The Ligandable Human Proteome

Proteasome, subunit alpha/beta

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	PSMA6	Proteasome subunit alpha type-6	CERVIX	-1.768	3
1	PSMA6	Proteasome subunit alpha type-6	THYROID	-2	3
1	PSMA6	Proteasome subunit alpha type-6	PLEURA	-1.83	7
1	PSMA6	Proteasome subunit alpha type-6	LIVER	-1.966	16
1	PSMA6	Proteasome subunit alpha type-6	ENDOMETRIUM	-2.033	16
1	PSMA6	Proteasome subunit alpha type-6	GANGLIA	-1.953	18
1	PSMA6	Proteasome subunit alpha type-6	STOMACH	-1.923	20
1	PSMA6	Proteasome subunit alpha type-6	KIDNEY	-2.028	20
1	PSMA6	Proteasome subunit alpha type-6	BONE	-1.965	23
1	PSMA6	Proteasome subunit alpha type-6	OESOPHAGUS	-1.951	24
1	PSMA6	Proteasome subunit alpha type-6	INTESTINE	-1.959	25
1	PSMA6	Proteasome subunit alpha type-6	PANCREAS	-1.944	26
1	PSMA6	Proteasome subunit alpha type-6	BREAST	-2.033	28
1	PSMA6	Proteasome subunit alpha type-6	SOFT_TISSUE	-2.024	31
1	PSMA6	Proteasome subunit alpha type-6	SKIN	-1.96	36
1	PSMA6	Proteasome subunit alpha type-6	OVARY	-1.966	36
1	PSMA6	Proteasome subunit alpha type-6	SYSTEM	-1.992	44
1	PSMA6	Proteasome subunit alpha type-6	TRACT	-1.913	53
1	PSMA6	Proteasome subunit alpha type-6	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.136	58
1	PSMA6	Proteasome subunit alpha type-6	LUNG	-1.913	73
2	PSMB2	Proteasome subunit beta type-2	THYROID	-1.155	3
2	PSMB2	Proteasome subunit beta type-2	CERVIX	-1.208	3
2	PSMB2	Proteasome subunit beta type-2	PLEURA	-1.189	7
2	PSMB2	Proteasome subunit beta type-2	ENDOMETRIUM	-1.288	16
2	PSMB2	Proteasome subunit beta type-2	LIVER	-1.299	16
2	PSMB2	Proteasome subunit beta type-2	GANGLIA	-1.426	18
2	PSMB2	Proteasome subunit beta type-2	KIDNEY	-1.257	20
2	PSMB2	Proteasome subunit beta type-2	STOMACH	-1.263	20
2	PSMB2	Proteasome subunit beta type-2	BONE	-1.167	23
2	PSMB2	Proteasome subunit beta type-2	OESOPHAGUS	-1.229	24
2	PSMB2	Proteasome subunit beta type-2	INTESTINE	-1.247	25
2	PSMB2	Proteasome subunit beta type-2	PANCREAS	-1.214	26
2	PSMB2	Proteasome subunit beta type-2	BREAST	-1.286	28
2	PSMB2	Proteasome subunit beta type-2	SOFT_TISSUE	-1.31	31
2	PSMB2	Proteasome subunit beta type-2	SKIN	-1.215	36
2	PSMB2	Proteasome subunit beta type-2	OVARY	-1.216	36
2	PSMB2	Proteasome subunit beta type-2	SYSTEM	-1.234	44
2	PSMB2	Proteasome subunit beta type-2	TRACT	-1.209	53
2	PSMB2	Proteasome subunit beta type-2	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.353	58
2	PSMB2	Proteasome subunit beta type-2	LUNG	-1.251	73
3	PSMB3	Proteasome subunit beta type-3	CERVIX	-2.004	3
3	PSMB3	Proteasome subunit beta type-3	THYROID	-2.253	3
3	PSMB3	Proteasome subunit beta type-3	PLEURA	-1.914	7
3	PSMB3	Proteasome subunit beta type-3	LIVER	-2.058	16
3	PSMB3	Proteasome subunit beta type-3	ENDOMETRIUM	-2.187	16
3	PSMB3	Proteasome subunit beta type-3	GANGLIA	-2.154	18
3	PSMB3	Proteasome subunit beta type-3	KIDNEY	-2.032	20
