| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | ACTR10 | Actin-related protein 10 | PLEURA | -1.039 | 7 |
| 1 | ACTR10 | Actin-related protein 10 | GANGLIA | -1.017 | 18 |
| 1 | ACTR10 | Actin-related protein 10 | KIDNEY | -1.021 | 20 |
| 1 | ACTR10 | Actin-related protein 10 | BONE | -1.035 | 23 |
| 1 | ACTR10 | Actin-related protein 10 | SYSTEM | -1.004 | 44 |
| 2 | ACTR8 | Actin-related protein 8 | CERVIX | -1.073 | 3 |
| 2 | ACTR8 | Actin-related protein 8 | PLEURA | -1.054 | 7 |
| 2 | ACTR8 | Actin-related protein 8 | LIVER | -1.015 | 16 |
| 2 | ACTR8 | Actin-related protein 8 | ENDOMETRIUM | -1.099 | 16 |
| 2 | ACTR8 | Actin-related protein 8 | GANGLIA | -1.073 | 18 |
| 2 | ACTR8 | Actin-related protein 8 | KIDNEY | -1.095 | 20 |
| 2 | ACTR8 | Actin-related protein 8 | INTESTINE | -1.077 | 25 |
| 2 | ACTR8 | Actin-related protein 8 | PANCREAS | -1.078 | 26 |
| 2 | ACTR8 | Actin-related protein 8 | BREAST | -1.004 | 28 |
| 2 | ACTR8 | Actin-related protein 8 | SOFT_TISSUE | -1.025 | 31 |
| 2 | ACTR8 | Actin-related protein 8 | SKIN | -1.036 | 36 |
| 2 | ACTR8 | Actin-related protein 8 | OVARY | -1.041 | 36 |
| 2 | ACTR8 | Actin-related protein 8 | TRACT | -1.067 | 53 |
| 2 | ACTR8 | Actin-related protein 8 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.035 | 59 |
| 2 | ACTR8 | Actin-related protein 8 | LUNG | -1.021 | 73 |
| 3 | ACTR6 | Actin-related protein 6 | THYROID | -1.042 | 3 |
| 3 | ACTR6 | Actin-related protein 6 | CERVIX | -1.119 | 3 |
| 3 | ACTR6 | Actin-related protein 6 | PLEURA | -1.094 | 7 |
| 3 | ACTR6 | Actin-related protein 6 | ENDOMETRIUM | -1.099 | 16 |
| 3 | ACTR6 | Actin-related protein 6 | GANGLIA | -1.126 | 18 |
| 3 | ACTR6 | Actin-related protein 6 | STOMACH | -1.058 | 20 |
| 3 | ACTR6 | Actin-related protein 6 | KIDNEY | -1.131 | 20 |
| 3 | ACTR6 | Actin-related protein 6 | BONE | -1.108 | 23 |
| 3 | ACTR6 | Actin-related protein 6 | SKIN | -1.029 | 36 |
| 3 | ACTR6 | Actin-related protein 6 | OVARY | -1.088 | 36 |
| 3 | ACTR6 | Actin-related protein 6 | SYSTEM | -1.101 | 44 |
| 3 | ACTR6 | Actin-related protein 6 | TRACT | -1.095 | 53 |
| 3 | ACTR6 | Actin-related protein 6 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.016 | 59 |
| 4 | ACTR1A | Alpha-centractin | GANGLIA | -1.147 | 18 |
| 4 | ACTR1A | Alpha-centractin | KIDNEY | -1.045 | 20 |
| 4 | ACTR1A | Alpha-centractin | BONE | -1.062 | 23 |
| 4 | ACTR1A | Alpha-centractin | OESOPHAGUS | -1.193 | 24 |
| 4 | ACTR1A | Alpha-centractin | BREAST | -1.065 | 28 |
| 4 | ACTR1A | Alpha-centractin | SOFT_TISSUE | -1.034 | 31 |
| 4 | ACTR1A | Alpha-centractin | SKIN | -1.029 | 36 |
| 4 | ACTR1A | Alpha-centractin | SYSTEM | -1.095 | 44 |
