The Ligandable Human Proteome

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	TARS2	Threonine--tRNA ligase, mitochondrial	LIVER	-1.007	16
1	TARS2	Threonine--tRNA ligase, mitochondrial	STOMACH	-1.072	20
1	TARS2	Threonine--tRNA ligase, mitochondrial	OESOPHAGUS	-1.151	24
1	TARS2	Threonine--tRNA ligase, mitochondrial	INTESTINE	-1.069	25
1	TARS2	Threonine--tRNA ligase, mitochondrial	BREAST	-1.081	28
1	TARS2	Threonine--tRNA ligase, mitochondrial	SOFT_TISSUE	-1.002	31
1	TARS2	Threonine--tRNA ligase, mitochondrial	TRACT	-1.092	53
1	TARS2	Threonine--tRNA ligase, mitochondrial	LUNG	-1.107	73
2	SARS	Serine--tRNA ligase, cytoplasmic	THYROID	-1.82	3
2	SARS	Serine--tRNA ligase, cytoplasmic	CERVIX	-2.16	3
2	SARS	Serine--tRNA ligase, cytoplasmic	PLEURA	-1.695	7
2	SARS	Serine--tRNA ligase, cytoplasmic	ENDOMETRIUM	-1.904	16
2	SARS	Serine--tRNA ligase, cytoplasmic	LIVER	-2.007	16
2	SARS	Serine--tRNA ligase, cytoplasmic	GANGLIA	-2.042	18
2	SARS	Serine--tRNA ligase, cytoplasmic	STOMACH	-1.948	20
2	SARS	Serine--tRNA ligase, cytoplasmic	KIDNEY	-1.998	20
2	SARS	Serine--tRNA ligase, cytoplasmic	BONE	-2.022	23
2	SARS	Serine--tRNA ligase, cytoplasmic	OESOPHAGUS	-2.036	24
2	SARS	Serine--tRNA ligase, cytoplasmic	INTESTINE	-1.965	25
2	SARS	Serine--tRNA ligase, cytoplasmic	PANCREAS	-1.969	26
2	SARS	Serine--tRNA ligase, cytoplasmic	BREAST	-2.024	28
2	SARS	Serine--tRNA ligase, cytoplasmic	SOFT_TISSUE	-2.015	31
2	SARS	Serine--tRNA ligase, cytoplasmic	OVARY	-2.012	36
2	SARS	Serine--tRNA ligase, cytoplasmic	SKIN	-2.017	36
2	SARS	Serine--tRNA ligase, cytoplasmic	SYSTEM	-1.893	44
2	SARS	Serine--tRNA ligase, cytoplasmic	TRACT	-1.908	53
2	SARS	Serine--tRNA ligase, cytoplasmic	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.032	58
2	SARS	Serine--tRNA ligase, cytoplasmic	LUNG	-1.965	73
3	GARS	Glycine--tRNA ligase	THYROID	-1.162	3
3	GARS	Glycine--tRNA ligase	CERVIX	-1.243	3
3	GARS	Glycine--tRNA ligase	ENDOMETRIUM	-1.134	16
3	GARS	Glycine--tRNA ligase	LIVER	-1.169	16
3	GARS	Glycine--tRNA ligase	GANGLIA	-1.168	18
3	GARS	Glycine--tRNA ligase	STOMACH	-1.075	20
3	GARS	Glycine--tRNA ligase	BONE	-1.201	23
3	GARS	Glycine--tRNA ligase	OESOPHAGUS	-1.164	24
3	GARS	Glycine--tRNA ligase	INTESTINE	-1.132	25
3	GARS	Glycine--tRNA ligase	PANCREAS	-1.067	26
3	GARS	Glycine--tRNA ligase	BREAST	-1.144	28
3	GARS	Glycine--tRNA ligase	SOFT_TISSUE	-1.114	31
3	GARS	Glycine--tRNA ligase	OVARY	-1.166	36
3	GARS	Glycine--tRNA ligase	SKIN	-1.234	36
3	GARS	Glycine--tRNA ligase	SYSTEM	-1.056	44
3	GARS	Glycine--tRNA ligase	TRACT	-1.093	53
3	GARS	Glycine--tRNA ligase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.17	59
3	GARS	Glycine--tRNA ligase	LUNG	-1.117	73
4	TARS	Threonine--tRNA ligase, cytoplasmic	CERVIX	-1.4	3
4	TARS	Threonine--tRNA ligase, cytoplasmic	THYROID	-1.606	3
4	TARS	Threonine--tRNA ligase, cytoplasmic	PLEURA	-1.653	7
4	TARS	Threonine--tRNA ligase, cytoplasmic	LIVER	-1.679	16
4	TARS	Threonine--tRNA ligase, cytoplasmic	ENDOMETRIUM	-1.687	16
4	TARS	Threonine--tRNA ligase, cytoplasmic	GANGLIA	-1.708	18
4	TARS	Threonine--tRNA ligase, cytoplasmic	STOMACH	-1.566	20
4	TARS	Threonine--tRNA ligase, cytoplasmic	KIDNEY	-1.69	20
4	TARS	Threonine--tRNA ligase, cytoplasmic	BONE	-1.569	23
4	TARS	Threonine--tRNA ligase, cytoplasmic	OESOPHAGUS	-1.606	24
4	TARS	Threonine--tRNA ligase, cytoplasmic	INTESTINE	-1.689	25
4	TARS	Threonine--tRNA ligase, cytoplasmic	PANCREAS	-1.606	26
4	TARS	Threonine--tRNA ligase, cytoplasmic	BREAST	-1.659	28
4	TARS	Threonine--tRNA ligase, cytoplasmic	SOFT_TISSUE	-1.674	31
4	TARS	Threonine--tRNA ligase, cytoplasmic	SKIN	-1.654	36
4	TARS	Threonine--tRNA ligase, cytoplasmic	OVARY	-1.674	36
4	TARS	Threonine--tRNA ligase, cytoplasmic	SYSTEM	-1.643	44
4	TARS	Threonine--tRNA ligase, cytoplasmic	TRACT	-1.54	53
4	TARS	Threonine--tRNA ligase, cytoplasmic	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.666	58
4	TARS	Threonine--tRNA ligase, cytoplasmic	LUNG	-1.59	73
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	CERVIX	-1.141	3
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	THYROID	-1.295	3
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	PLEURA	-1.162	7
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	ENDOMETRIUM	-1.151	16
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	LIVER	-1.163	16
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	GANGLIA	-1.237	18
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	KIDNEY	-1.064	20
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	STOMACH	-1.254	20
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	BONE	-1.184	23
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	OESOPHAGUS	-1.196	24
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	INTESTINE	-1.196	25
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	PANCREAS	-1.195	26
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	BREAST	-1.128	28
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	SOFT_TISSUE	-1.192	31
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	SKIN	-1.167	36
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	OVARY	-1.171	36
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	SYSTEM	-1.195	44
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	TRACT	-1.231	53
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.155	59
5	EPRS	Bifunctional glutamate/proline--tRNA ligase	LUNG	-1.172	73