein 3	NSHC SHCC	Q92529
72	SHC4	SHC-transforming protein 4	SHCD	Q6S5L8
73	SHD	SH2 domain-containing adapter protein D		Q96IW2
74	SHE	SH2 domain-containing adapter protein E		Q5VZ18
75	SHF	SH2 domain-containing adapter protein F		Q7M4L6
76	SLA	Src-like-adapter	SLAP SLAP1	Q13239
77	SLA2	Src-like-adapter 2	C20orf156 SLAP2	Q9H6Q3
78	SOCS1	Suppressor of cytokine signaling 1	SSI1 TIP3	O15524
79	SOCS2	Suppressor of cytokine signaling 2	CIS2 SSI2 STATI2	O14508
80	SOCS3	Suppressor of cytokine signaling 3	CIS3 SSI3	O14543
81	SOCS4	Suppressor of cytokine signaling 4	SOCS7	Q8WXH5
82	SOCS5	Suppressor of cytokine signaling 5	CIS6 CISH5 CISH6 KIAA0671	O75159
83	SOCS6	Suppressor of cytokine signaling 6	CIS4 SOCS4	O14544
84	SOCS7	Suppressor of cytokine signaling 7	NAP4 SOCS6	O14512
85	SRC	Proto-oncogene tyrosine-protein kinase Src	SRC1	P12931
86	SRMS	Tyrosine-protein kinase Srms	C20orf148	Q9H3Y6
87	STAP1	Signal-transducing adaptor protein 1	BRDG1	Q9ULZ2
88	STAP2	Signal-transducing adaptor protein 2	BKS	Q9UGK3
89	STAT1	Signal transducer and activator of transcription 1-alpha/beta		P42224
90	STAT2	Signal transducer and activator of transcription 2		P52630
91	STAT3	Signal transducer and activator of transcription 3	APRF	P40763
92	STAT4	Signal transducer and activator of transcription 4		Q14765
93	STAT5A	Signal transducer and activator of transcription 5A	STAT5	P42229
94	STAT5B	Signal transducer and activator of transcription 5B		P51692
95	STAT6	Signal transducer and activator of transcription 6		P42226
96	SUPT6H	Transcription elongation factor SPT6	KIAA0162 SPT6H	Q7KZ85
97	SYK	Tyrosine-protein kinase SYK		P43405
98	TEC	Tyrosine-protein kinase Tec	PSCTK4	P42680
99	TNS1	Tensin-1	TNS	Q9HBL0
100	TNS2	Tensin-2	KIAA1075 TENC1	Q63HR2
101	TNS3	Tensin-3	TEM6 TENS1 TPP	Q68CZ2
102	TNS4	Tensin-4	CTEN	Q8IZW8
103	TXK	Tyrosine-protein kinase TXK	PTK4 RLK	P42681
104	TYK2	Non-receptor tyrosine-protein kinase TYK2		P29597
105	VAV1	Proto-oncogene vav	VAV	P15498
106	VAV2	Guanine nucleotide exchange factor VAV2		P52735
107	VAV3	Guanine nucleotide exchange factor VAV3		Q9UKW4
108	YES1	Tyrosine-protein kinase Yes	YES	P07947
109	ZAP70	Tyrosine-protein kinase ZAP-70	SRK	P43403