| 4 | ACTR1A | Alpha-centractin | TRACT | -1.17 | 53 |
| 4 | ACTR1A | Alpha-centractin | LUNG | -1.047 | 73 |
| 5 | ACTR2 | Actin-related protein 2 | CERVIX | -1.113 | 3 |
| 5 | ACTR2 | Actin-related protein 2 | THYROID | -1.403 | 3 |
| 5 | ACTR2 | Actin-related protein 2 | PLEURA | -1.332 | 7 |
| 5 | ACTR2 | Actin-related protein 2 | ENDOMETRIUM | -1.328 | 16 |
| 5 | ACTR2 | Actin-related protein 2 | LIVER | -1.341 | 16 |
| 5 | ACTR2 | Actin-related protein 2 | GANGLIA | -1.115 | 18 |
| 5 | ACTR2 | Actin-related protein 2 | KIDNEY | -1.239 | 20 |
| 5 | ACTR2 | Actin-related protein 2 | STOMACH | -1.325 | 20 |
| 5 | ACTR2 | Actin-related protein 2 | BONE | -1.101 | 23 |
| 5 | ACTR2 | Actin-related protein 2 | OESOPHAGUS | -1.234 | 24 |
| 5 | ACTR2 | Actin-related protein 2 | INTESTINE | -1.32 | 25 |
| 5 | ACTR2 | Actin-related protein 2 | PANCREAS | -1.237 | 26 |
| 5 | ACTR2 | Actin-related protein 2 | BREAST | -1.158 | 28 |
| 5 | ACTR2 | Actin-related protein 2 | SOFT_TISSUE | -1.164 | 31 |
| 5 | ACTR2 | Actin-related protein 2 | OVARY | -1.26 | 36 |
| 5 | ACTR2 | Actin-related protein 2 | SKIN | -1.322 | 36 |
| 5 | ACTR2 | Actin-related protein 2 | SYSTEM | -1.218 | 44 |
| 5 | ACTR2 | Actin-related protein 2 | TRACT | -1.265 | 53 |
| 5 | ACTR2 | Actin-related protein 2 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.19 | 59 |
| 5 | ACTR2 | Actin-related protein 2 | LUNG | -1.164 | 73 |
| 6 | ACTL6A | Actin-like protein 6A | CERVIX | -1.327 | 3 |
| 6 | ACTL6A | Actin-like protein 6A | THYROID | -1.481 | 3 |
| 6 | ACTL6A | Actin-like protein 6A | PLEURA | -1.483 | 7 |
| 6 | ACTL6A | Actin-like protein 6A | ENDOMETRIUM | -1.394 | 16 |
| 6 | ACTL6A | Actin-like protein 6A | LIVER | -1.491 | 16 |
| 6 | ACTL6A | Actin-like protein 6A | GANGLIA | -1.216 | 18 |
| 6 | ACTL6A | Actin-like protein 6A | KIDNEY | -1.29 | 20 |
| 6 | ACTL6A | Actin-like protein 6A | STOMACH | -1.405 | 20 |
| 6 | ACTL6A | Actin-like protein 6A | BONE | -1.563 | 23 |
| 6 | ACTL6A | Actin-like protein 6A | OESOPHAGUS | -1.22 | 24 |
| 6 | ACTL6A | Actin-like protein 6A | INTESTINE | -1.47 | 25 |
| 6 | ACTL6A | Actin-like protein 6A | PANCREAS | -1.341 | 26 |
| 6 | ACTL6A | Actin-like protein 6A | BREAST | -1.44 | 28 |
| 6 | ACTL6A | Actin-like protein 6A | SOFT_TISSUE | -1.464 | 31 |
| 6 | ACTL6A | Actin-like protein 6A | OVARY | -1.371 | 36 |
| 6 | ACTL6A | Actin-like protein 6A | SKIN | -1.427 | 36 |
| 6 | ACTL6A | Actin-like protein 6A | SYSTEM | -1.431 | 44 |
| 6 | ACTL6A | Actin-like protein 6A | TRACT | -1.318 | 53 |
| 6 | ACTL6A | Actin-like protein 6A | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.479 | 59 |
| 6 | ACTL6A | Actin-like protein 6A | LUNG | -1.362 | 73 |