3	PSMB3	Proteasome subunit beta type-3	STOMACH	-2.123	20
3	PSMB3	Proteasome subunit beta type-3	BONE	-2.003	23
3	PSMB3	Proteasome subunit beta type-3	OESOPHAGUS	-1.936	24
3	PSMB3	Proteasome subunit beta type-3	INTESTINE	-2.061	25
3	PSMB3	Proteasome subunit beta type-3	PANCREAS	-2.066	26
3	PSMB3	Proteasome subunit beta type-3	BREAST	-2.202	28
3	PSMB3	Proteasome subunit beta type-3	SOFT_TISSUE	-2.155	31
3	PSMB3	Proteasome subunit beta type-3	OVARY	-2.157	36
3	PSMB3	Proteasome subunit beta type-3	SKIN	-2.179	36
3	PSMB3	Proteasome subunit beta type-3	SYSTEM	-2.004	44
3	PSMB3	Proteasome subunit beta type-3	TRACT	-2.038	53
3	PSMB3	Proteasome subunit beta type-3	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.241	58
3	PSMB3	Proteasome subunit beta type-3	LUNG	-2.021	73
4	PSMB5	Proteasome subunit beta type-5	CERVIX	-1.67	3
4	PSMB5	Proteasome subunit beta type-5	THYROID	-1.676	3
4	PSMB5	Proteasome subunit beta type-5	PLEURA	-1.622	7
4	PSMB5	Proteasome subunit beta type-5	ENDOMETRIUM	-1.65	16
4	PSMB5	Proteasome subunit beta type-5	LIVER	-1.765	16
4	PSMB5	Proteasome subunit beta type-5	GANGLIA	-1.815	18
4	PSMB5	Proteasome subunit beta type-5	KIDNEY	-1.43	20
4	PSMB5	Proteasome subunit beta type-5	STOMACH	-1.717	20
4	PSMB5	Proteasome subunit beta type-5	BONE	-1.821	23
4	PSMB5	Proteasome subunit beta type-5	OESOPHAGUS	-1.641	24
4	PSMB5	Proteasome subunit beta type-5	INTESTINE	-1.688	25
4	PSMB5	Proteasome subunit beta type-5	PANCREAS	-1.602	26
4	PSMB5	Proteasome subunit beta type-5	BREAST	-1.673	28
4	PSMB5	Proteasome subunit beta type-5	SOFT_TISSUE	-1.61	31
4	PSMB5	Proteasome subunit beta type-5	SKIN	-1.581	36
4	PSMB5	Proteasome subunit beta type-5	OVARY	-1.674	36
4	PSMB5	Proteasome subunit beta type-5	SYSTEM	-1.661	44
4	PSMB5	Proteasome subunit beta type-5	TRACT	-1.543	53
4	PSMB5	Proteasome subunit beta type-5	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.178	58
4	PSMB5	Proteasome subunit beta type-5	LUNG	-1.669	73
5	PSMB6	Proteasome subunit beta type-6	CERVIX	-1.838	3
5	PSMB6	Proteasome subunit beta type-6	THYROID	-1.882	3
5	PSMB6	Proteasome subunit beta type-6	PLEURA	-1.589	7
5	PSMB6	Proteasome subunit beta type-6	LIVER	-1.794	16
5	PSMB6	Proteasome subunit beta type-6	ENDOMETRIUM	-1.953	16
5	PSMB6	Proteasome subunit beta type-6	GANGLIA	-2.02	18
5	PSMB6	Proteasome subunit beta type-6	KIDNEY	-1.553	20
5	PSMB6	Proteasome subunit beta type-6	STOMACH	-1.735	20
5	PSMB6	Proteasome subunit beta type-6	BONE	-1.694	23
5	PSMB6	Proteasome subunit beta type-6	OESOPHAGUS	-1.836	24
5	PSMB6	Proteasome subunit beta type-6	INTESTINE	-1.812	25
5	PSMB6	Proteasome subunit beta type-6	PANCREAS	-1.89	26
5	PSMB6	Proteasome subunit beta type-6	BREAST	-1.743	28
5	PSMB6	Proteasome subunit beta type-6	SOFT_TISSUE	-1.924	31
5	PSMB6	Proteasome subunit beta type-6	OVARY	-1.953	36
5	PSMB6	Proteasome subunit beta type-6	SKIN	-1.968	36
