| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | THYROID | -1.16 | 3 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | CERVIX | -1.264 | 3 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | PLEURA | -1.117 | 7 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | ENDOMETRIUM | -1.091 | 16 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | LIVER | -1.217 | 16 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | GANGLIA | -1.203 | 18 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | STOMACH | -1.129 | 20 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | KIDNEY | -1.218 | 20 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | BONE | -1.211 | 23 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | OESOPHAGUS | -1.352 | 24 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | INTESTINE | -1.26 | 25 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | PANCREAS | -1.206 | 26 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | BREAST | -1.268 | 28 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | SOFT_TISSUE | -1.181 | 31 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | OVARY | -1.18 | 36 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | SKIN | -1.284 | 36 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | SYSTEM | -1.201 | 44 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | TRACT | -1.263 | 53 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.108 | 58 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | LUNG | -1.218 | 73 |