| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | CERVIX | -1.019 | 3 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | ENDOMETRIUM | -1.039 | 16 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | LIVER | -1.041 | 16 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | BONE | -1.022 | 23 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | BREAST | -1.023 | 28 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | OVARY | -1.024 | 36 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.015 | 58 |