5	PSMB6	Proteasome subunit beta type-6	SYSTEM	-1.568	44
5	PSMB6	Proteasome subunit beta type-6	TRACT	-1.795	53
5	PSMB6	Proteasome subunit beta type-6	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.764	58
5	PSMB6	Proteasome subunit beta type-6	LUNG	-1.836	73
6	PSMB4	Proteasome subunit beta type-4	CERVIX	-1.514	3
6	PSMB4	Proteasome subunit beta type-4	THYROID	-1.81	3
6	PSMB4	Proteasome subunit beta type-4	PLEURA	-1.609	7
6	PSMB4	Proteasome subunit beta type-4	LIVER	-1.616	16
6	PSMB4	Proteasome subunit beta type-4	ENDOMETRIUM	-1.807	16
6	PSMB4	Proteasome subunit beta type-4	GANGLIA	-1.639	18
6	PSMB4	Proteasome subunit beta type-4	KIDNEY	-1.627	20
6	PSMB4	Proteasome subunit beta type-4	STOMACH	-1.71	20
6	PSMB4	Proteasome subunit beta type-4	BONE	-1.662	23
6	PSMB4	Proteasome subunit beta type-4	OESOPHAGUS	-1.695	24
6	PSMB4	Proteasome subunit beta type-4	INTESTINE	-1.678	25
6	PSMB4	Proteasome subunit beta type-4	PANCREAS	-1.686	26
6	PSMB4	Proteasome subunit beta type-4	BREAST	-1.604	28
6	PSMB4	Proteasome subunit beta type-4	SOFT_TISSUE	-1.721	31
6	PSMB4	Proteasome subunit beta type-4	OVARY	-1.676	36
6	PSMB4	Proteasome subunit beta type-4	SKIN	-1.713	36
6	PSMB4	Proteasome subunit beta type-4	SYSTEM	-1.662	44
6	PSMB4	Proteasome subunit beta type-4	TRACT	-1.697	53
6	PSMB4	Proteasome subunit beta type-4	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.782	58
6	PSMB4	Proteasome subunit beta type-4	LUNG	-1.615	73
7	PSMA5	Proteasome subunit alpha type-5	CERVIX	-1.456	3
7	PSMA5	Proteasome subunit alpha type-5	THYROID	-1.679	3
7	PSMA5	Proteasome subunit alpha type-5	PLEURA	-1.446	7
7	PSMA5	Proteasome subunit alpha type-5	LIVER	-1.548	16
7	PSMA5	Proteasome subunit alpha type-5	ENDOMETRIUM	-1.615	16
7	PSMA5	Proteasome subunit alpha type-5	GANGLIA	-1.672	18
7	PSMA5	Proteasome subunit alpha type-5	STOMACH	-1.633	20
7	PSMA5	Proteasome subunit alpha type-5	KIDNEY	-1.653	20
7	PSMA5	Proteasome subunit alpha type-5	BONE	-1.55	23
7	PSMA5	Proteasome subunit alpha type-5	OESOPHAGUS	-1.527	24
7	PSMA5	Proteasome subunit alpha type-5	INTESTINE	-1.536	25
7	PSMA5	Proteasome subunit alpha type-5	PANCREAS	-1.561	26
7	PSMA5	Proteasome subunit alpha type-5	BREAST	-1.667	28
7	PSMA5	Proteasome subunit alpha type-5	SOFT_TISSUE	-1.649	31
7	PSMA5	Proteasome subunit alpha type-5	OVARY	-1.609	36
7	PSMA5	Proteasome subunit alpha type-5	SKIN	-1.689	36
7	PSMA5	Proteasome subunit alpha type-5	SYSTEM	-1.626	44
7	PSMA5	Proteasome subunit alpha type-5	TRACT	-1.543	53
7	PSMA5	Proteasome subunit alpha type-5	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.723	58
7	PSMA5	Proteasome subunit alpha type-5	LUNG	-1.584	73
8	PSMA4	Proteasome subunit alpha type-4	THYROID	-1.166	3
8	PSMA4	Proteasome subunit alpha type-4	CERVIX	-1.4	3
8	PSMA4	Proteasome subunit alpha type-4	PLEURA	-1.308	7
8	PSMA4	Proteasome subunit alpha type-4	ENDOMETRIUM	-1.387	16
8	PSMA4	Proteasome subunit alpha type-4	LIVER	-1.418	16
