The Ligandable Human Proteome

JAB1/MPN/MOV34 metalloenzyme domain

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	COPS5	COP9 signalosome complex subunit 5	THYROID	-1.191	3
1	COPS5	COP9 signalosome complex subunit 5	CERVIX	-1.5	3
1	COPS5	COP9 signalosome complex subunit 5	PLEURA	-1.417	7
1	COPS5	COP9 signalosome complex subunit 5	ENDOMETRIUM	-1.43	16
1	COPS5	COP9 signalosome complex subunit 5	LIVER	-1.444	16
1	COPS5	COP9 signalosome complex subunit 5	GANGLIA	-1.379	18
1	COPS5	COP9 signalosome complex subunit 5	KIDNEY	-1.299	20
1	COPS5	COP9 signalosome complex subunit 5	STOMACH	-1.403	20
1	COPS5	COP9 signalosome complex subunit 5	BONE	-1.356	23
1	COPS5	COP9 signalosome complex subunit 5	OESOPHAGUS	-1.4	24
1	COPS5	COP9 signalosome complex subunit 5	INTESTINE	-1.5	25
1	COPS5	COP9 signalosome complex subunit 5	PANCREAS	-1.372	26
1	COPS5	COP9 signalosome complex subunit 5	BREAST	-1.442	28
1	COPS5	COP9 signalosome complex subunit 5	SOFT_TISSUE	-1.387	31
1	COPS5	COP9 signalosome complex subunit 5	SKIN	-1.326	36
1	COPS5	COP9 signalosome complex subunit 5	OVARY	-1.365	36
1	COPS5	COP9 signalosome complex subunit 5	SYSTEM	-1.388	44
1	COPS5	COP9 signalosome complex subunit 5	TRACT	-1.339	53
1	COPS5	COP9 signalosome complex subunit 5	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.387	59
1	COPS5	COP9 signalosome complex subunit 5	LUNG	-1.434	73
2	COPS6	COP9 signalosome complex subunit 6	CERVIX	-1.653	3
2	COPS6	COP9 signalosome complex subunit 6	THYROID	-1.717	3
2	COPS6	COP9 signalosome complex subunit 6	PLEURA	-1.728	7
2	COPS6	COP9 signalosome complex subunit 6	ENDOMETRIUM	-1.66	16
2	COPS6	COP9 signalosome complex subunit 6	LIVER	-1.685	16
2	COPS6	COP9 signalosome complex subunit 6	GANGLIA	-1.508	18
2	COPS6	COP9 signalosome complex subunit 6	KIDNEY	-1.6	20
2	COPS6	COP9 signalosome complex subunit 6	STOMACH	-1.694	20
2	COPS6	COP9 signalosome complex subunit 6	BONE	-1.511	23
2	COPS6	COP9 signalosome complex subunit 6	OESOPHAGUS	-1.642	24
2	COPS6	COP9 signalosome complex subunit 6	INTESTINE	-1.647	25
2	COPS6	COP9 signalosome complex subunit 6	PANCREAS	-1.589	26
2	COPS6	COP9 signalosome complex subunit 6	BREAST	-1.625	28
2	COPS6	COP9 signalosome complex subunit 6	SOFT_TISSUE	-1.579	31
2	COPS6	COP9 signalosome complex subunit 6	SKIN	-1.515	36
2	COPS6	COP9 signalosome complex subunit 6	OVARY	-1.641	36
2	COPS6	COP9 signalosome complex subunit 6	SYSTEM	-1.44	44
2	COPS6	COP9 signalosome complex subunit 6	TRACT	-1.647	53
2	COPS6	COP9 signalosome complex subunit 6	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.641	59
2	COPS6	COP9 signalosome complex subunit 6	LUNG	-1.631	73
3	PRPF8	Pre-mRNA-processing-splicing factor 8	THYROID	-1.589	3
3	PRPF8	Pre-mRNA-processing-splicing factor 8	CERVIX	-1.605	3
3	PRPF8	Pre-mRNA-processing-splicing factor 8	PLEURA	-1.579	7
3	PRPF8	Pre-mRNA-processing-splicing factor 8	LIVER	-1.7	16
3	PRPF8	Pre-mRNA-processing-splicing factor 8	ENDOMETRIUM	-1.842	16
3	PRPF8	Pre-mRNA-processing-splicing factor 8	GANGLIA	-1.673	18
3	PRPF8	Pre-mRNA-processing-splicing factor 8	STOMACH	-1.739	20
3	PRPF8	Pre-mRNA-processing-splicing factor 8	KIDNEY	-1.764	20
3	PRPF8	Pre-mRNA-processing-splicing factor 8	BONE	-1.685	23
3	PRPF8	Pre-mRNA-processing-splicing factor 8	OESOPHAGUS	-1.668	24
3	PRPF8	Pre-mRNA-processing-splicing factor 8	INTESTINE	-1.601	25
3	PRPF8	Pre-mRNA-processing-splicing factor 8	PANCREAS	-1.676	26
3	PRPF8	Pre-mRNA-processing-splicing factor 8	BREAST	-1.796	28
3	PRPF8	Pre-mRNA-processing-splicing factor 8	SOFT_TISSUE	-1.763	31
3	PRPF8	Pre-mRNA-processing-splicing factor 8	SKIN	-1.678	36
3	PRPF8	Pre-mRNA-processing-splicing factor 8	OVARY	-1.746	36
3	PRPF8	Pre-mRNA-processing-splicing factor 8	SYSTEM	-1.7	44
3	PRPF8	Pre-mRNA-processing-splicing factor 8	TRACT	-1.667	53
