| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | TRRAP | Transformation/transcription domain-associated protein | CERVIX | -1.341 | 3 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | THYROID | -1.838 | 3 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | PLEURA | -1.37 | 7 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | ENDOMETRIUM | -1.312 | 16 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | LIVER | -1.481 | 16 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | GANGLIA | -1.538 | 18 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | KIDNEY | -1.274 | 20 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | STOMACH | -1.465 | 20 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | BONE | -1.489 | 23 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | OESOPHAGUS | -1.544 | 24 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | INTESTINE | -1.482 | 25 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | PANCREAS | -1.468 | 26 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | BREAST | -1.461 | 28 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | SOFT_TISSUE | -1.472 | 31 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | SKIN | -1.382 | 36 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | OVARY | -1.447 | 36 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | SYSTEM | -1.369 | 44 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | TRACT | -1.497 | 53 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.422 | 58 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | LUNG | -1.471 | 73 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | THYROID | -1.275 | 3 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | CERVIX | -1.354 | 3 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | PLEURA | -1.221 | 7 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | ENDOMETRIUM | -1.271 | 16 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | LIVER | -1.388 | 16 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | GANGLIA | -1.316 | 18 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | KIDNEY | -1.23 | 20 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | STOMACH | -1.235 | 20 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | BONE | -1.298 | 23 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | OESOPHAGUS | -1.2 | 24 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | INTESTINE | -1.242 | 25 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | PANCREAS | -1.268 | 26 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | BREAST | -1.267 | 28 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | SOFT_TISSUE | -1.325 | 31 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | OVARY | -1.312 | 36 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | SKIN | -1.38 | 36 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | SYSTEM | -1.242 | 44 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | TRACT | -1.184 | 53 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.295 | 58 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | LUNG | -1.267 | 73 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | CERVIX | -1.228 | 3 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | PLEURA | -1.024 | 7 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | LIVER | -1.043 | 16 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | GANGLIA | -1.006 | 18 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | STOMACH | -1.034 | 20 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | KIDNEY | -1.069 | 20 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | OESOPHAGUS | -1.099 | 24 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | INTESTINE | -1.046 | 25 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | PANCREAS | -1.101 | 26 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | BREAST | -1.048 | 28 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | SOFT_TISSUE | -1.03 | 31 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | SKIN | -1.003 | 36 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | OVARY | -1.095 | 36 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | TRACT | -1.046 | 53 |
| 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | LUNG | -1.046 | 73 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | CERVIX | -1.238 | 3 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | LIVER | -1.019 | 16 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | ENDOMETRIUM | -1.11 | 16 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | STOMACH | -1.077 | 20 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | BONE | -1.047 | 23 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | OESOPHAGUS | -1.08 | 24 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | INTESTINE | -1.063 | 25 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | PANCREAS | -1.032 | 26 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | BREAST | -1.058 | 28 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | SOFT_TISSUE | -1.049 | 31 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | OVARY | -1.106 | 36 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | SYSTEM | -1.052 | 44 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | TRACT | -1.03 | 53 |
| 4 | PI4KA | Phosphatidylinositol 4-kinase alpha | LUNG | -1.062 | 73 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | CERVIX | -1.169 | 3 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | THYROID | -1.553 | 3 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | PLEURA | -1.347 | 7 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | ENDOMETRIUM | -1.169 | 16 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | LIVER | -1.496 | 16 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | GANGLIA | -1.386 | 18 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | STOMACH | -1.291 | 20 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | KIDNEY | -1.483 | 20 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | BONE | -1.329 | 23 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | OESOPHAGUS | -1.262 | 24 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | INTESTINE | -1.279 | 25 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | PANCREAS | -1.37 | 26 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | BREAST | -1.28 | 28 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | SOFT_TISSUE | -1.371 | 31 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | SKIN | -1.268 | 36 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | OVARY | -1.34 | 36 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | SYSTEM | -1.373 | 44 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | TRACT | -1.256 | 53 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.346 | 58 |
| 5 | MTOR | Serine/threonine-protein kinase mTOR | LUNG | -1.278 | 73 |