8	PSMA4	Proteasome subunit alpha type-4	GANGLIA	-1.497	18
8	PSMA4	Proteasome subunit alpha type-4	KIDNEY	-1.389	20
8	PSMA4	Proteasome subunit alpha type-4	STOMACH	-1.456	20
8	PSMA4	Proteasome subunit alpha type-4	BONE	-1.479	23
8	PSMA4	Proteasome subunit alpha type-4	OESOPHAGUS	-1.264	24
8	PSMA4	Proteasome subunit alpha type-4	INTESTINE	-1.349	25
8	PSMA4	Proteasome subunit alpha type-4	PANCREAS	-1.367	26
8	PSMA4	Proteasome subunit alpha type-4	BREAST	-1.415	28
8	PSMA4	Proteasome subunit alpha type-4	SOFT_TISSUE	-1.475	31
8	PSMA4	Proteasome subunit alpha type-4	SKIN	-1.419	36
8	PSMA4	Proteasome subunit alpha type-4	OVARY	-1.474	36
8	PSMA4	Proteasome subunit alpha type-4	SYSTEM	-1.442	44
8	PSMA4	Proteasome subunit alpha type-4	TRACT	-1.378	53
8	PSMA4	Proteasome subunit alpha type-4	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.479	58
8	PSMA4	Proteasome subunit alpha type-4	LUNG	-1.34	73
9	PSMA3	Proteasome subunit alpha type-3	CERVIX	-1.827	3
9	PSMA3	Proteasome subunit alpha type-3	THYROID	-1.844	3
9	PSMA3	Proteasome subunit alpha type-3	PLEURA	-1.86	7
9	PSMA3	Proteasome subunit alpha type-3	LIVER	-1.996	16
9	PSMA3	Proteasome subunit alpha type-3	ENDOMETRIUM	-2.026	16
9	PSMA3	Proteasome subunit alpha type-3	GANGLIA	-2.102	18
9	PSMA3	Proteasome subunit alpha type-3	STOMACH	-1.986	20
9	PSMA3	Proteasome subunit alpha type-3	KIDNEY	-2.068	20
9	PSMA3	Proteasome subunit alpha type-3	BONE	-1.951	23
9	PSMA3	Proteasome subunit alpha type-3	OESOPHAGUS	-1.902	24
9	PSMA3	Proteasome subunit alpha type-3	INTESTINE	-2.014	25
9	PSMA3	Proteasome subunit alpha type-3	PANCREAS	-2.002	26
9	PSMA3	Proteasome subunit alpha type-3	BREAST	-2.015	28
9	PSMA3	Proteasome subunit alpha type-3	SOFT_TISSUE	-2.049	31
9	PSMA3	Proteasome subunit alpha type-3	OVARY	-1.957	36
9	PSMA3	Proteasome subunit alpha type-3	SKIN	-2.042	36
9	PSMA3	Proteasome subunit alpha type-3	SYSTEM	-1.971	44
9	PSMA3	Proteasome subunit alpha type-3	TRACT	-1.888	53
9	PSMA3	Proteasome subunit alpha type-3	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.142	58
9	PSMA3	Proteasome subunit alpha type-3	LUNG	-1.881	73
10	PSMA2	Proteasome subunit alpha type-2	CERVIX	-1.547	3
10	PSMA2	Proteasome subunit alpha type-2	THYROID	-1.783	3
10	PSMA2	Proteasome subunit alpha type-2	PLEURA	-1.512	7
10	PSMA2	Proteasome subunit alpha type-2	LIVER	-1.468	16
10	PSMA2	Proteasome subunit alpha type-2	ENDOMETRIUM	-1.681	16
10	PSMA2	Proteasome subunit alpha type-2	GANGLIA	-1.638	18
10	PSMA2	Proteasome subunit alpha type-2	STOMACH	-1.559	20
10	PSMA2	Proteasome subunit alpha type-2	KIDNEY	-1.589	20
10	PSMA2	Proteasome subunit alpha type-2	BONE	-1.625	23
10	PSMA2	Proteasome subunit alpha type-2	OESOPHAGUS	-1.503	24
10	PSMA2	Proteasome subunit alpha type-2	INTESTINE	-1.57	25
10	PSMA2	Proteasome subunit alpha type-2	PANCREAS	-1.512	26
10	PSMA2	Proteasome subunit alpha type-2	BREAST	-1.646	28