3	PRPF8	Pre-mRNA-processing-splicing factor 8	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.88	58
3	PRPF8	Pre-mRNA-processing-splicing factor 8	LUNG	-1.668	73
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	CERVIX	-1.958	3
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	THYROID	-2.232	3
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	PLEURA	-1.782	7
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	LIVER	-1.924	16
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	ENDOMETRIUM	-2.075	16
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	GANGLIA	-2.034	18
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	KIDNEY	-1.962	20
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	STOMACH	-2.014	20
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	BONE	-2.089	23
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	OESOPHAGUS	-1.97	24
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	INTESTINE	-1.914	25
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	PANCREAS	-2.007	26
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	BREAST	-2.027	28
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	SOFT_TISSUE	-1.952	31
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	OVARY	-2.035	36
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	SKIN	-2.066	36
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	SYSTEM	-1.914	44
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	TRACT	-1.912	53
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.211	58
4	PSMD7	26S proteasome non-ATPase regulatory subunit 7	LUNG	-1.922	73
5	EIF3H	Eukaryotic translation initiation factor 3 subunit H	LIVER	-1.033	16
5	EIF3H	Eukaryotic translation initiation factor 3 subunit H	GANGLIA	-1.153	18
5	EIF3H	Eukaryotic translation initiation factor 3 subunit H	INTESTINE	-1.041	25
5	EIF3H	Eukaryotic translation initiation factor 3 subunit H	SOFT_TISSUE	-1.022	31
5	EIF3H	Eukaryotic translation initiation factor 3 subunit H	SYSTEM	-1.004	44
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	THYROID	-1.624	3
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	CERVIX	-1.843	3
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	PLEURA	-1.652	7
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	LIVER	-1.799	16
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	ENDOMETRIUM	-1.844	16
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	GANGLIA	-1.959	18
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	KIDNEY	-1.747	20
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	STOMACH	-1.817	20
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	BONE	-1.84	23
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	OESOPHAGUS	-1.842	24
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	INTESTINE	-1.885	25
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	PANCREAS	-1.857	26
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	BREAST	-1.95	28
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	SOFT_TISSUE	-1.847	31
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	OVARY	-1.938	36
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	SKIN	-2.011	36
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	SYSTEM	-1.813	44
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	TRACT	-1.804	53
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.977	58
6	PSMD14	26S proteasome non-ATPase regulatory subunit 14	LUNG	-1.855	73
7	EIF3F	Eukaryotic translation initiation factor 3 subunit F	ENDOMETRIUM	-1.031	16
7	EIF3F	Eukaryotic translation initiation factor 3 subunit F	LIVER	-1.096	16
7	EIF3F	Eukaryotic translation initiation factor 3 subunit F	GANGLIA	-1.096	18
7	EIF3F	Eukaryotic translation initiation factor 3 subunit F	OESOPHAGUS	-1.002	24
7	EIF3F	Eukaryotic translation initiation factor 3 subunit F	SKIN	-1.019	36