| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | THYROID | -1.108 | 3 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | CERVIX | -1.355 | 3 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | PLEURA | -1.175 | 7 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | LIVER | -1.32 | 16 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | ENDOMETRIUM | -1.353 | 16 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | GANGLIA | -1.303 | 18 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | KIDNEY | -1.271 | 20 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | STOMACH | -1.403 | 20 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | BONE | -1.305 | 23 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | OESOPHAGUS | -1.327 | 24 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | INTESTINE | -1.343 | 25 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | PANCREAS | -1.278 | 26 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | BREAST | -1.325 | 28 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | SOFT_TISSUE | -1.299 | 31 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | SKIN | -1.308 | 36 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | OVARY | -1.375 | 36 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | SYSTEM | -1.262 | 44 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | TRACT | -1.248 | 53 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.403 | 58 |
| 1 | USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | LUNG | -1.284 | 73 |