10	PSMA2	Proteasome subunit alpha type-2	SOFT_TISSUE	-1.656	31
10	PSMA2	Proteasome subunit alpha type-2	SKIN	-1.602	36
10	PSMA2	Proteasome subunit alpha type-2	OVARY	-1.637	36
10	PSMA2	Proteasome subunit alpha type-2	SYSTEM	-1.601	44
10	PSMA2	Proteasome subunit alpha type-2	TRACT	-1.553	53
10	PSMA2	Proteasome subunit alpha type-2	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.765	58
10	PSMA2	Proteasome subunit alpha type-2	LUNG	-1.56	73
11	PSMA1	Proteasome subunit alpha type-1	CERVIX	-1.662	3
11	PSMA1	Proteasome subunit alpha type-1	THYROID	-1.794	3
11	PSMA1	Proteasome subunit alpha type-1	PLEURA	-1.867	7
11	PSMA1	Proteasome subunit alpha type-1	ENDOMETRIUM	-1.841	16
11	PSMA1	Proteasome subunit alpha type-1	LIVER	-1.853	16
11	PSMA1	Proteasome subunit alpha type-1	GANGLIA	-1.995	18
11	PSMA1	Proteasome subunit alpha type-1	STOMACH	-1.833	20
11	PSMA1	Proteasome subunit alpha type-1	KIDNEY	-1.918	20
11	PSMA1	Proteasome subunit alpha type-1	BONE	-1.872	23
11	PSMA1	Proteasome subunit alpha type-1	OESOPHAGUS	-1.811	24
11	PSMA1	Proteasome subunit alpha type-1	INTESTINE	-1.81	25
11	PSMA1	Proteasome subunit alpha type-1	PANCREAS	-1.808	26
11	PSMA1	Proteasome subunit alpha type-1	BREAST	-1.972	28
11	PSMA1	Proteasome subunit alpha type-1	SOFT_TISSUE	-1.898	31
11	PSMA1	Proteasome subunit alpha type-1	SKIN	-1.923	36
11	PSMA1	Proteasome subunit alpha type-1	OVARY	-1.959	36
11	PSMA1	Proteasome subunit alpha type-1	SYSTEM	-1.892	44
11	PSMA1	Proteasome subunit alpha type-1	TRACT	-1.842	53
11	PSMA1	Proteasome subunit alpha type-1	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.046	58
11	PSMA1	Proteasome subunit alpha type-1	LUNG	-1.84	73
12	PSMA7	Proteasome subunit alpha type-7	CERVIX	-1.178	3
12	PSMA7	Proteasome subunit alpha type-7	THYROID	-1.424	3
12	PSMA7	Proteasome subunit alpha type-7	PLEURA	-1.503	7
12	PSMA7	Proteasome subunit alpha type-7	LIVER	-1.497	16
12	PSMA7	Proteasome subunit alpha type-7	ENDOMETRIUM	-1.562	16
12	PSMA7	Proteasome subunit alpha type-7	GANGLIA	-1.493	18
12	PSMA7	Proteasome subunit alpha type-7	STOMACH	-1.456	20
12	PSMA7	Proteasome subunit alpha type-7	KIDNEY	-1.506	20
12	PSMA7	Proteasome subunit alpha type-7	BONE	-1.423	23
12	PSMA7	Proteasome subunit alpha type-7	OESOPHAGUS	-1.44	24
12	PSMA7	Proteasome subunit alpha type-7	INTESTINE	-1.481	25
12	PSMA7	Proteasome subunit alpha type-7	PANCREAS	-1.47	26
12	PSMA7	Proteasome subunit alpha type-7	BREAST	-1.537	28
12	PSMA7	Proteasome subunit alpha type-7	SOFT_TISSUE	-1.503	31
12	PSMA7	Proteasome subunit alpha type-7	OVARY	-1.496	36
12	PSMA7	Proteasome subunit alpha type-7	SKIN	-1.518	36
12	PSMA7	Proteasome subunit alpha type-7	SYSTEM	-1.471	44
12	PSMA7	Proteasome subunit alpha type-7	TRACT	-1.425	53
12	PSMA7	Proteasome subunit alpha type-7	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.699	58
12	PSMA7	Proteasome subunit alpha type-7	LUNG	-1.515	73