| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | TOP2A | DNA topoisomerase 2-alpha | CERVIX | -1.765 | 3 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | THYROID | -1.902 | 3 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | PLEURA | -1.485 | 7 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | ENDOMETRIUM | -1.499 | 16 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | LIVER | -1.613 | 16 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | GANGLIA | -1.641 | 18 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | KIDNEY | -1.598 | 20 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | STOMACH | -1.631 | 20 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | BONE | -1.636 | 23 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | OESOPHAGUS | -1.671 | 24 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | INTESTINE | -1.6 | 25 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | PANCREAS | -1.655 | 26 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | BREAST | -1.651 | 28 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | SOFT_TISSUE | -1.672 | 31 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | SKIN | -1.602 | 36 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | OVARY | -1.629 | 36 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | SYSTEM | -1.621 | 44 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | TRACT | -1.641 | 53 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.61 | 58 |
| 1 | TOP2A | DNA topoisomerase 2-alpha | LUNG | -1.624 | 73 |