| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SUPT16H | FACT complex subunit SPT16 | THYROID | -1.113 | 3 |
| 1 | SUPT16H | FACT complex subunit SPT16 | CERVIX | -1.13 | 3 |
| 1 | SUPT16H | FACT complex subunit SPT16 | PLEURA | -1.095 | 7 |
| 1 | SUPT16H | FACT complex subunit SPT16 | ENDOMETRIUM | -1.086 | 16 |
| 1 | SUPT16H | FACT complex subunit SPT16 | GANGLIA | -1.016 | 18 |
| 1 | SUPT16H | FACT complex subunit SPT16 | STOMACH | -1.022 | 20 |
| 1 | SUPT16H | FACT complex subunit SPT16 | KIDNEY | -1.207 | 20 |
| 1 | SUPT16H | FACT complex subunit SPT16 | BONE | -1.089 | 23 |
| 1 | SUPT16H | FACT complex subunit SPT16 | INTESTINE | -1.054 | 25 |
| 1 | SUPT16H | FACT complex subunit SPT16 | BREAST | -1.01 | 28 |
| 1 | SUPT16H | FACT complex subunit SPT16 | OVARY | -1.077 | 36 |
| 1 | SUPT16H | FACT complex subunit SPT16 | SKIN | -1.085 | 36 |
| 1 | SUPT16H | FACT complex subunit SPT16 | SYSTEM | -1.126 | 44 |
| 1 | SUPT16H | FACT complex subunit SPT16 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.11 | 58 |